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Your search keyword '"F. Craig Stevens"' showing total 2 results
Start Over Author "F. Craig Stevens" Topic chemical synthesis
2 results on '"F. Craig Stevens"'

1. Potent oxindole based human β3 adrenergic receptor agonists

Author

Droste Christine A, Cynthia Darshini Jesudason, Frank C. Tinsley, Aidas Kriauciunas, Anthony G. Borel, F. Craig Stevens, Mark L. Heiman, Marlene L. Cohen, William E. Bloomquist, and Daniel Jon Sall

Subjects
Agonist, medicine.medical_specialty, Indoles, medicine.drug_class, Clinical Biochemistry, Drug Evaluation, Preclinical, Pharmaceutical Science, Adrenergic, Adrenergic beta-3 Receptor Agonists, CHO Cells, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Cricetulus, Cricetinae, Tachycardia, Internal medicine, Drug Discovery, medicine, Animals, Humans, Moiety, Rats, Long-Evans, Oxindole, cardiovascular diseases, Receptor, Molecular Biology, Molecular Structure, Organic Chemistry, Adrenergic beta-Agonists, Alpha-1A adrenergic receptor, Oxindoles, Rats, Disease Models, Animal, Endocrinology, chemistry, Receptors, Adrenergic, beta-3, cardiovascular system, Molecular Medicine
Abstract

The synthesis and biological evaluation of a series of oxindole beta(3) adrenergic receptor agonists is described. A modulation of rat atrial tachycardia was observed with substitution at the 3-position of the oxindole moiety.

Published
2007

2. Synthesis and SAR of novel histamine H3 receptor antagonists

Author

Samuel W. Oldham, M. Joelle Dill, Brian Morgan Watson, Craig W. Lindsley, Don Richard Finley, Dana Sindelar, Lisa Selsam Beavers, Cynthia Darshini Jesudason, Philip Arthur Hipskind, Robert Alan Gadski, Ajay Singh, Christopher Stephen Siedem, Jeffrey W Cramer, R. Todd Pickard, and F. Craig Stevens

Subjects
Stereochemistry, Clinical Biochemistry, Substituent, Drug Evaluation, Preclinical, Pharmaceutical Science, Biochemistry, Chemical synthesis, chemistry.chemical_compound, Structure-Activity Relationship, Tetrahydroisoquinolines, Drug Discovery, Structure–activity relationship, Animals, Humans, Receptors, Histamine H3, Receptor, Molecular Biology, Molecular Structure, Tetrahydroisoquinoline, Organic Chemistry, Biological activity, Azepines, Rats, chemistry, Molecular Medicine, Histamine H3 receptor, Selectivity
Abstract

The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H(3) receptors are reported.

Published
2006

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