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The aim of this study was to investigate the effects of vegetable tablets containing Gamma-Aminobutyric Acid (GABA) intake on cardiovascular response and the autonomic nervous system in young adults. In a double-blind, randomized controlled trial, 7 healthy subjects were assigned to take vegetable tablets (10 g/trial) or control tablets (10 g/trial). We measured heart rate (HR), systolic and diastolic blood pressure, stroke volume, cardiac output, total peripheral resistance index, and the low- and high-frequency oscillatory components of heart rate variability (HRV). Two major spectral components were examined at low-frequency (LF: 0.04-0.15 Hz) and high-frequency (HF: 0.15-0.4 Hz) bands to indicate HRV. There were significant interactions in HR (p

In this study we present a design for a multi-frequency microwave radiometer aimed at prolonged monitoring of deep brain temperature in newborn infants and suitable for use during hypothermic neural rescue therapy. We identify appropriate hardware to measure brightness temperature and evaluate the accuracy of the measurements. We describe a method to estimate the tissue temperature distribution from measured brightness temperatures which uses the results of numerical simulations of the tissue temperature as well as the propagation of the microwaves in a realistic detailed three-dimensional infant head model. The temperature retrieval method is then used to evaluate how the statistical fluctuations in the measured brightness temperatures limit the confidence interval for the estimated temperature: for an 18 degrees C temperature differential between cooled surface and deep brain we found a standard error in the estimated central brain temperature of 0.75 degrees C. Evaluation of the systematic errors arising from inaccuracies in model parameters showed that realistic deviations in tissue parameters have little impact compared to uncertainty in the thickness of the bolus between the receiving antenna and the infant's head or in the skull thickness. This highlights the need to pay particular attention to these latter parameters in future practical implementation of the technique.

Clinical studies of hypothermal neural rescue therapy for newborn infants who have suffered hypoxia-ischaemia are currently hindered by the difficulty in measuring deep brain temperature. This paper addresses: the specific requirements for this measurement problem, the design of a proposed radiometer system, a method for retrieving the temperature profile within the cooled head, and an estimation of the precision of the measurement of deep brain temperature using the technique. A five-frequency-band radiometer with a contact-type antenna operating within the range 1-4 GHz is proposed to obtain brightness temperatures corresponding to temperature profiles predicted by a realistic thermal model of the cooled baby head. The problems of retrieving the temperature profile from this set of brightness temperatures, and the estimation of its precision, are solved using a combination of model fitting and Monte Carlo techniques. The results of this paper show that the proposed technique is feasible, that it is expected to provide a good estimate of the temperature profile within the cooled baby-head, and that the estimated precision (2/spl sigma/) of the temperature measured in the deep brain structures is better than 0.8 K, depending upon the estimation procedure used.

Preliminary experiments were carried out to investigate the feasibility of using an electroencephalogram and heart rates to evaluate the efficacy of finger acupressure on the key points of planta pedis (both soles). Continuous electroencephalograms were recorded from 19 electrodes based on the International 10-20 electrode placement system on 22 university students (21+/-2.3 years). Spectral power changes were obtained at each electrode site. The power of the alpha1 frequency range (8-10 Hz) increased slightly during acupressure although no statistical significance was observed, while heart rates decreased in all subjects (p

This paper describes a self-tuning method of membership functions in a fuzzy-logic-based cardiac pacing system and validates its feasibility in a double sensor system which has minute ventilation and oxygen saturation level as its guides for the rate regulation. Though the agreement between the pacing rates (fuzzy rates) calculated with three linguistic variables for each parameter and the target rates were not satisfactory, it was improved significantly by tuning the membership functions. Almost the same evaluated values with those obtained by using six linguistic variables for each parameter were obtained. Time required for the self-tuning process was about 40 s (386CPU, 20 MHz) which was fast enough for the system. The smaller number of linguistic labels results in a smaller number of rules, which is beneficial in implantable cardiac pacemakers with limited memory capacity. A fuzzy-logic-based cardiac pacing system is promising for the realization of custom-made cardiac pacemakers.

A small and light-weight wearable electrocardiograph (ECG) equipment with a tri-axis accelerometer (x, y and z-axis) was developed for prolonged monitoring of everyday stress. It consists of an amplifier, a microcomputer with an AD converter, a triaxial accelerometer, and a memory card. Four parameters can be sampled at 1 kHz for more than 24 h and a maximum of 27 h with a default battery and a memory card of one giga byte (1 GB). Off-line data processing includes motion information along three axes and autonomic nervous system (ANS) activity bispectral analysis and the tone-entropy method (T-E method) from HRV data. The availability of the system was tested through simulated office work and three-day monitoring by replacing the battery and the memory card every 24 h. Both short-term and circadian rhythms of ANS activity were clearly observed. In addition, sympathetic nervous activities gradually increased from the second to the third day. The experimental data presented verifies the functionality of the proposed system.

[1] Clinical trials of hypothermic brain treatment for newborn babies are currently hindered by the difficulty in measuring deep brain temperatures. As one of the possible methods for noninvasive and continuous temperature monitoring that is completely passive and inherently safe is passive microwave radiometry (MWR). We have developed a five-band microwave radiometer system with a single dual-polarized, rectangular waveguide antenna operating within the 1–4 GHz range and a method for retrieving the temperature profile from five radiometric brightness temperatures. This paper addresses (1) the temperature calibration for five microwave receivers, (2) the measurement experiment using a phantom model that mimics the temperature profile in a newborn baby, and (3) the feasibility for noninvasive monitoring of deep brain temperatures. Temperature resolutions were 0.103, 0.129, 0.138, 0.105 and 0.111 K for 1.2, 1.65, 2.3, 3.0 and 3.6 GHz receivers, respectively. The precision of temperature estimation (2σ confidence interval) was about 0.7°C at a 5-cm depth from the phantom surface. Accuracy, which is the difference between the estimated temperature using this system and the measured temperature by a thermocouple at a depth of 5 cm, was about 2°C. The current result is not satisfactory for clinical application because the clinical requirement for accuracy must be better than 1°C for both precision and accuracy at a depth of 5 cm. Since a couple of possible causes for this inaccuracy have been identified, we believe that the system can take a step closer to the clinical application of MWR for hypothermic rescue treatment.

A small and light-weight wearable electrocardiograph (ECG) equipment with three accelerometers (x, y and zaxis) was developed for prolonged monitoring of autonomic nervous system in daily life. It consists of an amplifier, a bandpass filter, a microcomputer with an AD converter, a triaxial accelerometer, and a memory card. Four parameters can be sampled at 1 kHz (10 bits) for more than 24 hours, maximum 27 hours, with a default battery and a memory card (1 GB). The availability of the system was tested for three subjects for three days by replacing the battery and the memory card every 24 hours under each environment. Both short-term and circadian rhythms of the autonomic nervous system were clearly observed. The change of the autonomic nervous system from body movement (i.e. walking or turning over) was observed by check acceleration data. The feasibility of the application in clinical practice is also discussed.

A method of retrieving a temperature-depth profile in biological object from a set of multi-frequency microwave radiometric data has been developed. The method is a combination of model-fitting and Monte Carlo techniques and is capable of estimating a profile and its confidence interval as a function of the depth. We use 2σ -intervals as a measure of the precision of tissue temperature measurements. The method was tested and supported by an experiment in which temperature distributions in a muscle equivalent agar phantom were measured using a 5-band, 1-3.8 GHz radiometer with the brightness temperature resolution of 0.05-0.07 K. A typical result of the experiment showed that 2σ -intervals were 1 K or less for 0 < z < 3 cm, 1.4 K at z = 4 cm, and 3 K at z = 5 cm. A numerical simulation study was made using this technique to assess effects of the selection of measurement frequencies, number of frequency bands, brightness temperature resolution of radiometer and thickness of fat layer on the precision. Resul...

The purpose of the study is to show the feasibility of a light-weight wearable electrocardiograph with three accelero-meters for monitoring stress in everyday life. It consists of an amplifier, a band pass filter, a microcomputer with an AD converter, a triaxial accelerometer, and a memory card. An ECG and three accelerations are sampled at 1 kHz for more than 24 hours, maximum 27 hours with a default battery and a memory card. The heart rate variability analysis program detects R waves and determines R-R intervals for 24 hours by a data acquisition algorithm. An algorithm was also developed. It was designed to reduce motion artifacts induced by body movements on ECG. Autonomic nervous activity levels are calculated based on the heart rate variability spectrum analysis. The availability of the system was tested for three subjects for three days by replacing the battery and memory card every 24 hours under each environment. Both short time rhythms and a circadian rhythm of autonomic nervous system were clearly observed. The feasibility of the system for monitoring the long-term stress level is discussed.

In order to find out the most suitable and accurate pointing methods to study the sound localizability of persons with visual impairment, we compared the accuracy of three different pointing methods for indicating the direction of sound sources in a semi-anechoic dark room. Six subjects with visual impairment (two totally blind and four with low vision) participated in this experiment. The three pointing methods employed were (1) directing the face, (2) directing the body trunk on a revolving chair and (3) indicating a tactile cue placed horizontally in front of the subject. Seven sound emitters were arranged in a semicircle 2.0 m from the subject, 0 degrees to +/-80 degrees of the subject's midline, at a height of 1.2 m. The accuracy of the pointing methods was evaluated by measuring the deviation between the angle of the target sound source and that of the subject's response. The result was that all methods indicated that as the angle of the sound source increased from midline, the accuracy decreased. The deviations recorded toward the left and the right of midline were symmetrical. In the whole frontal area (-80 degrees to +80 degrees from midline), both the tactile cue and the body trunk methods were more accurate than the face-pointing method. There was no significant difference in the center (-40 degrees to +40 degrees from midline). In the periphery (-80 degrees and +80 degrees ), the tactile cue pointing method was the most accurate of all and the body trunk method was the next best. These results suggest that the most suitable pointing methods to study the sound localizability of the frontal azimuth for subjects who are visually impaired are the tactile cue and the body trunk methods because of their higher accuracy in the periphery.

One of the recent problems for pacemaker (PM) patients is an anti-shoplifting system which is called the electronic article surveillance (EAS) system. Electromagnetic field patterns of the two types of EAS system, radio frequency (RF) and electromagnetic (EM) systems, are simulated with in Irnich model which consists of saline and a pacemaker. The voltage differences induced between a PM casing main body and the tips of pacing leads and those between both leads (ventricular and atrium) are estimated. The voltages induced between PM body and the ventricular lead are about 300 mV and 1 mV by RF and EM systems, respectively. Considering the input characteristics of the PM circuit, these voltages will not bring about serious errors in the PM system if the patient goes through the EAS gate at a normal pace. Acousto-magnetic EAS systems which use lower frequencies may be more harmful to the PM system.

An assessment is made of the degradation that is caused by a water-filled bolus in the precision of tissue temperature measured noninvasively by a five-band microwave radiometry scheme. The precision is expressed in terms of the confidence interval of tissue temperature estimated from a set of five brightness temperatures measured with an experimental instrument operating at center frequencies of 1.2, 1.8, 2.5, 2.9, and 3.6 GHz, with a 0.4-GHz bandwidth. Results show that degradation due to a bolus having a thickness of about 1 cm is small when it is filled with deionized or distilled water. It is concluded that the use of water-filled bolus is permissible for microwave radiometric measurement. This is of a practical importance when the technique is used in combination with electromagnetic heating for hyperthermic treatment of cancer. >

A chaotic approach was applied to the quantitative analysis of Parkinson's disease (PD). Finger tapping tests were performed to analyze the degree of bradykinesia in PD patients. The voltage variation obtained from the tapping tests was sampled at 200 Hz, and the data for 15 seconds were used in the analysis. Sampled data were embedded into the phase space with various combinations of the dimension and delay time. The embedding dimension and the delay time used in this study were 16 and 13, respectively. Fractal dimension of 5 PD patients was calculated in the phase space and compared with those of 5 volunteers.

A method of temperature profiling in biological objects is described. In this method, thermal radiation from the object is measured as the brightness temperature by a multi-channel, topically five, 1 - 4 GHz radiometer via a contact-type, dielectric loaded waveguide antenna with a 15 X 20 mm2 aperture. Coupling between the antenna and the object is analyzed under 1-dimensional approximation. The radiometric data are analyzed by a combined method of model fitting and Monte Carlo techniques to retrieve a temperature profile in tissue and its 2 (sigma) -intervals along the axis of the antenna view field. The method has been tested by numerical simulation and agar phantom experiments to demonstrate its capability of temperature profiling in muscle with 2(sigma)

Fuzzy theory was applied to the rate control of a cardiac pacemaker which uses two parameters, respiratory rate and temperature, as the parameters for rate regulation. Using 25 fuzzy reasoning rules derived from five mongrel dogs, the pacing rates in three animals were calculated and compared with the intrinsic heart rates. It is concluded that the fuzzy method is well suited for the rate determination of a multi-parameter rate-responsive cardiac pacemaker.

A new method using respiratory rate and temperature as the guides for optimal pacing is proposed. A pacemaker was fabricated which senses these two parameters simultaneously. The pacemaker functions by calculating the cardiac rate, which would be derived from the respiratory rate and the blood temperature. The higher of the two rates is adopted as the cardiac pacing rate, i.e., at which stimuli will be delivered. The operation was tested in a mongrel dog with complete atrioventricular block. After the induction of anesthesia, a thermistor temperature probe was inserted into right atrium and a respiratory rate sensor was attached around the chest. After administration of a pyrogenic drug, both respiratory rate and blood temperature increased. The pacing rate was increased from 178 beats/minute(bpm) at 36.4 degrees C, blood temperature, and 26.5 acts/minute(apm), respiratory rate, to 233 bpm at 40.1 degrees C and 40.0 apm. Cardiac output was increased from 2.15 liters/minute(l/pm) at the beginning to 2.50 l/pm at maximum. The transition of the guide from respiratory rate to temperature was observed at about 38 degrees C.

A large waveguide applicator is proposed for deep regional hyperthermia, where a part of a patient's body is exposed to the TE/sub 10/ -mode waves in the rectangular waveguide through the holes made to fit the body cross section in the broad walls. The electric field and the specific absorption rate distribution produced by the applicator in a realistic model of a human body cross section calculated by a two-dimensional (2-D) numerical method are given.

GaP LPE layers were successfully grown from indium solvent. The lowest temperature at which a smooth layer was obtained was 580° C. The background carrier concentrations of the undoped layers grown at temperatures below 670° C were 1−6 × 10 15 cm -3 . It was found that this low background value was not due to the high level compensation. Low temperature growth is found to be effective to obtain high purity GaP crystals.

A radio-telemetry system using a microcomputer has been constructed to measure both the heart-rate (HR) and right atrial blood-temperature in dogs. The telemeter incorporates a thermistor temperature probe, which allows blood-temperature measurements in the range of 35 degrees-42 degrees C with an available resolution of +/- 0.02 degree C. The output of the receiver is connected to active filters, a frequency counter and an HR meter, and finally to a microcomputer, through an appropriate interface circuit, for data linearization and storage.

An artificial cardiac pacemaker which is sensitive to the temperature of blood in the right atrium has been fabricated. For a temperature change of 20 degrees C the circuit achieves 90% of its final response within a period of 18 s. In the authors' opinion this is satisfactory since changes in blood temperature are generally small. Cardiac output in dogs rose from 2.37 +/- 0.65 to 4.54 +/- 1.15 l/min when the rate was increased from 202.6 beats/min(b.p.m.) at 37.6 degrees C to 231.6 b.p.m. at 41 degrees C. Cardiac output was found, from statistical observation, to be improved at temperatures over 39.6 degrees C.

A microcomputer-based temperature-sensitive cardiac pacemaker system and some preliminary experiments are described. The system consists of a microcomputer, a twin 5 in floppy disk unit, expansion and interface units, a visual display unit and a printer. It senses the blood temperature in the right atrium, determines the pacing rate and supplies the heart with stimulating pulses. System-heart interfacing is performed by the separate pacing and sensing units which communicate with the computer via a peripheral interface IC in an expansion unit. The pacing rate is determined by software, rather than a combination of hardware elements. The temperature response time of the system, from 25 degrees C to 40 degrees C is about 26 s, and this would seem to be satisfactory given that smaller and slower changes in blood temperature are normal.

A reduction in dislocation density, typically by a factor of 3–8, was observed across the interface between LEC GaP (111)B substrate and an n‐type In‐doped GaP layer grown from indium solvent by liquid‐phase epitaxy. Doping of the epitaxial layer with indium contributed to the reduction in dislocation density in the epitaxial layer.