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In order to cut the costs and overcome the leakage current of batteries caused in traditional method, this study introduces an improved voltage transfer method for lithium battery string management chip. This proposed circuit based on the improved voltage transfer method is fabricated in 180‐nm Bipolar‐CMOS‐DMOS is correct technology, and has been successfully applied to a three lithium batteries string management chip. These measurements indicate that this circuit transfers each cell’s voltage reliably and adopt protection against abnormal conditions. Furthermore, analysis of 50 samples shows that the improved method can greatly eliminate the battery leakage. The circuit reduces the leakage current to nanoampere scale and is integrated into the lithium battery string management chip, which is helpful for battery voltage balance and low cost.

In order to suppress leakage current caused in the traditional multi-cells series Li-ion battery pack protection system, a new battery voltage transfer method is presented in this paper, which uses the current generated in the transfer process of one of the batteries to compensate for the leakage of itself and other cells except the top cell. Based on the 0.18 µm Bipolar and CMOS and DMOS technology, this proposed circuit has been integrated into a 7-cells Li-ion battery charge and discharge protection chip successfully. The experimental results of cell balancing confirm that the balancing algorithm can help with the shortage of the voltage transfer circuit. Furthermore, analysis of 20 samples shows that the new method can greatly suppress the battery leakage. Compared with the traditional solution, the voltage transfer circuit proposed in this paper greatly reduces the leakage current, which helps to extend the service life of the battery.

BACKGROUND Gastric cancer (GC) is one of the most aggressive malignancies, with a high incidence and poor prognosis worldwide. Recently, accumulating evidence has illustrated that long noncoding RNAs (lncRNAs) play pivotal roles in many cancers. It has been reported that LINC00511 contributes to tumorigenesis in various diseases. However, the role of LINC00511 in GC cell growth remains mostly unknown. AIM To determine whether the lncRNA LINC00511 exerted its carcinogenic function in GC via the miR-124-3p/PDK4 axis. METHODS Cell culture and transfection, RNA extraction and quantitative real-time PCR, CCK-8 assay, Colony formation assay, Luciferase reporter assay, RIP assay, RNA pull-down assay, and Western blot analysis were used to show expression and mechanisms of LINC00511 in GC progression and apoptosis. Rescue assays were performed to verify the relationships among LINC00511, miR-124-3p and PDK4 further. RESULTS The expression of LINC00511 was remarkably upregulated in GC cells compared to that in corresponding normal cell lines. Compared to the controls, cell proliferation was inhibited, and cell apoptosis was increased upon LINC00511 knockdown, demonstrating that LINC00511 influenced GC cell growth. An exploration of the molecular mechanism revealed that LINC00511 functioned as a molecular sponge of miR-124-3p and that PDK4 was a downstream target of miR-124-3p in GC. Rescue assays showed that the overexpression of PDK4 could partly restore the inhibitory function of si-LINC00511 in GC. CONCLUSION These data demonstrate that LINC00511 promotes gastric cancer cell growth by acting as a ceRNA to regulate the miR-124-3p/PDK4 axis, which may be a promising therapeutic target for GC.

The drug response sensitivity and related prognosis of prostate cancer varied from races, while the original mechanism remains rarely understood. In this study, the comprehensive signature including transcriptomics, epigenome and single nucleotide polymorphisms (SNPs) of 485 PCa cases- including 415 Whites, 58 Blacks and 12 Asians from the TCGA database were analyzed to investigate the drug metabolism differences between races. We found that Blacks and Whites had a more prominent drug metabolism, cytotoxic therapy resistance, and endocrine therapy resistance than Asians, while Whites were more prominent in drug metabolism, cytotoxic therapy resistance and endocrine therapy resistance than Blacks. Subsequently, the targeted regulation analysis indicated that the racial differences in cytotoxic therapy resistance, endocrine therapy resistance, might originate from drug metabolisms, and 19 drug metabolism-related core genes were confirmed in the multi-omics network for subsequent analysis. Furthermore, we verified that CYP1A1, CYP3A4, CYP2B6, UGT2B17, UGT2B7, UGT1A8, UGT2B11, GAS5, SNHG6, XIST significantly affected antineoplastic drugs sensitivities in PCa cell lines, and these genes also showed good predictive efficiency of drug response and treatment outcomes for PCa in this cohort of patients. These findings revealed a comprehensive signature of drug metabolism differences for the Whites, Blacks and Asians, and it may provide some evidence for making individualized treatment strategies.

In this paper, we propose a user centric bandwidth allocation scheme for low latency data transmission in ultra dense vehicular networks. Various mobile devices such as mobile phones, sensors of vehicles or autonomous driving systems,require low latency and bandwidth intensive packet delivery between the devices and the Internet aiming to support real-time applications. In the ultra dense vehicular network, small base stations (SBSs) are densely deployed in a fixed geographic area to provides higher date rate. In further, each SBS cooperates with others to form clusters to better support seamless wireless data transmissions, and each mobile device dynamically plans its wireless connectivity for data transmission when it moves in the network. Specifically, each mobile device pre-allocates the amount of bandwidth from a cluster, formed by several SBSs, based on its expected movement, the delay and band-width requirement of the packet transmission and the resource availability of each cluster. Moreover, to effectively utilize the available network resource, each cluster also redistributes its residual bandwidth to the mobile devices pre-allocate bandwidth from it. Consequently, the latency of the data transmission can be better sustained in the ultra dense vehicular network.

In this paper, a new high-voltage level shifter (HVLS) structure is proposed, which has a significantly improved transient response over existing structures. To overcome signal transfer delay of the conventional HVLS caused by parasitic capacitance due to high-voltage MOSFETs, this structure employs a novel circuit module "inverse Schmitt trigger" to drive the pull-up transistors of conventional HVLS. As a result, the "Miller Plateau" caused by parasitic capacitance can be minimized. Hence, the overall transfer delay of the structure is significantly reduced. The simulation results based on SPECTRE and 0.5 $$\upmu $$μm high-voltage CMOS process show that compared to other currently available structures whose transfer delays are several nanoseconds on average, the proposed structure is able to provide a nanosecond transfer delay without using large boost capacitors which are impractical to be integrated or using complex logic units which decrease reliability of circuit. Also, the typical transfer delay of the proposed structure is a constant 1.3 ns, which is irrelevant to parasitic capacitance and insensitive to transfer voltage level.

To assist various intelligent applications, IoT devices send their monitored data to Internet for further process. WiFi access points (APs) would be a candidate to support data transmission in IoTs due to its large wireless service coverage and low cost. An AP connects to the Internet through Ethernet to provide Internet connectivity to its connected IoT devices. However, data transmission may be failed when an AP loses its Ethernet connectivity. To resolve this problem, a software define networking (SDN) and wireless distribution system (WDS) assisted fault recovery automation scheme, SDWDS, is proposed. In SDWDS, packets can be directly and wirelessly forwarded between two APs when the Ethernet link fails at one of the APs. Specifically, when the Ethernet link failure of an AP is detected by the SDN controller, the AP will switch to WDS mode to wirelessly connect to its neighboring APs. The SDN controller in further reroutes corresponding packets through the newly associated AP. Consequently, the IoT devices can sustain Internet access even though their associated AP cannot directly communicate with the Internet via Ethernet. Additionally, the proposed SDWDS is implemented in commercial APs for performance evaluation. Preliminary results show the SDWDS can automatically recover more than one Ethernet link failures in the network. However, due to the limitation of the commercial AP, the creation of WDS requires rebooting the AP which costs about 20 seconds recovery latency. In the future, we will introduce virtualization or multi- connectivity techniques to more efficiently support the fault recovery automation in IoTs.

This paper provides a solution for a self-powered light direction detection with digitized output. Light direction sensors, energy harvesting photodiodes, real-time adaptive tracking digital output unit and other necessary circuits are integrated on a single chip based on a standard 0.18 µm CMOS process. Light direction sensors proposed have an accuracy of 1.8 degree over a 120 degree range. In order to improve the accuracy, a compensation circuit is presented for photodiodes' forward currents. The actual measurement precision of output is approximately 7 ENOB. Besides that, an adaptive under voltage protection circuit is designed for variable supply power which may undulate with temperature and process.

In recent years, the construction of subway in China is in a period of an rapid development. The passengers are in high density within the subway during the operation time, the problem of safety in emergencies has attracted more and more attentions. The structure of atrium metro station is special, fire partition area in the station is difficult to divide. And there is a hidden danger of fire, which is not easy to realize effective exhaust and smoke control. Once there is a fire the magnitude of injuries will be overwhelmingly disastrous. Therefore, more attention should be paid on pedestrian’s evacuation in subway stations. Therefore, an atrium subway station in Beijing is selected, hot smoke test and STEPS software simulation were carried out. We also analyzed the escape environment and escape routes, reasonable evacuation time is obtained, as well as a reasonable escape strategy.

Based on the analysis of a new type of air spring and the nonlinear finite element theory, this paper, taking the mechanical properties of the new type air spring into consideration, put forward an assessment method: the Mooney-Rivlin model with higher order term simulates rubber layer, the rebar model represents the cord thread layer, the stiffness of the listrium and the controllable damping shock absorber is rigid body, the gas flow and the pneumatophore are in coupling. In addition, the method has been tested and verified by applying to a new type vehicle air spring. This paper offers a new assessment method for the development of air springs in vehicle suspension.

Considering the tradeoff between efficiency and output ripple over a wide load range, a monolithic dc-dc buck converter with switch-on-demand modulation (SODM) and switch size control (SSC) is presented in this paper. SODM achieves a hybrid mode of pulse skip and pulse width modulation (PWM) without mode detection circuit. The converter's on time is adaptively adjusted with the load demand, achieving low output voltage ripple. Detecting the output of the error amplifier by a comparator, the SSC circuit can select appropriate switch size according to load current for reducing switching loss in a light load. The threshold level of the comparator varies with respect to the amount of slope compensation, which maintains a substantially constant switch size changing point. Experimental results show that the fabricated converter with the proposed scheme achieves high efficiency from 83% to 96% over a wide load range from 10 mA to 5 A. The switch size is 1/4 of the maximum value when load current is below 1 A with 0.5-A hysteresis. Also, the measured maximum output ripple is less than 10 mV.

Our preliminary results show that huperzine A, an acetylcholinesterase inhibitor used to treat Alzheimer's disease (AD) patients in China, exhibits different pharmacokinetic features in elderly and young healthy subjects. However, its pharmacokinetic data in elderly subjects remains unavailable to date. Thus, we developed a population pharmacokinetic (PPK) model of huperzine A in elderly Chinese people, and identified the covariate affecting its pharmacokinetics for optimal individual administration.A total of 341 serum huperzine A concentration records was obtained from 2 completed clinical trials (14 elderly healthy subjects in a phase I pharmacokinetic study; 35 elderly AD patients in a phase II study). Population pharmacokinetic analysis was performed using the non-linear mixed-effect modeling software Phoenix NLME1.1.1. The effects of age, gender, body weight, height, creatinine, endogenous creatinine clearance rate as well as drugs administered concomitantly were analyzed. Bootstrap and visual predictive checks were used simultaneously to validate the final population pharmacokinetics models.The plasma concentration-time profile of huperzine A was best described by a one-compartment model with first-order absorption and elimination. Age was identified as the covariate having significant influence on huperzine A clearance. The final PPK model of huperzine A was: CL (L/h)=2.4649(*)(age/86)((-3.3856)), Ka=0.6750 h(-1), V (L)=104.216. The final PPK model was demonstrated to be suitable and effective by the bootstrap and visual predictive checks.A PPK model of huperzine A in elderly Chinese subjects is established, which can be used to predict PPK parameters of huperzine A in the treatment of elderly AD patients.

The diffusion coefficient is one of the basic physical parameters of reflecting the property of wooden building materials, and it is the indispensable datum to calculate the dehydration time, estimate qualitatively the corrosion extent, provide the theoretical parameters for the protection technoiogy of the wooden building materials. The method of measuring diffusion coefficient of the wooden building materials is provided on the basis of Fick’s second law in this paper. The diffusion coefficient can be calculated using the given method by measuring the dehydration time, the initial water content and the stable water content after dehydration. The testing method is simple and feasible. Take a wooden materials for example, the experimental result is analyzed which indicates that the measurement method is reasonable.

Grammar-based test generation (GBTG) has seen extensive study and practical use since the 1970s. GBTG was introduced to generate source code for testing compilers from context-free grammars specifying language syntax. More recently, GBTG has been applied to many other testing problems, including the generation of eXtensible Markup Language (XML) documents and the generation of packets for testing communications protocols. Recent research has shown how to integrate covering-array techniques such as pairwise testing into GBTG tools. While the integration offers considerable power to the tester, there are few practical demonstrations in the literature. We present two case studies showing how to use grammars and covering arrays for automated software testing. The first case study exposes HTML injection vulnerabilities in an RSS feed parser. The second case study determines the effectiveness of network firewalls when faced with TCP flag attacks. The case studies illustrate the use of covering arrays in a GBTG context, the use of visualization to understand large test logs, and the issues and tradeoffs in the design of fully automated GBTG test suites.

Purpose The present study aimed to confirm the efficacy and safety of topical and intravenous tranexamic acid (TXA) compared with that of topical placebo and to assess the noninferiority between the two application methods of TXA in patients undergoing unilateral primary total hip arthroplasty. Methods Our randomized controlled trial investigated 170 patients with 1:1:1 allocation to two doses of 10-mg/kg intravenous TXA, 3-g topical TXA, and topical placebo of 60-ml physiological saline groups. The primary outcome, total blood loss, was calculated with Nadler and Gross formula. The secondary outcomes included allogeneic blood transfusion requirement, drain blood loss, decreased hemoglobin level. Noninferiority would be established when the upper limit 95% CI is lower than 250 ml of the noninferiority margin for the mean difference of total blood loss between topical and intravenous TXA. Thromboembolic complication incidence was considered as a safety outcome. Results The total blood loss of patients administered intravenous (mean±standard deviation, 1125±514 ml) and topical TXA (1211±425 ml) was significantly reduced compared with that of those administered topical placebo (1464±556 ml) (p = 0.0012). Drain blood loss and hemoglobin level reduction in patients administered with TXA were also significantly lower than those in patients administered topical placebo. The mean difference of total blood loss between topical and intravenous TXA is 86 ml (95% CI, -88 to 260 ml). The complications were comparable between patients managed with TXA and patients with topical placebo. Conclusion The noninferiority of topical TXA to intravenous TXA can not be concluded. Considering no significant difference was found in all efficacy outcomes between the two administration methods. Any of the two TXA administration methods can be adopted for blood loss prevention in total hip arthroplasty.

Grammars are traditionally used to recognize or parse sentences in a language, but they can also be used to generate sentences. In grammar-based test generation (GBTG), context-free grammars are used to generate sentences that are interpreted as test cases. A generator reads a grammar G and generates L(G), the language accepted by the grammar. Often L(G) is so large that it is not practical to execute all of the generated cases. Therefore, GBTG tools support ‘tags’: extra-grammatical annotations which restrict the generation. Since its introduction in the early 1970s, GBTG has become well established: proven on industrial projects and widely published in academic venues. Despite the demonstrated effectiveness, the tool support is uneven; some tools target specific domains, e.g. compiler testing, while others are proprietary. The tools can be difficult to use and the precise meaning of the tags are sometimes unclear. As a result, while many testing practitioners and researchers are aware of GBTG, few have detailed knowledge or experience. We present YouGen, a new GBTG tool supporting many of the tags provided by previous tools. In addition, YouGen incorporates covering-array tags, which support a generalized form of pairwise testing. These tags add considerable power to GBTG tools and have been available only in limited form in previous GBTG tools. We provide semantics for the YouGen tags using parse trees and a new construct, generation trees. We illustrate YouGen with both simple examples and a number of industrial case studies. Copyright © 2010 John Wiley & Sons, Ltd.

Objectives. To understand the current risk of HIV infection and transmission and further elucidate the underlying risk factors among men who have sex with men and women (MSMW) in China.Methods. Following PRISMA guidelines, we conducted a systematic review and meta-analysis of searching through Chinese and English available literature databases between January 2000 and June 2014 to identify articles.Results. Thirty-six articles (including 19,730 MSMW and 53,536 MSMO) met the selection criteria and the aggregated results found that MSMW have significantly higher HIV prevalence than MSMO (6.6% versus 5.4%, OR = 1.27, 95% CI = 1.01–1.58). A higher proportion of MSMW had commercial male partners in the past 6 months (18.3% versus 12.2%, OR = 1.56, 95% CI = 1.01–2.42). Additionally, substance use in the past 6 months was significantly more frequent among MSMW than MSMO (alcohol use: 27.1% versus 13.1%, OR = 2.53, 95% CI = 2.14–2.99; illicit drug use: 5.3% versus 2.5%, OR = 2.09, 95% CI = 1.48–2.95).Conclusion. A higher proportion of commercial sex and substance use among MSMW may be a potentially indicative factor for significantly higher HIV prevalence compared to MSMO. Targeted interventions should aim at increasing the frequency of HIV/STIs screening and preventing high risk commercial sex and substance use among MSMW to decrease their HIV transmission to the general population.

Surgeons often can contribute failure of sphincter-preserving procedure to a limitation of pelvis anatomy; however, they cannot determine definitely which anatomic diameter or spatial factor actually affected the success of the procedure. Colorectal surgeons, radiologists, and research fellows collaborated closely to establish a three-dimensional digital model of the pelvis with spiral computerized tomography scanning data of patients with rectal cancer. Retrospective analysis on data of 97 patients with low rectal cancer was performed with this model to identify geometric factors that might affect a successful sphincter preservation procedure for low rectal cancer. A digital pelvic model was established. Multivariate analysis demonstrated that distance from the anal verge, body mass index, and pelvic factors affected the success of sphincter preservation. Sphincter preservation was more likely to succeed when the distance from anal verge was ≥5 cm and body mass index was

Copyright: © 2013 Wang H. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Plasma insulin must traverse the vascular endothelium to reach its major sites of action on myocytes and adipocytes. In study simultaneously measuring plasma and lymphatic insulin concentrations in normal, conscious dogs during euglycemic insulin clamps it was found that the steady-state plasma insulin concentration was consistently higher than lymph with a rough ratio of 3:2 during the basal period. In addition, while plasma insulin concentration rose quickly to reach the steady-state during the insulin clamp, the lymph insulin concentration rose very slowly indicating a barrier function of the vascular endothelium. Most importantly, this study showed that the dynamics of glucose disposal correlated very strikingly with the insulin concentration in lymph but not plasma, suggesting that trans-capillary insulin transport is a rate limiting step for peripheral insulin action [1]. Consistent with this, direct injection of insulin into canine skeletal muscle in vivo was recently noted to significantly hasten the onset of muscle glucose utilization compared with intravenously delivered insulin [2]. Multiple other studies also support such an important role of vascular endothelium during insulin clamp by measurement of the insulin concentration within skeletal muscle interstitium in humans and animals using either lymphatic sampling or microdialysis methods [3-7]. Results obtained using either method indicate that even after several hours of steady state hyperinsulinemia, muscle interstitial insulin concentration is only 40-50% of that in plasma and the time course for insulin-mediated glucose disposal during the euglycemic clamp correlates strongly with interstitial but not plasma insulin concentrations. Based on these findings, it has been estimated that slow trans-endothelial insulin transport may account for 30-40% of insulin resistance seen with human obesity or type-2 diabetes [3,8,9].

Objective: To study the association of DNA ploidy abnormality and p53 overexpression with the carcinogenesis of colorectal cancer. Methods: DNA ploidy and p53 expression were measured in a series of 42 colorectal adenocarcinomas by means of flow cytometry and immunohistochemical test. Results: 17 tumors (40%) were diploid and 25 (60%) aneuploid. The aneuploid tumors were significantly more common in the distal colon than in the proximal colon (P

Covering arrays and context-free grammars have seen extensive use in software test generation. A covering-array algorithm takes a list of domains and generates a subset of the cartesian product of the domains. A grammar-based test generation (GBTG) algorithm takes a grammar G and generates a subset of the language accepted by G. Covering arrays and GBTG are usually applied independently. We show that CFG rules and covering-array specifications can be freely intermixed, with precise, intuitive semantics and efficient generation. We present a novel approach for ``tagging'' grammars with specifications for mixed-strength covering arrays, a generalization of conventional covering arrays. We have developed algorithms for test generation and implemented a tool for generating test cases from tagged grammars.

Background: Intravenous injection or topical application of tranexamic acid during total hip arthroplasty has been shown to effectively reduce blood loss. There is no consensus on differences in clinical efficacy and safety between these two administration methods. To determine the optimal clinical efficacy of tranexamic acid during hip replacement, we will compare differences between these two administration methods during total hip arthroplasty. Methods/Design: The study protocol is a prospective, paired (1:1:1), double-blind, randomized controlled clinical trial. A total of 174 patients who will receive hip replacement at Ruijin Hospital, Shanghai Jiao Tong University, China will be randomly divided into three groups, with 58 patients per group. Before the end of surgery, in the placebo group, 60 mL of physiological saline will be used to soak the articular cavity for at least 3 minutes and then be sucked away; in the topical tranexamic acid group, 60 mL of physiological saline containing 3 g tranexamic acid will be used and then sucked away; in the intravenous tranexamic acid group, 100 mL of physiological saline containing 10 mg/kg tranexamic acid will be intravenously administered 15 minutes before surgery and then again 3 hours later. The primary outcome is total blood loss on postoperative day 3, which is calculated using Nadler's and Gross's formula. Secondary outcomes include blood transfusion rates, drainage output within 2 days postoperation, amount of human serum albumin used during hospitalization, postoperative blood coagulation indices, and incidences of deep venous thrombosis and other thromboembolic events during postoperative day 1-week 6. Discussion: This protocol is powered to provide reference information for the rational use of tranexamic acid by comparing clinical efficacy of the drug between intravenous and topical administration routes. Trial registration: ClinicalTrials.gov identifier: NCT02312440; registered on 28 November 2014. Ethical approval: This study protocol was approved by the Ethics Committee of Ruijin Hospital, Shanghai Jiao Tong University, China (permission No. (2014)-47-2) and will be performed in accordance with the Declaration of Helsinki.

This paper presents an improved sample/hold (S/H) circuit design for analog LCD applications. The circuit possesses the dual characteristics of high sampling precision and low switch noise and is thus suitable for video signal sampling applications. In order to increase accuracy of sampling and to reduce switch noise, the design uses an operational amplifier with current-mode switch, which incorporates an improved buffer amplifier, and introduces a noise elimination technique by using a differential amplifier. The simulation results show that for a typical signal sampling application and its BiCMOS implementation, the design has achieved a minimal signal distortion and significantly reduced noise effect.

The recording of multiplexing hologram on one holo film has been studied theoretically and verified experimentally in this paper, and it has been put forward that when multiframe holograms are recorded on one holo film, superposition and modulation of the interference fringes is the main cause to reduce the diffraction efficiency of some holograms having disperse fringes in the multiframe holograms.© (1994) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.

Production of surface pressure, plasma formation and momentum transfer of target is analyzed in interaction between laser and target material in this paper, a low-energy and high-power 1.06 micrometers YAG laser with a pulse width of 15 ns is applied to act upon different target material surfaces, and by using a pendulum shift technique to measure displacement of the target surface, momentum transfer and momentum coupling coefficient are obtained at different conditions.© (1993) COPYRIGHT SPIE--The International Society for Optical Engineering. Downloading of the abstract is permitted for personal use only.