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Thyrotropin-secreting pituitary adenomas: diagnosis and management of patients from one Chinese center
- Source :
- Wiener klinische Wochenschrift. 124(19-20)
- Publication Year :
- 2012
-
Abstract
- Thyrotropin-secreting pituitary adenoma (TSHoma) is rare and it is also a rare cause of thyrotoxicosis. Failure to detect the presence of TSHoma may result in dramatic consequences. This study is a review of our experience in the management of TSHoma at Huashan Hospital, China. We followed up eight patients with TSHoma (five males and three females) between 2006 and 2011. The patients’ medical records were retrieved, and the demographic data, clinical presentation and management, final outcomes and follow-up were reviewed, and surgery performed. All the eight patients had unsuppressed TSH levels with elevated thyroid hormone levels; and neuroimaging revealed pituitary lesions. Five patients (62.5 %) were previously misdiagnosed as primary hyperthyroidism. They received pituitary adenomectomy, somatostatin analogs, and/or radiotherapy after definitive diagnosis. Serum TSH and thyroid hormone levels of all the patients restored to the normal levels during the follow-up. Adenomectomy is not curative in many TSHoma patients, it should be adjuvantly treated by pharmacological and/or radiotherapy, frequently. A combination of adenomectomy, somatostatin analogs, and radiotherapy is often required for long-term management of the disease.
- Subjects :
- Primary Hyperthyroidism
Adenoma
Adult
Male
endocrine system
medicine.medical_specialty
Pathology
Hypophysectomy
endocrine system diseases
Adolescent
medicine.medical_treatment
Thyrotropin
Antineoplastic Agents
Pituitary neoplasm
Gastroenterology
Young Adult
Pituitary adenoma
Internal medicine
Medicine
Humans
Pituitary Neoplasms
business.industry
Thyroid
General Medicine
Middle Aged
medicine.disease
Combined Modality Therapy
Radiation therapy
Somatostatin
medicine.anatomical_structure
Treatment Outcome
Female
Radiotherapy, Conformal
business
Subjects
Details
- ISSN :
- 16137671
- Volume :
- 124
- Issue :
- 19-20
- Database :
- OpenAIRE
- Journal :
- Wiener klinische Wochenschrift
- Accession number :
- edsair.doi.dedup.....23f4623e14a8cfea51a451035a5f4c6c