1. Squamous cell carcinoma of the nasal vestibule in the Netherlands: A clinical and epidemiological review of 763 cases (2008-2021).
- Author
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van de Velde LJ, Scheurleer WFJ, Braunius WW, Devriese LA, de Ridder M, de Bree R, Breimer GE, van Dijk BA, and Rijken JA
- Subjects
- Humans, Netherlands epidemiology, Male, Female, Aged, Middle Aged, Incidence, Adult, Aged, 80 and over, Neoplasm Staging, Disease-Free Survival, Survival Rate, Nose Neoplasms pathology, Nose Neoplasms epidemiology, Nose Neoplasms mortality, Nose Neoplasms therapy, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell epidemiology, Carcinoma, Squamous Cell mortality, Nasal Cavity pathology, Registries
- Abstract
Background: Squamous cell carcinoma of the nasal vestibule (SCCNV) is a rare disease, distinctly different in presentation, treatment, and outcome from squamous cell carcinoma (SCC) of the nasal cavity and paranasal sinuses. However, these are often not analyzed separately., Methods: The Netherlands Cancer Registry (NCR) and pathology reports from the Dutch Nationwide Pathology Databank (PALGA) were used to identify all newly diagnosed SCCNV cases in the Netherlands between 2008 and 2021., Results: A total of 763 patients were included. The yearly incidence rate displayed a significant downward trend with an annual percentage change (APC) of -3.9%. The 5-year overall survival (OS) and disease-free survival were 69.0% and 77.2%, respectively. The 5-year relative survival was 77.9% and improved slightly over the inclusion period. OS for patients who were staged cT3 appeared to be worse than those staged cT4a, calling the applicability of the TNM-classification into question., Conclusion: SCC of the nasal vestibule is rare, with declining incidence rates. Introducing a specific topography code for SCCNV is recommended to enhance registration accuracy. The TNM classification seems poorly applicable to SCCNV, suggesting the need to explore alternative staging methods., (© 2024 The Authors. Head & Neck published by Wiley Periodicals LLC.)
- Published
- 2024
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