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Your search keyword '"Gridley, Thomas"' showing total 2 results
Start Over Author "Gridley, Thomas" Topic cellular signal transduction Topic notch genes
2 results on '"Gridley, Thomas"'

1. Notch Signaling during Oogenesis in Drosophila melanogaster.

Author

Jingxia Xu and Gridley, Thomas

Subjects
*OOGENESIS, *NOTCH genes, *CELLULAR signal transduction, *DROSOPHILA melanogaster, *INSECT reproduction, *EMBRYOLOGY, *CELL differentiation, *STEM cells
Abstract

The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism that is required for embryonic development, cell fate specification, and stem cell maintenance. Discovered and studied initially in Drosophila melanogaster, the Notch pathway is conserved and functionally active throughout the animal kingdom. In this paper, we summarize the biochemical mechanisms of Notch signaling and describe its role in regulating one particular developmental pathway, oogenesis in Drosophila [ABSTRACT FROM AUTHOR]

Published
2012
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2. Notch signaling regulates left-right asymmetry determination by inducing Nodal expression.

Author

Krebs, Luke T., Iwai, Naomi, Nonaka, Shigenori, Welsh, Ian C., Yu Lan, Rulang Jiang, Saijoh, Yukio, O'Brien, Timothy P., Hamada, Hiroshi, and Gridley, Thomas

Subjects
*NOTCH genes, *GENE expression, *CELLULAR signal transduction, *PHYSIOLOGY, *GENETIC regulation
Abstract

Investigates the role of Notch signaling pathway in the establishment of left-right asymmetry in mice. Regulation of Nodal gene expression; Physiology of the Notch signaling pathway; Presence of Nodal cilia in DII1 mutant embryos; Significance of Nodal gene expression to the determination of left-right axis.

Published
2003
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