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1. Study for online range monitoring with the interaction vertex imaging method

Author

J. Krimmer, Cédric Ray, J. Baudot, D. Juliani, V. Reithinger, Etienne Testa, M. Vanstalle, Julie Constanzo, Y. Karakaya, Marc Rousseau, Ch. Finck, Ilaria Rinaldi, R. Rescigno, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), PRISME (PRISME), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Institut Lumière Matière [Villeurbanne] (ILM), Université Claude Bernard Lyon 1 (UCBL), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Strasbourg (UNISTRA)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Ion beam, Dose profile, Heavy Ion Radiotherapy, Bragg peak, Imaging phantom, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Optics, Humans, Radiology, Nuclear Medicine and imaging, Computer vision, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics, Radiological and Ultrasound Technology, Phantoms, Imaging, business.industry, Detector, Radiotherapy Dosage, Radiotherapy, Computer-Assisted, Vertex (geometry), Inflection point, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Artificial intelligence, Protons, business
Abstract

International audience; Ion beam therapy enables a highly accurate dose conformation delivery to the tumor due to the finite range of charged ions in matter (i.e. Bragg peak (BP)). Consequently, the dose profile is very sensitive to patients anatomical changes as well as minor mispositioning, and so it requires improved dose control techniques. Proton interaction vertex imaging (IVI) could offer an online range control in carbon ion therapy. In this paper, a statistical method was used to study the sensitivity of the IVI technique on experimental data obtained from the Heidelberg Ion-Beam Therapy Center.The vertices of secondary protons were reconstructed with pixelized silicon detectors. The statistical study used the x2 test of the reconstructed vertex distributions for a given displacement of the BP position as a function of the impinging carbon ions. Different phantom configurations were used with or without bone equivalent tissue and air inserts.The inflection points in the fall-off region of the longitudinal vertex distribution were computed using different methods, while the relation with the BP position was established. In the present setup, the resolution of the BP position was about 4–5 mm in the homogeneous phantom under clinical conditions (106 incident carbon ions). Our results show that the IVI method could therefore monitor the BP position with a promising resolution in clinical conditions.

Published
2017

2. Trimethyl Bismuth Optical Properties for Particle Detection and the CaLIPSO Detector

Author

G. Tauzin, Y. Bulbul, Christophe Flouzat, P. Starzynski, J.-P. Bard, P. Verrecchia, J. P. Mols, A. Marcel, D. Dubreuil, Matthieu Hamel, D. Desforge, D. Yvon, V. Sharyy, V. Reithinger, R. Granelli, E. Ramos, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Capteurs et Architectures Electroniques (LCAE), Département Métrologie Instrumentation & Information (DM2I), Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Technologique (CEA) (DRT (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA)), and Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Laboratoire d'Intégration des Systèmes et des Technologies (LIST (CEA))

Subjects
Nuclear and High Energy Physics, positron emission tomography, Materials science, Physics::Optics, chemistry.chemical_element, Dielectric, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Bismuth, 010309 optics, Optics, Biomedical imaging, Transmission curve, 0103 physical sciences, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Electrical and Electronic Engineering, Absorption (electromagnetic radiation), [CHIM.ORGA]Chemical Sciences/Organic chemistry, 010308 nuclear & particles physics, business.industry, Detector, position sensitive particle detectors, gamma-ray detectors, Wavelength, PET, Nuclear Energy and Engineering, chemistry, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Particle, Optoelectronics, business, calorimetry, Refractive index
Abstract

International audience; Trimethyl bismuth (TMBi) is a "heavy" transparent and dielectric organometallic liquid. This paper focuses on the measurement of TMBi's optical properties relevant for particle detection. We measured the TMBi transmission curve and refraction index versus wavelength, as well as the light production yield and the timing performance on a small size cell.

Published
2015

3. Collimated prompt gamma TOF measurements with multi-slit multi-detector configurations

Author

C. La Tessa, M.-H. Richard, Marco Pinto, J. Krimmer, Etienne Testa, V. Reithinger, Denis Dauvergne, George Dedes, Jean Michel Létang, M. Chevallier, M. De Rydt, Christoph Schuy, Julie Constanzo, Nicolas Freud, Ilaria Rinaldi, R. Pleskac, Cédric Ray, P. Henriquet, F. Roellinghoff, M. Testa, Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Biophysics Department [Darmstadt], Helmholtz Centre for Heavy Ion Research (GSI), Heidelberg Ion Beam Therapy Center - HIT, and Heidelberg University Clinic

Subjects
medicine.medical_specialty, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, PET PET/CT, 01 natural sciences, Electromagnetic radiation, Collimated light, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, 0302 clinical medicine, Optics, Instrumentation for hadron therapy, law, 0103 physical sciences, medicine, Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Coronary CT angiography (CTA), Gamma camera, SPECT, Instrumentation, Mathematical Physics, coronary CT angiography (CTA), Physics, 010308 nuclear & particles physics, business.industry, Scattering, Detector, Collimator, Electromagnetic shielding, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Physics::Accelerator Physics, business, Beam (structure)
Abstract

International audience; Longitudinal prompt-gamma ray profiles have been measured with a multi-slit multi-detector configuration at a 75 MeV/u 13C beam and with a PMMA target. Selections in time-of-flight and energy have been applied in order to discriminate prompt-gamma rays produced in the target from background events. The ion ranges which have been extracted from each individual detector module agree amongst each other and are consistent with theoretical expectations. In a separate dedicated experiment with 200 MeV/u 12C ions the fraction of inter-detector scattering has been determined to be on the 10%-level via a combination of experimental results and simulations. At the same experiment different collimator configurations have been tested and the shielding properties of tungsten and lead for prompt-gamma rays have been measured.

Published
2015

4. Development of a Compton camera for medical applications based on silicon strip and scintillation detectors

Author

M. Magne, H. Mathez, J. Krimmer, L. Lestand, Denis Dauvergne, Gerard Montarou, Jean Michel Létang, C. Abellan, J.-L. Ley, M. Dahoumane, B. Joly, D. Lambert, Marco Pinto, X. Chen, C. Morel, V. Reithinger, L. Caponetto, Voichita Maxim, Cédric Ray, Nicolas Freud, J.-P. Cachemiche, Y. Zoccarato, Etienne Testa, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre de Physique des Particules de Marseille (CPPM), Aix Marseille Université (AMU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université Grenoble Alpes - UFR Langage, lettres et arts du spectacle, information et communication - Dpt Journalisme (UGA UFR LLASIC J), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
Physics, Nuclear and High Energy Physics, Scintillation, Silicon, business.industry, Detector, chemistry.chemical_element, STRIPS, Bismuth germanate, 030218 nuclear medicine & medical imaging, law.invention, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Optics, chemistry, Stack (abstract data type), Hodoscope, law, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], business, Instrumentation, Beam (structure)
Abstract

International audience; A Compton camera is being developed for the purpose of ion-range monitoring during hadrontherapy via the detection of prompt-gamma rays. The system consists of a scintillating fiber beam tagging hodoscope, a stack of double sided silicon strip detectors (90 Â 90 Â 2 mm 3 , 2 Â 64 strips) as scatter detectors, as well as bismuth germanate (BGO) scintillation detectors (38 Â 35 Â 30 mm 3 , 100 blocks) as absorbers. The individual components will be described, together with the status of their characterization.

Published
2015

5. CaLIPSO: TMBi properties for particles detection

Author

D. Yvon, E. Ramos, G. Tauzin, V. Reithinger, and P. Verrecchia

Subjects
Materials science, business.industry, Liquid dielectric, Analytical chemistry, chemistry.chemical_element, Bismuth, Wavelength, Optics, chemistry, Transmission curve, Ionization, Yield (chemistry), business, Refractive index, Group 2 organometallic chemistry
Abstract

Trimethyl bismuth (TMBi) is a "heavy" organometallic liquid: 82% by weight of Bismuth. TMBi is a transparent and dielectric liquid that efficiently converts through the photo-electric effect photons of energies below 1 MeV. Charge and light produced in the liquid are both detected in a CaLIPSO detector. This paper focuses on the measurement of the TMBi physical properties relevant for particles detection. We measured the TMBi transmission curve, the TMBi refraction index versus wavelength, the light production yield. In addition we present preliminary measurements on ionization. These are however sufficient to demonstrate the mobility of charges in TMBi. A first measurement of the free ion yield of the TMBi normalized to the well known free ion yield of the TMSi indicates that both liquids have similar ionization yields. The purification of the TMBi is still ongoing; electron lifetime in the TMBi is estimated by using the ionization yields together with an equation based on Onsager's theory.

Published
2012

6. 111: Real-time monitoring of the ion range during hadrontherapy: An update on the beam tagging hodoscope

Author

H. Mathez, M. De Rydt, J. Krimmer, Cédric Ray, J.-L. Ley, E. Testa, Denis Dauvergne, Y. Zoccarato, V. Reithinger, L. Caponetto, S. Deng, X. Chen, and Michel Chevallier

Subjects
Range (particle radiation), Optics, Materials science, Oncology, Hodoscope, business.industry, Radiology, Nuclear Medicine and imaging, Hematology, business, Nuclear medicine, Beam (structure), Ion
Published
2014

7. 148 REAL-TIME PROMPT GAMMA RAY MONITORING FOR PROTON AND CARBON THERAPY: MONTE CARLO NUCLEAR MODELS EVALUATION AND IMPROVEMENTS

Author

Cédric Ray, Marco Pinto, Marius Chevallier, J. Krimmer, Denis Dauvergne, E. Testa, V. Reithinger, Jean Michel Létang, M. De Rydt, Georgios Dedes, M.-H. Richard, Nicolas Freud, and F. Roellinghoff

Subjects
Carbon therapy, Materials science, Proton, business.industry, Monte Carlo method, Gamma ray, Hematology, 030218 nuclear medicine & medical imaging, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, Nuclear medicine, business
Published
2012

8. 240 SPATIAL CORRELATIONS BETWEEN IMAGES DERIVED FROM DYNAMIC FDG-PET

Author

Nicolas Freud, Denis Dauvergne, Jean Michel Létang, Cédric Ray, J. Krimmer, P. Henriquet, Georgios Dedes, M.-H. Richard, E. Testa, M. De Rydt, V. Reithinger, and Michel Chevallier

Subjects
03 medical and health sciences, 0302 clinical medicine, Oncology, business.industry, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, Hematology, Nuclear medicine, business, 030218 nuclear medicine & medical imaging
Published
2012

9. 136 REAL-TIME MONITORING OF THE BRAGG PEAK DURING ION THERAPY: RECENT DEVELOPMENTS OF THE BEAM DETECTION SYSTEM

Author

Denis Dauvergne, Jean Michel Létang, Etienne Testa, M. De Rydt, Y. Zoccaratto, V. Reithinger, S. Deng, F. Roellinghoff, Georgios Dedes, M.-H. Richard, Marco Pinto, M. Chevallier, J. Krimmer, H. Mattez, Nicolas Freud, and Cédric Ray

Subjects
Materials science, business.industry, Bragg peak, Hematology, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Optics, Oncology, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, business, Beam (structure)
Published
2012

10. Simulation toolkit with CMOS detector in the framework of hadrontherapy

Author

J. Krimmer, D. Juliani, Etienne Testa, J. Baudot, Marc Rousseau, Ch. Finck, R. Rescigno, G. Dedes, Denis Dauvergne, Marc Winter, V. Reithinger, Cédric Ray, Institut Pluridisciplinaire Hubert Curien (IPHC), Université de Strasbourg (UNISTRA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)

Subjects
Physics, CMOS sensor, 010308 nuclear & particles physics, business.industry, QC1-999, Detector, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Reconstruction algorithm, Tracking system, 01 natural sciences, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, CMOS, 0103 physical sciences, Carbon ion therapy, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Hardware_INTEGRATEDCIRCUITS, Proton imaging, Electronic engineering, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], business
Abstract

International audience; Proton imaging can be seen as a powerful technique for on-line monitoring of ion range during carbon ion therapy irradiation. The protons detection technique uses, as three-dimensional tracking system, a set of CMOS sensor planes. A simulation toolkit based on GEANT4 and ROOT is presented including detector response and reconstruction algorithm.

Published
2014

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