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G Protein β3 Subunit Polymorphism and Long-Term Prognosis of Functional Dyspepsia
- Source :
- Gut and Liver
- Publication Year :
- 2014
- Publisher :
- The Editorial Office of Gut and Liver, 2014.
-
Abstract
- Background/Aims A link between G protein β3 (GNB3) polymorphism and functional dyspepsia (FD) has been suggested. The aim of this study was to determine the role of GNB3 polymorphism in the long-term prognosis of FD in Koreans. Methods FD patients and normal healthy controls were recruited from patients who visited our center between December 2006 and June 2007. All of the subjects completed Rome III questionnaires before undergoing upper gastrointestinal endoscopy and colonoscopy. Genomic DNA was extracted for GNB3 genotyping. After 5 years, the subjects were reevaluated using the same questionnaires. Results GNB3 825T carrier status was significantly related to FD in Koreans (p=0.04). After 5 years, 61.0% of the initial FD patients and 12.2% of the initial normal subjects were diagnosed with FD (odds ratio [OR], 11.7; 95% confidence interval [CI], 4.3 to 31.1; p
- Subjects :
- Male
Functional dyspepsia
medicine.medical_specialty
Rome III
Genotype
G protein
Gastroenterology
G protein β3
Gene Frequency
β3 subunit
Internal medicine
medicine
Humans
Prospective Studies
Polymorphism
Dyspepsia
Allele frequency
Genetics
Polymorphism, Genetic
Alimentary Tract
Hepatology
business.industry
Case-control study
Middle Aged
Prognosis
Rome iii
Heterotrimeric GTP-Binding Proteins
Case-Control Studies
Original Article
Female
business
GNB3 POLYMORPHISM
GNB3
Subjects
Details
- ISSN :
- 20051212 and 19762283
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Gut and Liver
- Accession number :
- edsair.doi.dedup.....4216e45b89c796f32a3fdce3eda15781