7 results on '"Inaba, Shinji"'
Search Results
2. Restricted left atrial dilatation can visually differentiate cardiac amyloidosis from hypertrophic cardiomyopathy.
- Author
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Higashi H, Inoue K, Inaba S, Nakao Y, Kinoshita M, Miyazaki S, Miyoshi T, Akazawa Y, Kawakami H, Uetani T, Aono J, Nagai T, Nishimura K, Ikeda S, Saito M, and Yamaguchi O
- Subjects
- Dilatation, Humans, Reproducibility of Results, Retrospective Studies, Amyloidosis complications, Amyloidosis diagnosis, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnosis
- Abstract
Aims: Cardiac amyloidosis (CA) is an infiltrative myocardial disease that occasionally mimics hypertrophic cardiomyopathy (HCM). The aim of this study is to investigate the discriminatory ability of visual assessment of left atrial (LA) function between CA and HCM on echocardiography., Methods and Results: In total, 93 patients with cardiac magnetic resonance imaging (CMR)-confirmed HCM and 34 with cardiac biopsy-confirmed CA were retrospectively assessed. LA dilatation was assessed via echocardiography in an apical four-chamber view. Visual assessment was performed to identify LA dilatation grade (preserved = 1, abnormal = 2, and restricted = 3) based on the extent of outward expansion in the LA reservoir phase. Regarding the reproducibility of visually assessing LA dilatation grade, the kappa values between intra- and inter-observer measurements were 0.82 and 0.70, respectively. Of 127 participants, 57 (45%), 42 (33%), and 28 (22%) presented with LA dilatation Grades 1, 2, and 3, respectively. All 57 patients with preserved LA dilatation (Grade 1) had HCM, and 20 of 28 patients (71%) with restricted LA dilatation (Grade 3) presented with CA. Patients with CA had a higher LA dilatation grade than those with HCM (P < 0.01). LA emptying fraction and reservoir strain were also quantitatively evaluated. The area under the curves of LA dilatation grade (0.88) and LA emptying fraction (0.88) for differentiation of these two diseases were higher than that of LA reservoir strain (0.73) (P < 0.01, respectively). During follow-up, nine patients with HCM and 16 with CA experienced cardiac event (cardiac death or hospitalization due to heart failure). In Kaplan-Meier analysis including both groups of HCM and CA, the incidence of cardiac events was higher in patients with restricted LA dilatation than in those with preserved or abnormal LA dilatation (log-rank test, P < 0.01)., Conclusions: Restricted LA dilatation is an indicator for the diagnosis of CA. Further, visual assessment of abnormal LA motion may facilitate diagnosis in patients with CA and high-risk patients with HCM., (© 2021 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of European Society of Cardiology.)
- Published
- 2021
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3. Clinical significance of global two-dimensional strain as a surrogate parameter of myocardial fibrosis and cardiac events in patients with hypertrophic cardiomyopathy.
- Author
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Saito M, Okayama H, Yoshii T, Higashi H, Morioka H, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Shigematsu Y, Hamada M, and Higaki J
- Subjects
- Cardiomyopathy, Hypertrophic diagnostic imaging, Cardiomyopathy, Hypertrophic physiopathology, Contrast Media, Endomyocardial Fibrosis diagnostic imaging, Endomyocardial Fibrosis physiopathology, Female, Humans, Male, Middle Aged, Prognosis, Regression Analysis, Cardiomyopathy, Hypertrophic complications, Cardiomyopathy, Hypertrophic diagnosis, Echocardiography, Doppler, Endomyocardial Fibrosis complications, Endomyocardial Fibrosis diagnosis, Magnetic Resonance Imaging
- Abstract
Aims: Late gadolinium enhancement (LGE) on contrast-enhanced magnetic resonance imaging (MRI) in hypertrophic cardiomyopathy (HCM) has been reported to be associated with myocardial fibrosis and cardiac events. In patients with HCM, two-dimensional (2D) strain can identify subclinical global systolic dysfunction despite normal left ventricular (LV) chamber function. Therefore, this study tested the hypothesis that global 2D strain could detect subtle myocardial fibrosis and serve as a novel prognostic parameter in HCM patients., Methods and Results: Echocardiography and MRI were performed in 48 consecutive patients with HCM and normal chamber function. We measured global longitudinal strain (GLS) in apical two-chamber, four-chamber, and long-axis views using speckle-tracking analysis. The extent of LGE (%LGE = LGE volume/total LV volume) and LV mass index were calculated by MRI using Simpson's rule and custom software. All patients were followed up for major cardiac events. Global longitudinal strain in patients with LGE was significantly lower than that without LGE (-11.8 ± 2.8 vs. -15.0 ± 1.7%, P < 0.001). Multivariate analysis showed that GLS was an independent predictor of %LGE (standard coefficient = 0.627, P < 0.001). During a mean follow-up period of 42 ± 12 months, five patients had cardiac events. When the patients were stratified based on the median level of GLS (-12.9%), all events were observed in the worse GLS group (P = 0.018)., Conclusion: These results suggest that global 2D strain might provide useful information on myocardial fibrosis and cardiac events in HCM patients with normal chamber function.
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- 2012
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4. The differences in left ventricular torsional behavior between patients with hypertrophic cardiomyopathy and hypertensive heart disease.
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Saito M, Okayama H, Yoshii T, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Ohtsuka T, Funada J, Shigematsu Y, and Higaki J
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- Aged, Cardiomyopathy, Hypertrophic diagnosis, Female, Heart Diseases diagnosis, Heart Diseases physiopathology, Humans, Hypertension diagnosis, Hypertrophy, Left Ventricular diagnosis, Male, Middle Aged, Torsion Abnormality diagnosis, Ventricular Dysfunction, Left diagnosis, Ventricular Dysfunction, Left physiopathology, Cardiomyopathy, Hypertrophic physiopathology, Hypertension physiopathology, Hypertrophy, Left Ventricular physiopathology, Torsion Abnormality physiopathology
- Abstract
Background: The aim of this study was to investigate the differences in left ventricular (LV) twisting behavior between patients with hypertrophic cardiomyopathy (HCM) and hypertensive heart disease (HHD)., Methods: Forty-four patients with HCM (mean age, 63±15 years), 35 patients with HHD (mean age, 63±13 years) and 20 age and sex-matched control subjects were evaluated. After a standard echocardiographic examination, LV twist and twisting velocity profiles from apical and basal short-axis images were analyzed using two-dimensional speckle tracking imaging., Results: LV diastolic and systolic dimensions, and ejection fraction were not significantly different among the groups. LV mass index and early diastolic mitral annular velocity were not significantly different between the HCM and HHD groups. The peak torsion in the HCM and HHD groups was significantly greater than that in the control group. The peak untwisting velocity in the HCM group was comparable with that in the control group. However, when the peak untwisting velocity was corrected by peak torsion, this ratio was significantly decreased in the HCM group compared with the values in the HHD and control groups. The time to peak untwisting velocity in the HCM group was significantly longer than the values in the HHD and control groups., Conclusions: These results suggest that enhanced peak torsion in HCM may improve untwisting behavior, but this mechanism fails to fully compensate for impaired untwisting behavior compared with HHD., (Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.)
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- 2011
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5. Myocardial fibrosis attenuates the effect of cibenzoline on left ventricular diastolic function in patients with hypertrophic cardiomyopathy.
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Saito M, Okayama H, Yoshii T, Hiasa G, Sumimoto T, Inaba S, Nishimura K, Inoue K, Ogimoto A, Shigematsu Y, Funada J, Hamada M, and Higaki J
- Subjects
- Cardiomyopathy, Hypertrophic physiopathology, Diastole drug effects, Diastole physiology, Female, Fibrosis, Humans, Imidazoles pharmacology, Male, Middle Aged, Cardiomyopathy, Hypertrophic drug therapy, Cardiomyopathy, Hypertrophic pathology, Imidazoles therapeutic use, Myocardium pathology, Ventricular Function, Left drug effects, Ventricular Function, Left physiology
- Abstract
The aim of this study was to investigate the relationship between late gadolinium enhancement (LGE) and the effect of cibenzoline (CBZ) on left ventricular (LV) diastolic function in hypertrophic cardiomyopathy (HCM) patients. Echocardiography before and after intravenous CBZ (1.4 mg/kg over 5 minutes) and magnetic resonance imaging (MRI) were performed in 22 consecutive patients with HCM [mean age: 65 ± 14 years, obstructive HCM: 14, nonobstructive HCM (HNCM): 8]. The extent of LGE (%LGE = LGE volume/total LV volume) was obtained by contrast-enhanced MRI using custom software. LGE was observed in 19 patients (mean %LGE = 5.1% ± 3.9%). The propagation velocity of LV early filling flow (Vp) increased significantly in patients with obstructive HCM (26 ± 7 to 36 ± 14 cm/s, P = 0.001) and nonobstructive HCM (25 ± 9 to 36 ± 16 cm/s, P = 0.007). A significant negative correlation was observed between the change in Vp and %LGE in patients with HCM (r = 20.542, P = 0.009). Less extensive myocardial fibrosis, as demonstrated by LGE on contrast-enhanced MRI, may predict the ability of CBZ to improve LV diastolic function in HCM.
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- 2011
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6. Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles.
- Author
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Hamada M, Aono J, Ikeda S, Watanabe K, Inaba S, Suzuki J, Ohtsuka T, and Shigematsu Y
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- Aged, Anti-Arrhythmia Agents administration & dosage, Anti-Arrhythmia Agents blood, Atrial Natriuretic Factor blood, Blood Pressure drug effects, Blood Pressure physiology, Catecholamines blood, Female, Humans, Imidazoles administration & dosage, Imidazoles blood, Infusions, Intravenous, Laser-Doppler Flowmetry, Male, Middle Aged, Anti-Arrhythmia Agents therapeutic use, Cardiomyopathy, Hypertrophic drug therapy, Cardiomyopathy, Hypertrophic physiopathology, Imidazoles therapeutic use, Ventricular Dysfunction, Left drug therapy, Ventricular Dysfunction, Left physiopathology
- Abstract
Background: Cibenzoline is able to improve left ventricular (LV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), but the exact mechanism remains to be determined., Methods and Results: The present study was designed to elucidate the effect of intravenous administration of 1.4 mg/kg of cibenzoline on aortic and LV pressures, and transmitral Doppler flow pattern in 7 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 9 patients with hypertrophic nonobstructive cardiomyopathy (HNCM). Before and at the end of the administration, aortic and LV pressures, LV pressure gradient (LVPG) and transmitral Doppler velocity profiles were examined. After the administration of cibenzoline, LV minimal and end-diastolic pressures decreased from 9+/-4 mmHg to 1+/-5 mmHg (p=0.0049) and from 22+/-7 mmHg to 14+/-5 mmHg (p=0.0106) in patients with HOCM, and from 9+/-5 mmHg to 5+/-3 mmHg (p=0.0036) and from 20+/-6 mmHg to 14+/-3 mmHg (p=0.0033) in patients with HNCM. LVPG decreased in all patients with HOCM. E-wave velocity increased, A-wave velocity decreased, and thus the E/A ratio increased from 0.77+/-0.29 to 1.20+/-0.48 (p=0.0004)., Conclusions: Reduction of LV diastolic pressures by intravenous administration of cibenzoline may be related to an improvement in the E/A ratio in patients with HCM.
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- 2007
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7. Antiarrhythmic drug cibenzoline attenuates left ventricular pressure gradient and improves transmitral Doppler flow pattern in patients with hypertrophic obstructive cardiomyopathy caused by midventricular obstruction.
- Author
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Hamada M, Shigematsu Y, Inaba S, Aono J, Ikeda S, Watanabe K, Ogimoto A, Ohtsuka T, Hara Y, and Higaki J
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- Aged, Blood Flow Velocity drug effects, Blood Pressure drug effects, Cardiomyopathy, Hypertrophic etiology, Cardiomyopathy, Hypertrophic physiopathology, Echocardiography, Doppler, Female, Humans, Male, Middle Aged, Mitral Valve Insufficiency diagnostic imaging, Mitral Valve Insufficiency etiology, Mitral Valve Insufficiency physiopathology, Ventricular Outflow Obstruction complications, Ventricular Outflow Obstruction physiopathology, Anti-Arrhythmia Agents administration & dosage, Cardiomyopathy, Hypertrophic drug therapy, Imidazoles administration & dosage, Ventricular Outflow Obstruction drug therapy
- Abstract
Background: Recent interventional and surgical therapies to attenuate left ventricular pressure gradient (LVPG) can be difficult to perform in patients with hypertrophic obstructive cardiomyopathy (HOCM) caused by midventricular obstruction (MVO), owing to the risk of inducing or deteriorating mitral regurgitation., Methods and Results: The effects of the antiarrhythmic drug, cibenzoline, on LVPG and left ventricular (LV) diastolic function estimated by the change in the transmitral Doppler flow pattern were examined in 23 patients with HOCM and MVO. Hemodynamic changes 2 h after a single dose of 200 mg of cibenzoline and 3 months after oral administration of 300-450 mg of cibenzoline per day were examined. At 2 h after the treatment, LVPG decreased from 79+/-37 mmHg to 24+/-21 mmHg (p < 0.0001). E-wave velocity significantly increased and A-wave velocity significantly decreased, and thus the E/A ratio increased from 0.83+/-0.39 to 1.36+/-0.50 (p < 0.0001). After 3 months of treatment, LVPG remained decreased, and the E-wave and A-wave velocities and the E/A ratio remained improved., Conclusions: Cibenzoline can attenuate LVPG and ameliorate LV diastolic dysfunction in patients with HOCM caused by MVO, which suggests a new strategy for the management of this condition.
- Published
- 2005
- Full Text
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