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A one-pot synthesis of new oxindole-fused polycyclic scaffolds is reported. The process involves a three-component [3+2] cycloaddition followed by cyclization through an intramolecular Michael addition. The reaction gives easy access to oxindole-fused spirotetrahydrofurochromans in moderate to good yields with high regio- and diastereoselectivity. These compounds could be useful for for drug discovery. Further modification was achieved by reduction of the nitro group, and intramolecular amide formation to give the corresponding lactams. The resulting heterocyclic products show good inhibitory activity against the enzyme PTP1B in vitro. [ABSTRACT FROM AUTHOR]

The chiral RhI-diene-catalyzed asymmetric three-component reaction of aryldiazoacetates, aromatic amines, and β-nitroacrylates was achieved to obtain γ-nitro-α-amino-succinates in good yields and with high diastereo- and enantioselectivity. This reaction is proposed to proceed through the enantioselective trapping of RhI-associated ammonium ylides by nitroacrylates. This new transformation represents the first example of RhI-carbene-induced ylide transformation. [ABSTRACT FROM AUTHOR]

Abstract: A three-component reaction based on trapping of ammonium ylides with formaldehyde was first reported. This reaction offers a new strategy for the synthesis of α-aryl serine derivatives and can be extended to the preparation of α-aryl threonine derivatives. Synthetic application of the three component reaction for the preparation of hydroquinoxaline derivative was also demonstrated. [Copyright &y& Elsevier]

The article presents chemical equations related to the article on the synthesis of Aryl Serine derivatives by C. Wang and colleagues, published in the "Tetrahedron" in 2013.

The article mentions the advancement of chiral bronsted acids as cooperative catalysts for multicomponent and cascade reactions, published in the 2013 issue of "Asian Journal of Organic Chemistry."

Abstract: Three-component reactions of aryl diazoacetates, arylamines and N-sulfonyl aldimines cooperatively catalyzed by squaramides and dirhodium acetate are reported to afford N-sulfonyl α,β-diamino acid derivatives in moderate to good yields and diastereoselectivity. [Copyright &y& Elsevier]

An iron porphyrin-catalyzed three-component reaction of ethyl diazoacetate with aliphatic amines and β,γ-unsaturated α-keto esters is reported. The use of iron porphyrin catalyst allows aliphatic amines to be used as the substrate without encountering catalyst poisoning issue and a series of β-hydroxy-α-amino esters are produced in high yields with excellent regioselectivities. [ABSTRACT FROM AUTHOR]

The article presents information on a chemical reaction for construction of chiral hydroxy-amino acid derivatives.

The first example of chiral secondary amine and iridium(I) co-catalyzed enantioselective three-component reaction of aryldiazoacetates, indoles and enals is developed to afford 3-substituted indole derivatives in good yields and with moderate diastereoselectivity as well as excellent enantioselectivity. [ABSTRACT FROM AUTHOR]

Ammonium ylides generated in situ from aryldiazo acetates and arylamines undergo Mannich-type reaction with N-sulfonyl aldimines to produce α,β-diamino acid derivatives. [ABSTRACT FROM AUTHOR]

The structure of the product (IVd) is confirmed by X-ray analysis. [ABSTRACT FROM AUTHOR]