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Introduction: The incidence of breast cancer has increased every year, mostly in developing countries. However, breast cancer awareness in women is still insufficient. A woman must be aware of breast cancer disease earlier. This study aimed to describe breast cancer awareness in female adolescents . Methods: The research design was used descriptive-analytic. The study population consisted of female adolescents in 10th-11th grade at Vocational High School in Surabaya, East Java, Indonesia. The sample was taken using stratified random sampling. There are 206 female adolescents aged 15-18 years old who participated in this study. Data collected using a self-structured breast cancer awareness questionnaire arranged by Breast Cancer Awareness Measurement (BCAM) guideline. The questionnaire consisted of breast cancer knowledge (disease, signs and symptoms, risk factors), perception, and BSE . The statistical analysis was using distribution frequency. Results: The result presented that the majority of female adolescents had high awareness (67,5%). The maximum score was knowledge of disease (3.28 ± 0.54) (table 3). The minimum score was risk factors knowledge (1.95 ± 0.69) and BSE (1.81 ± 0.78). Conclusion: The respondents have good knowledge of breast cancer disease yet understanding of risk factors is low. It is necessary to do counseling programs in school, particularly women's reproductive health and breast self-examination (BSE) due to improve knowledge of risk factors in female adolescents.

Lime (Citrus Aurantifolia) contains of main flavonoid in limes, that is herperidin. Hesperidin can help reducing total Cholesterol level and has the property of hypercholesterolemic. Hypercholesterolemia is the main factor independent risk factor of coronary heart disease (CHD). This study intend to determine whether or not the effect od water lime extract orally with cholesterol level in the hypercholesterolemia mice. This isi an experimental study designed following randomize control design and post test only control group design by using 24 mice (Mus musculus) adult male strain DD Webster divided into 4 groups: control group (P0) that Given adlibitum, (P1) that given hypercholesterolemia 0,2 cc, (P3) that given hypercholesterolemia 0,2 cc and water lime extract 0,3 cc by gastric sonde once a day for 15 days. In the day46 mice are done neck dislocation. Data result was analyzed by One Way- Anova test and continuous and continued with post-hoc test. Result of this study showed that giving of water lime extract 0,3 cc orally per mice could reduced cholesterol level of mice hypercholesterolemia than giving water lime extract 0,1 cc orraly per mice.