1. Rebubbling and graft failure in Descemet membrane endothelial keratoplasty: a prospective Dutch registry study
- Author
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Mor Dickman, Pieter Jan Kruit, Frank J.H.M. van den Biggelaar, Bjorn Winkens, Rudy M.M.A. Nuijts, Suryan Dunker, RS: MHeNs - R3 - Neuroscience, Oogheelkunde, RS: CAPHRI - R6 - Promoting Health & Personalised Care, FHML Methodologie & Statistiek, MUMC+: *AB Refractie Chirurgie Oogheelkunde (9), MUMC+: MA UECM Oogartsen MUMC (9), and MUMC+: MA UECM Oogartsen ZL (9)
- Subjects
medicine.medical_specialty ,Graft failure ,CELL DENSITY ,Descemet membrane ,Registry study ,Visual Acuity ,Logistic regression ,DETACHMENT ,Organ transplantation ,Corneal Diseases ,treatment surgery ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,0302 clinical medicine ,Cornea ,cornea ,medicine ,Humans ,Registries ,Descemet Membrane ,Retrospective Studies ,OUTCOMES ,business.industry ,Endothelium, Corneal ,Fuchs' Endothelial Dystrophy ,Sensory Systems ,Surgery ,Endothelial cell density ,Transplantation ,Ophthalmology ,medicine.anatomical_structure ,dystrophy ,030221 ophthalmology & optometry ,business ,Descemet Stripping Endothelial Keratoplasty ,030217 neurology & neurosurgery - Abstract
AimsTo identify risk factors for rebubbling, and early graft failure after Descemet membrane endothelial keratoplasty (DMEK).MethodsIn this prospective registry study, all consecutive DMEK procedures registered in the Netherlands Organ Transplant Registry were assessed (n=752). Univariable and multivariable analysis was performed using logistic regression. The effect of rebubbling on endothelial cell density was analysed using a linear mixed model.Results144 of 752 (19%) eyes underwent rebubbling. Rebubbling was successful in 101 eyes (70%). In eyes that underwent rebubbling, the graft failure rate was significantly higher than eyes that did not undergo rebubbling (30% vs 9%, respectively; OR: 4.28, 95% CI 2.72 to 6.73, pConclusionsThis Dutch registry study identified independent risk factors for DMEK graft detachment leading to rebubbling, namely recipient age and surgical complication, and early graft failure, namely transplantation before 2016 and surgical complication. Rebubbling was associated with significantly higher endothelial cell loss in the first year after surgery.
- Published
- 2023