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6,674 results on '"Carmona, A."'

1. Influencia del volumen peritoneal residual en los resultados de la prueba de equilibrio peritoneal. Estudio prospectivo

Author: Daniela Astudillo, Leticia García Gago, Marta Blanco Pardo, Luis Falcao, Miguel Pérez Fontán, Ana Rodríguez-Carmona, and Catuxa Rodríguez Magariños
Subjects: Nephrology, business.industry, Medicine, business
Abstract: Resumen Introduccion y objetivos La categorizacion de la capacidad de ultrafiltracion durante la prueba de equilibrio peritoneal (PEP) es parte habitual de la monitorizacion del funcionalismo peritoneal en pacientes tratados con dialisis peritoneal (DP). La estimacion del volumen residual (Vr) tras el cambio previo (Vrpre) y el de la propia PEP (Vrpost) podria ayudar a mejorar la precision de la prueba. Metodo Siguiendo un diseno prospectivo, estimamos el Vrpre y Vrpost en 116 pacientes incidentes o prevalentes en DP que fueron sometidos a una o dos (n = 27) PEP con solucion de glucosa al 3,86/4,25% y drenaje completo a los 60 minutos. Valoramos la consistencia del Vr comparando Vrpre y Vrpost y tambien estos parametros en PEP sucesivas. Analizamos la posible influencia de factores demograficos y clinicos en la cuantia del Vr, asi como el impacto de la correccion para Vr de la ultrafiltracion durante la PEP sobre la categorizacion de la capacidad de ultrafiltracion. Resultados El Vrpost fue mayor que el Vrpre, por lo que la ultrafiltracion corregida para Vr fue signficativamente mayor que la calculada por procedimiento estandar (494 vs. 449 mL, p 200 mL) de la ultrafiltracion corregida para Vr frente al valor estandar. Sin embargo, un 21,1% de los pacientes que cumplian criterio de fallo de ultrafiltracion por metodo estandar, no lo hacian si se aplicaba la correccion para Vr. Conclusiones La correccion para Vr modifica escasamente, como media, la estimacion de la capacidad de ultrafiltracion durante la PEP al 3,86/4,25%, aunque tiene un impacto significativo en 12,9% de las pruebas. No hemos detectado factores predictivos del Vr durante la PEP, lo que sugiere un componente de aleatoriedad en la mecanica del cambio peritoneal. Sugerimos que este parametro debe ser estimado si se observan inconsistencias en los resultados de la PEP en lo relativo a la capacidad de ultrafiltracion.
Published: 2023

2. An international assessment of the adoption of enhanced recovery after surgery (ERAS®) principles across colorectal units in 2019–2020

Author: Pinkney T., Taylor H., Tong C., Schmitz N. -D., Morton D. G., Pinkney T. D., Bhangu A., Blackwell S., Dardanov D., Dulskas A., Gallo G., Glasbey J., Keatley J., Knowles C., Li Y. E., McCourt V., Minaya-Bravo A., Neary P., Nepogodiev D., Pata F., Pellino G., Sivrikoz E., van Ramshorst G., Zmora O., Perry R., Magill E. L., Abdalkoddus M., Abelevich A., Abraham S., Abraham-Nordling M., Adamina M., Agalar C., Agresta F., Ahallat M., Ahmad N., Aiupov R., Akca O., Aleksic A., Aleotti F., Alias D., Alonso J., Alonso Goncalves S., Alonso Martin J., Alonso Poza A., Alonso-Hernandez N., Alos Company R., Al-Saeedi M., Alvarez-Laso C., Alvarez-Gallego M., Amanatidis T., Americano M., Amorim E., Anandan L., Anania G., Ancans G., Andreev P., Andrejevic P., Antonacci N., Anwer M., Aonzo P., Arencibia B., Argeny S., Arieli H., Arnold S., Ashraf M., Aslam M., Atanasov B., Atif M., Atladottir J., Avital S., Awny S., Aytac B., Azahr N., Aznar-Puig S., Bailey S., Balalis D., Baldi C., Baldonedo R., Balducci G., Balestra F., Balestri R., Balfour A., Baloyiannis I., Banky B., Baral J., Baranyai Z., Barbashinov N., Bargallo J., Barisic G., Barugola G., Batashki I., Battersby N., Belev N., Belli A., Beltran de Heredia J., Bemelman W., Benavides Buleje J., Benckert A., Bernal-Sprekelsen J., Bertocchi E., Beuran M., Bhan C., Bianco F., Bilali S., Bilali V., Bintintan V., Birindelli A., Birsan T., Blanco Antona F., Blas J., Blasco-Segura T., Blom R., Bocchetti T., Boerma E., Bogdan M., Boland M., Bomans B., Borda N., Bowen M., Bradulskis S., Branagan G., Brankovic B., Brenna M., Brewer H., Broadhurst J., Bronder C., Brouwer R., Buccianti P., Buchs N., Buchwald P., Bugatti A., Bui A., Burcos T., Buskens C., Bustamante C., Caceres N., Cagigas Fernandez C., Calero-Lillo A., Camps I., Canda A., Caravaca-Garcia I., Carballo F., Carcoforo P., Carlander J., Carlos S., Caro A., Carpelan A., Carrasco Prats M., Carrillo Lopez M., Carvello M., Casal E., Casoni Pattacini G., Castellvi Valls J., Castillo Diego J., Cavallesco G., Cavenaile V., Cayetano L., Ceccotti A., Cervera-Aldama J., Chabok A., Chafai N., Chandrasinghe P., Chandratreya N., Chaudhri S., Chaudhry Z., Cherdancev D., Chernov A., Chevallay M., Chirletti P., Chouillard E., Chouliaras C., Chowdri N., Cillo M., Cini C., Ciubotaru C., Ciuce C., Claeys D., Cocorullo G., Codina-Cazador A., Colak E., Coletta D., Colombo F., Copaescu C., Corte Real J., Corver M., Cosic J., Costa S., Costa Pereira J., Costa Pereira C., Costa-Navarro D., Cotte E., Cracco N., Cristian D., Cuadrado M., Cuk V., Cunha M., Cunha J., Curinga R., Curletti G., Curtis N., Dabic D., Dainius E., d'Alessandro A., Daniels I., Darvin V., Dauser B., David G., Davidova O., Davies E., de Andres Asenjo B., De franciscis S., de Graaf E., De la Portilla F., De Luca E., De Nisco C., De Toma G., Defoort B., Den Boer F., Di Candido F., Di Saverio S., Diaz Pavon J., Dieguez Fernandez B., Diez-Alonso M., Dimitrijevic I., Dindelegan G., Djuric M., Domingos H., Doornebosch P., Dos Santos M., Drami I., Dudarovaska H., Dusek T., Dzhumabaev H., Eden Y., Egenvall M., Eismiontas V., El Sorogy M., Elgeidie A., Elhemaly M., El-Hussuna A., Ellul S., Elmore U., ElNakeeb A., Elrefai M., Emile S., Enrriquez-Navascues J., Epstein J., Escartin J., Escola D., Escuder J., Espin E., Espina B., Estefania D., Etienne J., Fabbri S., Falato A., Fares R., Farina P., Farkasova M., Farres R., Fasolini F., Fatayer T., Febles G., Feliu F., Feo C., Feoktistov D., Fernandez F., Fernandez Isart M., Fernando J., Ferreira G., Ferrer R., Ferreras Garcia C., Ferri M., Figueiredo N., Finotti E., Fitzgerald J., Flateh Backe I., Flor-Lorente B., Forero-Torres A., Foschi D., Francart D., Francois Y., Frasson M., Freil-Lanter C., Frois Borges M., Fuzun M., Gala T., Galleano R., Galvez P., Galvez Saldana A., Gamundi Cuesta M., Garcia Cabrera A., Garcia Egea J., Garcia Olmo D., Garcia-Gonzalez J., Garcia-Granero A., Garcia-Granero E., Garcia-Septiem J., Gardea A., Garipov M., Gefen R., Geraghty A., Gerkis S., Germanos S., Ghaffari S., Ghilles E., Gianotti L., Gil Santos M., Gilsanz Martin C., Gingert C., Gklavas A., Glehen O., Golda T., Gomez N., Gomez R., Gomez Ruiz M., Gonzalez Santin V., Graham B., Grainger J., Grama F., Gregoir T., Gregori M., Grolich T., Grosek J., Guadalajara H., Guckenheimer S., Guevara J., Gulotta G., Gupta S., Gurevich N., Gurjar S., Haapaniemi S., Hahnloser D., Hamad Y., Hamid M., Hanly A., Harris G., Harsanyi L., Hartig N., Hawkin P., Henriques P., Herbst F., Hermann N., Hernandez Garcia M., Hoch J., Hrora A., Huhtinen H., Iarumov N., Ilkanich A., Insua C., Ioannidis P., Iqbal M., Iqbal A., Isik A., Ismaiel M., Ivlev D., Jadhav V., Jareno S., Jehaes C., Jimenez V., Jimenez-Toscano M., Jimenez-Miramon J., Jimenez-Rodriguez R., Jonsson T., Jotautas V., Julia D., Juloski J., Jung B., Kala Z., Kalayci M., Kara Y., Karachun A., Karagul S., Karvonen J., Katorkin S., Katsoulis I., Katsounis D., Kaubrys M., Kaul N., Kefalou E., Keijzers M., Kelly M., Kenic M., Kennelly R., Khan J., Khan M., Kho H., Kinas V., Knight J., Kocian P., Koeter T., Kokobelyan A., Konsten J., Koolen L., Kosir J., Kostic I., Krdzic I., Kreisler Moreno E., Krivokapic Z., Krstev P., Krsul D., Kumarasinghe N., La Torre F., Labarga F., Ladra M., Lage Laredo A., Lahodzich N., Lai C., Lakkis Z., Lal R., Lamas S., Lang T., Latkauskas T., Lawes D., Lazar G., Lebedev K., Lebedeva M., Lefevre J., Lekic Vitlov V., Lemma M., Leo C., Leon C., Leventoglu S., Levy B., Li L., Licari L., Lizdenis P., Loftas P., Longhi M., Longstaff L., Lopez Dominguez J., Lopez-Lara M., Lora P., Lorenzon L., Lorusso D., Lozev I., Lozoya Trujillo R., Lukic D., Lunins R., Luzan R., Luzzi A., Maderuelo V., Madsboll T., Mahotin D., Majbar M., Makhmudov A., Malik K., Maly O., Mamaloudis I., Mamedli Z., Manatakis D., Mandi D., Mangell P., Marharint T., Mariani N., Maric B., Marimuthu K., Marinello F., Marino F., Markiewicz S., Markovic V., Marom G., Maroni N., Maroulis I., Marsanic P., Marsman H., Martens M., Marti M., Martinek L., Martinez S., Martinez D., Martinez Manzano A., Martins R., Maslyankov S., McArdle K., McDermott F., Mege D., Mehraj A., Mehta A., Mendrila D., Menendez P., Mercantini P., Metwally I., Mikalauskas S., Millan M., Mingoli A., Mirshekar-Syahkal B., Moggia E., Mohan S., Moller P., Mompart Garcia S., Monami B., Moniz Pereira P., Montroni I., Morel P., Moshev B., Mostovoy E., Mothe S., Mukhtar H., Muller P., Munch S., Munoz Camarena J., Munoz-Collado S., Muratore A., Muscara F., Muysoms F., Myrelid P., N. Lah N., Nail S., Narayanan A., Nastos K., Negoi I., Nesbakken A., Nestler G., Nestorovic M., Nesytykh A., Newton K., Ng Y., Ngu J., Nguyen B., Nijs Y., Nikberg M., Nimmersgern T., Nogues E., Norcic G., Nutautiene V., Nygren J., O'Brien J., Ochogavia Segui A., O'Kelly J., Oliveira-Cunha M., Omar W., Omar G., Onishchenko S., Onody P., Opocher E., Orhalmi J., Oshowo A., Otero J., Ozgen U., Pace K., Padin H., Papaconstantinou I., Papadopoulos A., Papadopoulos G., Papandrea M., Paral J., Parc Y., Paredes J., Parmar M., Parra Banos P., Parray F., Pascual Damieta M., Pascual Miguelanez I., Passot G., Pastor C., Paszt A., Patel P., Paterson H., Patron Uriburu J., Paulos A., Pavlov V., Pcolkins A., Pecic V., Pena Ros E., Penkov R., Pera Roman M., Perunicic V., Pery R., Petrovic D., Pezzolla F., Photi E., Pikarsky A., Piramanayagam B., Pisani Ceretti A., Planellas P., Platt E., Pletinckx P., Podda M., Poskus T., Poskus E., Pozdnyakov A., Pravosudov I., Previsic A., Prieto D., Prochazka V., Prodan A., Proud D., Psaila J., Psaras G., Pulighe F., Pullig F., Qureshi M., Rachadell J., Radovanovic Z., Radovanovic D., Raguan B., Rahman M., Raiss M., Ramirez Faraco M., Ramos J., Ramos-Prada J., Rantala A., Rao M., Rasulov A., Ratnatunga K., Raymond T., Refky B., Reggiani L., Regusci L., Reyes Diaz M., Richardson J., Richiteanu G., Rios A., Ris F., Rodriguez Garcia P., Roffi N., Romairone E., Romano G., Romero I., Romero de Diego A., Romero-Simo M., Roque C., Rosati R., Rossi B., Rossi E., Rossini R., Ruano A., Rubbini M., Rubio-Perez I., Ruffo G., Ruiz H., Ruiz Carmona M., Ryska O., Sabia D., Sacchi M., Sacco R., Sakr A., Saladzinskas Z., Salamone G., Salomon M., Salvans Ruiz S., Sammarco G., Sampietro G., Samsonov D., Samsonyuk V., Sanchez J., Sanchez Romero A., Sanchez-Guillen L., Santak G., Santamaria-Olabarrieta M., Santos J., Saraceno F., Saralegui Y., Sarici I., Savino G., Scabini S., Schafli J., Schiltz B., Schofield A., Schon M., Scurtu R., Segalini E., Segelman J., Segura-Sampedro J., Seicean R., Sekulic A., Selniahina L., Seretis F., Serrano Paz P., Shaikh I., Shalaby M., Shams N., Sharma A., Sharma G., Shukla A., Shussman N., Shweejawee Z., Sielezneff I., Sigurdsson H., Sileri P., Silva M., Simcikas D., Simoes J., Simonka Z., Singh B., Sivins A., Skroubis G., Skull A., Slavchev M., Slavin M., Smart N., Smart C., Smart P., Smedh K., Smolarek S., Sokmen S., Sokolov M., Solana Bueno A., Solar L., Sorrentino L., Sotona O., Spacca D., Spinelli A., Stanojevic G., Stearns A., Stefan S., Stift A., Stijns J., Stoyanov V., Straarup D., Strupas K., Stubbs B., Subocius A., Sudlow A., Suero C., Sungurtekin U., Svagzdys S., Syk I., Tamelis A., Tamhane R., Tamini N., Tamosiunas A., Tanis P., Tarasov N., Tate S., Tennakoon A., Teo N., Terzi C., Tezas S., Thabet W., Tham J., Thavanesan N., Theodosopoulos T., Thomas W., Tiret E., Tiselius C., Todorov G., Tomazic A., Tomulescu V., Torkington J., Totis M., Trostchansky I., Truan N., Tulchinsky H., Tutino R., Tzivanakis A., Tzovaras G., Ugolini G., Unger L., Upanishad I., Urbani L., Uth Ovesen A., Vaizey C., Vallribera F., Valsdottir E., Valverde I., Valverde-Sintas J., Van Belle K., Van Cleven S., van Hagen P., van Loon Y., van Ruler O., Van Wijck K., Varabei A., Varcada M., Varpe P., Vartic M., Velchuru V., Vencius J., Venskutonis D., Vercher D., Vermaas M., Vertruyen M., Verza L., Vescio G., Vezakis A., Vieira P., Vignali A., Vigorita V., Vila Tura M., Vinson-Bonnet B., Viso Pons L., Voloshin S., Voronin Y., Vukusic L., Wang X., Wang J., Wani R., Warusavitarne J., Wasserberg N., Weerts J., Weiss D., Weizman A., Westerduin E., Wheat J., White I., Wik T., Wilson J., Winter D., Wolthuis A., Wong M., Yahia S., Yamamoto T., Yanishev A., Yao C., Yildiz A., Yuksel O., Zain Z., Zakaria A., Zakaria Z., Zampitis N., Zarand A., Zarco-Pleguezuelos A., Zattoni D., Zelic M., Zeromskas P., Zhuravlev A., Zimmerman D., Zuhdy M., Zukanovic G., Surgery, CCA - Cancer Treatment and Quality of Life, Amsterdam Gastroenterology Endocrinology Metabolism, Graduate School, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Methodology, APH - Personalized Medicine, Pinkney, T, Taylor, H, Tong, C, Schmitz, N, Morton, D, Bhangu, A, Blackwell, S, Dardanov, D, Dulskas, A, Gallo, G, Glasbey, J, Keatley, J, Knowles, C, Li, Y, Mccourt, V, Minaya-Bravo, A, Neary, P, Nepogodiev, D, Pata, F, Pellino, G, Sivrikoz, E, van Ramshorst, G, Zmora, O, Perry, R, Magill, E, Abdalkoddus, M, Abelevich, A, Abraham, S, Abraham-Nordling, M, Adamina, M, Agalar, C, Agresta, F, Ahallat, M, Ahmad, N, Aiupov, R, Akca, O, Aleksic, A, Aleotti, F, Alias, D, Alonso, J, Alonso Goncalves, S, Alonso Martin, J, Alonso Poza, A, Alonso-Hernandez, N, Alos Company, R, Al-Saeedi, M, Alvarez-Laso, C, Alvarez-Gallego, M, Amanatidis, T, Americano, M, Amorim, E, Anandan, L, Anania, G, Ancans, G, Andreev, P, Andrejevic, P, Antonacci, N, Anwer, M, Aonzo, P, Arencibia, B, Argeny, S, Arieli, H, Arnold, S, Ashraf, M, Aslam, M, Atanasov, B, Atif, M, Atladottir, J, Avital, S, Awny, S, Aytac, B, Azahr, N, Aznar-Puig, S, Bailey, S, Balalis, D, Baldi, C, Baldonedo, R, Balducci, G, Balestra, F, Balestri, R, Balfour, A, Baloyiannis, I, Banky, B, Baral, J, Baranyai, Z, Barbashinov, N, Bargallo, J, Barisic, G, Barugola, G, Batashki, I, Battersby, N, Belev, N, Belli, A, Beltran de Heredia, J, Bemelman, W, Benavides Buleje, J, Benckert, A, Bernal-Sprekelsen, J, Bertocchi, E, Beuran, M, Bhan, C, Bianco, F, Bilali, S, Bilali, V, Bintintan, V, Birindelli, A, Birsan, T, Blanco Antona, F, Blas, J, Blasco-Segura, T, Blom, R, Bocchetti, T, Boerma, E, Bogdan, M, Boland, M, Bomans, B, Borda, N, Bowen, M, Bradulskis, S, Branagan, G, Brankovic, B, Brenna, M, Brewer, H, Broadhurst, J, Bronder, C, Brouwer, R, Buccianti, P, Buchs, N, Buchwald, P, Bugatti, A, Bui, A, Burcos, T, Buskens, C, Bustamante, C, Caceres, N, Cagigas Fernandez, C, Calero-Lillo, A, Camps, I, Canda, A, Caravaca-Garcia, I, Carballo, F, Carcoforo, P, Carlander, J, Carlos, S, Caro, A, Carpelan, A, Carrasco Prats, M, Carrillo Lopez, M, Carvello, M, Casal, E, Casoni Pattacini, G, Castellvi Valls, J, Castillo Diego, J, Cavallesco, G, Cavenaile, V, Cayetano, L, Ceccotti, A, Cervera-Aldama, J, Chabok, A, Chafai, N, Chandrasinghe, P, Chandratreya, N, Chaudhri, S, Chaudhry, Z, Cherdancev, D, Chernov, A, Chevallay, M, Chirletti, P, Chouillard, E, Chouliaras, C, Chowdri, N, Cillo, M, Cini, C, Ciubotaru, C, Ciuce, C, Claeys, D, Cocorullo, G, Codina-Cazador, A, Colak, E, Coletta, D, Colombo, F, Copaescu, C, Corte Real, J, Corver, M, Cosic, J, Costa, S, Costa Pereira, J, Costa Pereira, C, Costa-Navarro, D, Cotte, E, Cracco, N, Cristian, D, Cuadrado, M, Cuk, V, Cunha, M, Cunha, J, Curinga, R, Curletti, G, Curtis, N, Dabic, D, Dainius, E, D'Alessandro, A, Daniels, I, Darvin, V, Dauser, B, David, G, Davidova, O, Davies, E, de Andres Asenjo, B, De franciscis, S, de Graaf, E, De la Portilla, F, De Luca, E, De Nisco, C, De Toma, G, Defoort, B, Den Boer, F, Di Candido, F, Di Saverio, S, Diaz Pavon, J, Dieguez Fernandez, B, Diez-Alonso, M, Dimitrijevic, I, Dindelegan, G, Djuric, M, Domingos, H, Doornebosch, P, Dos Santos, M, Drami, I, Dudarovaska, H, Dusek, T, Dzhumabaev, H, Eden, Y, Egenvall, M, Eismiontas, V, El Sorogy, M, Elgeidie, A, Elhemaly, M, El-Hussuna, A, Ellul, S, Elmore, U, Elnakeeb, A, Elrefai, M, Emile, S, Enrriquez-Navascues, J, Epstein, J, Escartin, J, Escola, D, Escuder, J, Espin, E, Espina, B, Estefania, D, Etienne, J, Fabbri, S, Falato, A, Fares, R, Farina, P, Farkasova, M, Farres, R, Fasolini, F, Fatayer, T, Febles, G, Feliu, F, Feo, C, Feoktistov, D, Fernandez, F, Fernandez Isart, M, Fernando, J, Ferreira, G, Ferrer, R, Ferreras Garcia, C, Ferri, M, Figueiredo, N, Finotti, E, Fitzgerald, J, Flateh Backe, I, Flor-Lorente, B, Forero-Torres, A, Foschi, D, Francart, D, Francois, Y, Frasson, M, Freil-Lanter, C, Frois Borges, M, Fuzun, M, Gala, T, Galleano, R, Galvez, P, Galvez Saldana, A, Gamundi Cuesta, M, Garcia Cabrera, A, Garcia Egea, J, Garcia Olmo, D, Garcia-Gonzalez, J, Garcia-Granero, A, Garcia-Granero, E, Garcia-Septiem, J, Gardea, A, Garipov, M, Gefen, R, Geraghty, A, Gerkis, S, Germanos, S, Ghaffari, S, Ghilles, E, Gianotti, L, Gil Santos, M, Gilsanz Martin, C, Gingert, C, Gklavas, A, Glehen, O, Golda, T, Gomez, N, Gomez, R, Gomez Ruiz, M, Gonzalez Santin, V, Graham, B, Grainger, J, Grama, F, Gregoir, T, Gregori, M, Grolich, T, Grosek, J, Guadalajara, H, Guckenheimer, S, Guevara, J, Gulotta, G, Gupta, S, Gurevich, N, Gurjar, S, Haapaniemi, S, Hahnloser, D, Hamad, Y, Hamid, M, Hanly, A, Harris, G, Harsanyi, L, Hartig, N, Hawkin, P, Henriques, P, Herbst, F, Hermann, N, Hernandez Garcia, M, Hoch, J, Hrora, A, Huhtinen, H, Iarumov, N, Ilkanich, A, Insua, C, Ioannidis, P, Iqbal, M, Iqbal, A, Isik, A, Ismaiel, M, Ivlev, D, Jadhav, V, Jareno, S, Jehaes, C, Jimenez, V, Jimenez-Toscano, M, Jimenez-Miramon, J, Jimenez-Rodriguez, R, Jonsson, T, Jotautas, V, Julia, D, Juloski, J, Jung, B, Kala, Z, Kalayci, M, Kara, Y, Karachun, A, Karagul, S, Karvonen, J, Katorkin, S, Katsoulis, I, Katsounis, D, Kaubrys, M, Kaul, N, Kefalou, E, Keijzers, M, Kelly, M, Kenic, M, Kennelly, R, Khan, J, Khan, M, Kho, H, Kinas, V, Knight, J, Kocian, P, Koeter, T, Kokobelyan, A, Konsten, J, Koolen, L, Kosir, J, Kostic, I, Krdzic, I, Kreisler Moreno, E, Krivokapic, Z, Krstev, P, Krsul, D, Kumarasinghe, N, La Torre, F, Labarga, F, Ladra, M, Lage Laredo, A, Lahodzich, N, Lai, C, Lakkis, Z, Lal, R, Lamas, S, Lang, T, Latkauskas, T, Lawes, D, Lazar, G, Lebedev, K, Lebedeva, M, Lefevre, J, Lekic Vitlov, V, Lemma, M, Leo, C, Leon, C, Leventoglu, S, Levy, B, Li, L, Licari, L, Lizdenis, P, Loftas, P, Longhi, M, Longstaff, L, Lopez Dominguez, J, Lopez-Lara, M, Lora, P, Lorenzon, L, Lorusso, D, Lozev, I, Lozoya Trujillo, R, Lukic, D, Lunins, R, Luzan, R, Luzzi, A, Maderuelo, V, Madsboll, T, Mahotin, D, Majbar, M, Makhmudov, A, Malik, K, Maly, O, Mamaloudis, I, Mamedli, Z, Manatakis, D, Mandi, D, Mangell, P, Marharint, T, Mariani, N, Maric, B, Marimuthu, K, Marinello, F, Marino, F, Markiewicz, S, Markovic, V, Marom, G, Maroni, N, Maroulis, I, Marsanic, P, Marsman, H, Martens, M, Marti, M, Martinek, L, Martinez, S, Martinez, D, Martinez Manzano, A, Martins, R, Maslyankov, S, Mcardle, K, Mcdermott, F, Mege, D, Mehraj, A, Mehta, A, Mendrila, D, Menendez, P, Mercantini, P, Metwally, I, Mikalauskas, S, Millan, M, Mingoli, A, Mirshekar-Syahkal, B, Moggia, E, Mohan, S, Moller, P, Mompart Garcia, S, Monami, B, Moniz Pereira, P, Montroni, I, Morel, P, Moshev, B, Mostovoy, E, Mothe, S, Mukhtar, H, Muller, P, Munch, S, Munoz Camarena, J, Munoz-Collado, S, Muratore, A, Muscara, F, Muysoms, F, Myrelid, P, N. 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J., Benckert, A., Bernal-Sprekelsen, J., Bertocchi, E., Beuran, M., Bhan, C., Bianco, F., Bilali, S., Bilali, V., Bintintan, V., Birindelli, A., Birsan, T., Blanco Antona, F., Blas, J., Blasco-Segura, T., Blom, R., Bocchetti, T., Boerma, E., Bogdan, M., Boland, M., Bomans, B., Borda, N., Bowen, M., Bradulskis, S., Branagan, G., Brankovic, B., Brenna, M., Brewer, H., Broadhurst, J., Bronder, C., Brouwer, R., Buccianti, P., Buchs, N., Buchwald, P., Bugatti, A., Bui, A., Burcos, T., Buskens, C., Bustamante, C., Caceres, N., Cagigas Fernandez, C., Calero-Lillo, A., Camps, I., Canda, A., Caravaca-Garcia, I., Carballo, F., Carcoforo, P., Carlander, J., Carlos, S., Caro, A., Carpelan, A., Carrasco Prats, M., Carrillo Lopez, M., Carvello, M., Casal, E., Casoni Pattacini, G., Castellvi Valls, J., Castillo Diego, J., Cavallesco, G., Cavenaile, V., Cayetano, L., Ceccotti, A., Cervera-Aldama, J., Chabok, A., Chafai, N., Chandrasinghe, P., Chandratreya, N., Chaudhri, S., Chaudhry, Z., Cherdancev, D., Chernov, A., Chevallay, M., Chirletti, P., Chouillard, E., Chouliaras, C., Chowdri, N., Cillo, M., Cini, C., Ciubotaru, C., Ciuce, C., Claeys, D., Cocorullo, G., Codina-Cazador, A., Colak, E., Coletta, D., Colombo, F., Copaescu, C., Corte Real, J., Corver, M., Cosic, J., Costa, S., Costa Pereira, J., Costa Pereira, C., Costa-Navarro, D., Cotte, E., Cracco, N., Cristian, D., Cuadrado, M., Cuk, V., Cunha, M., Cunha, J., Curinga, R., Curletti, G., Curtis, N., Dabic, D., Dainius, E., D'Alessandro, A., Daniels, I., Darvin, V., Dauser, B., David, G., Davidova, O., Davies, E., de Andres Asenjo, B., De franciscis, S., de Graaf, E., De la Portilla, F., De Luca, E., De Nisco, C., De Toma, G., Defoort, B., Den Boer, F., Di Candido, F., Di Saverio, S., Diaz Pavon, J., Dieguez Fernandez, B., Diez-Alonso, M., Dimitrijevic, I., Dindelegan, G., Djuric, M., Domingos, H., Doornebosch, P., Dos Santos, M., Drami, I., Dudarovaska, H., Dusek, T., Dzhumabaev, H., Eden, Y., Egenvall, M., Eismiontas, V., El Sorogy, M., Elgeidie, A., Elhemaly, M., El-Hussuna, A., Ellul, S., Elmore, U., Elnakeeb, A., Elrefai, M., Emile, S., Enrriquez-Navascues, J., Epstein, J., Escartin, J., Escola, D., Escuder, J., Espin, E., Espina, B., Estefania, D., Etienne, J., Fabbri, S., Falato, A., Fares, R., Farina, P., Farkasova, M., Farres, R., Fasolini, F., Fatayer, T., Febles, G., Feliu, F., Feo, C., Feoktistov, D., Fernandez, F., Fernandez Isart, M., Fernando, J., Ferreira, G., Ferrer, R., Ferreras Garcia, C., Ferri, M., Figueiredo, N., Finotti, E., Fitzgerald, J., Flateh Backe, I., Flor-Lorente, B., Forero-Torres, A., Foschi, D., Francart, D., Francois, Y., Frasson, M., Freil-Lanter, C., Frois Borges, M., Fuzun, M., Gala, T., Galleano, R., Galvez, P., Galvez Saldana, A., Gamundi Cuesta, M., Garcia Cabrera, A., Garcia Egea, J., Garcia Olmo, D., Garcia-Gonzalez, J., Garcia-Granero, A., Garcia-Granero, E., Garcia-Septiem, J., Gardea, A., Garipov, M., Gefen, R., Geraghty, A., Gerkis, S., Germanos, S., Ghaffari, S., Ghilles, E., Gianotti, L., Gil Santos, M., Gilsanz Martin, C., Gingert, C., Gklavas, A., Glehen, O., Golda, T., Gomez, N., Gomez, R., Gomez Ruiz, M., Gonzalez Santin, V., Graham, B., Grainger, J., Grama, F., Gregoir, T., Gregori, M., Grolich, T., Grosek, J., Guadalajara, H., Guckenheimer, S., Guevara, J., Gulotta, G., Gupta, S., Gurevich, N., Gurjar, S., Haapaniemi, S., Hahnloser, D., Hamad, Y., Hamid, M., Hanly, A., Harris, G., Harsanyi, L., Hartig, N., Hawkin, P., Henriques, P., Herbst, F., Hermann, N., Hernandez Garcia, M., Hoch, J., Hrora, A., Huhtinen, H., Iarumov, N., Ilkanich, A., Insua, C., Ioannidis, P., Iqbal, M., Iqbal, A., Isik, A., Ismaiel, M., Ivlev, D., Jadhav, V., Jareno, S., Jehaes, C., Jimenez, V., Jimenez-Toscano, M., Jimenez-Miramon, J., Jimenez-Rodriguez, R., Jonsson, T., Jotautas, V., Julia, D., Juloski, J., Jung, B., Kala, Z., Kalayci, M., Kara, Y., Karachun, A., Karagul, S., Karvonen, J., Katorkin, S., Katsoulis, I., Katsounis, D., Kaubrys, M., Kaul, N., Kefalou, E., Keijzers, M., Kelly, M., Kenic, M., Kennelly, R., Khan, J., Khan, M., Kho, H., Kinas, V., Knight, J., Kocian, P., Koeter, T., Kokobelyan, A., Konsten, J., Koolen, L., Kosir, J., Kostic, I., Krdzic, I., Kreisler Moreno, E., Krivokapic, Z., Krstev, P., Krsul, D., Kumarasinghe, N., La Torre, F., Labarga, F., Ladra, M., Lage Laredo, A., Lahodzich, N., Lai, C., Lakkis, Z., Lal, R., Lamas, S., Lang, T., Latkauskas, T., Lawes, D., Lazar, G., Lebedev, K., Lebedeva, M., Lefevre, J., Lekic Vitlov, V., Lemma, M., Leo, C., Leon, C., Leventoglu, S., Levy, B., Li, L., Licari, L., Lizdenis, P., Loftas, P., Longhi, M., Longstaff, L., Lopez Dominguez, J., Lopez-Lara, M., Lora, P., Lorenzon, L., Lorusso, D., Lozev, I., Lozoya Trujillo, R., Lukic, D., Lunins, R., Luzan, R., Luzzi, A., Maderuelo, V., Madsboll, T., Mahotin, D., Majbar, M., Makhmudov, A., Malik, K., Maly, O., Mamaloudis, I., Mamedli, Z., Manatakis, D., Mandi, D., Mangell, P., Marharint, T., Mariani, N., Maric, B., Marimuthu, K., Marinello, F., Marino, F., Markiewicz, S., Markovic, V., Marom, G., Maroni, N., Maroulis, I., Marsanic, P., Marsman, H., Martens, M., Marti, M., Martinek, L., Martinez, S., Martinez, D., Martinez Manzano, A., Martins, R., Maslyankov, S., Mcardle, K., Mcdermott, F., Mege, D., Mehraj, A., Mehta, A., Mendrila, D., Menendez, P., Mercantini, P., Metwally, I., Mikalauskas, S., Millan, M., Mingoli, A., Mirshekar-Syahkal, B., Moggia, E., Mohan, S., Moller, P., Mompart Garcia, S., Monami, B., Moniz Pereira, P., Montroni, I., Morel, P., Moshev, B., Mostovoy, E., Mothe, S., Mukhtar, H., Muller, P., Munch, S., Munoz Camarena, J., Munoz-Collado, S., Muratore, A., Muscara, F., Muysoms, F., Myrelid, P., N. Lah, N., Nail, S., Narayanan, A., Nastos, K., Negoi, I., Nesbakken, A., Nestler, G., Nestorovic, M., Nesytykh, A., Newton, K., Ng, Y., Ngu, J., Nguyen, B., Nijs, Y., Nikberg, M., Nimmersgern, T., Nogues, E., Norcic, G., Nutautiene, V., Nygren, J., O'Brien, J., Ochogavia Segui, A., O'Kelly, J., Oliveira-Cunha, M., Omar, W., Omar, G., Onishchenko, S., Onody, P., Opocher, E., Orhalmi, J., Oshowo, A., Otero, J., Ozgen, U., Pace, K., Padin, H., Papaconstantinou, I., Papadopoulos, A., Papadopoulos, G., Papandrea, M., Paral, J., Parc, Y., Paredes, J., Parmar, M., Parra Banos, P., Parray, F., Pascual Damieta, M., Pascual Miguelanez, I., Passot, G., Pastor, C., Paszt, A., Patel, P., Paterson, H., Patron Uriburu, J., Paulos, A., Pavlov, V., Pcolkins, A., Pecic, V., Pena Ros, E., Penkov, R., Pera Roman, M., Perunicic, V., Pery, R., Petrovic, D., Pezzolla, F., Photi, E., Pikarsky, A., Piramanayagam, B., Pisani Ceretti, A., Planellas, P., Platt, E., Pletinckx, P., Podda, M., Poskus, T., Poskus, E., Pozdnyakov, A., Pravosudov, I., Previsic, A., Prieto, D., Prochazka, V., Prodan, A., Proud, D., Psaila, J., Psaras, G., Pulighe, F., Pullig, F., Qureshi, M., Rachadell, J., Radovanovic, Z., Radovanovic, D., Raguan, B., Rahman, M., Raiss, M., Ramirez Faraco, M., Ramos, J., Ramos-Prada, J., Rantala, A., Rao, M., Rasulov, A., Ratnatunga, K., Raymond, T., Refky, B., Reggiani, L., Regusci, L., Reyes Diaz, M., Richardson, J., Richiteanu, G., Rios, A., Ris, F., Rodriguez Garcia, P., Roffi, N., Romairone, E., Romano, G., Romero, I., Romero de Diego, A., Romero-Simo, M., Roque, C., Rosati, R., Rossi, B., Rossi, E., Rossini, R., Ruano, A., Rubbini, M., Rubio-Perez, I., Ruffo, G., Ruiz, H., Ruiz Carmona, M., Ryska, O., Sabia, D., Sacchi, M., Sacco, R., Sakr, A., Saladzinskas, Z., Salamone, G., Salomon, M., Salvans Ruiz, S., Sammarco, G., Sampietro, G., Samsonov, D., Samsonyuk, V., Sanchez, J., Sanchez Romero, A., Sanchez-Guillen, L., Santak, G., Santamaria-Olabarrieta, M., Santos, J., Saraceno, F., Saralegui, Y., Sarici, I., Savino, G., Scabini, S., Schafli, J., Schiltz, B., Schofield, A., Schon, M., Scurtu, R., Segalini, E., Segelman, J., Segura-Sampedro, J., Seicean, R., Sekulic, A., Selniahina, L., Seretis, F., Serrano Paz, P., Shaikh, I., Shalaby, M., Shams, N., Sharma, A., Sharma, G., Shukla, A., Shussman, N., Shweejawee, Z., Sielezneff, I., Sigurdsson, H., Sileri, P., Silva, M., Simcikas, D., Simoes, J., Simonka, Z., Singh, B., Sivins, A., Skroubis, G., Skull, A., Slavchev, M., Slavin, M., Smart, N., Smart, C., Smart, P., Smedh, K., Smolarek, S., Sokmen, S., Sokolov, M., Solana Bueno, A., Solar, L., Sorrentino, L., Sotona, O., Spacca, D., Spinelli, A., Stanojevic, G., Stearns, A., Stefan, S., Stift, A., Stijns, J., Stoyanov, V., Straarup, D., Strupas, K., Stubbs, B., Subocius, A., Sudlow, A., Suero, C., Sungurtekin, U., Svagzdys, S., Syk, I., Tamelis, A., Tamhane, R., Tamini, N., Tamosiunas, A., Tanis, P., Tarasov, N., Tate, S., Tennakoon, A., Teo, N., Terzi, C., Tezas, S., Thabet, W., Tham, J., Thavanesan, N., Theodosopoulos, T., Thomas, W., Tiret, E., Tiselius, C., Todorov, G., Tomazic, A., Tomulescu, V., Torkington, J., Totis, M., Trostchansky, I., Truan, N., Tulchinsky, H., Tutino, R., Tzivanakis, A., Tzovaras, G., Ugolini, G., Unger, L., Upanishad, I., Urbani, L., Uth Ovesen, A., Vaizey, C., Vallribera, F., Valsdottir, E., Valverde, I., Valverde-Sintas, J., Van Belle, K., Van Cleven, S., van Hagen, P., van Loon, Y., van Ruler, O., Van Wijck, K., Varabei, A., Varcada, M., Varpe, P., Vartic, M., Velchuru, V., Vencius, J., Venskutonis, D., Vercher, D., Vermaas, M., Vertruyen, M., Verza, L., Vescio, G., Vezakis, A., Vieira, P., Vignali, A., Vigorita, V., Vila Tura, M., Vinson-Bonnet, B., Viso Pons, L., Voloshin, S., Voronin, Y., Vukusic, L., Wang, X., Wang, J., Wani, R., Warusavitarne, J., Wasserberg, N., Weerts, J., Weiss, D., Weizman, A., Westerduin, E., Wheat, J., White, I., Wik, T., Wilson, J., Winter, D., Wolthuis, A., Wong, M., Yahia, S., Yamamoto, T., Yanishev, A., Yao, C., Yildiz, A., Yuksel, O., Zain, Z., Zakaria, A., Zakaria, Z., Zampitis, N., Zarand, A., Zarco-Pleguezuelos, A., Zattoni, D., Zelic, M., Zeromskas, P., Zhuravlev, A., Zimmerman, D., Zuhdy, M., and Zukanovic, G.
Subjects: medicine.medical_specialty, Prehabilitation, medicine.medical_treatment, MEDLINE, Colorectal Neoplasm, Perioperative Care, NO, medicine, Humans, 03.02. Klinikai orvostan, Perioperative Optimisation, Enhanced recovery after surgery, Digestive System Surgical Procedures, LS7_4, Enhanced Recovery After Surgery (ERAS), business.industry, Gastroenterology, Digestive System Surgical Procedure, Guideline, Colorectal surgery, Surgery, Family medicine, Perioperative care, Nasogastric intubation, Preoperative fasting, Colorectal Neoplasms, Enhanced Recovery After Surgery, business, Colorectal Surgery, Human
Abstract: Aim The Enhanced Recovery After Surgery (ERAS® ) Society guidelines aim to standardise perioperative care in colorectal surgery via 25 principles. We aimed to assess the variation in uptake of these principles across an international network of colorectal units. Method An online survey was circulated amongst European Society of Coloproctology members in 2019/20. For each ERAS® principle, respondents were asked to score how frequently the principle was implemented in their hospital, from 1 ('rarely') to 4 ('always'). Respondents were also asked to recall whether practice had changed since 2017. Subgroup analyses based on hospital characteristics were conducted. Results Of hospitals approached, 58% responded to the survey (195/335), with 296 individual responses (multiple responses were received from some hospitals). The majority were European (163/195 [83.6%]). Overall, respondents indicated they 'most often' or 'always' adhered to most individual ERAS® principles (18/25 [72%]). Variability in uptake of principles was reported, with universal uptake of some principles (e.g., prophylactic antibiotics; early mobilisation) and inconsistency from 'rarely' to 'always' in others (e.g., no nasogastric intubation; no preoperative fasting and carbohydrate drinks). In alignment with 2018 ERAS® guideline updates, adherence to principles for prehabilitation, managing anaemia, and postoperative nutrition appears to have increased since 2017. Conclusions Uptake of ERAS® principles varied across hospitals, and not all 25 principles were equally adhered to. Whilst some principles exhibited a high level of acceptance, others had a wide variability in uptake indicative of controversy or barriers to uptake. Further research into specific principles is required to improve ERAS® implementation.
Published: 2021

3. Epidemiology and factors associated with acute stress disorder in burned patients: a case-control study

Author: Lina Escobar-Gómez, Carlos Cardeno-Castro, Alejandra Tamayo-Gómez, Diana Ortiz-Carmona, Juliana Velásquez-Suárez, Vladimir Cortés-López, Carlos Federico Molina-Castaño, and Lina Páramo-Duque
Subjects: medicine.medical_specialty, Burn injury, Visual analogue scale, Population, Pain, Critical Care and Intensive Care Medicine, law.invention, law, medicine, Humans, education, Stress Disorders, Traumatic, Acute, Retrospective Studies, education.field_of_study, business.industry, Burns, Electric, General Medicine, Odds ratio, Length of Stay, Intensive care unit, Acute Stress Disorder, Electrical burn, Case-Control Studies, Cohort, Emergency medicine, Emergency Medicine, Surgery, Burns, business
Abstract: Introduction A burn injury is a very painful experience, with subsequent emotional problems, which have been gaining relevance to the extent that survival from burns has improved. Among the alterations of the mental sphere in this population is Acute Stress Disorder (ASD) that has been described in up to one-third of patients with major burns. Methodology A nested case-control study was carried out in a cohort of hospitalized patients in a burn referral unit, in patients over 16 years of age. A total of 135 patients, 41 cases, and 94 controls were included. All of them underwent a psychiatric interview, a standardized form was filled out on sociodemographic and clinical information, and the PID-5-BF scale was applied to evaluate associated personality elements. The diagnosis of acute stress was made with the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) criteria. Results The incidence of acute stress was 23.4%. When the clinical and sociodemographic characteristics of both the cases and the controls were compared, the risk factors were subsidized insurance, flame burn, burn in a special area, third-degree burn, high pain, stay in the Intensive Care Unit (ICU), peritraumatic amnesia and life threat. Patients also had a higher percentage of burned body surface, higher average pulse, longer hospital length of stay, higher average in the negative affect variable and in the psychoticism variable of the PID-5-BF scale. But for the multivariate analysis using logistic regression, the model that best explains the presence of acute stress only includes the variables life threat (Odds Ratio adjusted (ORa): 117.0; Confidence Interval (CI): 10.9-1258.5), severe pain (ORa: 9.9; CI: 1.8-52.8), electrical burn (ORa: 20.8; CI: 17.2-250), burn in a special area (ORa: 8.9; CI: 1, 0-76.8), third-degree burn (ORa: 10.4; CI: 0.7-166.7). Conclusion Acute stress disorder is frequent in the hospitalised burn population, and is more frequent than in other types of trauma. Associated factors with the presentation of Acute Stress Disorder are the feeling of life threat at the time of the burn, having pain classified as strong (Visual Analog Scale (VAS) 5-10), electrical burn, and burns in special areas.
Published: 2022

4. Variaciones de los plexos coroideos y las barreras cerebrales en la hipertensión arterial y el envejecimiento

Author: Emilia M. Carmona-Calero, Ibrahim González-Marrero, Luis G. Hernández-Abad, Leandro Castañeyra-Ruiz, and Agustín Castañeyra-Perdomo
Subjects: 0301 basic medicine, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, business.industry, Medicine, Neurology (clinical), business, Humanities, 030217 neurology & neurosurgery
Abstract: Resumen Introduccion Los plexos coroideos, los vasos sanguineos y las barreras cerebrales estan intimamente relacionados tanto morfologica como funcionalmente. Por otro lado, la hipertension produce cambios en el flujo sanguineo y en los pequenos vasos y capilares cerebrales. El proposito de la presente revision es estudiar los efectos de la hipertension arterial sobre los plexos coroideos y las barreras cerebrales. Desarrollo Los plexos coroideos (PC) son una estructura del cerebro situada en los ventriculos cerebrales, altamente conservada filogenetica y ontogenicamente. Los PC se desarrollan temprano durante la embriogenesis y constituyen una barrera funcional en las primeras semanas de gestacion. Estan compuestos por tejido epitelial altamente vascularizado, cubiertos por microvellosidades y su funcion principal es la produccion del liquido cefalorraquideo (LCR). El sistema nervioso central se encuentra aislado y protegido por la barrera hematoencefalica (BHE) y por la barrera sangre-LCR (BSLCR). Mientras que la BHE se localiza al nivel de las celulas endoteliales en la microvasculatura del encefalo, la BSLCR esta formada por las celulas epiteliales de los plexos coroideos. La hipertension arterial cronica induce una remodelacion vascular para adaptarse a los valores elevados de presion arterial, con lo que se evita el riesgo de hiperperfusion ante presiones elevadas, pero se incrementa el riesgo de isquemia a presiones bajas; en cambio, en las personas normotensas la circulacion cerebral se autorregula y el flujo sanguineo permanece constante y se mantiene la integridad de la BHE. Conclusiones La hipertension arterial induce variaciones en los plexos coroideos que afecta al estroma, los vasos sanguineos, la produccion de LCR y agrava el deterioro de los PC producidos por envejecimiento. Ademas, la hipertension tambien produce alteraciones en las barreras cerebrales que son mas ostensibles en la BSLCR que en BHE; estos danos de las barreras cerebrales se podrian determinar detectando los niveles en sangre de S100β y TTRm.
Published: 2022

5. Antimicrobial peptides, a promising alternative for the treatment of infectious diseases

Author: Jorge Ismael Castañeda-Sánchez, Grecia Sánchez-Evangelista, Susan Janneth Islas-Arrollo, María del Carmen Galicia-Sánchez, Israel Carmona-Navarrete, Kevin Samael Olascoaga-Del Angel, and Angélica Gómez-Luna
Subjects: business.industry, Antimicrobial peptides, Medicine, General Medicine, business, Microbiology
Published: 2023

6. Prevalence of pericardial effusion in systemic diseases

Author: Héctor A Carmona-Ruiz and Oscar Orihuela-Rodríguez
Subjects: medicine.medical_specialty, business.industry, Internal medicine, Cardiology, medicine, General Medicine, medicine.disease, business, Pericardial effusion
Published: 2023

7. Immunocompetent patient with cerebral cryptococcosis: case report

Author: Daniel San-Juan, Luis Cuitláhuac Becerra-Pedraza, Daniel Arturo Martínez-Piña, and Génesis Rocío Calles-Carmona
Subjects: Pathology, medicine.medical_specialty, business.industry, Cerebral cryptococcosis, medicine, General Medicine, business
Published: 2023

8. An enhanced auto adaptive vector evaluated-based metaheuristic for solving real-world problems

Author: João Costa, Leticia de Fatima Corrêa Costa, and Omar Andres Carmona Cortes
Subjects: 0209 industrial biotechnology, 020901 industrial engineering & automation, Computer science, business.industry, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, 02 engineering and technology, Artificial intelligence, business, Metaheuristic
Abstract: This article investigates the enhancement of a vector evaluat-ed-based adaptive metaheuristics for solving two multiobjective problems called environmental-economic dispatch and portfolio optimization. The idea is to evolve two populations independently, and exchange information between them, i.e., the first population evolves according to the best individual of the second population and vice-versa. The choice of which algorithm will be executed on each generation is carried out stochastically among three evolutionary algorithms well-known in the literature: PSO, DE, ABC. To assess the results, we used an established metric in multiobjective evolutionary algorithms called hypervolume. Tests solving the referred problem have shown that the new approach reaches the best hypervolumes in power systems comprised of six and forty generators and five different datasets of portfolio optimization. The experiments were performed 31 times, using 250, 500, and 1000 iterations in both problems. Results have also shown that our proposal tends to overcome a variation of a hybrid SPEA2 compared to their cooperative and competitive approaches.
Published: 2022

9. Revisión sistemática del uso de metotrexato por vía parenteral en enfermedades reumáticas

Author: María Piedad Rosario, Teresa Otón, Jose Luis Andreu, Estíbaliz Loza, and Loreto Carmona
Subjects: Gynecology, medicine.medical_specialty, Rheumatology, business.industry, medicine, business
Abstract: Resumen Objetivo Analizar la eficacia, adherencia, satisfaccion del paciente, seguridad, farmacodinamica y costo-efectividad del metotrexato (MTX) parenteral en pacientes con enfermedades reumaticas. Metodos Se llevo a cabo una revision sistematica basada en una estrategia de busqueda en Medline, Embase y Cochrane Library (inicio-06/2019). Se identificaron estudios que incluyeran pacientes adultos con enfermedades reumaticas en tratamiento con MTX parenteral y que analizaran datos de eficacia, adherencia, satisfaccion, seguridad, farmacocinetica o costo-efectividad. En cuanto a los disenos se permitieron revisiones sistematicas, ensayos clinicos o estudios observacionales, incluyendo transversales y estudios con muestras pequenas si eran estudios de farmacocinetica. Resultados De 4.160 articulos identificados, se incluyeron finalmente 80. El MTX parenteral parece util de manera general y en especial en aquellos pacientes con respuesta insuficiente a MTX oral. La via parenteral no parece aumentar la tasa ni la gravedad de los eventos adversos con respecto a la oral y podria reducir costes en aquellos pacientes con respuesta inadecuada a MTX oral. La adherencia y satisfaccion se ven favorecidas por programas de entrenamiento en la via parenteral. Los resultados en enfermedades reumaticas distintas a la artritis reumatoide (AR) son muy escasos y no permiten obtener datos concluyentes. Conclusiones El MTX por via parenteral podria ser una alternativa al uso de MTX oral, por su perfil de eficacia, seguridad, adherencia, satisfaccion y resultados farmaco-economicos, especialmente en pacientes con AR.
Published: 2022

10. Long-term evolution of continence and quality of life after sphincteroplasty for obstetric fecal incontinence

Author: Vicente Pla-Mart, Maria Dolores Ruiz-Carmona, Jose Vicente Roig-Vila, Stephanie García-Botello, Alejandro Espí-Macías, José Martín-Arévalo, Rosa Marti-Fernandez, David Moro-Valdezate, and Miguel Minguez-Perez
Subjects: medicine.medical_specialty, Longitudinal study, business.industry, Gastroenterology, Quality of life scale, Surgery, Quality of life, medicine, Fecal incontinence, medicine.symptom, Surgical treatment, business, Depression (differential diagnoses)
Abstract: Purpose: This study was performed to evaluate the long-term evolution of continence and patient’s quality of life after surgical treatment for obstetric fecal incontinence.Methods: A prospective longitudinal study was conducted including consecutive patients who underwent sphincteroplasty for severe obstetric fecal incontinence. The first phase analyzed changes in continence and impact on quality of life. The second phase studied the long-term evolution reevaluating the same group of patients 6 years later. Degree of fecal incontinence was calculated using the Cleveland Clinic Score (CCS). Quality of life assessment was carried out with the Fecal Incontinence Quality of Life scale.Results: Thirty-five patients with median age of 55 years (range, 28 to 73 years) completed the study. Phase 1 results: after a postoperative follow-up of 30 months (4 to 132 months), CCS had improved significantly from a preoperative of 15.7 ± 3.1 to 6.1 ± 5.0 (P < 0.001). Phase 2 results: median follow-up in phase 2 was 110 months (76 to 204 months). The CCS lowered to 8.4 ± 4.9 (P = 0.04). There were no significant differences between phases 1 and 2 in terms of quality of life; lifestyle (3.47 ± 0.75 vs. 3.16 ±1.04), coping/behavior (3.13 ±0.83 vs. 2.80 ±1.09), depression/self-perception (3.65 ±0.80 vs. 3.32 ± 0.98), and embarrassment (3.32 ± 0.90 vs. 3.12 ± 1.00).Conclusion: Sphincteroplasty offers good short-medium term outcomes in continence and quality of life for obstetric fecal incontinence treatment. Functional clinical results deteriorate over time but did not impact on patients’ quality of life.
Published: 2022

11. Clinical Clues for the Current Diagnosis of Acute Lower Limb Ischemia: A Contemporary Case Series

Author: Albert Clarà, Lorena Romero, Alina Velescu, Carlos Ruiz-Carmona, Eduard Casajuana, and Lidia Marcos
Subjects: Male, medicine.medical_specialty, Time Factors, Arterial embolism, Embolism, Logistic regression, Risk Assessment, Amputation, Surgical, Decision Support Techniques, Diagnosis, Differential, Popliteal aneurysm, Peripheral Arterial Disease, Ischemia, Predictive Value of Tests, Risk Factors, Internal medicine, Epidemiology, medicine, Humans, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Thrombosis, Atrial fibrillation, General Medicine, Middle Aged, Limb Salvage, medicine.disease, Intermittent claudication, Treatment Outcome, Lower Extremity, Acute Disease, Female, Surgery, Differential diagnosis, medicine.symptom, Cardiology and Cardiovascular Medicine, business
Abstract: Background: Acute lower limb ischemia (ALI) is a limb and life-threatening condition whose treatment largely depends on the underlying cause. The clinical distinction between the main causes may have changed over the years because of changes in the epidemiology of this syndrome. The objective of this study was to determine the clinical pattern associated with the main causes of ALI in a contemporary series of cases. Methods: We retrospectively reviewed all consecutive ALI cases admitted to a tertiary hospital between 2007 and 2019. ALI secondary to other conditions than embolism or NAT were excluded. The association between clinical variables and the ALI cause was assessed with multiple logistic regressions and the discriminative power of the resulting clinical predictive scores with the area under the ROC curve. Results: The study group included 243 patients (mean age 77.2 years; 52.7% male), of which 140 (57.6%) were caused by an arterial embolism and 103 (42.4%) by a NAT. Among these latter, 78 (75.7%) were related to an atherosclerotic NAT and 25 (24.3%) to a complicated popliteal aneurysm. Independent risk factors associated with embolism included atrial fibrillation (OR 10.26, 95% CI 5.1-20.67) or female gender (OR 5.44, 95% CI 2.76-10.71), but not the severity of the episode or the presence of contralateral pulses. Those related to a NAT included a previous symptomatic peripheral arterial disease (OR 2.68, 95% CI 1.35-5.35) and seeking consultation more than 24 hours after the beginning of symptoms (OR 2.57, 95% CI 1.32-5), but not a higher rate of other vascular risk factors. Among patients with NAT, previous intermittent claudication (OR 8.34, 95% CI 2.42-28.72) and >24 hours delay of arrival of the patient (OR 4.78, 95% CI 1.48-15.43) were more frequent among those related to an atherosclerotic NAT, whereas higher hemoglobin levels (OR 1.60, 95% CI 1.21-2.11) and non-significantly the history of tobacco smoking (OR 2.95, 95% CI 0.84-10.36) among those with a popliteal aneurysm-related NAT. The discriminative power of the two clinical models resulting from these predictive variables for differentiating embolism from NAT and atherosclerosis-related NAT from popliteal aneurysm-related NAT was excellent (0.86 and 0.85, respectively). Conclusions: Certain clinical features appear to be no longer useful in the distinction between embolism and NAT, while others may help in the differential diagnosis between atherosclerotic and popliteal aneurysm-related NAT. Surgeons must be aware of possible changes in the presentation of ALI because time constraints are frequent and clinical data remain essential.
Published: 2022

12. Development of Anatomically Accurate Brain Model of Small Animals for Experimental Verification of Transcranial Magnetic Stimulation

Author: Chirayu Nimonkar, Eli Knight, Ivan C. Carmona, and Ravi L. Hadimani
Subjects: Transcranial magnetic stimulation, Brain model, business.industry, medicine.medical_treatment, Medicine, Electrical and Electronic Engineering, business, Neuroscience, Electronic, Optical and Magnetic Materials
Published: 2022

13. Systemic and Local Cytokines Profile Determine Severity and Prognosis in Human Septic Arthritis

Author: Jorge A. Gonzalez-Chapa, Mario C. Salinas-Carmona, Víctor M. Peña-Martínez, Adrian G. Rosas-Taraco, and Jose Felix Vilchez-Cavazos
Subjects: Arthritis, Infectious, medicine.medical_specialty, WOMAC, business.industry, medicine.medical_treatment, General Medicine, Osteoarthritis, Prognosis, medicine.disease, Proinflammatory cytokine, Immune system, Cytokine, Internal medicine, Synovial Fluid, Quality of Life, Etiology, medicine, Cytokines, Humans, Synovial fluid, Septic arthritis, business
Abstract: Septic arthritis (SA) is a medical emergency. The most common etiological agents are bacteria, which activate the local immune response coordinated by cytokines; however, little is known about the cytokine profile in human SA.To determine the association of local and systemic cytokine profiles with the severity and prognosis of patients with SA.Patients with clinical and laboratory diagnosed SA were enrolled as well as a control group. Serum and synovial fluid (SF) samples were obtained for determining cytokines and glucose levels; SF samples were used for histological analysis. Osteochondral damage and general health status and quality of life (SF-36) were evaluated during recruitment day. WOMAC osteoarthritis index score and SF-36 questionnaire were used a year after recruitment day as a follow up.A systemic and local proinflammatory cytokine profile was found in patients compared to the control group (p0.05). IL-6 was 28 and 525 times higher than controls in sera and SF, respectively (p0.0001). Systemic IL-6 correlated negatively with general mental health score (p = 0.0184) and was associated with a higher osteoarthritis index after one year follow-up in the patients (p = 0.0352). HMGB1 in SF was found higher in patients with SA (p0.0001), and it was associated with osteochondral damage (p = 0.0042). TNF-α in SF correlated negatively with SF-36 questionnaire one year after patients' recruitment in role limitation score (p = 0.0318), body pain score (p = 0.0315), and general mental health score (p = 0.0197).Serum and SF cytokine signatures are associated with disease severity and prognosis in patients with SA.
Published: 2022

14. Differences in the management and survival of metastatic colorectal cancer in Europe. A population-based study

Author: Anne-Marie Bouvier, Valérie Jooste, Maria José Sanchez-Perez, Maria José Bento, Jessica Rocha Rodrigues, Rafael Marcos-Gragera, Maria Carmen Carmona-Garcia, Miguel Angel Luque-Fernandez, Pamela Minicozzi, Véronique Bouvier, Kaire Innos, Milena Sant, L. Van Eycken, K. Henau, T. Grozeva, Z. Valerianova, K. Innos, M. Mägi, V. Bouvier, G. Launoy, M. Robaszkiewicz, A.M. Bouvier, V. Jooste, V. Babaev, A. Katalinic, E.J. Ólafsdóttir, L. Tryggvadóttir, C. Amati, P. Baili, S. Bonfarnuzzo, C. Margutti, E. Meneghini, P. Minicozzi, G. Moretti, M. Sant, C. Cirilli, G. Carrozzi, E. Spata, R. Tumino, P. Giorgi Rossi, M. Vicentini, F. Stracci, F. Bianconi, P. Contiero, G. Tagliabue, W. Kycler, M. Oko, P. Macek, J. Smok-Kalwat, M. Bielska-Lasota, M.J. Bento, J Rodrigues, A. Mayer-da-Silva, A. Miranda, M. Primic-Žakelj, K. Jarm, E. Almar, A. Mateos, J. Bidaurrazaga, M. de la Cruz, C. Alberich, A. Torrella-Ramos, J.M. Díaz García, AI Marcos-Navarro, C. Carmona-Garcia, R. Marcos-Gragera, M.A. Luque-Fernandez, M.J. Sánchez-Pérez, E. Ardanaz, M. Guevara, C. Bouchardy, and E. Fournier
Subjects: Male, Oncology, medicine.medical_specialty, Survival, Colorectal cancer, Population, Antineoplastic Agents, Logistic regression, Metastasis, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Health care, medicine, Humans, Registries, Neoplasm Metastasis, Disease management (health), education, Aged, Retrospective Studies, Aged, 80 and over, education.field_of_study, Hepatology, business.industry, Gastroenterology, Disease Management, Cancer, Odds ratio, Middle Aged, medicine.disease, Europe, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business
Abstract: The management regarding metastatic colorectal cancer throughout Europe is not well known.To draw a European comparison of the management and prognosis of metastatic colorectal cancers.Factors associated with chemotherapy administration were identified through logistic regressions. Net survival was estimated and crude probabilities of death related to cancer and other causes using a flexible cumulative hazard model.Among the 13 227 patients with colorectal cancer diagnosed between 2010 and 2013 in cancer registries from 10 European countries, 3140 were metastatic. 62% of metastatic patients received chemotherapy. Compared to Spain, the related adjusted odds ratios ranged from 0.7 to 4.0 (P0.001) according to country. The 3-year net survival by country ranged between 16% and 37%. The survival gap between countries diminished from 21% to 10% when adjusting for chemotherapy, age and sex. Geographical differences in the crude probability of death related to cancer were large for patients70 or ≥80 years at diagnosis.Heterogeneity in the application of European guidelines partly explain these differences. General health between populations, accessibility to a reference centre, or provision of health care could also be involved. Further population-based studies are warranted to disentangle between these possible explanations.
Published: 2021

15. Evaluation of Nutritional Practices in the Critical Care patient (The ENPIC study): Does nutrition really affect ICU mortality?

Author: Lluís Servia-Goixart, Juan C. Lopez-Delgado, Teodoro Grau-Carmona, Javier Trujillano-Cabello, M Luisa Bordeje-Laguna, Esther Mor-Marco, Esther Portugal-Rodriguez, Carol Lorencio-Cardenas, Juan C. Montejo-Gonzalez, Paula Vera-Artazcoz, Laura Macaya-Redin, Juan Francisco Martinez-Carmona, Rayden Iglesias-Rodriguez, Diana Monge-Donaire, José L. Flordelis-Lasierra, Beatriz Llorente-Ruiz, Eva M. Menor-Fernández, Itziar Martínez de Lagrán, Juan C. Yebenes-Reyes, Joan Escobar-Ortiz, Neus Montserrat-Ortiz, Amalia Zapata-Rojas, Iris Bautista-Redondo, Ana Cruz-Ramos, Laura Diaz-Castellanos, Miriam Morales-Cifuentes, Montserrat Plaza- Bono, Juan Carlos Montejo-Gonzalez, Susana Temprano-Vazquez, Veronica Arjona-Diaz, Carlos Garcia-Fuentes, Carolina Mudarra-Reche, Maria Orejana-Martin, Juan Carlos Lopez-Delgado, Africa Lores-Obradors, Laura Anguela-Calvet, Gloria Muñoz-Del Río, Pamela Alejandra Revelo-Esquibel, Henry Alanez-Saavedra, Pau Serra-Paya, Stephani Maria Luna-Solis, Alvaro Salinas-Canovas, Fernando De Frutos-Seminario, Oriol Rodriguez-Queralto, Carlos Gonzalez-Iglesias, Monica Zamora-Elson, Eugenia de la Fuente-O'Connor, Carlos Seron- Arbeloa, Nestor Bueno-Vidales, Ana Martin-Luengo, Angel Sanchez-Miralles, Enrique Marmol-Peis, Miriam Ruiz-Miralles, Maria Gonzalez-Sanz, Arantzazu Server-Martinez, Belen Vila-Garcia, Raquel Flecha-Viguera, Sara Aldunate-Calvo, Jose Luis Flordelis-Lasierra, Irene Jimenez-del Rio, Jose Ramon Mampaso-Recio, Jose Manuel Rodriguez-Roldan, Rosa Gastaldo-Simeon, Josefina Gimenez-Castellanos, Juan Francisco Fernandez-Ortega, Juan F. Martinez-Carmona, Esther Lopez-Luque, Ane Ortega-Ordiales, Monica Crespo-Gomez, Victor Ramirez-Montero, Esther Lopez-García, Arturo Navarro-Lacalle, Pilar Martinez-Garcia, Maria Inmaculada Dominguez-Fernandez, Marta Izura-Gomez, Susana Hernandez-Duran, Ma Luisa Bordeje-Laguna, Yaiza Rovira-Valles, Viridiana Philibert, Maravillas de las Nieves Alcazar-Espin, Aurea Higon-Cañigral, Enrique Calvo-Herranz, Diego Manzano-Moratinos, David Andaluz-Ojeda, Laura Parra-Morais, Rafael Citores-Gonzalez, Maria Teresa Garcia-Gonzalez, Gloria Renedo Sanchez-Giron, Elisabeth Navas-Moya, Carles Ferrer-Pereto, Cristina Lluch-Candal, Jessica Ruiz-Izquierdo, Silvia Castor-Bekari, Cristina Leon-Cinto, Itziar Martinez de Lagran, Juan Carlos Yebenes-Reyes, Beatriz Nieto-Martino, Clara Vaquerizo-Alonso, Susana Almanza-Lopez, Sonia Perez-Quesada, Jose Luis Anton-Pascual, Judith Marin-Corral, Maite Sistachs-Baquedano, Maria Hacer-Puig, Marina Picornell-Noguera, Lidon Mateu-Campos, Clara Martinez-Valero, Andrea Ortiz-Suñer, María Cristina Martinez-Diaz, Maria Trascasa- Muñoz De La Peña, Diego Anibal Rodriguez-Serrano, Leticia Fernandez-Salvatierra, Mireia Barcelo-Castello, Paula Millan-Taratiel, Antonio Tejada-Artigas, Ines Martinez-Arroyo, Pilar Araujo-Aguilar, Maria Fuster-Cabre, Laura Andres-Gines, Sonia Soldado-Olmo, Eva Mª Menor-Fernandez, Lucas Lage-Cendon, Alberto Touceda-Bravo, Laura Sanchez-Ales, Laura Almorin-Gonzalvez, Maria Gero-Escapa, Esther Martinez-Barrio, Sergio Ossa-Echeverri, [Servia-Goixart L, Trujillano-Cabello J] Hospital Universitari Arnau de Vilanova, Intensive Care Department, Lleida, Spain. IRBLLeida (Institut de Recerca Biomedica de Lleida Fundacio Dr. Pifarré, Lleida Biomedical Research Institute's Dr. Pifarré Foundation, Lleida, Spain. [Lopez-Delgado JC] Hospital Universitari de Bellvitge, Intensive Care Department, Hospitalet de Llobregat, Spain. IDIBELL (Institut d’Investigacio Biomédica Bellvitge, Biomedical Investigation Institute of Bellvitge, Hospitalet de Llobregat, Spain. [Grau-Carmona T] Hospital Universitario 12 de Octubre, Intensive Care Department, Madrid, Spain. i+12 (Instituto de Investigacion Sanitaria Hospital 12 de Octubre, Research Institute Hospital 12 de Octubre), Madrid, Spain. [Bordeje-Laguna ML, Mor-Marco E] Hospital Universitario Germans Trias i Pujol, Intensive Care Department, Badalona, Spain. [Iglesias-Rodriguez R] Hospital General de Granollers, Intensive Care Department, Granollers, Spain, and Hospital General de Granollers
Subjects: Adult, Parenteral Nutrition, Pediatrics, medicine.medical_specialty, Multivariate analysis, Critical Care, Endocrinology, Diabetes and Metabolism, Nutritional Status, Enteral administration, Nutritional therapy, Enteral Nutrition, Medicina intensiva, Epidemiology and Biostatistics::Biostatistics::Information Storage and Retrieval::Mortality Registries [PUBLIC HEALTH], Intensive care, Mortalitat, Medicine, Humans, Nutrició enteral, Critical care medicine, Intensive care unit, Medical nutrition therapy, Mortality, Nutrició, vigilancia sanitaria de los servicios de salud::centros sanitarios::hospitales::unidades hospitalarias::unidades de cuidados intensivos [VIGILANCIA SANITARIA], Nutrition, Therapeutics::Feeding Methods::Enteral Nutrition [ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT], Nutrition and Dietetics, epidemiología y bioestadística::bioestadística::almacenamiento y recuperación de la información::registros de mortalidad [SALUD PÚBLICA], business.industry, Hazard ratio, Parenteral nutrition, Confidence interval, Intensive Care Units, terapéutica::métodos de alimentación::nutrición enteral [TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS], Observational study, Health Surveillance of Health Services::Health Facilities::Hospitals::Hospital Units::Intensive Care Units [HEALTH SURVEILLANCE], business, Enteral nutrition
Abstract: Background: The importance of artificial nutritional therapy is underrecognized, typically being considered an adjunctive rather than a primary therapy. We aimed to evaluate the influence of nutritional therapy on mortality in critically ill patients.Methods: This multicenter prospective observational study included adult patients needing artificial nutritional therapy for >48 h if they stayed in one of 38 participating intensive care units for ≥72 h between April and July 2018. Demographic data, comorbidities, diagnoses, nutritional status and therapy (type and details for ≤14 days), and outcomes were registered in a database. Confounders such as disease severity, patient type (e.g., medical, surgical or trauma), and type and duration of nutritional therapy were also included in a multivariate analysis, and hazard ratios (HRs) and 95% confidence intervals (95%CIs) were reported.Results: We included 639 patients among whom 448(70.1%) and 191(29.9%) received enteral and parenteral nutrition, respectively. Mortality was 25.6%, with non-survivors having the following characteristics: older age; more comorbidities; higher Sequential Organ Failure Assessment (SOFA) scores (6.6±3.3 vs 8.4±3.7; P); greater nutritional risk (Nutrition Risk in the Critically Ill [NUTRIC] score: 3.8±2.1 vs 5.2±1.7; P); more vasopressor requirements (70.4% vs 83.5%; P=0.001); and more renal replacement therapy (12.2% vs 23.2%; P=0.001). Multivariate analysis showed that older age (HR: 1.023; 95% CI: 1.008–1.038; P=0.003), higher SOFA score (HR: 1.096; 95% CI: 1.036–1.160; P=0.001), higher NUTRIC score (HR: 1.136; 95% CI: 1.025–1.259; P=0.015), requiring parenteral nutrition after starting enteral nutrition (HR: 2.368; 95% CI: 1.168–4.798; P=0.017), and a higher mean Kcal/Kg/day intake (HR: 1.057; 95% CI: 1.015–1.101; P=0.008) were associated with mortality. By contrast, a higher mean protein intake protected against mortality (HR: 0.507; 95% CI: 0.263–0.977; P=0.042).Conclusions: Old age, higher organ failure scores, and greater nutritional risk appear to be associated with higher mortality. Patients who need parenteral nutrition after starting enteral nutrition may represent a high-risk subgroup for mortality due to illness severity and problems receiving appropriate nutritional therapy. Mean calorie and protein delivery also appeared to influence outcomes.Trial Registration: ClinicaTrials.gov NCT: 03634943.
Published: 2022

16. Assessment of a digital game as a neuropsychological test for postoperative cognitive dysfunction

Author: Ananaira Alves Goulart, André Lucatelli, Paulo Sérgio Panse Silveira, Valéria Fontenelle Angelim Pereira, Joaquim Edson Vieira, José de Oliveira Siqueira, Livia Stocco Sanches Valentin, and Maria José Carvalho Carmona
Subjects: Adult, Male, Work activity, medicine.medical_specialty, medicine.medical_treatment, Neuropsychological Tests, Cognition, Postoperative Cognitive Complications, Cognitive dysfunction, Anesthesiology, Patient performance, medicine, Postoperative period, Humans, Statistical analysis, Anesthesia, RD78.3-87.3, Aged, Analysis of covariance, Rehabilitation, medicine.diagnostic_test, business.industry, Computers, General Medicine, Neuropsychological test, Middle Aged, medicine.disease, Diagnostic self evaluation, Memory, Short-Term, Physical therapy, Female, business, Postoperative cognitive dysfunction
Abstract: Objective Postoperative cognitive dysfunction may result from worsening in a condition of previous impairment. It causes greater difficulty in recovery, longer hospital stays, and consequent delay in returning to work activities. Digital games have a potential neuromodulatory and rehabilitation effect. In this study, a digital game was used as a neuropsychological test to assess postoperative cognitive dysfunction, with preoperative patient performance as control. Methods It was a non-controlled study, with patients selected among candidates for elective non-cardiac surgery, evaluated in the pre- and postoperative periods. The digital game used has six phases developed to evaluate selective attention, alternating attention, visuoperception, inhibitory control, short-term memory, and long-term memory. The digital game takes about 25 minutes. Scores are the sum of correct answers in each cognitive domain. Statistical analysis compared these cognitive functions pre- and post-surgery using a generalized linear mixed model (ANCOVA). Results Sixty patients were evaluated, 40% male and 60% female, with a mean age of 52.7 ± 13.5 years. Except for visuoperception, a reduction in post-surgery scores was found in all phases of the digital game. Conclusion The digital game was able to detect decline in several cognitive functions postoperatively. As its completion is faster than in conventional tests on paper, this digital game may be a potentially recommended tool for assessing patients, especially the elderly and in the early postoperative period.
Published: 2022

17. Correlación entre la endoscopia y la ecografía intestinal para la evaluación de la recurrencia posquirúrgica de la enfermedad de Crohn

Author: María Dolores Martín Arranz, Jorge Yebra Carmona, Cristina Suárez Ferrer, Javier Lucas Ramos, María Sánchez Azofra, Irene Andaluz García, Jose Luis Rueda García, Joaquín Poza Cordón, and Eduardo Arranz
Subjects: Gynecology, Crohn's disease, medicine.medical_specialty, Hepatology, business.industry, Gastroenterology, medicine.disease, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, medicine, 030211 gastroenterology & hepatology, Ultrasonography, business
Abstract: Resumen Objetivo La ecografia intestinal se considera una alternativa para la evaluacion de la recurrencia posquirurgica (RPQ) de la enfermedad de Crohn. El objetivo de este estudio es evaluar la correlacion entre los hallazgos ecograficos y endoscopicos. Metodos Se recogieron de forma retrospectiva los datos de pacientes con enfermedad de Crohn y reseccion ileocecal en los que se habia realizado una colonoscopia y una ecografia intestinal para la deteccion de RPQ. La RPQ se evaluo empleando el indice de Rutgeerts (IR). Los hallazgos ecograficos analizados fueron el grosor de la pared intestinal, la hiperemia parietal por Doppler, la desestructuracion del patron de capas y la proliferacion fibrograsa. Resultados Se incluyo a un total de 31 pacientes, 15 (48,4%) sin recurrencia (IR? Conclusiones En nuestra experiencia, la ecografia tiene una alta rentabilidad diagnostica para la deteccion de RPQ y puede considerarse en muchas ocasiones como una alternativa valida y no invasiva a la ileocolonoscopia.
Published: 2022

18. Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis

Author: Yoshihiro Noda, Guillermo Horga, Fernando Caravaggio, Clifford M. Cassidy, Ariel Graff-Guerrero, Edgardo Torres-Carmona, Sho Moriguchi, Shiori Honda, Vincenzo De Luca, Sakiko Tsugawa, Philip Gerretsen, Shinichiro Nakajima, Yusuke Iwata, Fumihiko Ueno, and Jose M. Rubio
Subjects: Oncology, Postmortem studies, medicine.medical_specialty, Cognitive Neuroscience, Substantia nigra, behavioral disciplines and activities, Article, Behavioral Neuroscience, Neuromelanin, Dopamine, Internal medicine, mental disorders, medicine, Humans, Melanins, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Substantia Nigra, Neuropsychology and Physiological Psychology, Schizophrenia, Meta-analysis, Biomarker (medicine), business, medicine.drug
Abstract: Although schizophrenia is associated with increased presynaptic dopamine function in the striatum, it remains unclear if neuromelanin levels, which are thought to serve as a biomarker for midbrain dopamine neuron function, are increased in patients with schizophrenia. We conducted a systematic review and meta-analysis of magnetic resonance imaging (MRI) and postmortem studies comparing neuromelanin (NM) levels between patients with schizophrenia and healthy controls (HCs). Standard mean differences were calculated to assess group differences in NM accumulation levels between patients with schizophrenia and HCs. This study included 7 articles in total. Five studies employed NM-sensitive MRI (NM-MRI) and two were postmortem brain studies. The patient group (n = 163) showed higher NM levels in the substantia nigra (SN) than HCs (n = 228) in both the analysis of the seven studies and the subgroup analysis of the 5 NM-MRI studies. This analysis suggest increased NM levels in the SN may be a potential biomarker for stratifying schizophrenia, warranting further research that accounts for the heterogeneity of this disorder.
Published: 2022

19. Effect of continuous positive airway pressure in very elderly with moderate-to-severe obstructive sleep apnea pooled results from two multicenter randomized controlled trials

Author: David Gozal, Laura Vigil, A. Muriel, E. Chiner, B. Orosa, A. Martinez, C. Carmona, L. Hernandez, E. Pastor, M. Mayos, Grace Oscullo, Silvia Ponce, Alberto García-Ortega, Miguel Ángel Martínez-García, P. Catalán, José Daniel Gómez-Olivas, Thais Beauperthuy, and Amina Bekki
Subjects: Quality of life, medicine.medical_specialty, medicine.medical_treatment, law.invention, OSA, Randomized controlled trial, CPAP, law, Internal medicine, medicine, Clinical endpoint, Humans, Continuous positive airway pressure, Aged, Randomized Controlled Trials as Topic, Aged, 80 and over, Sleep Apnea, Obstructive, Continuous Positive Airway Pressure, business.industry, Epworth Sleepiness Scale, Snoring, Very elderly, General Medicine, medicine.disease, Neurocognitive, Obstructive sleep apnea, nervous system diseases, respiratory tract diseases, Clinical trial, Blood pressure, Quality of Life, business
Abstract: Study objective: There is very limited information about the effect of continuous positive airway pressure (CPAP) in the very elderly. Here we aimed to analysed the effect of CPAP on a clinical cohort of patients with obstructive sleep apnea (OSA) >= 80 years old. Methods: Post-hoc pooled analysis of two open-label, multicenter clinical trials aimed to determine the effect of CPAP in a consecutive clinical cohort of elderly (>= 70 years old) with moderate-to-severe OSA (apnea-hipopnea index >= 15 events/hour) randomized to receive CPAP or no CPAP for three months. Those consecutive patients >= 80 years old were included in the study. The primary endpoint was the change in Epworth Sleepiness scale (ESS). Secondary outcomes included sleep-related symptoms, quality of life, neurocognitive and mood status as well as office blood pressure measurements. Results: From the initial 369 randomized individuals with >= 70 years, 97 (26.3%) with >= 80 years old were included (47 in the CPAP group and 50 in the no-CPAP group). The mean (SD) age was 81.5 (2.4) years. Average use of CPAP was 4.3 (2.6) hours/night (53% with good adherence) Patients in the CPAP group significantly improved snoring and witnessed apneas as well as AHI (from 41.9 to 4.9 events/hour). However no clinical improvements were seen in ESS (>= 1.2 points, 95%CI, 0.2 to >= 2.6), any domain of QSQ, any neurocognitive test, OSA-related symptoms, depression/anxiety or blood pressure levels. Conclusions: The present study does not support the use of CPAP in very elderly patients with moderateto-severe OSA. (C) 2021 Elsevier B.V. All rights reserved.
Published: 2022

20. Estudio prospectivo multicéntrico de experiencia en práctica clínica real en el control de medidas de desenlace reportadas por el paciente (PRO) diagnosticado de artritis psoriásica y/o espondiloartritis y que inicia tratamiento con secukinumab

Author: Clara Molina Almela, Cristina Campos Fernández, Isabel Balaguer Trull, Antonio Pérez Torres, Antonio Gracia Pérez, María Dolores Pastor Cubillo, Javier Calvo Catalá, Amalia Rueda Cid, Loreto Carmona, and Juan José Lerma Garrido
Subjects: 030203 arthritis & rheumatology, Ankylosing spondylitis, medicine.medical_specialty, business.industry, medicine.disease, 03 medical and health sciences, Psoriatic arthritis, 0302 clinical medicine, Rheumatology, Quality of life, Psoriasis, medicine, Physical therapy, Observational study, Secukinumab, 030212 general & internal medicine, business, Spondylitis, BASDAI
Abstract: Objective To analyse the effect of secukinumab on self-reported variables of patients diagnosed with psoriatic arthritis and/or ankylosing spondylitis in relation to their health status, pain, fatigue, sleep and quality of life. Methods A six-month, observational, longitudinal, prospective, multicentre study was conducted with 39 patients who initiated treatment with secukinumab as therapy for psoriatic arthritis and/or spondylitis. The main variables were changes in patient-reported measures and they were evaluated by means of the questionnaires: FACIT-fatigue, Insomnia Severity Index, EuroQol-3L-5D and PsAQoL. In addition, depending on the type of disease (peripheral psoriasis or spondyloarthritis) the DAS28 with ESR or the BASDAI were calculated, respectively. Results Levels of fatigue, moderate and severe insomnia significantly reduced after 6 months of treatment with secukinumab. At the same time, patient-reported quality of life increased significantly (P = .006). Data on pain and discomfort also show significant improvement after the treatment. Conclusions Patients with psoriatic arthritis and/or ankylosing spondylitis who start treatment with secukinumab show improvement at 6 months in all effect sizes of the treatment, particularly in sleep, fatigue and quality of life. Furthermore, patient-reported outcome measures are of additional clinical value and allow more accurate and closer assessment of their real status of health and well-being.
Published: 2022

21. Restrictive or liberal transfusion for cardiac surgery: Spanish results of a randomized multicenter international parallel open-label clinical trial

Author: Maria José Martinez-Zapata, J Galan, E. Mateo, L Gajate, C D Mazer, Paula Carmona, and Spanish Trics Iii Investigators
Subjects: Clinical trial, medicine.medical_specialty, business.industry, General surgery, medicine, MEDLINE, Open label, Critical Care and Intensive Care Medicine, business, Cardiac surgery
Published: 2022

22. Sofosbuvir-velpatasvir in Mexican patients with hepatitis C: A retrospective review

Author: M.V. Ramos-Gómez, A. Torre-Delgadillo, Linda Muñoz-Espinoza, L.E. Cisneros-Garza, Margarita Dehesa-Violante, G.E. Castro-Narro, José Luis Pérez-Hernández, A. Carmona-Castañeda, F. Higuera-de la Tijera, R. Lehmann-Mendoza, N. García-Casarreal, R. Contreras-Omaña, I. Aiza-Haddad, C.A. Arce-Salinas, L. Juárez-Chavez, E. Cerda-Reyes, and J.A. Velarde-Ruiz-Velasco
Subjects: medicine.medical_specialty, Cirrhosis, Genotype, Sofosbuvir, RC799-869, Antiviral Agents, Heterocyclic Compounds, 4 or More Rings, Sofosbuvir/velpatasvir, Estudios retrospectivos, chemistry.chemical_compound, Internal medicine, medicine, Humans, Adverse effect, Mexico, Retrospective Studies, Retrospective review, business.industry, Ribavirin, General Medicine, Hepatitis C, Hepatitis C, Chronic, Diseases of the digestive system. Gastroenterology, medicine.disease, chemistry, Virologic response, Agentes antivirales, Respuesta virológica sostenida, Carbamates, business, medicine.drug
Abstract: Introduction: The sofosbuvir-velpatasvir (SOF/VEL) combination is a direct-acting antiviral therapy that is authorized and available in Mexico, making the performance of a real-world multicenter study that evaluates the sustained virologic response at 12 weeks post-treatment a relevant undertaking. Methods: A retrospective review of the case records of 241 patients seen at 20 hospitals in Mexico was conducted to assess hepatitis C treatment with the SOF/VEL combination (n = 231) and the sofosbuvir/velpatasvir/ribavirin (SOF/VEL/RBV) combination (n = 10). The primary efficacy endpoint was the percentage of patients that achieved SVR at 12 weeks after the end of treatment. Results: Overall SVR was 98.8% (95% CI 97.35–100%). Only three patients did not achieve SVR, two of whom had cirrhosis and a history of previous treatment with peg-IFN. Of the subgroups analyzed, all the patients with HIV coinfection, three patients with genotype 3, and the patients treated with the SOF/VEL/RBV combination achieved SVR. The subgroups with the lower success rates were patients that were treatment-experienced (96.8%) and patients with F1 fibrosis (95.5%). The most frequent adverse events were fatigue, headache, and insomnia. No serious adverse events were reported. Conclusion: Treatments with SOF/VEL and SOF/VEL/RBV were highly safe and effective, results coinciding with those of other international real-world studies. Resumen: Introducción: La combinación de sofosbuvir-velpatasvir (SOF/VEL) es una terapia antiviral de acción directa que está autorizada y disponible en México. Esto hace que la evaluación de la respuesta virológica sostenida (RVS) 12 semanas después del tratamiento, por medio de la realización de una revisión multicentro en el mundo real, sea una tarea relevante. Métodos: Se efectuó una revisión retrospectiva de los registros de 241 casos de pacientes atendidos en 20 hospitales en México para evaluar el tratamiento contra la hepatitis C con la combinación SOF/VEL (n = 231) y sofosbuvir/velpatasvir/ribavirin (SOF/VEL/RBV) (n = 10). El objetivo de eficacia primario fue el porcentaje de pacientes que lograron la RVS 12 semanas posterior a la finalización del tratamiento. Resultados: En general, la RVS fue de 98.8% (IC 95% 97.35 a 100%). Solo tres pacientes no lograron la RVS, de los cuales dos padecían cirrosis y una tenía historia previa de tratamiento con interferón pegilado (peg-IFN). De los subgrupos analizados, todos los casos con infección de virus de la inmunodeficiencia humana (VIH), tres con genotipo 3 y aquellos tratados con la combinación SOF/VEL/RBV, lograron RVS. Los subgrupos con tasas menores de éxito fueron los pacientes que tenían experiencia con tratamiento (96.8%) y pacientes con fibrosis F1 (95.5%). Los eventos adversos más frecuentes fueron fatiga, cefalea e insomnio. No se reportaron eventos adversos graves. Conclusión: Los tratamientos con SOF/VEL y SOF/VEL/RBV fueron altamente seguros y efectivos y los resultados coinciden con los de otros estudios internacionales realizados en el mundo real.
Published: 2022

23. Clinical benefits of empagliflozin in very old patients with type 2 diabetes hospitalized for acute heart failure

Author: Jaime Sanz-Cánovas, Ricardo Gómez-Huelgas, Miguel Ángel Barbancho, Manuel F. Jiménez-Navarro, María Rosa Bernal-López, María D. López-Carmona, Mercedes Millán-Gómez, Almudena López-Sampalo, Michele Ricci, J.P. Lara, Julio Osuna-Sánchez, and Luis M. Pérez-Belmonte
Subjects: medicine.medical_specialty, Acute decompensated heart failure, business.industry, medicine.medical_treatment, Insulin, Type 2 diabetes, medicine.disease, Discontinuation, Regimen, Internal medicine, Heart failure, medicine, Empagliflozin, Geriatrics and Gerontology, Diuretic, business
Abstract: Background There is little evidence on the use of sodium-glucose cotransporter 2 (SGLT2) inhibitors in older patients with heart failure. This work analyzed the clinical efficacy and safety of empagliflozin continuation in very old patients with type 2 diabetes hospitalized for acute decompensated heart failure. Methods We conducted a real-world observational study between September 2015 and June 2021. Patients ≥80 years were grouped by antihyperglycemic regimen: (1) continuation of preadmission empagliflozin combined with basal insulin regimen and (2) conventional basal-bolus insulin regimen. A propensity score matching analysis matched patients in both groups in a 1:1 manner. The primary outcome was differences in clinical efficacy measured by the visual analogue scale dyspnea score, NT-proBNP levels, diuretic response, and cumulative urine output. Safety endpoints such as adverse events, worsening heart failure, discontinuation of empagliflozin, length of hospital stay, and in-hospital deaths were also analyzed. Results After propensity score matching, 79 patients were included in each group. At discharge, the N-terminal pro-brain natriuretic peptide (NT-proBNP) levels were lower in the empagliflozin continuation group than in the insulin group (1699 ± 522 vs. 2303 ± 598 pg/ml, p = 0.021). Both the diuretic response and cumulative urine output were greater in patients treated with empagliflozin than in patients with basal-bolus insulin during the hospitalization (at discharge: -0.14 ± -0.06 vs. -0.24 ± -0.10, p = 0.044; and 16,100 ± 1510 vs. 13,900 ± 1220 ml, p = 0.037, respectively). No differences were observed in safety outcomes. Conclusions In very old patients with type 2 diabetes hospitalized for acute heart failure, continuing preadmission empagliflozin reduced NT-proBNP levels and increased diuretic response and urine output compared to a basal-bolus insulin regimen. The empagliflozin regimen also showed a good safety profile.
Published: 2021

24. Does pain after delivery unequivocally lead to postpartum depression? The moderating role of religious coping

Author: Javier Carmona, Carlos Suso-Ribera, Cecilia Peñacoba, Patricia Catala, and Dolores Marín-Morales
Subjects: Postpartum depression, Pregnancy, Coping (psychology), business.industry, Obstetrics and Gynecology, postpartum pain, medicine.disease, Moderation, Interaction studies, religious coping, Reproductive Medicine, postpartum depression, Pediatrics, Perinatology and Child Health, Childbirth, Medicine, pregnancy, Longitudinal cohort, business, General Psychology, Depression (differential diagnoses), Clinical psychology
Abstract: Objective The objective of this work is to explore whether the relationship between pain after delivery and postpartum depression is increased or decreased by the use of religion as a coping strategy (moderation). Methods A longitudinal cohort study was conducted. The sample was evaluated on three occasions: third trimester of pregnancy (religious coping), after birth (pain severity) and four months after delivery (postpartum depression). Participants were 122 women (mean age = 31.29; SD = 4.9: range = [22, 42 years]) with low obstetric risk. Results Both pain severity and religious coping contributed to postpartum depression (r = .20, p = .029 and r = .28, p = .04, respectively). Religious coping exacerbated the relationship between pain after delivery and postpartum depression (B = -0.11, t = -2.48, p = .014, [-0.20, -0.02]). Depression was highest in participants using religious coping irrespective of pain severity levels. Conclusion These findings support the importance of person-environment interaction studies and provide new evidence on the deleterious role of religious coping in the well-being of women after childbirth.
Published: 2021

25. Clinical Testing of Head Impulse Paradigm and Suppression Head Impulse Paradigm Using a Diagnostic Headband: Combined Clinical Sign for Improved Performance

Author: Rodrigo Noboa, José Cuervo Road, Maria Julia Monaco, Carlos Vicente Alcayaga Palazón, Susana Fernández Fuentes, Guillermo Zalazar, Ricardo D’Albora, Carlos Agustín Fau Moreno, Ligia Silveira, Sergio Carmona, and Marcos Cvizonas Gutman
Subjects: medicine.medical_specialty, business.industry, Reflex, Vestibulo-Ocular, Audiology, Predictive value, Semicircular Canals, Sensory Systems, Improved performance, Otorhinolaryngology, Corrective saccade, Healthy individuals, Saccades, Combined test, Humans, Medicine, Prospective Studies, Neurology (clinical), business, Head Impulse Test, Sign (mathematics)
Abstract: OBJECTIVE We developed a clinical sign that improves the sensitivity, specificity, and predictive values of the Head Impulse Paradigm (HIMP) Test by adding the Suppression Head Impulse Paradigm (SHIMP) Test using a diagnostic headband. METHODS Prospective and descriptive study analyzing the function of 1,255 horizontal semicircular canals of subjects with differing vestibulo-ocular reflex (VOR) gains who showed-up with symptoms related to neurotology (Montevideo, Uruguay, March 2017 to March 2019). The clinical HIMP and SHIMP tests were assessed and the amplitudes of overt saccades were compared to each other. Clinical findings were contrasted against vHIT gains. CONCLUSION The HIMP and SHIMP combined test using the H/S headband has high specificity and low sensibility. This test association can identify healthy individuals among individuals typically misdiagnosed as ill by the conventional HIT or HIMP maneuver of the HIMP test, as originally described by Halmagyi and Curthoys. Therefore, we recommend using the headband assisted HIMP/SHIMP test, instead of exclusively relying on positive HIMP results.
Published: 2021

26. Intra-articular therapies: patient preferences and professional practices in European countries

Author: Sebastian C. Rodriguez-García, V. Vardanyan, Irene A Pitsillidou, Raul Castellanos-Moreira, Francis Berenbaum, Jacqueline Uson, Mikael Boesen, Terence W O'Neill, Lene Terslev, Jenny de la Torre-Aboki, Esperanza Naredo, Hemant Pandit, Elena Nikiphorou, Michael Doherty, Ingrid Möller, Loreto Carmona, W. U. Kampen, and Maria Antonietta D'Agostino
Subjects: medicine.medical_specialty, Bursitis, education, Immunology, Professional practice, Osteoarthritis, Clinical practice, Surveys, Crystal arthritis, Intra articular, Rheumatology, Surveys and Questionnaires, Health care, medicine, Humans, Immunology and Allergy, Glucocorticoids, RHEUMATOLOGY, Infiltrations, JOINT, business.industry, Patient Preference, Professional Practice, EFFICACY, medicine.disease, Patient preference, Intraarticular therapies, SOFT-TISSUE INJECTIONS, Europe, Family medicine, KNEE, Professional association, Patient's experience, business
Abstract: To assess patient perspective and professional practice of intraarticular therapies (IATs) across Europe, an expert international multidisciplinary panel designed two open web-based surveys: one targeting people who had experienced at least two IATs (44 items); and one targeting health care providers (HCPs) (160 items). Surveys were disseminated via patient and professional associations and social media. A descriptive analysis was performed. The surveys were answered by 200 patients and 186 HCPs from 26 countries, showing that IAT is routinely performed by rheumatologists (97%) and orthopaedic surgeons (89%), with specific training being compulsory in a few countries. The most frequent indications for IAT are arthritis (76%), osteoarthritis (74%), crystal arthritis (71%) and bursitis (70%); the most frequently injected joints are knee (78%) and shoulder (70%); and the most used compounds are glucocorticoids. The majority of HCPs report informing patients about side-effects (73%), benefits (72%), and the nature of the procedure (72%), which coincides with 27% of patients reporting that they had not been informed about benefits or potential complications of IATs; 73% of patients had not been asked whether they wanted an anaesthetic. Few HCPs (10%) obtain written consent (56% get oral consent, being mandatory for 32%), a procedure deemed necessary by 41% of the patients. 50% of patients reported a clear benefit of IAT and 20% experienced complications including pain, impaired mobility, rashes, or swelling. In summary, the practice of IAT is variable across Europe, and although patients perceive it as relatively safe and usually effective procedure, some gaps were identified.
Published: 2021

27. Transvaginal ultrasound for diagnosis of deep endometriosis involving uterosacral ligaments, torus uterinus and posterior vaginal fornix: prospective study

Author: Meritxell Gracia, M Valdés-Bango, Marta Tortajada, C. de Guirior, Isabel Matas, M.A. Martínez-Zamora, Francesc Carmona, Mariona Rius, Cristina Ros, and E Mension
Subjects: Adult, Laparoscopic surgery, Sacrum, medicine.medical_treatment, Endometriosis, Sensitivity and Specificity, Likelihood ratios in diagnostic testing, Obstetrics and gynaecology, Predictive Value of Tests, medicine, Humans, Radiology, Nuclear Medicine and imaging, Prospective Studies, Laparoscopy, Prospective cohort study, Round Ligament of Uterus, Ultrasonography, Ligaments, Radiological and Ultrasound Technology, medicine.diagnostic_test, business.industry, Uterus, Ultrasound, Obstetrics and Gynecology, General Medicine, medicine.disease, medicine.anatomical_structure, Reproductive Medicine, Vagina, Vaginal fornix, Female, Nuclear medicine, business
Abstract: OBJECTIVE To evaluate the accuracy of transvaginal ultrasound (TVS) in diagnosing deep endometriosis (DE) involving the uterosacral ligaments (USLs), torus uterinus (TU) or posterior vaginal fornix (PVF) in women with suspected endometriosis scheduled for laparoscopic surgery. METHODS In this prospective study, consecutive women with clinically suspected pelvic endometriosis who were scheduled for laparoscopic surgery were invited to participate. TVS was performed before surgery. TVS findings were compared with those obtained at laparoscopy and confirmed histologically. The accuracy of TVS for diagnosing DE involving the USLs, TU or PVF was assessed. Additionally, the association of DE involving the USLs, TU or PVF on TVS with symptoms and with DE affecting other pelvic locations was assessed. RESULTS In total, 172 patients were included. The global sensitivity and specificity of TVS in diagnosing DE affecting the USLs, TU and/or PVF were 92% and 87%, respectively. For DE involving the USLs, the accuracy, sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), positive likelihood ratio and negative likelihood ratio of TVS were 89.5%, 96.6%, 82.1%, 85.0%, 95.8%, 5.41 and 0.04, respectively; the respective values for DE involving the TU were 86.6%, 83.9%, 89.4%, 89.0%, 84.4%, 7.92 and 0.18, and the respective values for DE involving the PVF were 93.6%, 87.0%, 94.6%, 71.4%, 97.9%, 16.20 and 0.14. Logistic regression analysis showed a significant association between DE affecting the USLs, TU and/or PVF and DE affecting the rectosigmoid (odds ratio, 5.43; P
Published: 2021

28. Outpatient treatment in acute uncomplicated diverticulitis

Author: Á Reina Duarte, M García Redondo, Z Gómez Carmona, I Blesa Sierra, M Ferrer Márquez, and P Moya Forcén
Subjects: medicine.medical_specialty, business.industry, medicine, General Medicine, business, Surgery, Uncomplicated diverticulitis
Abstract: Resumen La mayoría de los casos de inflamación diverticular son leves y solo requieren tratamiento médico con dieta líquida y antibióticos. Hasta hace poco, este tratamiento requería ingreso hospitalario con los consiguientes costes. El tratamiento ambulatorio de estos pacientes con diverticulitis no complicada ha demostrado ser eficaz y seguro. El objetivo de esta revisión es describir el tratamiento ambulatorio con antibiótico oral y los resultados publicados.
Published: 2021

29. Incidence of colorectal cancer after acute diverticulitis

Author: M Ferrer Márquez, P Moya Forcén, I Teruel Lillo, FA Rubio Gil, J Jorge Cerrudo, Z Gómez Carmona, and Á Reina Duarte
Subjects: medicine.medical_specialty, Acute diverticulitis, Colorectal cancer, business.industry, Incidence (epidemiology), Internal medicine, medicine, General Medicine, medicine.disease, business, Gastroenterology
Abstract: Resumen Tras un episodio de diverticulitis aguda la realización de una colonoscopia de rutina ha sido defendida en las guías de práctica clínica de numerosas sociedades. Sin embargo, en los últimos años en contraposición a esto, numerosos estudios han intentado demostrar que no existe esta necesidad en todos los casos. ya que la incidencia de adenomas de alto grado (AA) y cáncer colorrectal (CCR) en la diverticulitis aguda no complicada es bajo y prácticamente similar al que encontramos en la población sometida a programas de screening, mientras que sería necesaria en pacientes con diverticulitis aguda complicada.
Published: 2021

30. Damage control surgery in acute complicated diverticulitis

Author: J Jorge Cerrudo, FA Rubio Gil, Á Reina Duarte, I Blesa Sierra, B Estébanez Ferrero, Z Gómez Carmona, and P Moya Forcén
Subjects: medicine.medical_specialty, Damage control surgery, business.industry, medicine, General Medicine, Diverticulitis, business, medicine.disease, Surgery
Abstract: Resumen La peritonitis diverticular generalizada es una enfermedad potencialmente mortal y requiere una operación de emergencia inmediata. Se trata de una patología cada vez más frecuente. En los últimos años se han desarrollado nuevas estrategias para el tratamiento de la diverticulitis aguda complicada, para mejorar la supervivencia, que se han denominado "cirugía de control de daños" (CCD), concepto que presupone la realización de una laparotomía abreviada que evita complicaciones vitales y puede ser útil para pacientes con sepsis abdominal con inestabilidad hemodinámica y alteración extrema de la fisiología, pudiendo mejorar los resultados y reducir la tasa de formación de colostomía y mejora la tasa de anastomosis primaria. A pesar de las experiencias prometedoras, el manejo del abdomen abierto es controvertido y es una técnica no exenta de riesgos y altos costos. Quedan por abordar cuestiones mediante estudios rigurosos. Su uso debe adaptarse a cada paciente y no debe abusarse de ésta herramienta. Se debe intentar el cierre abdominal tan pronto como el paciente pueda tolerarlo fisiológicamente valorando el restablecimiento de tránsito intestinal.
Published: 2021

31. Predicting PTSS in general population during COVID-19 pandemic: The mediating role of health anxiety

Author: José Luis Carballo and Ainhoa Coloma-Carmona
Subjects: Male, Cross-sectional study, Population, Anxiety, Social support, Psychiatric history, Health anxiety, Pandemic, Humans, Medicine, education, Pandemics, Depression (differential diagnoses), Post-traumatic stress symptoms, education.field_of_study, Depression, SARS-CoV-2, business.industry, Incidence (epidemiology), COVID-19, Anxiety Disorders, Coronavirus, Psychiatry and Mental health, Clinical Psychology, Cross-Sectional Studies, Quarantine, Female, medicine.symptom, business, Research Paper, Clinical psychology
Abstract: BACKGROUND: Despite health anxiety (HA) is associated with higher incidence of anxiety disorders, no studies have examined the association between this variable and the increased levels of Post-Traumatic Stress Symptoms (PTSS) reported during COVID pandemic. METHODS: This study was conducted online between April and May 2020. Data were collected from 468 men and women from the Spanish general population. Sociodemographic and COVID-19-related data, health anxiety, PTSS, fear of becoming infected, social support, sleep problems and past/current psychological/psychiatric history were assessed. The mediating effect of HA when predicting PTSS was explored with mediational analyses. Moderated mediational analyses were also performed to test if receiving psychological treatment during pandemic changes the mediating effect of HA. RESULTS: Prevalence of PTSS was higher in high-scorers in HA (p
Published: 2021

32. Preperitoneal ropivacaine infusion versus epidural ropivacaine–morphine for postoperative analgesia in dogs undergoing ovariohysterectomy: a randomized clinical trial

Author: Setefilla Quirós-Carmona, Juan M. Domínguez, Rocío Navarrete-Calvo, David F. Latorre, J. Andrés Fernández-Sarmiento, Juan Manuel Serrano-Rodríguez, Juan Morgaz, and M.M. Granados
Subjects: Visual analogue scale, Sedation, law.invention, Dogs, Randomized controlled trial, law, medicine, Animals, Ropivacaine, Dog Diseases, Prospective Studies, Anesthetics, Local, Epidural administration, Pain, Postoperative, Morphine, General Veterinary, business.industry, Continuous wound infusion, Amides, Pain management, Analgesia, Epidural, Analgesics, Opioid, Catheter, Anesthesia, Epidural, Analgesia, medicine.symptom, business, Surgical incision, medicine.drug
Abstract: Objective To assess the effect of continuous wound infusion (CWI) with preperitoneal ropivacaine on postoperative analgesia and compare it with the epidural administration of ropivacaine and morphine in bitches undergoing ovariohysterectomy. Study design A parallel, randomized, clinical, prospective and nonblinded study. Animals A group of 38 Greyhound bitches. Methods In the catheter group (CathG), CWI with ropivacaine 1% (1 mg kg–1 + 0.8 mg kg–1 hour–1) was applied to the preperitoneal space over the surgical incision. In the epidural group (EpiG), ropivacaine 0.5% (1.3 mg kg–1) and morphine (0.1 mg kg–1) were epidurally administered. Occipital-coccygeal length was used to calculate the volume for the epidural. Pain was scored using a dynamic interactive visual analogue scale (DIVAS) and Glasgow composite measure pain scale–short form (CMPS-SF) before anaesthesia and at 2, 4, 6, 18, 21 and 24 hours after extubation. Incisional sensitivity using a dynamometer (MWTs-incision) was evaluated simultaneously. Plasma ropivacaine and cortisol concentrations, degree of sedation, motor blockade and response to interdigital clamping were measured or assessed. A two-way mixed analysis of variance and a Mann–Whitney U test were used to analyse data; p Results No differences were detected in the DIVAS (p = 0.301), CMPS-SF (p = 0.600) scores, MWTs-incision measurements (p = 0.257) and cortisol values (p = 0.878) between the groups. Rescue analgesia was required in two dogs, one in each group, at 2 hours. Sedation, motor blockade and negative response to interdigital clamping were detected in EpiG at 2, 4 and 6 hours. Mean plasma ropivacaine values were higher in CathG (0.475 ± 0.164 ng mL–1) than in EpiG (0.184 ± 0.213 ng mL–1; p = 0.001). Conclusion and clinical relevance Compared with epidural ropivacaine and morphine, CWI with preperitoneal ropivacaine is an effective analgesic technique for postoperative pain management in bitches undergoing ovariohysterectomy without motor blockade.
Published: 2021

33. La eficiencia no basta. Análisis ético y recomendaciones para la distribución de recursos escasos en situación de pandemia

Author: David Rodríguez-Arias, Javier Padilla-Bernáldez, Rosana Triviño, Àngel Puyol, Maite Cruz-Piqueras, María Isabel Tamayo-Velázquez, María Teresa López de la Vieja, Miguel Melguizo-Jiménez, Txetxu Ausín, and Joaquín Hortal-Carmona
Subjects: Ética de la salud pública, Coronavirus disease 2019 (COVID-19), Health efficiency, Theoretical models, Distribution (economics), Public health ethics, Primary care, 03 medical and health sciences, 0302 clinical medicine, Political science, Pandemic, Health care, 030212 general & internal medicine, Racionamiento, Pandemics, Health equity, Equidad en salud, Pandemia, Equity (economics), business.industry, 030503 health policy & services, Welfare economics, Public Health, Environmental and Occupational Health, Rationing, Eficiencia en salud, Public aspects of medicine, RA1-1270, 0305 other medical science, Nursing homes, business
Abstract: Resumen: Objetivo: Elaborar una herramienta de apoyo que ayude a tomar decisiones en el marco de la pandemia de COVID-19. Método: Se parte de una búsqueda de diferentes recomendaciones éticas surgidas en España sobre priorización de recursos sanitarios escasos en la pandemia de COVID-19, así como de una revisión narrativa de modelos teóricos sobre distribución en pandemias para definir una fundamentación ética. Finalmente, se extraen recomendaciones para su posible aplicación en distintos ámbitos asistenciales. Resultados: Se identifican tres principios, igualdad estricta, equidad y eficiencia, que se sustancian en criterios de distribución específicos. Conclusiones: Se propone un modelo de distribución de recursos sanitarios escasos en situación de pandemia que parte de un procedimiento de toma de decisiones y adapta los criterios de distribución a los escenarios de la atención sanitaria: atención primaria, residencias sociosanitarias y atención hospitalaria. Abstract: Objective: To develop a support tool to decision-making in the framework of the COVID-19 pandemic. Method: Different ethical recommendations that emerged in Spain on prioritizing scarce health resources in the COVID-19 pandemic first wave were searched; it was conducted a narrative review of theoretical models on distribution in pandemics to define an ethical foundation. Finally, recommendations are drawn to be applied in different healthcare settings. Results: Three principles are identified; strict equality, equity and efficiency, which are substantiated in specific distribution criteria. Conclusions: A model for the distribution of scarce health resources in a pandemic situation is proposed, starting with a decision-making procedure and adapting the distribution criteria to different healthcare scenarios: primary care settings, nursing homes and hospitals.
Published: 2021

34. Noninvasive intracranial pressure real-time waveform analysis monitor during prostatectomy robotic surgery and Trendelenburg position: case report

Author: Vinícius Caldeira Quintão, Maria José Carvalho Carmona, S Zeferino, Rafael F. Coelho, Gabriela Tognini Saba, Claudia Marquez Simões, Gustavo Henrique Frigieri Vilela, William C. Nahas, and Arnaldo Fazoli
Subjects: Intracranial pressure, Prostatectomy, business.industry, medicine.medical_treatment, Trendelenburg position, Robotic Surgical Procedures, General Medicine, Head-Down Tilt, Compliance (physiology), Head-down tilt, Anesthesiology, Anesthesia, medicine, Robotic surgical procedures, RD78.3-87.3, Robotic surgery, Cognitive decline, business
Abstract: Both robotic surgery and head-down tilt increase intracranial pressure by impairing venous blood outflow. Prostatectomy is commonly performed in elderly patients, who are more likely to develop postoperative cognitive disorders. Therefore, increased intracranial pressure could play an essential role in cognitive decline after surgery. We describe a case of a 69-year-old male who underwent a robotic prostatectomy. Noninvasive Brain4careTM intraoperative monitoring showed normal intracranial compliance during anesthesia induction, but it rapidly decreased after head-down tilt despite normal vital signs, low lung pressure, and adequate anesthesia depth. We conclude that there is a need for intraoperative intracranial compliance monitoring since there are major changes in cerebral compliance during surgery, which could potentially allow early identification and treatment of impaired cerebral complacency.
Published: 2021

35. Systematic review of the impact of drugs on diffuse interstitial lung disease associated with rheumatoid arthritis

Author: Paloma Vela Casasempere, Carmen Carrasco Cubero, and Eugenio Chamizo Carmona
Subjects: Oncology, medicine.medical_specialty, MEDLINE, Rheumatoid Arthritis, Artritis reumatoide, law.invention, Arthritis, Rheumatoid, Randomized controlled trial, law, Internal medicine, medicine, Humans, Enfermedad pulmonar intersticial difusa, Leflunomide, business.industry, Disease modifying antirheumatic drugs, Abatacept, Revisión sistemática, Interstitial lung disease, General Medicine, Diffuse interstitial lung disease, medicine.disease, Systematic review, Pharmaceutical Preparations, Antirheumatic Agents, Rheumatoid arthritis, Tumor Necrosis Factor Inhibitors, Rituximab, Lung Diseases, Interstitial, Fármacos antirreumáticos modificadores de enfermedad, business, medicine.drug
Abstract: OBJECTIVE: To review the available evidence on the impact of rheumatoid arthritis (RA) treatments in associated diffuse interstitial lung disease (ILD). METHODS: Systematic review of studies evaluating the impact of pharmacological treatment in patients with RA and ILD. A bibliographic search in MEDLINE, EMBASE and Cochrane, a selection of articles and the methodological quality assessment (FLC 3.0 OSTEBA) and grading of the level of evidence (SING) of the selected articles were performed. RESULTS: 1,720 references were identified in primary search and 7 in manual or indirect. Forty-three articles were included: 7 systematic reviews, 2 randomized clinical trials, 5 cohort studies, 8 case-control studies and 21 case series. Methotrexate (MTX) and leflunomide (LEF) do not increase incidence, complications or mortality due to ILD. Although the results are not uniform, anti-TNF have often had worse outcomes in incidence, progression and mortality due to ILD than MTX, LEF, abatacept (ABA) and rituximab (RTX). The evidence found is scarce for JAK kinase and antifibrotic inhibitors, and controversial for IL-6 inhibitors. CONCLUSIONS: There is no evidence that MTX or LEF worsens the prognosis of patients with AR-EPID. RTX and ABA seem to have better results than other biologicals, such as anti-TNF, often achieving stabilization and, in some cases, the improvement of ILD in patients with RA.
Published: 2021

36. Pinzamiento femoroacetabular tratado con luxación quirúrgica de la cadera: resultados a corto plazo

Author: Camilo Restrepo, C. Sarassa, Daniela Carmona, Daniel Vanegas, A.M. Herrera, and L. Gomez
Subjects: Orthopedic surgery, Gynecology, 030222 orthopedics, medicine.medical_specialty, business.industry, Surgical dislocation of the hip, Mean age, Outcomes, 03 medical and health sciences, 0302 clinical medicine, Medicine, Orthopedics and Sports Medicine, Surgery, Complication rate, 030212 general & internal medicine, business, Femoroacetabular impingement, RD701-811
Abstract: Resumen: Antecedentes y objetivo: La mayoría de los estudios disponibles en la literatura relacionados con el tratamiento del pinzamiento femoroacetabular (PFA) con luxación quirúrgica de cadera (LQC) provienen de Europa y América del Norte. Este estudio describe los resultados a corto plazo de la técnica de LQC para tratar el PFA en una cohorte de pacientes colombianos. Pacientes y métodos: Analizamos retrospectivamente 42 casos de PFA tratados con LQC desde el año 2006 al 2018. El mismo cirujano ortopédico realizó todas las cirugías. El resultado clínico se evaluó utilizando las puntuaciones de Merle d’Aubigné, mientras que la evaluación radiológica se realizó con la puntuación de Tönnis. Resultados: Se incluyeron 15 mujeres y 25 varones en el estudio, con una edad promedio de 36,3 años. Dos pacientes presentaron afectación sintomática bilateral. De los 42 casos, hubo 13 de tipo cam, 11 tipo pincer y 18 mixtos. Preoperatoriamente, 31 caderas se clasificaron como pobres y moderadas y 11 como buenas según la escala Merle d’Aubigné. La clasificación radiológica Tönnis prequirúrgica mostró grado 0 en la mitad de los casos. La duración media del seguimiento fue de 24 meses (12-37). Las últimas puntuaciones postoperatorias de Merle d’Aubigné clasificaron 7 casos como pobres o moderados y 35 como buenos y excelentes (p
Published: 2021

37. Incidence and characteristics of falls in hospitalized patients: A cohort study

Author: Manuel Acevedo-García, Elia Pérez-Fernández, José Luis Camacho-Pastor, Raquel Domínguez-Rincón, Carmen Noguera-Quijada, Fernando José García-Hedrera, Sira Sanz-Márquez, José Javier Martínez-Simón, Beatriz González-Piñero, and F. Javier Carmona-Monge
Subjects: Male, Inpatients, Pediatrics, medicine.medical_specialty, Univariate analysis, Hospitalized patients, business.industry, Incidence, Incidence (epidemiology), Electronic medical record, Specialty, General Medicine, medicine.disease, Comorbidity, Cohort Studies, Health services, medicine, Humans, business, Aged, Retrospective Studies, Cohort study
Abstract: Objective To estimate the incidence of falls and to know their characteristics in terms of location, temporality and injuries produced, and to analyse the sociodemographic and clinical characteristics of the patients who suffer falls. Methodology A retrospective observational cohort study was carried out in a level 2 hospital of the Madrid Health Service. Falls in hospitalized patients between July 1, 2018 and June 30, 2019 were studied. The incidence rate of falls per 1000 days of stay was estimated considering a Poisson distribution. The characteristics of the falls are described: temporality, injuries produced, location of the injuries and prescribed drugs. Sociodemographic and clinical characteristics of patients who suffered a fall were registered. A univariate analysis was performed to compare the results by gender. All data were obtained from the electronic medical record. Results One hundred and thirty-two falls were studied, which represent a rate of 1.61 falls per 1,000 days of stay. Men, older age, and admission to a medical specialty showed a significantly higher fall rate. The patients who suffered a fall had a mean age of 77.5 years (SD: 11.7), and had a median of 12.5 drugs prescribed (IQR: 9.25-15). Of the falls, 63.6% did not present any injury. Difference in gender was only found in the situation in which the fall occurred. Conclusions Our data report an incidence of falls similar to other institutions in our environment. The profile of the patient who suffers a fall is an older man, admitted under the charge of a medical specialty, with longer hospital stay, with associated comorbidity and polymedicated, without an obvious temporal feature.
Published: 2021

38. Assessment of Sexual Quality of Life and Satisfaction in Couple Relationships Among Women With Deep Infiltrating Endometriosis and Adenomyosis

Author: Cristina Ros, Ana María Alcalde, María Ángeles Martínez-Zamora, Meritxell Gracia, Mariona Rius, and Francisco Carmona
Subjects: medicine.medical_specialty, Obstetrics, business.industry, Endometriosis, Personal Satisfaction, medicine.disease, Deep infiltrating endometriosis, Clinical Psychology, Transvaginal ultrasound, Quality of life, Sexual life, Quality of Life, medicine, Humans, Population study, Female, Adenomyosis, business, Ultrasonography
Abstract: Adenomyosis and endometriosis are similar gynecological diseases that decrease sexual quality of life and, in the case of endometriosis, satisfaction in couple relationships. This study aimed to assess sexual quality of life and couple satisfaction in women diagnosed with adenomyosis (AD) or deep infiltrating endometriosis (DIE). The study population included three groups of couples: one composed of 58 couples in which the woman was diagnosed with AD by transvaginal ultrasound (AD group), a second group comprising 55 couples in which the woman was diagnosed with isolated DIE by transvaginal ultrasound (DIE group), and a third group composed of 60 couples in which the women did not have AD or endometriosis (non-AD/DIE group). All women completed the Sexual Quality of Life-Female (SQOL-F) questionnaire, and all the couples completed the Dyadic Adjustment Scale (DAS). Sexual quality of life was significantly worse in women with AD or DIE compared with non-AD/DIE controls. Dyadic adjustment was significantly worse in the AD and DIE groups compared with the non-AD/DIE group. AD and DIE may impair quality of sexual life and couple relationships. Clinicians should be aware of this issue when treating women with AD or DIE.
Published: 2021

39. Alzheimer's disease associated with Down syndrome: a genetic form of dementia

Author: Sigan L. Hartley, Shahid Zaman, Michael S. Rafii, Maria Carmona-Iragui, Elizabeth Head, and Juan Fortea
Subjects: Pediatrics, medicine.medical_specialty, education.field_of_study, Down syndrome, business.industry, Population, Disease, medicine.disease, Intellectual disability, medicine, Dementia, Disease prevention, Neurology (clinical), business, education, Very high risk, Cause of death
Abstract: Summary Adults with Down syndrome develop the neuropathological hallmarks of Alzheimer's disease and are at very high risk of developing early-onset dementia, which is now the leading cause of death in this population. Diagnosis of dementia remains a clinical challenge because of the lack of validated diagnostic criteria in this population, and because symptoms are overshadowed by the intellectual disability associated with Down syndrome. In people with Down syndrome, fluid and imaging biomarkers have shown good diagnostic performances and a strikingly similar temporality of changes with respect to sporadic and autosomal dominant Alzheimer's disease. Most importantly, there are no treatments to prevent Alzheimer's disease, even though adults with Down syndrome could be an optimal population in whom to conduct Alzheimer's disease prevention trials. Unprecedented research activity in Down syndrome is rapidly changing this bleak scenario that will translate into disease-modifying therapies that could benefit other populations.
Published: 2021

40. Long-term Follow-up of Sexual Quality of Life after Laparoscopic Surgery in Patients with Deep Infiltrating Endometriosis

Author: Meritxell Gracia, Jose Luis Coloma, M.A. Martínez-Zamora, Mariona Rius, Camil Castelo-Branco, and Francisco Carmona
Subjects: Quality of life, Laparoscopic surgery, medicine.medical_specialty, medicine.medical_treatment, Endometriosis, Psychological intervention, Cirurgia laparoscòpica, Relacions sexuals, Sexual intercourse, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Prospective Studies, Endometriosi, Laparoscopy, Tubal ligation, 030219 obstetrics & reproductive medicine, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, Hypoactive sexual desire disorder, medicine.disease, Distress, Qualitat de vida, Case-Control Studies, 030220 oncology & carcinogenesis, Quality of Life, Female, business, Follow-Up Studies
Abstract: Study Objective We performed a long-term follow-up to quantify the impairment of sexual quality of life (SQL) and health-related QL (HRQL) in sexually active women after laparoscopic excision of deep infiltrating endometriosis (DIE). Design Prospective case-control study. Setting Hospital Clinic of Barcelona. Patients A total of 193 patients (after dropout and exclusions) were divided into 2 groups: one hundred twenty-nine premenopausal women with DIE (DIE group) and 64 healthy women who underwent tubal ligation (C group). Interventions All patients underwent laparoscopic surgery: laparoscopic endometriosis surgery in the DIE group and laparoscopic tubal ligation in the C group. All women were followed for at least 36 months, and they completed the Medical Outcomes Study 36-item short form questionnaire to assess their HRQL and 3 self-administered questionnaires that evaluate different aspects of SQL: the generic Sexual Quality of Life–Female questionnaire, the Female Sexual Distress Scale to evaluate “sexually related distress,” and the Brief Profile of Female Sexual Function to screen hypoactive sexual desire disorder. The patients with DIE as well as the controls completed the 4 questionnaires before surgery, and the patients with DIE also completed the questionnaires at 6 and 36 months after surgery. Measurements and Main Results A comparison of the patients and controls before surgery showed a statistically significant impairment in SQL and HRQL among the patients with DIE. A statistically significant improvement in SQL and HRQL was observed in the DIE group 6 months after surgery, with scores being similar to those of the C group. An evaluation 36 months after surgery showed that SQL and HRQL were better than presurgical SQL and HRQL in the DIE group, with a slight reduction compared with the 6-month evaluation. Conclusion SQL and HRQL improved in patients with DIE undergoing complete laparoscopic endometriosis resection and were comparable to those of healthy women at 6 months after surgery, showing a slight reduction at 36 months of follow-up.
Published: 2021

41. Acciones de empresas mexicanas para afrontar la pandemia COVID-19

Author: C. A. Rogel-Galvez, J. A. Colina-Sánchez, A. Huerta-Estévez, and J. C. Carmona-Fuentes
Subjects: Government, HF5001-6182, business.industry, Social distance, Geography, Planning and Development, pandemia, Commerce, General Business, Management and Accounting, Gross domestic product, Social actions, HF1-6182, Work (electrical), covid-19, Content analysis, producto interno bruto, Business, Economic impact analysis, Marketing, Financial services
Abstract: Este trabajo tiene como objetivo identificar las acciones que las 50 empresas más importantes en México han implementado para afrontar la pandemia COVID-19, para lo cual se utilizó un análisis de contenido que servirá para la identificación de ideas expresadas en estructuras de información escritas. Se pudo identificar que algunas de las acciones más socorridas por las empresas para cumplir con las medidas de confinamiento y distanciamiento social que el gobierno de México estableció son cierres temporales de sucursales, reducción de empleados, establecer nuevos medios y canales de ventas, implementación de protocolos de higiene, trabajo remoto desde casa, así como donaciones económicas y en especie, siendo las acciones de orden social las más implementadas representando el 35.19% y sectores como el Holding, Alimentos y servicios financieros fueron los que más acciones instauraron. Al final, estas acciones llegan a tener un impacto económico negativo, ya que el Producto Interno Bruto del país para el año 2020 disminuyo en 8.3% en relación al año anterior.
Published: 2021

42. Comparación entre una sutura transfixiante y el taponamiento nasal en la septoplastia y turbinoplastia

Author: Daniel López Campos, Luisa Lostau Ull, Diego Macias Rodriguez, Francisco Arias Marzan, Gabriela Muñoz Cordero, Cecilia Salom Lucena, Gemma de Lucas Carmona, Esteban Reinaldo Pacheco Coronel, and Alicia Pérez Orribo
Subjects: Gynecology, 03 medical and health sciences, medicine.medical_specialty, 0302 clinical medicine, Otorhinolaryngology, business.industry, medicine, 030206 dentistry, 030223 otorhinolaryngology, business
Abstract: Resumen Introduccion No existe un consenso sobre la necesidad del taponamiento nasal despues de una septoplastia. El uso de los taponamientos ha sido propuesto con el fin de reducir las hemorragias, sinequias o hematomas despues de este procedimiento. A pesar de estas ventajas la evidencia del uso de un taponamiento nasal es baja. Adicionalmente este procedimiento no es agradable para el paciente y puede tener complicaciones. Objetivo El proposito de este estudio es investigar la eficacia de la sutura transfixiante o transeptal comparada con el taponamiento nasal. Analizar el control de la epistaxis, hematomas y sinequias despues de una septoplastia. Material y metodos Setenta y seis pacientes con indicacion de septoplastia y turbinoplastia con radiofrecuencia fueron incluidos en el estudio. Pseudoaleatoriamente se utilizo una sutura transfixiante en 50 pacientes y taponamiento nasal en 26 pacientes despues de la cirugia. En los 2 grupos se comparo el porcentaje de epistaxis, hematomas y sinequias. Ademas, el dolor y la epistaxis de los pacientes al retirar el taponamiento nasal. Resultados Tanto la sutura transfixiante como el taponamiento nasal tienen resultados similares en cuanto al control de las epistaxis, sinequias y hematomas despues de la septoplastia con radiofrecuencia de cornetes. Los pacientes con taponamiento nasal presentaron dolor y epistaxis autolimitada en el momento de retirar el taponamiento nasal. Conclusion El uso de la sutura transfixiante despues de una septoplastia y turbinoplastia con radiofrecuencia es igual de eficaz que el taponamiento nasal para el control de epistaxis, sinequias y hematomas.
Published: 2021

43. High prevalence of variants in skeletal dysplasia associated genes in individuals with short stature and minor skeletal anomalies

Author: Silvia Modamio-Høybjør, Isabel González-Casado, Angel Campos-Barros, Francisca Díaz-González, José Antonio Bermúdez de la Vega, Fernando Santos-Simarro, Atilano Carcavilla, Ana C Barreda-Bonis, Carolina de la Torre, Purificación Ros-Pérez, Inés Mulero-Collantes, Sara Benito-Sanz, Angela del Pozo, Mario Solís, Jesús González de Buitrago Amigo, Julián Nevado, Lucia Sentchordi-Montané, André M. Travessa, Pablo Prieto, Miriam Aza-Carmona, Pilar Bahíllo-Curieses, Elena Vallespín, Jaime Cruz-Rojo, Manuel Parrón-Pajares, Joaquín Ramírez-Fernández, Karen E. Heath, Pablo Ruiz-Ocaña, Carlos Goetz, and Carolina Bezanilla-López
Subjects: Male, Proband, Heterozygote, medicine.medical_specialty, Adolescent, Skeletal anomalies, Endocrinology, Diabetes and Metabolism, Dwarfism, Osteochondrodysplasias, Bioinformatics, Short stature, Bone and Bones, Endocrinology, Internal medicine, Prevalence, Humans, Medicine, Growth Plate, Child, Gene, High prevalence, Anthropometry, business.industry, Genetic Variation, High-Throughput Nucleotide Sequencing, Infant, General Medicine, medicine.disease, Body Height, Pedigree, PTPN11, Dysplasia, Child, Preschool, Female, medicine.symptom, business, General Economics, Econometrics and Finance
Abstract: Objective Next generation sequencing (NGS) has expanded the diagnostic paradigm turning the focus to the growth plate. The aim of the study was to determine the prevalence of variants in genes implicated in skeletal dysplasias in probands with short stature and mild skeletal anomalies. Design Clinical and radiological data were collected from 108 probands with short stature and mild skeletal anomalies. Methods A customized skeletal dysplasia NGS panel was performed. Variants were classified using ACMG recommendations and Sherloc. Anthropometric measurements and skeletal anomalies were subsequently compared in those with or without an identified genetic defect. Results Heterozygous variants were identified in 21/108 probands (19.4%). Variants were most frequently identified in ACAN (n = 10) and IHH (n = 7) whilst one variant was detected in COL2A1, CREBBP, EXT1, and PTPN11. Statistically significant differences (P < 0.05) were observed for sitting height/height (SH/H) ratio, SH/H ratio standard deviation score (SDS), and the SH/H ratio SDS >1 in those with an identified variant compared to those without. Conclusions A molecular defect was elucidated in a fifth of patients. Thus, the prevalence of mild forms of skeletal dysplasias is relatively high in individuals with short stature and mild skeletal anomalies, with variants in ACAN and IHH accounting for 81% of the cases. An elevated SH/H ratio appears to be associated with a greater probability in detecting a variant, but no other clinical or radiological feature has been found determinant to finding a genetic cause. Currently, we cannot perform extensive molecular studies in all short stature individuals so detailed clinical and radiological phenotyping may orientate which are the candidate patients to obtain worthwhile results. In addition, detailed phenotyping of probands and family members will often aid variant classification.
Published: 2021

44. Impact of Adenomyosis on Women's Psychological Health and Work Productivity: A Comparative Cross-Sectional Study

Author: Ana María Alcalde, Meritxell Gracia, Inmaculada Nicolás, Mariona Rius, Francisco Carmona, Cristina Ros, and María Ángeles Martínez-Zamora
Subjects: Adult, Gerontology, Work productivity, Adolescent, Cross-sectional study, business.industry, Efficiency, General Medicine, medicine.disease, Psychological health, Cross-Sectional Studies, Quality of life, Surveys and Questionnaires, Absenteeism, Quality of Life, medicine, Humans, Anxiety, Female, Adenomyosis, medicine.symptom, business, Depression (differential diagnoses)
Abstract: Background: Quality of life in adenomyosis (AD) patients has been poorly investigated. Previous data suggest that AD has negative impact on the quality of life in these women. Methods: From Septemb...
Published: 2021

45. Femoracetabular impingement treated with surgical hip dislocation: Short-term results

Author: C. Sarassa, Camilo Restrepo, Daniela Carmona, Daniel Vanegas, A.M. Herrera, and L. Gomez
Subjects: medicine.medical_specialty, business.industry, Nonunion, Mean age, medicine.disease, Femoracetabular Impingement, Surgery, Radiological weapon, Cohort, Orthopedic surgery, Medicine, Orthopedics and Sports Medicine, Heterotopic ossification, business, Femoroacetabular impingement
Abstract: BACKGROUND AND OBJECTIVE Most of the studies available in the literature related to the treatment of femoroacetabular impingement (FAA) with surgical hip dislocation (CLD) come from Europe and North America. This study describes the short-term results of the LQC technique for treating PFA in a cohort of Colombian patients. PATIENTS AND METHODS We retrospectively analysed 42 cases of PFA treated with LQC from 2006 to 2018. The same orthopaedic surgeon performed all surgeries. Clinical outcome was assessed using the Merle d'Aubigne scores, while radiological assessment was performed using the Tonnis score. RESULTS Fifteen women and 25 men were included in the study, with a mean age of 36.3 years. Two patients had bilateral symptomatic involvement. Of the 42 cases, there were 13 cam type, 11 pincer type and 18 mixed. Preoperatively, 31 hips were classified as poor and moderate, and 11 as good according to the Merle d'Aubigne scale. The preoperative Tonnis radiological classification showed grade 0 in half of the cases. The mean duration of follow-up was 24 months (12 to 37). The final postoperative Merle d'Aubigne scores classified 7 cases as poor or moderate, and 35 as good to excellent (p
Published: 2021

46. Winning Hearts and Minds Through a Policy Promoting the Agroecological Paradigm in Universities

Author: Fábio Grigoletto, Fernando Silveira Franco, Ricardo Serra Borsatto, Henrique Carmona Duval, and Vanilde Ferreira de Souza-Esquerdo
Subjects: Higher education, business.industry, 050204 development studies, 05 social sciences, 0507 social and economic geography, Participant observation, Public relations, Peasant, Development studies, Political science, 0502 economics and business, Environmental sociology, Symbolic power, business, 050703 geography, Agronomy and Crop Science, Agroecology, Legitimacy
Abstract: Brazil stands out at the global level for having implemented several policies intending to promote agroecology as a productive paradigm for small-holder farmers. However, the impacts of this process of institutionalization of agroecology still lack research and debates that evaluate the effectiveness of these policies. In this paper, we assess and discuss the impacts of a policy specifically focused on education in agroecology, the support to the establishment of Centers for the Study of Agroecology and Organic Production (NEAs) in higher education institutions throughout Brazil. NEAs bring together teachers, researchers, and students who engage in teaching, research, and extension activities in partnerships with peasant farmers, their organizations, and rural extension workers. The hypothesis that guides our analysis is that this support to establish NEAs allowed redistribution of symbolic power in the universities where they were established, supporting agroecology to gain greater legitimacy inside and outside the university field. Based on an in-depth study of four NEAs, the NEAs are evaluated from the perspective of social fields in dispute. Our findings suggest that the State support to university groups dedicated to the promotion of agroecology has allowed the construction of what we have named agroecological spaces, which symbolically dispute the dominant paradigms in educational institutions, supporting the constitution of agroecological territories., RESUMEN. El Brasil se destaca a nivel mundial por haber implementado varias políticas destinadas a promover la agroecología como paradigma productivo para los pequeños agricultores. Sin embargo, los impactos de este proceso de institucionalización de la agroecología aún carecen de investigaciones y debates que evalúen la efectividad de estas políticas. En este trabajo, evaluamos y discutimos los impactos de una política específicamente centrada en la educación en agroecología, el apoyo al establecimiento de Centros para el Estudio de la Agroecología (NEAs) en educación superior en todo Brasil. Los NEAs reúnen a maestros, investigadores y estudiantes que participan en actividades de enseñanza, investigación y extensión en asociación con campesinos, sus organizaciones y trabajadores de extensión rural. La hipótesis que guía nuestro análisis es que este apoyo para establecer NEAs permitió la redistribución del poder simbólico en las universidades donde se establecieron, apoyando a la agroecología para ganar mayor legitimidad dentro y fuera del ámbito universitario. Sobre la base de un estudio en profundidad de cuatro NEAs, los NEAs se evalúan desde la perspectiva de los campos sociales en disputa. Nuestros hallazgos sugieren que el apoyo del Estado a los grupos universitarios dedicados a la promoción de la agroecología ha permitido la construcción de lo que hemos denominado espacios agroecológicos, que simbólicamente disputan los paradigmas dominantes en las instituciones educativas, apoyando la constitución de territorios agroecológicos., O Brasil se destaca em nível global por ter implementado políticas com a intenção de promover a agroecologia como paradigma produtivo para a agricultura familiar. No entanto, a eficácia dessas políticas ainda carece de pesquisas e debates que permitam a sua avaliação e a compreensão dos impactos desse processo de institucionalização da agroecologia. Neste artigo, avaliamos e discutimos o apoio à criação de Núcleos de Estudo em Agroecologia (NEAs) em instituições de ensino superior em todo o Brasil. Os NEAs reúnem professores, pesquisadores e estudantes que se engajam em atividades de ensino, pesquisa e extensão em parcerias com camponeses, suas organizações e extensionistas rurais. A hipótese que norteia nossa análise é que o apoio ao estabelecimento dos NEAs permitiu uma redistribuição do poder simbólico dentro das universidades onde eles foram estabelecidos, permitindo que a agroecologia ganhasse maior legitimidade. Com base em um estudo aprofundado de quatro NEAs, os avaliamos na perspectiva de campos sociais em disputa. Nossos achados sugerem que o apoio do Estado aos grupos universitários dedicados à promoção da agroecologia permitiu a construção do que chamamos de espaços agroecológicos, que simbolicamente contestam os paradigmas dominantes nas instituições de ensino, apoiando a constituição dos territórios agroecológicos. Palavras-chave: poder simbólico, agroecologia, transdisciplinaridade, educação superior, Brasil. Winning Hearts and Minds Through a Policy Promoting the Agroecological Paradigm in Universities ABSTRACT. Brazil stands out at the global level for having implemented several policies intending to promote agroecology as a productive paradigm for small-holder farmers. However, the impacts of this process of institutionalization of agroecology still lack research and debates that evaluate the effectiveness of these policies. In this paper, we assess and discuss the impacts of a policy specifically focused on education in agroecology, the support to the establishment of Centers for the Study of Agroecology and Organic Production (NEAs) in higher education institutions throughout Brazil. NEAs bring together teachers, researchers, and students who engage in teaching, research, and extension activities in partnerships with peasant farmers, their organizations, and rural extension workers. The hypothesis that guides our analysis is that this support to establish NEAs allowed redistribution of symbolic power in the universities where they were established, supporting agroecology to gain greater legitimacy inside and outside the university field. Based on an in-depth study of four NEAs, the NEAs are evaluated from the perspective of social fields in dispute. Our findings suggest that the State support to university groups dedicated to the promotion of agroecology has allowed the construction of what we have named agroecological spaces, which symbolically dispute the dominant paradigms in educational institutions, supporting the constitution of agroecological territories. Keywords: symbolic power, agroecology, transdisciplinary, higher education, Brazil. Ganar corazones y mentes a través de una política que promueva el paradigma agroecológico en las universidades RESUMEN. El Brasil se destaca a nivel mundial por haber implementado varias políticas destinadas a promover la agroecología como paradigma productivo para los pequeños agricultores. Sin embargo, los impactos de este proceso de institucionalización de la agroecología aún carecen de investigaciones y debates que evalúen la efectividad de estas políticas. En este trabajo, evaluamos y discutimos los impactos de una política específicamente centrada en la educación en agroecología, el apoyo al establecimiento de Centros para el Estudio de la Agroecología (NEAs) en educación superior en todo Brasil. Los NEAs reúnen a maestros, investigadores y estudiantes que participan en actividades de enseñanza, investigación y extensión en asociación con campesinos, sus organizaciones y trabajadores de extensión rural. La hipótesis que guía nuestro análisis es que este apoyo para establecer NEAs permitió la redistribución del poder simbólico en las universidades donde se establecieron, apoyando a la agroecología para ganar mayor legitimidad dentro y fuera del ámbito universitario. Sobre la base de un estudio en profundidad de cuatro NEAs, los NEAs se evalúan desde la perspectiva de los campos sociales en disputa. Nuestros hallazgos sugieren que el apoyo del Estado a los grupos universitarios dedicados a la promoción de la agroecología ha permitido la construcción de lo que hemos denominado espacios agroecológicos, que simbólicamente disputan los paradigmas dominantes en las instituciones educativas, apoyando la constitución de territorios agroecológicos. Palabras clave: poder simbólico, agroecología, transdisciplinar, educación superior, Brasil.
Published: 2022

47. Early versus late sphenopalatine ganglion block with ropivacaine in postdural puncture headache: an observational study

Author: Maria M. Castro, Maria L. Font, Nelson S. Santos, Joana Nunes, and Cristina Carmona
Subjects: Epidural blood patch, Activities of daily living, Sphenopalatine Ganglion Block, Ropivacaine, business.industry, Pain relief, Length of hospitalization, General Medicine, Postdural puncture headache, Anesthesia, medicine, Observational study, Timing, Sphenopalatine ganglion block, Complication, business, medicine.drug
Abstract: Background Postdural puncture headache (PDPH) is a common complication of neuraxial techniques which delays patients’ discharge. Sphenopalatine ganglion block (SPGB) is a safe bedside technique with comparable efficacy to Epidural Blood Patch, the gold-standard treatment. There is no evidence on the ideal timing for SPGB performance. We aimed to evaluate the difference between early versus late SPGB concerning efficacy, symptom recurrence and hospital length of stay. Methods We present an observational study with 41 patients diagnosed with PDPH who were submitted to SPGB with ropivacaine 0,75%. The study sample (n = 41) was divided in two groups: an early (less than 24 hours after diagnosis) and a late (more than 24 hours after diagnosis) SPGB group. Pain was evaluated 15 minutes after the block and follow up occurred daily until patients were discharged. Patients’ demographic characteristics, neuraxial technique, timing of SPGB, qualitative pain relief and post-SPGB length of stay were registered and analyzed with SPSS statistics (v26) software. Results Early SPGB resulted in a significant reduction in length of stay (p = 0,009) and symptom recurrence (p = 0,036), showing equally effective pain relief, compared to late SPGB. Conclusions SPGB was equally effective in both groups. Data showed that early SPGB reduces length of hospital stay and symptom recurrence, which potentially allows early resumption of daily activities and a reduction in total health costs.
Published: 2022

48. Association between enhanced recovery after surgery protocol compliance and clinical complications: a cohort study

Author: D. S. dos Santos, Afonso Félix-Oliveira, Marta Pereira, Maria Ana Máximo, and Cristina Carmona
Subjects: medicine.medical_specialty, Univariate analysis, Surgical stress, business.industry, General Medicine, Perioperative, Logistic regression, Colorectal surgery, Anesthesiology, Internal medicine, medicine, Clinical endpoint, business, Enhanced recovery after surgery, Cohort study, Compliance, Perioperative care
Abstract: Background Enhanced Recovery After Surgery (ERAS) protocol is composed by evidence-based interventions that aim to improve recovery through a reduction in surgical stress response. Although ERAS protocols have been introduced across the globe, exhaustive implementation is not as common. We aimed to study the ERAS protocol compliance in colorectal surgery, assessing the relationship between compliance and postoperative complications. Methods A single-center cohort study was conducted. All consecutive patients admitted to elective colorectal surgery were included. We assessed study endpoints according to ERAS protocol perioperative compliance score above 75%. Our primary endpoint was a composite of postoperative events, which includes in-hospital postoperative complications and need for reoperation after 30 days and need for readmission after discharge. Secondary endpoints were surgery-to-discharge time, postoperative use of only non-opioid adjuvants and the individual components of the primary endpoint. Results A total of 224 colorectal patients were included. The primary endpoint occurred in 59.2% (n = 58) of non-compliant patients comparing to 34.1% (n = 43) in compliant patients. In univariate analysis, compliance to ERAS protocol had an inferior risk for the primary endpoint (p< 0.001). In a logistic regression model, compliance was independently associated with a reduced risk for the primary endpoint with a odds-ratio of 0.42 (95% CI 0.23-0.75, p= 0.004). Conclusion Compliance with the ERAS protocol is associated with less complications, a reduced surgery-to-discharge time and use of only non-opioid adjuvants in the postoperative period. More studies are needed to target the most appropriate compliance goal.
Published: 2022

49. Metadona como fármaco de rescate para el control de la sedoanalgesia difícil en pacientes con SDRA asociado a infección por SARS-CoV-2

Author: M.A. Romera-Ortega, S. Alcántara-Carmona, R. Fernández-Tobar, B. Castiñeiras-Amor, C. Chamorro-Jambrina, and M. Pérez-Torres
Subjects: Gynecology, medicine.medical_specialty, business.industry, medicine, Critical Care and Intensive Care Medicine, business
Published: 2022

50. Editorial: Biotechnology for Arsenic Detection and Bioremediation

Author: Manuel Carmona, Gonzalo Durante-Rodríguez, Manoj Kumar, Natalia González-Benítez, Ministerio de Ciencia e Innovación (España), Universidad Rey Juan Carlos, González-Benítez, Natalia, Durante-Rodríguez, Gonzalo, Carmona, Manuel, González-Benítez, Natalia [0000-0003-0240-8221], Durante-Rodríguez, Gonzalo [0000-0003-3113-9868], and Carmona, Manuel [0000-0002-1591-7618]
Subjects: Microbiology (medical), biology, business.industry, Arsenic bioremediation, chemistry.chemical_element, biology.organism_classification, Microbiology, Endophyte, QR1-502, Arsenic, Phytoremediation, Biotechnology, Arsenic resistance, Bioremediation, chemistry, Environmental science, business
Abstract: 3p.-1 fig., This work was supported by grants PID2019-110612RB-I00 from Ministry of Science and Innovation of Spain and DRIADES Project from Universidad Rey Juan Carlos (AYUDA PUENTE).
Published: 2021

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