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Global Histone H3K27 Methylation Levels are Different in Localized and Metastatic Prostate Cancer.
- Source :
- Cancer Investigation; Feb2012, Vol. 30 Issue 2, p92-97, 6p
- Publication Year :
- 2012
-
Abstract
- Global histone modification patterns have been shown to be a predictive factor of recurrence in various cancers. We analyzed global histone-3-lysine-27 (H3K27) methylation in prostate cancer (PCA) tissues. H3K27 mono-, di-, and tri-methylation patterns were different in nonmalignant prostate tissue, localized PCA, metastatic PCA, and castration-resistant PCA. H3K27 mono-methylation was correlated with pT-stage, capsular penetration, seminal vesicle infiltration, and Gleason score in localized PCA and may therefore indicate adverse prognosis. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 07357907
- Volume :
- 30
- Issue :
- 2
- Database :
- Complementary Index
- Journal :
- Cancer Investigation
- Publication Type :
- Academic Journal
- Accession number :
- 70359304
- Full Text :
- https://doi.org/10.3109/07357907.2011.636117