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Your search keyword '"Leandro Augusto Barbosa"' showing total 2 results
Start Over Author "Leandro Augusto Barbosa" Topic cell line, tumor
2 results on '"Leandro Augusto Barbosa"'

1. Cytotoxicity of AMANTADIG - a semisynthetic digitoxigenin derivative - alone and in combination with docetaxel in human hormone-refractory prostate cancer cells and its effect on Na

Author

Izabella Thaís, Silva, Jennifer, Munkert, Elke, Nolte, Naira Fernanda Zanchett, Schneider, Sayonarah Carvalho, Rocha, Ana Carolina Pacheco, Ramos, Wolfgang, Kreis, Fernão Castro, Braga, Rodrigo Maia, de Pádua, Alex G, Taranto, Vanessa, Cortes, Leandro Augusto, Barbosa, Sven, Wach, Helge, Taubert, and Cláudia Maria Oliveira, Simões

Subjects
Male, Cell Survival, Survivin, Cell Cycle, Prostatic Neoplasms, Apoptosis, Drug Synergism, Docetaxel, Gene Expression Regulation, Neoplastic, Molecular Docking Simulation, Necrosis, Cell Line, Tumor, Humans, RNA, Messenger, Sodium-Potassium-Exchanging ATPase, Digitoxigenin, Cell Proliferation
Abstract

Cardiac glycosides (CGs) are natural compounds used to treat congestive heart failure. They have garnered attention as a potential cancer treatment option, especially because they bind to Na

Published
2018

2. Effects of digoxin and Na, K-ATPase immunoexpression on human oral squamous carcinomas

Author

Aline Lauda Freitas, Chaves, Priscila Oliveira, De Lima, João Marcos Arantes, Soares, Hélio Batista, Dos Santos, Ana Gabriela, Silva, Luciana Vieira, Muniz, Fábio Vieira, Dos Santos, Michele Conceição, Pereira, Rosy Iara Maciel, De Azambuja Ribeiro, and Leandro Augusto, Barbosa

Subjects
Digoxin, Protein Subunits, Cell Survival, Risk Factors, Cell Line, Tumor, Carcinoma, Squamous Cell, Humans, Mouth Neoplasms, Enzyme Inhibitors, Neoplasm Grading, Sodium-Potassium-Exchanging ATPase, Neoplasm Staging
Abstract

The present study evaluated the expression of α1 and β1 Na,K-ATPase, as well as the effects of digoxin (DGX) on oral squamous cell carcinomas (OSCCs).Immunohistochemical expression of α1 and β1 Na,K-ATPase were evaluated in 60 patients who underwent treatment at the São João de Deus Hospital. SCC-25 viability was assessed by the colorimetric assay. Chi-square or Fisher's exact tests were used to analyze the association of α1 and β1 Na,K-ATPase expression with the variables.Immunoexpression of α1 and β1 Na,K-ATPase were observed in 28% and 55% of the tumors, however these proteins were not significant prognostic factors. Tobacco was significantly associated with α1 expression. SCC-25 viability decreased significantly after treatment with 1 μM DGX at 24 h.The smoking status of OSCC patients was significantly associated with α1 expression and DGX affected the SCC-25 viability in a dose- and duration-dependent manner.

Published
2014

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