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DAF-16/FoxO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage
- Source :
- Nature cell biology, Mueller, M M, Castells-Roca, L, Babu, V, Ermolaeva, M A, Mueller, R-U, Frommolt, P, Williams, A B, Greiss, S, Schneider, J I, Benzing, T, Schermer, B & Schumacher, B 2014, ' DAF-16/FOXO and EGL-27/GATA promote developmental growth in response to persistent somatic DNA damage ', Nature Cell Biology, vol. 16, no. 12, pp. 1168–1179 . https://doi.org/10.1038/ncb3071
- Publication Year :
- 2014
-
Abstract
- Genome maintenance defects cause complex disease phenotypes characterized by developmental failure, cancer susceptibility and premature ageing. It remains poorly understood how DNA damage responses function during organismal development and maintain tissue functionality when DNA damage accumulates with ageing. Here we show that the FOXO transcription factor DAF-16 is activated in response to DNA damage during development, whereas the DNA damage responsiveness of DAF-16 declines with ageing. We find that in contrast to its established role in mediating starvation arrest, DAF-16 alleviates DNA-damage-induced developmental arrest and even in the absence of DNA repair promotes developmental growth and enhances somatic tissue functionality. We demonstrate that the GATA transcription factor EGL-27 co-regulates DAF-16 target genes in response to DNA damage and together with DAF-16 promotes developmental growth. We propose that EGL-27/GATA activity specifies DAF-16-mediated DNA damage responses to enable developmental progression and to prolong tissue functioning when DNA damage persists.
- Subjects :
- Paraquat
Aging
DNA Repair
DNA repair
DNA damage
PROTEIN
Biology
Article
PATHWAY
Animals, Genetically Modified
Transcription (biology)
Animals
TRANSCRIPTION
LONGEVITY
Caenorhabditis elegans
Caenorhabditis elegans Proteins
Gene
Transcription factor
INDUCED APOPTOSIS
GENE-EXPRESSION
LIFE-SPAN
NEMATODE CAENORHABDITIS-ELEGANS
2. Zero hunger
Regulation of gene expression
Herbicides
fungi
Gene Expression Regulation, Developmental
Forkhead Transcription Factors
Cell Biology
Cell biology
DNA-Binding Proteins
NUCLEOTIDE EXCISION-REPAIR
C-ELEGANS
GATA transcription factor
Nucleotide excision repair
DNA Damage
Signal Transduction
Transcription Factors
Subjects
Details
- Language :
- English
- ISSN :
- 14764679 and 14657392
- Volume :
- 16
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Nature cell biology
- Accession number :
- edsair.doi.dedup.....58af1758a5b2b8bfde585cbe44bc71b7