1. KLF-1 orchestrates a xenobiotic detoxification program essential for longevity of mitochondrial mutants
- Author
-
Linda Baumann, Marija Herholz, Aleksandra Trifunovic, Alexandra Kukat, Estela Cepeda, Karolina Szczepanowska, Victor Pavlenko, Peter Frommolt, Johannes Hermeling, and Sarah Maciej
- Subjects
Male ,0301 basic medicine ,Somatic cell ,media_common.quotation_subject ,Science ,Longevity ,Kruppel-Like Transcription Factors ,General Physics and Astronomy ,02 engineering and technology ,urologic and male genital diseases ,Article ,General Biochemistry, Genetics and Molecular Biology ,Xenobiotics ,03 medical and health sciences ,chemistry.chemical_compound ,Mediator ,Detoxification ,Animals ,heterocyclic compounds ,Caenorhabditis elegans ,Caenorhabditis elegans Proteins ,lcsh:Science ,media_common ,Cell Nucleus ,Multidisciplinary ,biology ,Effector ,organic chemicals ,Cytochrome P450 ,General Chemistry ,respiratory system ,021001 nanoscience & nanotechnology ,Mitochondria ,3. Good health ,Cell biology ,Ageing ,enzymes and coenzymes (carbohydrates) ,030104 developmental biology ,chemistry ,Mitochondrial biogenesis ,Inactivation, Metabolic ,biology.protein ,Female ,lcsh:Q ,0210 nano-technology ,Xenobiotic - Abstract
Most manipulations that extend lifespan also increase resistance to various stress factors and environmental cues in a range of animals from yeast to mammals. However, the underlying molecular mechanisms regulating stress resistance during aging are still largely unknown. Here we identify Krüppel-like factor 1 (KLF-1) as a mediator of a cytoprotective response that dictates longevity induced by reduced mitochondrial function. A redox-regulated KLF-1 activation and transfer to the nucleus coincides with the peak of somatic mitochondrial biogenesis that occurs around a transition from larval stage L3 to D1. We further show that KLF-1 activates genes involved in the xenobiotic detoxification programme and identified cytochrome P450 oxidases, the KLF-1 main effectors, as longevity-assurance factors of mitochondrial mutants. Collectively, these findings underline the importance of the xenobiotic detoxification in the mitohormetic, longevity assurance pathway and identify KLF-1 as a central factor in orchestrating this response., Cytochrome P450 oxidases (CYPs) are enzymes that participate in the xenobiotic detoxification and their expression is enhanced in long-lived model organisms. Here the authors show that KLF-1 promotes cyp expression and ensures lifespan extension in C. elegans mitomutants by activating mitohormesis.
- Published
- 2019