1. Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer.
- Author
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Ellinger, Jörg, Kahl, Philip, von der Gathen, Johannes, Heukamp, Lukas C., Gütgemann, Ines, Walter, Bernhard, Hofstädter, Ferdinand, Bastian, Patrick J., von Ruecker, Alexander, Müller, Stefan C., and Rogenhofer, Sebastian
- Subjects
PROSTATE cancer ,METASTASIS ,HISTONES ,METHYLATION ,CASTRATION ,CANCER relapse ,SEMINAL vesicles ,STATISTICAL correlation - Abstract
Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 2012
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