1. Methylsulfonylmethane Induces Cell Cycle Arrest and Apoptosis, and Suppresses the Stemness Potential of HT-29 Cells
- Author
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Kyoung-Jin Jang, Nipin Sp, Doh Hoon Kim, Alexis Rugamba, Eun Seong Jo, Young Mok Yang, and Dong Young Kang
- Subjects
Cancer Research ,Methylsulfonylmethane ,Cell cycle checkpoint ,Cell Survival ,Colorectal cancer ,medicine.medical_treatment ,Apoptosis ,chemistry.chemical_compound ,Breast cancer ,Spheroids, Cellular ,Tumor Cells, Cultured ,medicine ,Humans ,Dimethyl Sulfoxide ,Sulfones ,Cell Self Renewal ,Chemotherapy ,Dose-Response Relationship, Drug ,Cell Cycle Checkpoints ,General Medicine ,Cell cycle ,medicine.disease ,In vitro ,Mitochondria ,Oncology ,chemistry ,Neoplastic Stem Cells ,Cancer research ,HT29 Cells - Abstract
Background/aim Colorectal cancer is one of the most common malignancies worldwide. Small molecule-based chemotherapy is an attractive approach for the chemoprevention and treatment of colorectal cancer. Methylsulfonylmethane (MSM) is a natural organosulfur compound with anticancer properties, as revealed by studies on in vitro models of gingival, prostate, lung, hepatic, and breast cancer. However, the molecular mechanisms underlying the effects of MSM in colon cancer cells remain unclear. Materials and methods Here, we investigated the effects of MSM, especially on the cell cycle arrest and apoptosis, in HT-29 cells. Results MSM suppressed the viability of HT-29 cells by inducing apoptosis and cell cycle arrest at the G0/G1 phase. MSM suppressed the sphere-forming ability and expression of stemness markers in HT-29 cells. Conclusion MSM has anti-cancer effects on HT-29 cells, and induces cell cycle arrest and apoptosis, while suppressing the stemness potential.
- Published
- 2020
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