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1. Un intento de reducir intervenciones quirúrgicas innecesarias... ¿Pueden ayudar las características ecográficas a diferenciar el adenoma del carcinoma en las neoplasias tiroideas foliculares?

Author

Tomás Ganado, Cristina Familiar, S. Merino, I. Subhi, J. Lloret, L. Moreno, and P. Suárez

Subjects
Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, business.industry, 030220 oncology & carcinogenesis, Medicine, Radiology, Nuclear Medicine and imaging, business, Follicular carcinoma, 030218 nuclear medicine & medical imaging
Abstract

Resumen Introduccion y objetivos Los nodulos tiroideos requieren con frecuencia evaluacion mediante ecografia y puncion aspiracion con aguja fina (PAAF). No obstante, la PAAF no permite la diferenciacion entre adenoma y carcinoma folicular en lesiones de tipo IV segun la clasificacion de Bethesda. Esto provoca numerosas intervenciones quirurgicas innecesarias porque no es posible garantizar el caracter benigno de las lesiones, ni siquiera cuando la mayoria de las muestras corresponden a adenomas o incluso a otras lesiones benignas. El objetivo de este estudio es establecer si hay caracteristicas ecograficas que nos ayudarian a pronosticar el riesgo de malignidad de los nodulos con un diagnostico anatomopatologico de neoplasia folicular para conseguir un abordaje mas conservador de los nodulos sin sospecha de malignidad. Material y metodos Estudiamos 61 nodulos en 61 pacientes (51 mujeres y 10 varones) que se habian sometido a intervencion quirurgica de la glandula tiroides y tenian resultados histopatologicos de adenoma o carcinoma folicular. Se analizaron diversas caracteristicas ecograficas de los nodulos (composicion, ecogenicidad, borde, estado de calcificacion, presencia de halo y sospecha general de malignidad segun el observador) y se establecio su correlacion con el analisis histopatologico. Resultados Observamos una relacion estadisticamente significativa entre el carcinoma folicular y la presencia de calcificaciones, bordes mal definidos y la sospecha o impresion general del observador (definida por sospecha clara de signos ecograficos de malignidad, como calcificacion, borde mal definido y un nodulo solido marcadamente hipoecoico; y signos ecograficos de benignidad, como composicion ecogenica predominantemente quistica y presencia de halo hipoecogenico perinodular). Sin embargo, todas estas caracteristicas han mostrado una sensibilidad baja en el estudio que nos ocupa (30%, 30% y 50%, respectivamente). En cambio, la ausencia del signo de halo ha demostrado una sensibilidad del 100% y un valor predictivo negativo del 100% en nuestro estudio. Conclusiones La presencia de calcificaciones, los bordes mal definidos y la impresion o sospecha general de malignidad se asocian con un riesgo mayor de carcinoma folicular en nodulos tiroideos de tipo IV segun la clasificacion de Bethesda, pero su ausencia no permite pronosticar el caracter benigno de estos nodulos. En cambio, cuando se observa una lesion con signo de halo, deberia considerarse una neoplasia folicular benigna.

Published
2023

2. Colangitis crónicas: diagnóstico diferencial y papel de la resonancia magnética

Author

E. Cebada Chaparro, J. Lloret del Hoyo, and R. Méndez Fernández

Subjects
medicine.medical_specialty, Magnetic resonance cholangiopancreatography, Cirrhosis, medicine.diagnostic_test, business.industry, Usually asymptomatic, medicine.disease, Gastroenterology, Inflammatory bowel disease, 030218 nuclear medicine & medical imaging, Primary sclerosing cholangitis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, 030211 gastroenterology & hepatology, Radiology, Nuclear Medicine and imaging, Digestive tract, Differential diagnosis, business, Cholangitides
Abstract

The idiopathic chronic cholangitides comprise a group of hepatobiliary diseases of probable autoimmune origin that are usually asymptomatic in the initial stages and can lead to cirrhosis of the liver. Elevated cholestatic enzymes on blood tests raise suspicion of these entities. Among the idiopathic cholangitides, the most common is primary sclerosing cholangitis, which is associated with inflammatory bowel disease and with an increased incidence of hepatobiliary and digestive tract tumors. It is important to establish the differential diagnosis with IgG4-associated cholangitis, primary biliary cholangitis, and secondary cholangitides, because the therapeutic management is different. Magnetic resonance cholangiopancreatography (MRCP) is the best test to evaluate the intrahepatic and extrahepatic biliary tract, and MRI also provides information about the liver and other abdominal organs. An appropriate MRCP protocol and knowledge of the different findings that are characteristic of each entity are essential to reach the correct diagnosis.

Published
2020

3. Thoracic wall reconstruction with bioabsorbable plates in pediatric malignant thoracic wall tumors

Author

Laura Sánchez García, G. Guillén, J Lloret, Marhuenda C, J.A. Molino, S. López, F. Pellisé, and C.G. Fontecha

Subjects
Male, medicine.medical_specialty, Adolescent, Postoperative radiotherapy, Ribs, Scoliosis, Sarcoma, Ewing, Resection, Chest wall reconstruction, 03 medical and health sciences, 0302 clinical medicine, Postoperative Complications, Absorbable Implants, medicine, Humans, Child, Thoracic Wall, Retrospective Studies, Rib cage, Osteosarcoma, business.industry, Ewing's sarcoma, General Medicine, Plastic Surgery Procedures, Thoracic Neoplasms, Thoracic Surgical Procedures, medicine.disease, Surgery, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Pediatrics, Perinatology and Child Health, 030211 gastroenterology & hepatology, Female, Radiology, Neoplasm Recurrence, Local, business, Thoracic wall
Abstract

Aim Childhood malignant chest wall tumors may require extensive surgical resection and reconstruction with musculoskeletal flaps or non-resorbable prosthetic materials. Implant-related complications and scoliosis often occur. This study analyzes the outcomes of chest wall reconstruction using resorbable plates as an alternative approach. Methods Retrospective review (2007–2015) of patients who underwent resection of malignant primary chest wall tumors in 2 tertiary pediatric centers. Reconstruction was performed using copolymer (l-lactic and glycolic acid) plates, fixed to the ribs and surrounding structures with copolymer screws and/or polyglactin sutures. Results Eight patients aged 10.6+2.6years were treated. There were no operative complications, and implant removal was not required in any case. Six patients received postoperative radiotherapy. Over follow-up (39.6months, range 9.4–78), chest wall shape was maintained in all, and there were no radiological artifacts. Three patients developed scoliosis (Cobb 17°–33°), but treatment was needed only in one, who had undergone hemivertebrectomy. There were no cases of local tumor relapse. One patient died because of metastatic spread. Conclusions Implantation of bioabsorbable l-lactic and glycolic acid copolymer plates with a relatively simple technique provided a rigid, stable reconstruction with only mild mid-/long-term complications. Resorbable plates may be a good alternative for pediatric chest wall reconstruction. Level of evidence: IV.

Published
2016

4. Spinal anaesthesia for inguinal herniotomy in preterm infants sedated with nitrous oxide: a comparison of lumbar puncture in the lateral or sitting position

Author

J. Lloret, R. Vilà, F. Munar, and J. Vinzo

Subjects
Bupivacaine, medicine.medical_specialty, medicine.diagnostic_test, business.industry, Local anesthetic, medicine.drug_class, Lumbar puncture, Sedation, medicine.disease, Sitting, Surgery, Anesthesiology and Pain Medicine, Lumbar, Anesthesia, Heart rate, Medicine, Hernia, medicine.symptom, business, medicine.drug
Abstract

This study compares spinal anaesthesia for inguinal herniotomy in preterm infants in the lateral or sitting position. Thirty patients were randomly divided into two equal groups. One hour before spinal anaesthesia, a eutetic mixture of local anaesthetic cream was applied to the lower lumbar spine. Sedation with nitrous oxide 50% in oxygen was given to all patients before and during induction of spinal anaesthesia, and throughout surgery. Lumbar punctures were performed at the L4-5 interspace using a 2.5 cm 22 G needle. Isobaric bupivacaine 0.5% with epinephrine 1 : 200 000 at a bupivacaine dose of 1 mg.kg-1 was injected in the lateral or sitting position. Measurements included heart rate, blood pressure, oxygen saturation, maximum sensory block height and duration of motor block and analgesia. There were no statistically significant differences between the groups in any measured parameters. Median [range] maximum block height was T5[T4-T7] in the lateral group and T5[T4-T5] in the sitting group. The median [range] duration of motor blockade was 67 [50-85] min in the lateral group and 63 [50-80] min in the sitting group. Our results indicate that in preterm infants sedated with nitrous oxide, spinal anaesthesia for inguinal herniotomy performed with isobaric bupivacaine 0.5% at a dose 1.0 mg.kg-1 in the lateral or sitting position is equally effective and is associated with minimal side effects.

Published
2002

5. Retro-esophageal subclavian artery: a case report

Author

F. Sánchez del Campo, J. Correa-Lacarcel, F. F. Terol, V. Almenar-Garcia, J. Lloret, and J. Robles

Subjects
Male, Aortic arch, Subclavian Artery, Dissection (medical), Electronic Supplementary Material, Pathology and Forensic Medicine, Esophagus, Cadaver, medicine.artery, medicine, Humans, Radiology, Nuclear Medicine and imaging, Subclavian artery, Aged, Aged, 80 and over, business.industry, Mediastinum, Aberrant right subclavian artery, Anatomy, medicine.disease, medicine.anatomical_structure, Surgery, business
Abstract

This case report presents the finding of an aberrant right subclavian artery during the routine dissection of 230 human adults specimens. The case which we describe appeared in an 82-year-old male donor, in whom the right retro-esophageal subclavian artery was observed as the last branch of the aortic arch. The rate of occurrence of this variation is stated to be less than 1%. This variation is described in detail; embryology and anatomy are reviewed and we discuss it in relation to other cases. The aortic arch was dissected, and its branches were described as regards their relations, length and diameter. The French version of this article is available in the form of electronic supplementary material and can be obtained by using the Springer Link server located at http://dx.doi.org/10.1007/s00276-002-0047-0

Published
2002

6. Hemorragia subaracnoidea aneurismática. Introducción a algunos de los aspectos más importantes de esta enfermedad

Author

J. Lloret, R. Martínez Rumbo, Franklyn Ruiz, J. Campollo, P.A. Gómez López, José M. Roda, A. Ley Garcia, R. Díez Lobato, J.M. González Darder, A. García Allut, G. Conesa, A. de la Riva, Justina Prada, M. Soto, and Alfonso Lagares

Subjects
business.industry, Medicine, Surgery, Neurology (clinical), business, Humanities
Abstract

Resumen Se revisan la epidemiologia, historia natural, metodologia diagnostica y recomendaciones para el tratamiento quirurgico y endovascular de los aneurismas intracraneales. Las recomendaciones propuestas deben considerarse como una guia general de manejo de esta patologia. Sin embargo, pueden ser modificadas, incluso de manera significativa por las circunstancias propias de cada caso clinico, o las variaciones en los recursos diagnosticos y terapeuticos del centro hospitalario que reciba al paciente.

Published
2000

7. Absceso bulbar: Presentación de un caso y revisión de la literatura

Author

J. Lloret García and P. Moreno López

Subjects
business.industry, Medicine, Surgery, Neurology (clinical), business, Humanities
Abstract

Resumen Presentamos el caso de un paciente de 61 anos, quien tras tres semanas de una rinitis alergica, desarrolla un cuadro neurologico agudo de afectacion bulbar y vias largas El cuadro clinico neurologico y la resonancia nuclear magnetica dieron el diagnostico de presuncion. La paciente fue intervenida de urgencia mediante una craniectomia suboccipital y acceso microquirurgico. Se aspiro un contenido purulento de una cavidad quistica alargada que se extendia desde el bulbo a la union bulbo medular. La evolucion fue muy favorable y la enferma fue dada de alta con un pequeno deficit del nervio glosofaringeo derecho que esta recuperando paulatinamente. Se revisa la bibliografia y se discuten las distintas opciones terapeuticas.

Published
1999

8. Changes in growth, growth hormone, and insulin-like growth factor-I (IGF-I) after orthotopic liver transplantation

Author

Broto J, D Infante, J Lloret, C. Castro de Kolster, V. Martínez, N. Potau, and R Tormo

Subjects
Male, medicine.medical_specialty, Orthotopic liver transplantation, medicine.medical_treatment, Radioimmunoassay, Growth, Growth hormone, Chronic liver disease, Insulin-like growth factor, Internal medicine, medicine, Humans, Insulin-Like Growth Factor I, Child, business.industry, Liver Diseases, Growth factor, General Medicine, medicine.disease, Pathophysiology, Liver Transplantation, Transplantation, Treatment Outcome, Endocrinology, Liver, Child, Preschool, Growth Hormone, Chronic Disease, Pediatrics, Perinatology and Child Health, Female, Surgery, Liver function, business, Follow-Up Studies
Abstract

Growth failure is an important consequence of chronic liver disease in childhood. Insulin-like growth factor-I (IGF-I), which is synthesized and released by the liver, plays an important role as a growth regulator in humans. We examined the growth hormone (GH)/IGF-I axis before and after orthotopic liver transplantation (LT) in 14 children aged between 2 and 11 years (mean 5.6 +/- 1.1 years). Pre-transplantation serum GH levels (7.5 +/- 1.2 ng/ml) were significantly higher (P0.001) compared with controls (5 +/- 0.5 ng/ml). However, post-transplantation levels (1.8 +/- 0.8 ng/ml) did not differ from those in the control group. Serum IGF-I levels showed a statistically significant increase after LT (20.1 +/- 9.4 vs 190 +/- 66.2 ng/ml; P0.001) and became indistinguishable from the levels in the control group (180 +/- 96 ng/ml). In comparison with pre-transplantation data (z - 2.70), there was an increase in height 4 years postoperatively (z - 1.68). Catch-up growth was highly significant, in particular during the 1st year after LT (z -1. 58 +/- 1.63 vs 2.59 +/- 5.29; P0.01). We conclude that a GH resistance state found in patients with severe chronic liver disease reverted following LT. Given that IGF-1 depends upon liver function, this could be one of the main factors in the significant catch-up growth in pediatric LT recipients.

Published
1998

9. Hemorragia en un quiste simple de la glándula pineal. Presentación de un caso

Author

J. Lloret García, F. Ruiz-García, J.M. García de Quirós, P. Moreno López, and M. Trigueros Mateos

Subjects
Gynecology, medicine.medical_specialty, Pineal Glial Cyst, business.industry, Pineal Cyst, medicine, Obstructive hydrocephalus, Surgery, Neurology (clinical), business
Abstract

Resumen Se presenta el caso de una mujer de 50 anos con una hemorragia en el seno de un quiste simple de la glandula pineal, que debuta con intensa cefalea, vomitos y signos radiologicos de hidrocefalia aguda, siendo tratada con una derivacion ventriculo-peritoneal de urgencia y posteriormente con la reseccion total, mediante craniectomia suboccipital, via supracerebelosa infratentorial. La localizacion de la lesion se establecio con TC y RM. El diagnostico anatomopatologico resulto ser el de un quiste simple glial de la epifisis con hemorragia en su interior. Se realiza una amplia revision de la bibliografia y se estudia este tipo de lesion, que, por su comportamiento clinico y por su aspecto radiologico, produce controversias en el diagnostico y en la eleccion del tratamiento mas oportuno. Se comenta la tecnica quirurgica empleada y su resultado y, finalmente, se analiza su naturaleza y su origen.

Published
1997

10. Pancreatectomy extension in persistent hyperinsulinaemic hypoglycaemia: a new strategy

Author

Boix-Ochoa J, J. Lloret, A. Carrascosa, P. Abad, V. Martinez-Ibanez, M. Gussinyer, and N. Toran

Subjects
Gynecology, medicine.medical_specialty, business.industry, Vasodilator Agents, Diazoxide, Infant, Newborn, Infant, Adenoma, Islet Cell, Survival Analysis, Hypoglycemia, Surgery, Pancreatic Neoplasms, Hyperinsulinaemic hypoglycaemia, Pancreatectomy, Child, Preschool, Hyperinsulinism, Pediatrics, Perinatology and Child Health, medicine, Humans, business, Selection criterion, Child, Algorithms, Retrospective Studies
Abstract

Introduction: L'hypoglycemie hyperinsulinique persistante neonatale et infantile (PNHH) est une entite rare qui doit etre elucidee, mais qui est souvent associee a des lesions severes chez les patients pediatriques. Le but de cette etude est de presenter notre strategie chirurgicale habituelle pour cette maladie, basee sur nos constatations pathologiques et notre experience clinique. Materiel et Methodes: Ceci est une etude retrospective de 29 patients traites medicalement et chirurgicalement dans notre centre. Chez 15 patients, la morphologie, la morphometrie et l'immunohistochimie pour l'insuline, la somatostatine et le glucagon ont ete realises et il a ete possible d'etablir qu'il s'agissait d'une forme focale ou diffuse. Resultat: Chez 29 patients etudies, 25 etaient diagnostiques avant un an et 4 entre la premiere et la seconde annee de vie. Parmi les 25 patients, un est decede 7 heures apres l'accouchement. Douze patients ont recus un traitement medical seul: un est decede a 45 jours de vie et les autres ont un devenir correct. Les autres 12 patients ont ete traites chirurgicalement. Chez 2 de ceux-ci, un adenome etait observe et enleve et les patients gueris. Une pancreatectomie sub-totale etait realisee chez les 10 autres. (Un cas etait normal et gueri et les 9 autres avaient une lesion de type diffuse). Parmi les 9 patients avec une forme diffuse, 4 sont morts, 3 sont gueris et 2 ont necessite une reintervention chirurgicale. Parmi les 4 patients diagnostiques plus tard, 3 ont subi une intervention chirurgicale, 2 avec un adenome et 1 avec une forme diffuse. Les autres ont recu un traitement medical seul. Conclusion: Nous donnons regulierement un traitement medical pour tous les types et formes de PNHH. Si le patient est resistant au traitement, un adenome est recherche. Si cet adenome est diagnostique, il est enleve. S'il s'agit d'une forme diffuse, une pancreatectomie sub-totale est realisee avec une biopsie per-operatoire. En cas d'hyperplasie ou de forme mixte, nous recommandons une pancreatectomie totale et en cas de nesidioblastose, une pancreatectomie partielle.

Published
2002

11. P-272 Dysplasia and aberrant DNA methyation profiles in risk and lungcancer patients

Author

E. Arellano, Josep Ramírez, J. Gupta, M. Fernadez, Rafael Rosell, J. Lloret, N. Rodríguez, N. de la Torre, Miquel Taron, and Antoni Rosell

Subjects
Pulmonary and Respiratory Medicine, Cancer Research, Pathology, medicine.medical_specialty, chemistry.chemical_compound, Oncology, chemistry, Dysplasia, business.industry, medicine, medicine.disease, business, DNA
Published
2005

12. Pólipo fibrovascular esofágico gigante

Author

A. Obrador, J. Reyes, L. Bonet, A. Escarda, J. Roldán, A. Llompart, J. Gayà, Daniel Ginard, J. Lloret, and L. Barranco

Subjects
medicine.medical_specialty, Esophagus surgery, Hepatology, business.industry, Treatment outcome, Gastroenterology, medicine, MEDLINE, business, Surgery
Published
2004

13. Differences in antipsychotic combination (monotherapy versus polytherapy) between patients with schizophrenia and patients with other psychoses

Author

N. Morales, Isama, M. Lucas, M. Portela, M.C. Diaz, J. Ruiz, M.D. Martinez, J. Lloret, A. Mayordomo, David Fraguas, and F.J. Ruiz

Subjects
Pediatrics, medicine.medical_specialty, Delusional disorder, business.industry, medicine.medical_treatment, Not Otherwise Specified, Brief psychotic disorder, Schizoaffective disorder, medicine.disease, Psychiatry and Mental health, Schizophrenia, medicine, Schizophreniform disorder, Antipsychotic, Psychiatry, business, Diagnosis of schizophrenia
Abstract

IntroductionAntipsychotic therapy is the cornerstone of the treatment of schizophrenia and other psychoses. Although clinical guidelines tend to recommend the use of antipsychotics in monotherapy, combination of two or more antipsychotics (that is, polytherapy) is a common habit in clinical practice.ObjectivesTo assess differences in antipsychotic combination profile between patients with schizophrenia and patients with other psychoses.MethodsA total of 241 patients (40.2% females, mean age 39.7+/−13.0 years) consecutively admitted during 2009 to a psychiatric inpatient ward with diagnosis of schizophrenia and other psychoses were assessed.Results145 (60.2%) patients were diagnosed with schizophrenia while 96 patients (39.8%) were diagnosed with other psychoses (schizoaffective disorder n = 35, delusional disorder n = 8, schizophreniform disorder n = 8, brief psychotic disorder n = 13, psychotic disorder not otherwise specified n = 27, and other psychoses n = 5). Out of the total sample, polytherapy was used in 150 (62.2%) patients. A total of 100 (69.0%) patients with schizophrenia were on polytherapy, compared to 52.1% of those with other psychoses (p = 0.008). After controlling for age and gender, the association between a diagnosis of schizophrenia and being in polytherapy remained significant (p = 0.046).ConclusionsPatients diagnosed with schizophrenia are more prone to be in polytherapy than those with other psychoses.

Published
2011

14. 1. Abordaje microquirúrgico a la región pineal; importancia de las variaciones anatómicas y de las relaciones de esta glándula

Author

F. Ruiz-García, V. Almenar García, J. Lloret García, A. Pérez Perelló, and P. Moreno López

Subjects
business.industry, Medicine, Surgery, Neurology (clinical), business, Humanities
Abstract

La region pineal situada en la cisterna cuadrigemina y bordeada por la cisterna ambiens, contiene la glandula pineal, el sistema venoso profundo de drenaje del diencefalo, las arterias coroideas posteromediales y el ultimo segmento de la arteria cerebral posterior. Esta region es de dificil manipulacion quirurgica por las estructuras cerebrales que la delimitan y tambien por el complejo sistema venoso que la atraviesa. El 1 % de todos los tumores cerebrales se desarrolla en esta region. En este estudio se expone y se ilustra con casos practicos una vision microquirurgica de la zona asi como sus principales accidentes y variaciones anatomicas relacionados con la via de abordaje.

Published
2001

15. Myocardial uptake on technetium-99m glucarate occurs in acute regional myocardial necrosis but not in diffuse ongoing myocardial damage

Author

Jagat Narula, Montserrat Estorch, I. Carrió, M. Santaló, Ll Bernà, J.C Martín, A. Flotats, Ana M. Catafau, Manel Ballester, Carina Mari, and J Lloret

Subjects
medicine.medical_specialty, business.industry, Internal medicine, medicine, Cardiology, Radiology, Nuclear Medicine and imaging, Myocardial necrosis, Cardiology and Cardiovascular Medicine, business, Technetium-99m
Published
1999

16. La fatiga de los musculos respiratorios

Author

R. Navarro Ivañez, J. Lloret solves, and G. Juan Samper

Subjects
Pulmonary and Respiratory Medicine, business.industry, Medicine, business, Humanities
Published
1987

17. Pseudoquistes pulmonares postraumaticos

Author

J. Beltran, I. Ferreres, and J. Lloret

Subjects
Pulmonary and Respiratory Medicine, business.industry, Medicine, business, Humanities
Abstract

Resumen El pseudoquiste postraumatico es una complicacion relativamente rara de los traumatismos toracicos. Sus caracteristicas radiologicas, evolucion y mecanismos de produccion son comentados brevemente, presentandose dos casos clinicos significativos, haciendose una revision de la literatura.

Published
1981

18. Cortisol response to surgical stress in neonates

Author

J Lloret, V Martínez Ibáñez, N. Potau, and Boix-Ochoa J

Subjects
medicine.medical_specialty, Surgical stress, business.industry, Radioimmunoassay, General Medicine, Normal limit, Plasma cortisol, Endocrinology, Internal medicine, Recien nacido, Pediatrics, Perinatology and Child Health, Pediatric surgery, medicine, Surgery, Circadian rhythm, business, Hydrocortisone, medicine.drug
Abstract

To determine the metabolic response of newborns to surgical stress, 36 neonates between 2 h and 3 weeks of age and 11 infants of 1–3 months were included in a 7-year study. Plasma cortisol levels were determined by radioimmunoassay with blood samples taken before, during, and after surgery until they were within normal limits; the response to chemical stress (ACTH) was also studied and compared. The preliminary conclusions on cortisol response were: (1) absence of the circadian cycle in all neonates in the study; (2) a statistical relationship was observed between age and cortisol response; and (3) in newborns less than 9–10 days of age, the response to surgical stress was statistically different from that of newborns older than 10 days, whose response was similar to that of infants. These results suggest that there are two different stages during the neonatal period that correspond to different degrees of neuroendocrinological maturation.

Published
1987

20. 67. ORTHOTOPIC LIVER TRANSPLANTATION IN CHILDREN

Author

J Iqlesias, F Barranco, J Lloret, R Tormo, A Ballabriga, P Domínquez, Broto J, Boix-Ochoa J, D Infante, V Martínez Ibáñez, and Carlos Margarit

Subjects
medicine.medical_specialty, medicine.diagnostic_test, Orthotopic liver transplantation, business.industry, medicine.disease, Gastroenterology, Surgery, Liver biopsy, Internal medicine, Pediatrics, Perinatology and Child Health, medicine, Prednisolone, Coagulopathy, Alkaline phosphatase, Bolus (digestion), business, Serum transaminase, Drug induced hepatotoxicity, medicine.drug
Abstract

Orthotopic liver transplantation(OLT) is a therapeutic option for children with end-stage liver diseases. Once the OLT has been completed inmunosupression with prednisolone(P) and cyclosporine(C) is started. The two major problems in the postoperative period(POP)are related to rejection and drug induced hepatotoxicity (DIH) both manifested by similar byochemical and clinical symptomatology. To evaluate both problems is the aim of this paper. METHODS: The POP of 13 children that underwent OLT with succes, has been reviewed. The evidence of rejection or DIH, have been searched for. RESULTS: All patients presented in the POP a coagulopathy rise in serum transaminases, gamaGT, alkaline phosphatase and bilirrubin. 12 of them improved with P bolus, and later on, C levels and liver biopsy, proved to be a rejection crisis. Other one did not improve with P bolus, and subsequent C dosage and liver biopsy, confirmed DIH. CONCLUSIONS: If ther is doubt on rejection or DIH, P bolus must be administered in order to treat a possible rejection crisis, till the liver biopsy and other byochemical paramenters stablish the diagnosis with accuracy.

Published
1987

21. Expansion cone for the 3-inch PMTs of the KM3NeT optical modules

Author

Adrian-Martinez, S.as, Ageron, M.i, Aguilar, J.A.p, Aharonian, F.k, Aiello, S.u, Albert, A.m, Alexandri, M.n, Ameli, M.ac, Anassontzis, E.G.d, Anghinolfi, M.w, Anton, G.l, Anvar, S.f, Ardid, M.as, Assis Jesus, A.am, Aubert, J.-J.i, Bakker, R.an, Ball, A.E.ao, Barbarino, G.aa, Barbarito, E.r, Barbato, F.aa, Baret, B.c, De Bel, M.b, Belias, A.nao, Bellou, N.ah, Berbee, E.am, Berkien, Bersani, A.w, Bertin, V.i, Beurthey, S.i, Biagi, S.s, Bigongiari, C.p, Bigourdan, B.q, Billault, De Boer, R.am, Boer Rookhuizen, H.am, Bonori, M.ad, Borghini, M.h, Bou-Cabo, Bouhadef, B.ab, Bourlis, G.o, Bouwhuis, M.am, Bradbury, S.aj, Brown, A.i, Bruni, F.aq, Brunner, J.i, Brunoldi, Busto, Cacopardo, G.x, Caillat, L.i, Calvo Díaz-Aldagalán, D.p, Calzas, Canals, M.e, Capone, A.ad, Carr, Castorina, E.ab, Cecchini, Ceres, A.r, Cereseto, R.w, Chaleil, Th.f, Chateau, F.f, Chiarusi, T.s, Choqueuse, D.q, Christopoulou, P.E.o, Chronis, G.n, Ciaffoni, O.y, Circella, M.r, Cocimano, R.x, Cohen, F.m, Colijn, F.ah, Coniglione, Cordelli, M.y, Cosquer, Costa, M.x, Coyle, P.i, Craig, J.a, Creusot, A.c, Curtil, C.i, D'Amico, A.x, Damy, G.q, De Asmundis, R.z, De Bonis, G.ad, Decock, G.f, Decowski, P.am, Delagnes, E.f, De Rosa, Distefano, C.x, Donzaud, C.cat, Dornic, D.i, Dorosti-Hasankiadeh, Q.ai, Drogou, J.q, Drouhin, D.m, Druillole, Drury, L.k, Durand, D.f, G.A.f, Eberl, T.l, Emanuele, U.p, Enzenhöfer, A.l, Ernenwein, J.-P.i, Escoffier, Espinosa, V.as, Etiope, G.ae, Favali, P.ae, Felea, D.ag, Ferri, Ferry, Flaminio, V.ab, Folger, F.l, Fotiou, A.ao, Fritsch, U.l, Gajanana, D.am, Garaguso, R.ab, Gasparini, G.P.h, Gasparoni, Gautard, V.f, Gensolen, F.i, Geyer, K.l, Giacomelli, G.s, Gialas, I.o, Giordano, V.x, Giraud, J.f, Gizani, N.o, Gleixner, Gojak, Gómez-González, J.P.p, Graf, Grasso, D.ab, Grimaldi, A.u, Groenewegen, Guédé, Z.q, Guillard, G.af, Guilloux, Habel, R.y, Hallewell, G.i, Van Haren, H.an, Van Heerwaarden, J.an, Heijboer, Heine, Hernández-Rey, J.J.p, Herold, B.l, Van De Hoek, Hogenbirk, J.am, Hößl, J.l, Hsu, C.C.am, Imbesi, Jamieson, A.a, Jansweijer, De Jong, Jouvenot, F.ak, Kadler, M.lau, Kalantar-Nayestanaki, N.ai, Kalekin, O.l, Kappes, Karolak, M.f, Katz, U.F.l, Kavatsyuk, O.ai, Keller, Kiskiras, Y.ao, Klein, R.l, Kok, Kontoyiannis, H.n, Kooijman, P.bamar, Koopstra, J.bam, Kopper, C.amav, Korporaal, Koske, P.ah, Kouchner, Koutsoukos, S.d, Kreykenbohm, I.l, Kulikovskiy, V.waw, Laan, M.an, La Fratta, C.ae, Lagier, Lahmann, Lamare, Larosa, G.as, Lattuada, D.x, Leisos, A.o, Lenis, D.o, Leonora, E.u, Le Provost, H.f, Lim, G.b, Llorens, C.D.an, Lloret, Löhner, H.ai, Lo Presti, D.v, Lotrus, P.f, Louis, Lucarelli, F.ad, Lykousis, V.n, Malyshev, D.kax, Mangano, S.p, Marcoulaki, E.C.al, Margiotta, A.s, Marinaro, Marinelli, A.ab, Maris, O.ag, Markopoulos, E.ao, Markou, C.al, Martínez-Mora, J.A.as, Martini, A.y, Marvaldi, Masullo, R.ad, Maurin, G.fay, Migliozzi, P.z, Migneco, E.x, Minutoli, S.w, Miraglia, Mollo, C.M.z, Mongelli, Monmarthe, Morganti, M.ab, Mos, S.am, Motz, H.laz, Moudden, Y.f, Mul, G.am, Musico, P.w, Musumeci, Naumann, Ch.fba, Neff, M.l, Nicolaou, C.j, Orlando, Palioselitis, Papageorgiou, K.o, Papaikonomou, A.d, Papaleo, Papazoglou, I.A.al, P?v?las, G.E.ag, Peek, H.Z.am, Perkin, J.ap, Piattelli, P.x, Popa, V.ag, Pradier, T.af, Presani, Priede, I.G.a, Psallidas, Rabouille, C.g, Racca, C.m, Radu, A.ag, Randazzo, N.u, Rapidis P.a.al, Razis, P.j, Real, Reed, C.am, Reito, Resvanis, L.K.dao, Riccobene, Richter, Roensch, Rolin, Rose, J.aj, Roux, Rovelli, Russo, A.aa, G.V.v, Salesa, F.p, Samtleben, Sapienza, Schmelling, J.-W.am, Schmid, Schnabel, Schroeder, K.h, Schuller, J.-P.f, Schussler, Sciliberto, D.u, Sedita, Seitz, Shanidze, Simeone, Siotis, I.al, Sipala, V.t, Sollima, C.ab, Sparnocchia, S.h, Spies, Spurio, M.s, Staller, T.ah, Stavrakakis, Stavropoulos, G.ao, Steijger, Stolarczyk, Stransky, D.l, Taiuti, Taylor, A.k, Thompson, L.ap, Timmer, Tonoiu, Toscano, Touramanis, C.ak, Trasatti, L.y, Traverso, P.h, Trovato, Tsirigotis, Tzamarias, S.o, Tzamariudaki, E.al, Urbano, Vallage, B.f, Van Elewyck, V.c, Vannoni, Vecchi, Vernin, Viola, S.x, Vivolo, D.aa, Wagner, S.l, Werneke, White, R.J.aj, Wijnker, Wilms, De Wolf, E.bam, Yepes, H.p, Zhukov, V.ao, Zonca, Zornoza, J.D.p, Zúñiga, J.p, KM3NeT (IHEF, IoP, FNWI), KVI - Center for Advanced Radiation Technology, S., Adrián-Martínez, M., Ageron, Aguilar, J. A., F., Aharonian, S., Aiello, A., Albert, M., Alexandri, F., Ameli, Anassontzis, E. G., M., Anghinolfi, G., Anton, S., Anvar, M., Ardid, A., Assis Jesu, Aubert, J. -J., R., Bakker, Ball, A. E., G., Barbarino, E., Barbarito, F., Barbato, B., Baret, M., de Bel, A., Belia, N., Bellou, E., Berbee, A., Berkien, A., Bersani, V., Bertin, S., Beurthey, S., Biagi, C., Bigongiari, B., Bigourdan, M., Billault, R., de Boer, H., Boer Rookhuizen, M., Bonori, M., Borghini, M., Bou-Cabo, B., Bouhadef, G., Bourli, M., Bouwhui, S., Bradbury, A., Brown, F., Bruni, J., Brunner, M., Brunoldi, J., Busto, G., Cacopardo, L., Caillat, D., Calvo Díaz-Aldagalán, A., Calza, M., Canal, A., Capone, J., Carr, E., Castorina, S., Cecchini, A., Cere, R., Cereseto, Th., Chaleil, F., Chateau, T., Chiarusi, D., Choqueuse, Christopoulou, P. E., G., Chroni, O., Ciaffoni, M., Circella, R., Cocimano, F., Cohen, F., Colijn, R., Coniglione, M., Cordelli, A., Cosquer, M., Costa, P., Coyle, J., Craig, A., Creusot, C., Curtil, A., D’Amico, G., Damy, R., De Asmundi, G., De Boni, G., Decock, P., Decowski, E., Delagne, G., De Rosa, C., Distefano, C., Donzaud, D., Dornic, Q., Dorosti-Hasankiadeh, J., Drogou, D., Drouhin, F., Druillole, L., Drury, D., Durand, Durand, G. A., T., Eberl, U., Emanuele, A., Enzenhöfer, Ernenwein, J. -P., S., Escoffier, V., Espinosa, G., Etiope, P., Favali, D., Felea, M., Ferri, S., Ferry, V., Flaminio, F., Folger, A., Fotiou, U., Fritsch, D., Gajanana, R., Garaguso, Gasparini, G. P., F., Gasparoni, V., Gautard, F., Gensolen, K., Geyer, G., Giacomelli, I., Giala, V., Giordano, J., Giraud, N., Gizani, A., Gleixner, C., Gojak, Gómez-González, J. P., K., Graf, D., Grasso, A., Grimaldi, R., Groenewegen, Z., Guédé, G., Guillard, F., Guilloux, R., Habel, G., Hallewell, H., van Haren, J., van Heerwaarden, A., Heijboer, E., Heine, Hernández-Rey, J. J., B., Herold, T., Hillebrand, M., van de Hoek, J., Hogenbirk, J., Hößl, Hsu, C. C., M., Imbesi, A., Jamieson, P., Jansweijer, M., de Jong, F., Jouvenot, M., Kadler, N., Kalantar-Nayestanaki, O., Kalekin, A., Kappe, M., Karolak, Katz, U. F., O., Kavatsyuk, P., Keller, Y., Kiskira, R., Klein, H., Kok, H., Kontoyianni, P., Kooijman, J., Koopstra, C., Kopper, A., Korporaal, P., Koske, A., Kouchner, S., Koutsouko, I., Kreykenbohm, V., Kulikovskiy, M., Laan, C., La Fratta, P., Lagier, R., Lahmann, P., Lamare, G., Larosa, D., Lattuada, A., Leiso, D., Leni, E., Leonora, H., Le Provost, G., Lim, Llorens, C. D., J., Lloret, H., Löhner, D., Lo Presti, P., Lotru, F., Loui, F., Lucarelli, V., Lykousi, D., Malyshev, S., Mangano, Marcoulaki, E. C., A., Margiotta, G., Marinaro, A., Marinelli, O., Mariş, E., Markopoulo, C., Markou, Martínez-Mora, J. A., A., Martini, J., Marvaldi, R., Masullo, G., Maurin, P., Migliozzi, E., Migneco, S., Minutoli, A., Miraglia, Mollo, C. M., M., Mongelli, E., Monmarthe, M., Morganti, S., Mo, H., Motz, Y., Moudden, G., Mul, P., Musico, M., Musumeci, Ch., Naumann, M., Neff, C., Nicolaou, A., Orlando, D., Palioseliti, K., Papageorgiou, A., Papaikonomou, R., Papaleo, Papazoglou, I. A., Păvălaş, G. E., Peek, H. Z., J., Perkin, P., Piattelli, V., Popa, T., Pradier, E., Presani, Priede, I. G., A., Psallida, C., Rabouille, C., Racca, A., Radu, N., Randazzo, Rapidis, P. A., P., Razi, D., Real, C., Reed, S., Reito, Resvanis, L. K., G., Riccobene, R., Richter, K., Roensch, J., Rolin, J., Rose, J., Roux, A., Rovelli, A., Russo, Russo, G. V., F., Salesa, D., Samtleben, P., Sapienza, Schmelling, J. -W., J., Schmid, J., Schnabel, K., Schroeder, Schuller, J. -P., F., Schussler, D., Sciliberto, M., Sedita, T., Seitz, R., Shanidze, F., Simeone, I., Sioti, V., Sipala, C., Sollima, S., Sparnocchia, A., Spie, M., Spurio, T., Staller, S., Stavrakaki, G., Stavropoulo, J., Steijger, Th., Stolarczyk, D., Stransky, M., Taiuti, A., Taylor, L., Thompson, P., Timmer, D., Tonoiu, S., Toscano, C., Touramani, L., Trasatti, P., Traverso, Trovato, A, A., Tsirigoti, S., Tzamaria, E., Tzamariudaki, F., Urbano, B., Vallage, V., Van Elewyck, G., Vannoni, M., Vecchi, P., Vernin, S., Viola, D., Vivolo, S., Wagner, P., Werneke, White, R. J., G., Wijnker, J., Wilm, E., de Wolf, H., Yepe, V., Zhukov, E., Zonca, Zornoza, J. D., J., Zúñiga TROVATO A, S., Adrian Martinez, J., Aguilar, M., Ameli, E., Anassontzi, A. A., Jesu, J., Aubert, A., Ball, Barbarino, Giancarlo, Barbato, FELICIA CARLA TIZIANA, M. D., Bel, R. D., Boer, H. B., Rookhuizen, M., Bou Cabo, D. C., D??????az Aldagal??????n, T., Chaleil, P., Christopoulou, A., D'Amico, R. D., Asmundi, G. D., Boni, DE ROSA, Gianfranca, Q., Dorosti Hasankiadeh, G., Durand, A., Enzenh??????fer, J., Ernenwein, G., Gasparini, J., G??????mez Gonz??????lez, Z., Gu??????d??????, H. V., Haren, J. V., Heerwaarden, J., Hern??????ndez Rey, M. V., De, J., H????????????l, C., Hsu, M. D., Jong, N., Kalantar Nayestanaki, U., Katz, C. L., Fratta, H. L., Provost, C., Lloren, H., L??????hner, D. L., Presti, E., Marcoulaki, O., Mari, J., Mart??????nez Mora, Migliozzi, Pasquale, C., Mollo, C., Naumann, I., Papazoglou, G., P??????v??????la, H., Peek, I., Priede, R. P., A., L., Resvani, G., Russo, J., Schmelling, J., Schuller, T., Stolarczyk, A., Trovato, V. V., Elewyck, Vivolo, Daniele, R., White, E. D., Wolf, J., Zornoza, J., Z????????????iga, Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), APC - Astrophysique des Hautes Energies (APC - AHE), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire des Sciences du Climat et de l'Environnement [Gif-sur-Yvette] (LSCE), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Océan et Interfaces (OCEANIS), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), KM3NeT Collaboration, Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-Alma Mater Studiorum Università di Bologna [Bologna] (UNIBO), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), S. Adri´an-Mart´ınez, M. Ageron, J.A. Aguilar, F. Aharonian, S. Aiello, A. Albert, M. Alexandri, F. Ameli, E.G. Anassontzi, M. Anghinolfi, G. Anton, S. Anvar, M. Ardid, A. Assis Jesu, J.-J. Aubert, R. Bakker, A.E. Ball, G. Barbarino, E. Barbarito, F. Barbato, B. Baret, M. de Bel, A. Belia, N. Bellou, E. Berbee, A. Berkien, A. Bersani, V. Bertin, S. Beurthey, S. Biagi, C. Bigongiari, B. Bigourdan, M. Billault, R. de Boer, H. Boer Rookhuizen, M. Bonori, M. Borghini, M. Bou-Cabo, B. Bouhadef, G. Bourli, M. Bouwhui, S. Bradbury, A. Brown, F. Bruni, J. Brunner, M. Brunoldi, J. Busto, G. Cacopardo, L. Caillat, D. Calvo D´ıaz-Aldagal´an, A. Calza, M. Canal, A. Capone, J. Carr, E. Castorina, S. Cecchini, A. Cere, R. Cereseto, Th. Chaleil, F. Chateau, T. Chiarusi, D. Choqueuse, P.E. Christopoulou, G. Chroni, O. Ciaffoni, M. Circella, R. Cocimano, F. Cohen, F. Colijn, R. Coniglione, M. Cordelli, A. Cosquer, M. Costa, P. Coyle, J. Craig, A. Creusot, C. Curtil, A. D’Amico, G. Damy, R. De Asmundi, G. De Boni, G. Decock, P. Decowski, E. Delagne, G. De Rosa, C. Distefano, C. Donzaud, D. Dornic, Q. Dorosti-Hasankiadeh, J. Drogou, D. Drouhin, F. Druillole, L. Drury, D. Durand, G.A. Durand, T. Eberl, U. Emanuele, A. Enzenh¨ofer, J.-P. Ernenwein, S. Escoffier, V. Espinosa, G. Etiope, P. Favali, D. Felea, M. Ferri, S. Ferry, V. Flaminio, Folger, A. Fotiou, U. Fritsch, D. Gajanana, R. Garaguso, G.P. Gasparini, F. Gasparoni, V. Gautard, F. Gensolen, K. Geyer, G. Giacomelli, I. Giala, V. Giordano, J. Giraud, N. Gizani, A. Gleixner, C. Gojak, J.P. G´omez-Gonz´alez, K. Graf, D. Grasso, A. Grimaldi, R. Groenewegen, Z. Gu´ed´e, G. Guillard, F. Guilloux, R. Habel, G. Hallewell, H. van Haren, J. van Heerwaarden, A. Heijboer, E. Heine, J.J. Hern´andez-Rey, B. Herold, M. van de Hoek, J. Hogenbirk, J. H¨oßl, C.C. Hsu, M. Imbesi, A. Jamieson, P. Jansweijer, M. de Jong, Jouvenot, M. Kadler, N. Kalantar-Nayestanaki, O. Kalekin, A. Kappe, M. Karolak, U.F. Katz, O. Kavatsyuk, P. Keller, Y. Kiskira, R. Klein, H. Kok, H. Kontoyianni, P. Kooijman, J. Koopstra, C. Kopper, A. Korporaal, P. Koske, A. Kouchner, S. Koutsouko, I. Kreykenbohm, V. Kulikovskiy, M. Laan, C. La Fratta, P. Lagier, R. Lahmann, P. Lamare, G. Larosa, D. Lattuada, A. Leiso, D. Leni, E. Leonora, H. Le Provost, G. Lim, C.D. Lloren, J. Lloret, H. L¨ohner, D. Lo Presti, P. Lotru, F. Loui, F. Lucarelli, V. Lykousi, D. Malyshev, S. Mangano, E.C. Marcoulaki, A. Margiotta, G. Marinaro, A. Marinelli, O. Mari, E. Markopoulo, C. Markou, J.A. Mart´ınez-Mora, A. Martini, J. Marvaldi, R. Masullo, G. Maurin, P. Migliozzi, E. Migneco, S. Minutoli, A. Miraglia, C.M. Mollo, M. Mongelli, E. Monmarthe, M. Morganti, S. Mo, H. Motz, Y. Moudden, G. Mul, P. Musico, M. Musumeci, Ch. Naumann, M. Neff, C. Nicolaou, A. Orlando, D. Palioseliti, K. Papageorgiou, A. Papaikonomou, R. Papaleo, I.A. Papazoglou, G.E. Pavala, H.Z. Peek, J. Perkin, P. Piattelli, V. Popa, T. Pradier, E. Presani, I.G. Priede, A. Psallida, C. Rabouille, C. Racca, A. Radu, N. Randazzo, P.A. Rapidi, P. Razi, D. Real, C. Reed, S. Reito, L.K. Resvani, G. Riccobene, R. Richter, K. Roensch, J. Rolin, J. Rose, J. Roux, A. Rovelli, A. Russo, G.V. Russo, F. Salesa, D. Samtleben, P. Sapienza, J.-W. Schmelling, J. Schmid, J. Schnabel, K. Schroeder, J.-P. Schuller, F. Schussler, D. Sciliberto, M. Sedita, T. Seitz, R. Shanidze, F. Simeone, I. Sioti, V. Sipala, C. Sollima, S. Sparnocchia, A. Spie, M. Spurio, T. Staller, S. Stavrakaki, G. Stavropoulo, J. Steijger, Th. Stolarczyk, D. Stransky, M. Taiuti, A. Taylor, L. Thompson, P. Timmer, D. Tonoiu, S. Toscano, C. Touramani, L. Trasatti, P. Traverso, A. Trovato, A. Tsirigoti, S. Tzamaria, E. Tzamariudaki, F. Urbano, B. Vallage, V. Van Elewyck, G. Vannoni, M. Vecchi, P. Vernin, S. Viola, D. Vivolo, S. Wagner, P. Werneke, R.J. White, G. Wijnker, J. Wilm, E. de Wolf, H. Yepe, V. Zhukov, E. Zonca, J.D. Zornoza and J. Z´u˜niga, Adrian-Martinez, S., Ageron, M., Aharonian, F., Aiello, S., Albert, A., Alexandri, M., Ameli, M., Anghinolfi, M., Anton, G., Anvar, S., Ardid, M., Assis Jesus, A., Bakker, R., Barbarino, G., Barbarito, E., Barbato, F., Baret, B., De Bel, M., Belias, A., Bellou, N., Berbee, E., Berkien, A., Bersani, A., Bertin, V., Beurthey, S., Biagi, S., Bigongiari, C., Bigourdan, B., Billault, M., De Boer, R., Boer Rookhuizen, H., Bonori, M., Borghini, M., Bou-Cabo, M., Bouhadef, B., Bourlis, G., Bouwhuis, M., Bradbury, S., Brown, A., Bruni, F., Brunner, J., Brunoldi, M., Busto, J., Cacopardo, G., Caillat, L., Calvo Diaz-Aldagalan, D., Calzas, A., Canals, M., Capone, A., Carr, J., Castorina, E., Cecchini, S., Ceres, A., Cereseto, R., Chaleil, Th., Chateau, F., Chiarusi, T., Choqueuse, D., Chronis, G., Ciaffoni, O., Circella, M., Cocimano, R., Cohen, F., Colijn, F., Coniglione, R., Cordelli, M., Cosquer, A., Costa, M., Coyle, P., Craig, J., Creusot, A., Curtil, C., D'Amico, A., Damy, G., De Asmundis, R., De Bonis, G., Decock, G., Decowski, P., Delagnes, E., De Rosa, G., Distefano, C., Donzaud, C., Dornic, D., Dorosti-Hasankiadeh, Q., Drogou, J., Drouhin, D., Druillole, F., Drury, L., Durand, D., Eberl, T., Emanuele, U., Enzenhofer, A., Escoffier, S., Espinosa, V., Etiope, G., Favali, P., Felea, D., Ferri, M., Ferry, S., Flaminio, V., Folger, F., Fotiou, A., Fritsch, U., Gajanana, D., Garaguso, R., Gasparoni, F., Gautard, V., Gensolen, F., Geyer, K., Giacomelli, G., Gialas, I., Giordano, V., Giraud, J., Gizani, N., Gleixner, A., Gojak, C., Gomez-Gonzalez, J. P., Graf, K., Grasso, D., Grimaldi, A., Groenewegen, R., Guede, Z., Guillard, G., Guilloux, F., Habel, R., Hallewell, G., Van Haren, H., Van Heerwaarden, J., Heijboer, A., Heine, E., Hernandez-Rey, J. J., Herold, B., Van De Hoek, M., Hogenbirk, J., Hossl, J., Imbesi, M., Jamieson, A., Jansweijer, P., De Jong, M., Jouvenot, F., Kadler, M., Kalantar-Nayestanaki, N., Kalekin, O., Kappes, A., Karolak, M., Kavatsyuk, O., Keller, P., Kiskiras, Y., Klein, R., Kok, H., Kontoyiannis, H., Kooijman, P., Koopstra, J., Kopper, C., Korporaal, A., Koske, P., Kouchner, A., Koutsoukos, S., Kreykenbohm, I., Kulikovskiy, V., Laan, M., La Fratta, C., Lagier, P., Lahmann, R., Lamare, P., Larosa, G., Lattuada, D., Leisos, A., Lenis, D., Leonora, E., Le Provost, H., Lim, G., Lloret, J., Lohner, H., Lo Presti, D., Lotrus, P., Louis, F., Lucarelli, F., Lykousis, V., Malyshev, D., Mangano, S., Margiotta, A., Marinaro, G., Marinelli, A., Maris, O., Markopoulos, E., Markou, C., Martinez-Mora, J. A., Martini, A., Marvaldi, J., Masullo, R., Maurin, G., Migliozzi, P., Migneco, E., Minutoli, S., Miraglia, A., Mongelli, M., Monmarthe, E., Morganti, M., Mos, S., Motz, H., Moudden, Y., Mul, G., Musico, P., Musumeci, M., Naumann, Ch., Neff, M., Nicolaou, C., Orlando, A., Palioselitis, D., Papageorgiou, K., Papaikonomou, A., Papaleo, R., Pavalas, G. E., Perkin, J., Piattelli, P., Popa, V., Pradier, T., Presani, E., Psallidas, A., Rabouille, C., Racca, C., Radu, A., Randazzo, N., Rapidis, P. a., Razis, P., Real, D., Reed, C., Reito, S., Riccobene, G., Richter, R., Roensch, K., Rolin, J., Rose, J., Roux, J., Rovelli, A., Russo, A., Salesa, F., Samtleben, D., Sapienza, P., Schmid, J., Schnabel, J., Schroeder, K., Schussler, F., Sciliberto, D., Sedita, M., Seitz, T., Shanidze, R., Simeone, F., Siotis, I., Sipala, V., Sollima, C., Sparnocchia, S., Spies, A., Spurio, M., Staller, T., Stavrakakis, S., Stavropoulos, G., Steijger, J., Stolarczyk, Th., Stransky, D., Taiuti, M., Taylor, A., Thompson, L., Timmer, P., Tonoiu, D., Toscano, S., Touramanis, C., Trasatti, L., Traverso, P., Trovato, A., Tsirigotis, A., Tzamarias, S., Tzamariudaki, E., Urbano, F., Vallage, B., Van Elewyck, V., Vannoni, G., Vecchi, M., Vernin, P., Viola, S., Vivolo, D., Wagner, S., Werneke, P., Wijnker, G., Wilms, J., De Wolf, E., Yepes, H., Zhukov, V., Zonca, E., Zuniga, J., Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Aix Marseille Université (AMU), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Dipartimento di Astronomia, Universita degli Studi di Bologna, Università di Bologna [Bologna] (UNIBO)-Università di Bologna [Bologna] (UNIBO), and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
Optical detector readout concepts, Instrument optimisation, Cherenkov detectors, Photomultiplier, [PHYS.ASTR.HE]Physics [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Cherenkov detector, Physics::Instrumentation and Detectors, 01 natural sciences, large detector systems for particle and astroparticle physics, optical detector readout concepts, cherenkov detectors, instrument optimization, Photocathode, law.invention, Telescope, Optics, law, 0103 physical sciences, NEUTRINO TELESCOPE, 010306 general physics, Instrumentation, Mathematical Physics, Cherenkov radiation, Physics, 010308 nuclear & particles physics, business.industry, Large detector systems for particle and astroparticle physics, [SDU.ASTR.HE]Sciences of the Universe [physics]/Astrophysics [astro-ph]/High Energy Astrophysical Phenomena [astro-ph.HE], Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Instrument optimization, INGENIERIA TELEMATICA, Optical detector readout concept, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], KM3NeT, Large detector systems for particle and astroparticle physic, Neutrino, business, PROJECT, 85.60.Ha Photomultipliers, phototubes and photocathodes, 42.15.Dp Wave fronts and ray tracing, 98.80.-k Cosmology, 95.55.Vj Neutrino, muon, pion, and other elementary particle detectors, cosmic ray detectors, 29.40.Ka Cherenkov detectors
Abstract

[EN] Detection of high-energy neutrinos from distant astrophysical sources will open a new window on the Universe. The detection principle exploits the measurement of Cherenkov light emitted by charged particles resulting from neutrino interactions in the matter containing the telescope. A novel multi-PMT digital optical module (DOM) was developed to contain 31 3-inch photomultiplier tubes (PMTs). In order to maximize the detector sensitivity, each PMT will be surrounded by an expansion cone which collects photons that would otherwise miss the photocathode. Results for various angles of incidence with respect to the PMT surface indicate an increase in collection efficiency by 30% on average for angles up to 45 degrees with respect to the perpendicular. Ray-tracing calculations could reproduce the measurements, allowing to estimate an increase in the overall photocathode sensitivity, integrated over all angles of incidence, by 27% (for a single PMT). Prototype DOMs, being built by the KM3NeT consortium, will be equipped with these expansion cones., This work is supported through the EU, FP6 Contract no. 011937, FP7 grant agreement no. 212252, and the Dutch Ministry of Education, Culture and Science.

Published
2013

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