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A two-directional approach to pyrrolizidines: total syntheses and biological evaluation of alkaloid cis-223B and (±)-xenovenine
- Source :
- Chemical Communications. 49:10507
- Publication Year :
- 2013
- Publisher :
- Royal Society of Chemistry (RSC), 2013.
-
Abstract
- Total syntheses of alkaloid cis-223B and xenovenine are reported in 3 and 4 steps respectively using a two-directional synthesis/triple reductive amination strategy, and their neurotoxic properties assessed.
- Subjects :
- Xenovenine
Patch-Clamp Techniques
Cell Survival
Stereochemistry
Stereoisomerism
Reductive amination
Catalysis
Cell Line, Tumor
Materials Chemistry
Humans
Organic chemistry
Receptors, Cholinergic
Pyrrolizidine Alkaloids
Cell survival
Amination
Biological evaluation
Neurons
Chemistry
Alkaloid
Metals and Alloys
Oxidation reduction
General Chemistry
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Oxidation-Reduction
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....f9928183b33d38d75f660c3c29d72c07
- Full Text :
- https://doi.org/10.1039/c3cc46800c