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Effect of intravenous administration of cibenzoline on left ventricular diastolic pressures in patients with hypertrophic cardiomyopathy: its relationship to transmitral Doppler flow profiles.
- Source :
-
Circulation journal : official journal of the Japanese Circulation Society [Circ J] 2007 Oct; Vol. 71 (10), pp. 1540-4. - Publication Year :
- 2007
-
Abstract
- Background: Cibenzoline is able to improve left ventricular (LV) diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM), but the exact mechanism remains to be determined.<br />Methods and Results: The present study was designed to elucidate the effect of intravenous administration of 1.4 mg/kg of cibenzoline on aortic and LV pressures, and transmitral Doppler flow pattern in 7 patients with hypertrophic obstructive cardiomyopathy (HOCM) and 9 patients with hypertrophic nonobstructive cardiomyopathy (HNCM). Before and at the end of the administration, aortic and LV pressures, LV pressure gradient (LVPG) and transmitral Doppler velocity profiles were examined. After the administration of cibenzoline, LV minimal and end-diastolic pressures decreased from 9+/-4 mmHg to 1+/-5 mmHg (p=0.0049) and from 22+/-7 mmHg to 14+/-5 mmHg (p=0.0106) in patients with HOCM, and from 9+/-5 mmHg to 5+/-3 mmHg (p=0.0036) and from 20+/-6 mmHg to 14+/-3 mmHg (p=0.0033) in patients with HNCM. LVPG decreased in all patients with HOCM. E-wave velocity increased, A-wave velocity decreased, and thus the E/A ratio increased from 0.77+/-0.29 to 1.20+/-0.48 (p=0.0004).<br />Conclusions: Reduction of LV diastolic pressures by intravenous administration of cibenzoline may be related to an improvement in the E/A ratio in patients with HCM.
- Subjects :
- Aged
Anti-Arrhythmia Agents administration & dosage
Anti-Arrhythmia Agents blood
Atrial Natriuretic Factor blood
Blood Pressure drug effects
Blood Pressure physiology
Catecholamines blood
Female
Humans
Imidazoles administration & dosage
Imidazoles blood
Infusions, Intravenous
Laser-Doppler Flowmetry
Male
Middle Aged
Anti-Arrhythmia Agents therapeutic use
Cardiomyopathy, Hypertrophic drug therapy
Cardiomyopathy, Hypertrophic physiopathology
Imidazoles therapeutic use
Ventricular Dysfunction, Left drug therapy
Ventricular Dysfunction, Left physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1346-9843
- Volume :
- 71
- Issue :
- 10
- Database :
- MEDLINE
- Journal :
- Circulation journal : official journal of the Japanese Circulation Society
- Publication Type :
- Academic Journal
- Accession number :
- 17895548
- Full Text :
- https://doi.org/10.1253/circj.71.1540