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The current IP architecture is faced with scalability, security and dynamic problems, while the current DNS also has the problems of centralized management and server security. The defects of IP system make it unable to adapt to the current rapid development of business. In the current solution, the Content Centric Network (CCN) in the Information Centric Network (ICN) is considered to be able to better meet the needs of users. It takes the content as the center for data transmission, and uses the data itself to name, which completely changes the original network transmission system. Blockchain is a distributed platform in peer-to-peer network environment, in which multiple nodes participate and reach a consensus through a specific consistency algorithm. It has the characteristics of unforgeability, tamper proof and traceability, and carries trusted data and computing services. Alliance chain is a kind of blockchain, the characteristics of the alliance's blockchain, such as decentralization, non tampering, traceability, access mechanism, and information disclosure within the network, point out the direction for the realization of a new domain name system of co management and co governance.This paper gives full play to the trustworthiness and non tampering characteristics of blockchain technology, integrates the naming and addressing scheme based on alliance chain into Name Data Network(NDN) architecture, and proposes an open system of independent naming and marking and exchanging data content index in peer-to-peer network environment. This system uses OpenID to identify any data content object, and combines with cryptography technology to realize the trusted transmission of data in peer-to-peer network. Experiments show that the system designed in this paper has the functions of data index registration, update, cancellation and query, the efficiency is basically the same as the existing domain name system, and has stronger security.

With the increasing demand for power services, the variety of services and the global energy resource scarcity, smart grid will become the development trend and strategic goal of the power system. Along with the rapid development of new 5G technologies, smart grids face new challenges and opportunities in the development and construction process, bringing new connotations to smart grids. This paper outlines the key technologies of 5G network slicing and the new demands of smart grid construction, studies the application and solutions of 5G network slicing technology in smart grid, and demonstrates the rationality, technicality and advancedness of 5G network slicing technology to help the innovation and development of smart grid.

With the continuous enrichment and development of power business types and quantities, the traditional technical methods have been unable to meet the requirements of State Grid Corporation for the intelligent and digital development of the business, and the relevant problems can be solved with the help of artificial intelligence technology. The article introduces the background and development of the integrated operation platform for electric power business, focuses on the architecture, business functions and data structure, and finally introduces the significance of the integrated operation platform for electric power business. By building the integrated operation platform for electric power business, the intelligence and digitization level of the power grid is gradually improved.

The wireless private network system in 230 MHz band is gradually applied to the power industry. However, a wide range of services is carried by the power wireless private network, and the network requirements are totally different. Thus, the adaptation of private network to existing services and new services is not clear, which leads to low utilization of communication resources. In this paper, the main services and network requirements of the power wireless private network are analyzed, and the system index of the power wireless private network is proposed. The theoretical analysis of the system delay is carried out, and the system delay values under different configuration conditions are obtained. Finally, combined with the current network test results of the State Grid Corporation of China, the analysis results of different power wireless private network system delay in 230 MHz band are given.

Objective To study the effects of D-methionine in a mouse model of noise-induced hearing loss (NIHL). Methods We investigated changes in auditory function and microscopic cochlear structure in a mouse model of NIHL, and carried out 4-hydroxynonenal (4-HNE) immunostaining and terminal deoxynucleotidyl transferase dUTP nick-end labeling, and examined expression levels of connexins 26 and 30 by western blot. Results The auditory brainstem response threshold was significantly increased by noise exposure. Noise exposure also damaged the inner and particularly the outer hair cells in the cochlear basement membrane, while histochemistry demonstrated only scattered loss of hair cells in the basement membrane in mice treated with D-methionine before or after noise exposure. D-methionine inhibited apoptosis in the cochlear basement membrane, stria vascularis, and spiral ligament. 4-HNE expression in the basement membrane, stria vascularis, and spiral collateral ligament was increased by noise exposure, but this increase was attenuated by D-methionine. Connexin 26 and connexin 30 expression levels were reduced by noise exposure, and this effect was similarly attenuated by D-methionine administered either before or after noise exposure. Conclusion D-methionine administered before or after noise exposure could rescue NIHL by protecting cochlear morphology, inhibiting apoptosis, and maintaining connexin 26 and 30 expression.

With the development of smart grid, IOT devices in the field of power control are widely used. The diversity of types, features and functions of IOT devices not only integrates detailed big data, but also challenges the real-time, compatibility and big data processing capability of system control. In this paper, the low-latency edge IoT agent device for ubiquitous power Internet of Things is studied, which performs nearby processing of massive intelligent electricity data to avoid the bottleneck of communication channel caused by massive data transmission, and meet the special requirements of energy management and control for quick response and accurate execution. The software and hardware decoupling and deep programmable ideas are proposed. In addition, adopting a common hardware platform and resource virtualization function platform to realize low latency guarantee mechanism and mode from three levels. Moreover, the low latency energy industrial application scenarios are selected to demonstrate the application, and the proposed scheme is proved to provide safe and fast control methods, and also make the system have stronger big data collection capability of electricity consumption information.

In order to satisfy the needs of smart grid terminal access and differentiated services, it is necessary to accelerate the integration and development of the Internet of Things and smart grids. Cloud computing and edge computing are the key to promoting the development of the Internet of Things. The synergistic integration of cloud computing and edge computing can shape the power of the Internet of Things. future. Therefore, this paper proposes a cloud-edge collaboration architecture based on the cloud-edge collaboration architecture by studying the cloud-edge collaboration method of the power Internet of Things, and discusses the deployment mode of cloud and edge IoT agent collaboration based on the cloud-edge collaboration architecture, and proposes a network performance optimization deployment plan under cloud-edge collaboration. This solution can realize the reasonable allocation of resources and optimize network performance under the cloud-edge collaborative architecture.

In the smart grid scenario, this article proposes a blockchain-based smart grid service system based on the alliance chain established by power plants, distribution network operators, energy storage operators, and power companies as nodes. Each node can flexibly change its role according to its own needs, and can be used as a service provider or as a user requesting service. In this service system, users and service providers store business data and transaction data through the blockchain, and match services through smart contracts. On this basis, this paper establishes a mathematical model of power business service quality, abstracts the user matching power business process as a service composition problem under the constraint of service quality, and uses the multi-objective optimization algorithm MOEA/D as the basis, based on price, time delay, Service quality indicators such as bandwidth are analyzed and optimized for optimization goals. On the one hand, in the smart grid scenario, it has achieved decentralization, improved power data security, and user privacy security. On the other hand, multi-objective optimization algorithms are used to optimize the different needs of users to improve the service quality of the smart grid system. The results of calculation examples verify the validity and rationality of the proposed framework.

Objective To study the in vitro antiproliferative effect and probable mechanism of solasonine on human breast cancer Bcap-37 cells, meanwhile, make comparison with solamargine. Methods The cytotoxicity was evaluated by MTT assay. The cell damage and type of cell death were examined through Hoechst33342/PI and Annexin V/PI staining, respectively. Mitochondrial membrane potential was detected by JC-1 staining. The expression of Bcl-2, Bcl-xL, Bax, and cytochrome c was determined by immunoblot method, and the activation of caspase-3 was analyzed by immunocytochemistry method. Results Solasonine showed the different extents of cytotoxicity on eight human tumor cell lines as well as four human normal cell lines, and the IC 50 values of solasonine ranged from 12.73 to 37.15 μmol/L. Cell apoptosis and mitochondria depolarization were observed in Bcap-37 cells after treatment with solasonine for 24 h, respectively. In immunoblot and immunocytochemistry analysis, solasonine obviously induced the up-regulation of Bax and down-regulation of Bcl-2 and Bcl-xL, caused the release of cytochrome c from mitochondria into cytosol, and increased the expression of both pro- and cleaved caspase-3. Solamargine exhibited stronger antipoliferative activity than solasonine, but the similar mechanism in Bcap-37 cells in this study. Conclusion Solasonine possesses the antiproliferative effect on tumor cells. Regulation of the levels of Bcl-2, Bcl-xL, Bax, and activation of mitochondria cytochrome c-dependent apoptosis pathway might be one of its main antitumor mechanisms against breast cancer cells. In view of the cytotoxic effect of solasonine and solamargine also shown on normal cells, the safety needs concern when the antitumor activity is studied.

The development of Earthquake Disaster Reduction System (EDRS) depends on the state of arts of computer technology, involving many fields of computer application skills and techniques. In this paper, first a key period after earth quake occurrence is discussed. Then a Web GIS based Information and Decision-making Support System (the System) for Earth quake Disaster Reduction is introduced, including of technical frame works, function composition, structure of software, redevelopment languages, data bases, and remote linking and calling of analysis modules. Mean while tested by a Ms5.1 earth quake in north-east China, the System showed the damage distribution maps, which include the comparison of isoseismals map and the damage of buildings map. Finally, several conclusions are presented.

Objectives The circulating, adipocyte-secreted hormone adiponectin (APN) exerts protective effects on the heart under stress conditions. Recent study demonstrated that APN induces a marked Ca 2+ influx in skeletal muscle. However, whether APN modulates [Ca 2+ ] i activity, especially modulates [Ca 2+ ] i transients in cardiomyocytes is still unknown. This study was designed to determine whether and how APN modulates [Ca 2+ ] i transients in cardiomyocytes. Methods Adult male wild-type (WT) and APN knock-out (APN KO) mice were subjected to myocardial ischaemia/reperfusion (I/R, 30 min/30 min) injury.We observed CaMKII-PLB phosphorylation and SR Ca 2+ -ATPase (SERCA2) activity were downregulated in I/R heart of WT mice (all P 2+ transient peaks, and number of Ca 2+ sparks (all P >0.05), but decreased [Ca 2+ ] i transients (P 2+ decay rate (P 2+ ] i transients (P 2+ ] i transients in APN KO myocytes via S1PR1/3 (all P Results Treatment of myocytes after hypoxia/reoxygenation with S1P also increased cell viability and reduced caspase-3 activity and apoptosis (all P Conclusions These data demonstrate that S1P is a novel regulator of SERCA2 by activating CaMKII-PLB signalling and mediates APN-induced cardioprotection.

A reflective surface plasmon resonance (SPR) sensor based on optical fiber microring is proposed. In such a sensor, plasmons on the outer surface of the metallized channels containing analyte can be excited by a fundamental mode of a thin-core fiber (TCF). The refractive index (RI) sensing can be achieved as the surface plasmons are sensitive to changes in the refrective index of the analyte. Numerical simulation results show that the resonance spectrum shifts toward the shorter wavelength gradually when the analyte refractive index increases from 1.0 to 1.33, whereas it shifts toward the longer wavelength gradually when the analyte refractive index increases from 1.33 to 1.43, and there is a turning point at the refractive index value of 1.33. The highest sensitivity achieved is up to 2.30×103 nm/RIU near the refractive index value of 1.0. Such a compact sensor has potential in gaseous substance monitoring.