1. G Protein β3 Subunit Polymorphism and Long-Term Prognosis of Functional Dyspepsia
- Author
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Hyung Seok Park, Jeong Hwan Kim, Sun-Young Lee, Choon Jo Jin, Heon Jeong Lee, Hyun Ah Chung, In Kyung Sung, and Chan Sup Shim
- Subjects
Male ,Functional dyspepsia ,medicine.medical_specialty ,Rome III ,Genotype ,G protein ,Gastroenterology ,G protein β3 ,Gene Frequency ,β3 subunit ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Polymorphism ,Dyspepsia ,Allele frequency ,Genetics ,Polymorphism, Genetic ,Alimentary Tract ,Hepatology ,business.industry ,Case-control study ,Middle Aged ,Prognosis ,Rome iii ,Heterotrimeric GTP-Binding Proteins ,Case-Control Studies ,Original Article ,Female ,business ,GNB3 POLYMORPHISM ,GNB3 - Abstract
Background/Aims A link between G protein β3 (GNB3) polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role of GNB3 polymorphism in the long-term prognosis of FD in Koreans. Methods FD patients and normal healthy controls were recruited from patients who visited our center between December 2006 and June 2007. All of the subjects completed Rome III questionnaires before undergoing upper gastrointestinal endoscopy and colonoscopy. Genomic DNA was extracted for GNB3 genotyping. After 5 years, the subjects were reevaluated using the same questionnaires. Results GNB3 825T carrier status was significantly related to FD in Koreans (p=0.04). After 5 years, 61.0% of the initial FD patients and 12.2% of the initial normal subjects were diagnosed with FD (odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to 31.1; p
- Published
- 2014