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Your search keyword '"Gurto RV"' showing total 3 results
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3 results on '"Gurto RV"'

1. [Evaluation of the linearity of pharmacokinetics of the phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intragastric administration].

Author

Smol'iakova VI, Chernysheva GA, Ianovskaia EA, Gurto RV, Kuchin AV, Chukicheva IIu, Udut VV, and Plotnikov MB

Subjects
Animals, Antioxidants administration & dosage, Antioxidants metabolism, Area Under Curve, Camphanes administration & dosage, Camphanes blood, Cresols administration & dosage, Cresols blood, Drug Administration Schedule, Intestinal Absorption physiology, Male, Rats, Rats, Wistar, Stomach, Antioxidants pharmacokinetics, Camphanes pharmacokinetics, Cresols pharmacokinetics, Intestinal Mucosa metabolism
Abstract

The linearity of pharmacokinetics of 4-methyl-2,6-diisobornylphenol after single intragastric administration in doses within 10 - 200 mg/kg has been studied in rats. It has been established that pharmacokinetics of 4-methyl-2,6-diisobornilphenol in the indicated dose range is not linear due to a limited absorption of the drug from the intestine.

Published
2014

2. [Distribution of 4-methyl-2,6-diisobornylphenol in rat tissues].

Author

Smol'iakova VI, Chernysheva GA, Ianovskaia EA, Gurto RV, Kuchin AV, Chukicheva IIu, Udut VV, and Plotnikov MB

Subjects
Adipose Tissue metabolism, Administration, Oral, Animals, Brain metabolism, Camphanes blood, Cresols blood, Female, Fibrinolytic Agents blood, Kidney metabolism, Liver metabolism, Male, Muscles metabolism, Myocardium metabolism, Rats, Rats, Wistar, Tissue Distribution, Camphanes pharmacokinetics, Cresols pharmacokinetics, Fibrinolytic Agents pharmacokinetics
Abstract

We have studied the distribution of the new compound 4-methyl-2,6-diisobornylphenol in rats after a single oral administration in a dose of 20 mg/kg. The pharmacokinetic parameters have been estimated by the noncompartmental method. It is established that the drug is nonuniformly distributed in the body and has a high affinity for liver and heart. A low penetration of 4-methyl-2,6-diisobornilphenol has been found in brain tissue. The accumulation of 4-methyl-2,6-diisobornilphenol in adipose tissues has not been found. It been showed that the drug is slowly eliminated from the body, especially from the heart tissues for which the mean retention time is MRT = 45 h.

Published
2014

3. [Pharmacokinetics of phenolic antioxidant 4-methyl-2,6-diisobornylphenol upon intravenous injection].

Author

Chernyshova GA, Smol'iakova VI, Plotnikov MB, Ianovskaia EA, Gurto RV, Udut VV, Kuchin AV, and Chukicheva IIu

Subjects
Animals, Antioxidants administration & dosage, Antioxidants chemistry, Camphanes administration & dosage, Camphanes blood, Camphanes chemistry, Cresols administration & dosage, Cresols blood, Cresols chemistry, Injections, Intravenous, Male, Organ Specificity, Rats, Rats, Wistar, Tissue Distribution, Antioxidants pharmacokinetics, Camphanes pharmacokinetics, Cresols pharmacokinetics, Models, Biological
Abstract

The pharmacokinetics of 4-methyl-2,6-diisobornylphenol (MDIBP) in rat blood plasma has been studied after intravenous injection. The drug concentration in the plasma was determined using a reverse-phase HPLC procedure. It is shown that MDIBP rapidly penetrates into intensively perfused organs, but is slowly eliminated from the organism (MRT value amounting to 9 h).

Published
2011

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