1. Prevalence of positive islet autoantibody in type 2 diabetes patients: a cross-sectional study in a Chinese community
- Author
-
Yi Wang, Rumei Li, Xiangyu Gao, Wanwan Sun, Yawen Zhang, Yehong Yang, and Jinya Huang
- Subjects
islet autoantibody ,medicine.medical_specialty ,Cross-sectional study ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,community patients ,Aspartate transaminase ,030209 endocrinology & metabolism ,Type 2 diabetes ,030204 cardiovascular system & hematology ,lcsh:Diseases of the endocrine glands. Clinical endocrinology ,03 medical and health sciences ,0302 clinical medicine ,Endocrinology ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,clinical characteristics ,geography ,lcsh:RC648-665 ,geography.geographical_feature_category ,biology ,business.industry ,Research ,Insulin ,Autoantibody ,medicine.disease ,Islet ,biology.protein ,type 2 diabetes ,business ,Body mass index - Abstract
Background Islet autoantibodies occur in type 2 diabetes. Our study aimed to investigate the prevalence of positive islet autoimmunity in community patients with type 2 diabetes. Methods A total of 495 community patients with type 2 diabetes were recruited using the method of cluster sampling in this cross-sectional study. Three islet autoantibodies including glutamic acid decarboxylase antibody (GADA), insulin autoantibody (IAA) and islet cell antibody (ICA) were measured, and clinical characteristics involved in those individuals were evaluated. Results The positive rate of islet autoantibodies was 28.5% in total, while combinations of different autoantibodies were rarely seen. Compared with GADA-negative group, positive counterparts significantly tended to have lower levels of body mass index (BMI), waist-hip ratio (WHR), and urinary microalbumin (mALB) (P P P P P = 0.064). Conclusion These data suggested that type 2 diabetic community patients with positive GADA tended to be lean and were able to maintain normal lipid metabolism, while patients with positivity of IAA were frequently accompanied with insulin treatment and more closely associated with diabetic liver damage.
- Published
- 2019