Patients are facing complex health care decisions everyday. They are given many different treatment paths and often do not understand or question if these are the best path for their health conditions. These patients often turn to the internet, including authorative healthcare web sites and social media, to explore which option is the best for them [1][2]. In their exploration of different treatment options, however, they often notice gaps in research. Much literature supports these dissatisfactory experiences of healthcare consumers [4][6][7]. Therefore, less healthcare research reaches the benefiting stage. Eventually, although patients are concerned and interested in research, they often do not have a way to connect to researchers. To properly tackle this problematic issue, we propose an online platform called Act Together and Connect for patient-centered outcome research or ACTONNECT in short. ACTONNECT is based on the grounded theory of action-based matchmaking and engagement [3][5]. Meaning, if there are established actions from both partners, the matchmaking process is more likely to be successful. Based on previous research, there are three levels of engagements in the matchmaking process: 1) The initial willingness from both parties, one who is looking to be connected with the other to develop rigorous research studies, 2) The two groups are engaged by actions, physically sharing in the activities of creating research studies, protocol and publishing's, and 3) The Engaged partnership, which is literally the 1 +1 > 2 partnership. Based on this concept, ACTONNECT allows the matchmaking at the highest level by allowing patients and researchers who share a common ground. Hence, we view ACTONNECT as a common platform for both patients and researchers. With the action-based matchmaking, the partnership between patients and researchers can be more sustainable. To properly tackle this problematic issue, we propose an online platform called Act Together and Connect for patient-centered outcome research or ACTONNECT in short. ACTONNECT is based on the grounded theory of action-based matchmaking and engagement [3][5]. Meaning, if there are established actions from both partners, the matchmaking process is more likely to be successful. Based on previous research, there are three levels of engagements in the matchmaking process: 1) The initial willingness from both parties, one who is looking to be connected with the other to develop rigorous research studies, 2) The two groups are engaged by actions, physically sharing in the activities of creating research studies, protocol and publishing's, and 3) The Engaged partnership, which is literally the 1 +1 > 2 partnership. Based on this concept, ACTONNECT allows the matchmaking at the highest level by allowing patients and researchers who share a common ground. Hence, we view ACTONNECT as a common platform for both patients and researchers. With the action-based matchmaking, the partnership between patients and researchers can be more sustainable. In order to facilitate dynamic interaction among various stakeholders around healthcare issues, ACTONNECT features following functions: 1) healthcare heterogeneous network visualization, 2) ACTONNECTION publisher, 3) ACTONNECTION matchmaker, and 4) research article recommender. Figure 1 illustrate the user interface of the system. First, stakeholders can explore the healthcare social media through investigating the extracted healthcare heterogeneous network and identifying related research articles form authoritative healthcare sites such as WebMD and Pub Med. A healthcare heterogeneous network [8] is a graph consisting of nodes and links, where. Each node belongs to one particular type from, such as Drug (R), Disease (D), Adverse Drug Reactionss (A), Treatment (T), Diagnostics (G), Users (U), etc. Each link belongs to one particular relation from, such as treat between T and D, cause between R and A, use between U and R, etc. We construct the healthcare heterogeneous network by extracting the healthcare related discussion threads in social media, annotating the messages, and computing the strength of association between the extracted entities. Users can click on the nodes and links to find relevant discussions on diseases, drugs, treatments, etc. In this work, the social media content is crawled from a healthcare social media site, MedHelp.org. Through researching the social media and authorative healthcare information, users find out the experience of other patients on various drug and treatment options as well as some other scientific findings. Patients and researchers are able to post their insights through pubishing their own ACTONNECTION in the system. The ACTONNECT system will recommend other Connections, based on the document similarity. Hence, users view the insights of other patients, caregivers, physicians and researchers. Users may connect to each other to discuss their findings and establish collaborations of new research problems.