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Your search keyword '"Alexandre Barthelme"' showing total 5 results
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5 results on '"Alexandre Barthelme"'

1. Scope of the Desulfinylative Palladium-Catalyzed Cross-Coupling of Aryl Sulfinates with Aryl Bromides

Author

Alexandre Barthelme, Steven Rioux, Sara Aly, Brigitte Desharnais, Pat Forgione, and Dirk H. Ortgies

Subjects
Reaction mechanism, Denticity, Scope (project management), Ligand, Aryl, Organic Chemistry, chemistry.chemical_element, Combinatorial chemistry, Catalysis, chemistry.chemical_compound, chemistry, Phosphine, Palladium
Abstract

Herein is described the full scope of a desulfinylative cross-coupling of aryl sulfinates with aryl bromides. Optimized conditions were established and a bidentate phosphine ligand was found to be the key in obtaining good cross-coupling yields. Preliminary efforts to elucidate the reaction mechanism suggest that a Pd(0)-catalyzed mechanism is operative.

Published
2013
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3. ChemInform Abstract: Scope of the Desulfinylative Palladium-Catalyzed Cross-Coupling of Aryl Sulfinates with Aryl Bromides

Author

Steven Rioux, Brigitte Desharnais, Sara Aly, Alexandre Barthelme, Dirk H. Ortgies, and Pat Forgione

Subjects
Coupling (electronics), chemistry.chemical_compound, chemistry, Scope (project management), Aryl, chemistry.chemical_element, General Medicine, Photochemistry, Combinatorial chemistry, Catalysis, Palladium
Abstract

Optimized conditions are developed to provide the synthesis of biphenyls by Pd(0)-catalyzed coupling.

Published
2013
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4. Combining two-directional synthesis and tandem reactions: a short formal synthesis of halichlorine

Author

Robert A. Stockman, Alexandre Barthelme, Marie-Lyne Alcaraz, Annabella F. Newton, Camille Gignoux, and William Lewis

Subjects
Formal synthesis, Alkaloids, Cascade reaction, Tandem, Chemistry, Halichlorine, Yield (chemistry), Organic Chemistry, Spiro Compounds, Physical and Theoretical Chemistry, Biochemistry, Combinatorial chemistry
Abstract

A short and efficient synthesis of an advanced intermediate (1) in the Clive route to halichlorine has been achieved in 12 steps and 13.2% yield by a combined two-directional synthesis/tandem reaction strategy.

Published
2011

5. A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine

Author

Ian R. Mellor, Robert A. Stockman, David Richards, and Alexandre Barthelme

Subjects
Xenovenine, Patch-Clamp Techniques, Cell Survival, Stereochemistry, Stereoisomerism, Reductive amination, Catalysis, Cell Line, Tumor, Materials Chemistry, Humans, Organic chemistry, Receptors, Cholinergic, Pyrrolizidine Alkaloids, Cell survival, Amination, Biological evaluation, Neurons, Chemistry, Alkaloid, Metals and Alloys, Oxidation reduction, General Chemistry, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Ceramics and Composites, Oxidation-Reduction
Abstract

Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.

Published
2013
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