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Synthesis and SAR of novel histamine H3 receptor antagonists
- Source :
- Bioorganicmedicinal chemistry letters. 16(13)
- Publication Year :
- 2006
-
Abstract
- The synthesis and biological evaluation of novel tetrahydroisoquinoline, tetrahydroquinoline, and tetrahydroazepine antagonists of the human and rat H(3) receptors are described. The substitution around these rings as well as the nature of the substituent on nitrogen is explored. Several compounds with high affinity and selectivity for the human and rat H(3) receptors are reported.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Substituent
Drug Evaluation, Preclinical
Pharmaceutical Science
Biochemistry
Chemical synthesis
chemistry.chemical_compound
Structure-Activity Relationship
Tetrahydroisoquinolines
Drug Discovery
Structure–activity relationship
Animals
Humans
Receptors, Histamine H3
Receptor
Molecular Biology
Molecular Structure
Tetrahydroisoquinoline
Organic Chemistry
Biological activity
Azepines
Rats
chemistry
Molecular Medicine
Histamine H3 receptor
Selectivity
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 16
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....0ac411e9c4aa2b7b111ec41de2547f44