40 results on '"Taro Hasegawa"'
Search Results
2. Fast polarization control for optical frequency combs
- Author
-
Taiki Kageyama and Taro Hasegawa
- Subjects
Materials science ,Optical fiber ,Birefringence ,business.industry ,Bandwidth (signal processing) ,Physics::Optics ,Polarization (waves) ,Waveguide (optics) ,Atomic and Molecular Physics, and Optics ,Compensation (engineering) ,law.invention ,Optics ,law ,business ,Phase modulation ,Voltage - Abstract
Polarization of an optical frequency comb is electrically controlled using a waveguide electro-optic phase modulator (WG-EOM). Owing to the low operation voltage and wide electric bandwidth of the WG-EOM, fast polarization control is possible. It is found that birefringence of the WG-EOM and polarization-maintaining optical fibers causes polarization-dependent pulse separation, which makes polarization control of the optical frequency comb impossible. Therefore, compensation of the birefringence is required for polarization control. In the experiment, a delay line in free space is used for birefringence compensation, and pulse-to-pulse polarization control of an optical frequency comb (with a repetition rate of 100 MHz) is demonstrated.
- Published
- 2021
3. Disease and injury trends among evacuees in a shelter located at the epicenter of the 2016 Kumamoto earthquakes, Japan
- Author
-
Sumie Yamamoto, Yoshihiro Suzuki, Takushi Sato, Shuko Takahashi, Takashi Yorifuji, Hideki Hayashi, Hayato Orui, Hiroshi Sashiyama, Shigeru Suganami, Taro Hasegawa, Taro Sakai, Toru Yoneda, Maki Okamoto, Daisuke Kato, and Yoshiomi Kishida
- Subjects
Adult ,Male ,0301 basic medicine ,Gerontology ,medicine.medical_specialty ,Adolescent ,Health, Toxicology and Mutagenesis ,Disease ,Toxicology ,Communicable Diseases ,Young Adult ,03 medical and health sciences ,Health problems ,0302 clinical medicine ,Japan ,Age groups ,Epidemiology ,Earthquakes ,medicine ,Humans ,Elderly people ,030212 general & internal medicine ,Child ,Noncommunicable Diseases ,Aged ,General Environmental Science ,Aged, 80 and over ,030109 nutrition & dietetics ,business.industry ,Incidence ,Infant, Newborn ,Public Health, Environmental and Occupational Health ,Infant ,Middle Aged ,medicine.disease ,Medical support ,Outpatient visits ,Child, Preschool ,Epicenter ,Wounds and Injuries ,Female ,Medical emergency ,business - Abstract
Two huge earthquakes struck Kumamoto, Japan, in April 2016, forcing residents to evacuate. Few studies have reported early-phase disease and injury trends among evacuees following major inland earthquakes. We evaluated the trends among evacuees who visited a medical clinic in a shelter located at the epicenter of the 2016 Kumamoto earthquakes. The clinic opened on April 15, the day after the foreshock, and closed 3 weeks later. We reviewed medical charts related to 929 outpatient visits and conducted descriptive analyses. The evacuees experienced mild injuries and common diseases. The types of diseases changed weekly. Elderly people needed medical support for longer than other age groups. Future earthquakes may be inevitable, but establishing arrangements for medical needs or making precautions for infectious diseases in shelters could reduce the effects of earthquake-related health problems.
- Published
- 2017
4. Robust Offset Locking of Laser Frequency with Electronically Tunable LC Circuits for Sub-Millihertz Uncertainty
- Author
-
Yuhei Seishu and Taro Hasegawa
- Subjects
Physics ,Quantum optics ,Offset (computer science) ,Physics and Astronomy (miscellaneous) ,business.industry ,General Engineering ,Optical physics ,Optical communication ,General Physics and Astronomy ,Physics::Optics ,LC circuit ,Physical optics ,Laser ,01 natural sciences ,law.invention ,010309 optics ,Phase-locked loop ,Optics ,Optical frequencies ,law ,0103 physical sciences ,Laser frequency ,010306 general physics ,business ,Diode - Abstract
Laser frequency stabilization is one of the essential technique in atomic, molecular, and optical physics, quantum optics, optical communications, and fundamental physics. Optical offset locking is the technique to stabilize optical frequency of a single-mode laser (slave laser) with respect to another well-stabilized laser (master laser). Optical phase lock loop (OPLL) [1] is one of the offset locking schemes, with which the slave laser frequency can be stabilized very precisely (less than the uncertainty of 10−18). However, especially in noisy experimental circumstances, the OPLL does not work because its capture range is not so wide that the locking fails for large amount of frequency jitters. In order to keep the locked condition, another offset locking with wider capture range is sometimes required. Examples of such locking schemes are digital processing technique, optical frequency locking to resonance frequency of a high-finesse cavity [2], offset locking with an electrical delay line [3], and offset locking with electric LC resonant circuit [4]. The offset locking with the electric LC circuit (LC locking) has been introduced by W.-Y. Cheng et al, and with employing this scheme with the OPLL the beat-note frequency can be stabilized as precise as one millihertz.
- Published
- 2019
5. 260 kHz mode-spacing optical frequency combs for scan-free high-resolution direct-comb spectroscopy
- Author
-
Taro Hasegawa
- Subjects
Materials science ,Absorption spectroscopy ,business.industry ,Physics::Optics ,Resonance ,Atomic and Molecular Physics, and Optics ,Laser linewidth ,Optics ,Phase noise ,Time-resolved spectroscopy ,business ,Spectroscopy ,Phase modulation ,Optical path length - Abstract
For scan-free high-resolution direct-comb spectroscopy, mode spacing of an optical frequency comb is reduced down to 260 kHz by phase modulation. It turns out that time-domain signal is degraded by averaging because of slow optical path length fluctuations and fast optical pulse timing jitter. In this study, compensation of these effects is introduced, and signal degradation by averaging is avoided. With demonstrations of direct-comb spectroscopy with the narrow-mode-spacing optical frequency comb, Doppler-limited absorption spectrum of methane and reflection spectrum from an optical ring cavity are observed. As a result, detailed resonance spectral line profile of 8 MHz linewidth for the optical ring cavity is obtained in 50 ms measurement time.
- Published
- 2020
6. Mode Density Multiplication of an Optical Frequency Comb by N2 with Phase Modulation
- Author
-
Taro Hasegawa and Hiroyuki Sasada
- Subjects
Physics ,Optical amplifier ,business.industry ,Mode (statistics) ,Physics::Optics ,01 natural sciences ,Square (algebra) ,010309 optics ,Optics ,Fiber laser ,0103 physical sciences ,Multiplication ,010306 general physics ,business ,Spectroscopy ,Phase modulation ,Integer (computer science) - Abstract
We introduce a simple scheme for mode density multiplication of an optical frequency comb by square of an arbitrary integer with phase modulation. The mode density of an Er fibercomb is multiplied by 42.
- Published
- 2018
7. Stabilization of the coupled resonant cavity without dither
- Author
-
Taro Hasegawa
- Subjects
Physics ,Heterodyne ,business.industry ,Astrophysics::Instrumentation and Methods for Astrophysics ,Physics::Optics ,Resonance ,Molecular spectroscopy ,Resonant cavity ,Laser ,Noise (electronics) ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,Optics ,law ,Dither ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,business ,Fourth harmonic generation - Abstract
A simple scheme without dither to obtain an error signal for the stabilization of the coupled-cavity configuration for efficient fourth harmonic generation of continuous-wave lasers is proposed and demonstrated. This scheme is an analogue of the noise immune cavity enhanced optical heterodyne molecular spectroscopy (NICEOHMS) technique. In the proposed scheme, the robust stabilization is expected in comparison with the dither lock technique. In the demonstration, the stabilization of the coupled resonant cavity at the resonance is successfully achieved without the noise caused by the dither.
- Published
- 2013
8. A Case of Atlanto-axial Rotatory Fixation Following Cochlear Implantation
- Author
-
Sawako Tanke, Taro Hasegawa, Atsuhiko Uno, Takao Imai, Yumi Ohta, Tetsuo Morihana, and Hidenori Inohara
- Subjects
Fixation (surgical) ,medicine.medical_specialty ,Otorhinolaryngology ,business.industry ,medicine ,Cochlear implantation ,business ,medicine.disease ,Surgery ,Torticollis - Published
- 2013
9. Fourth harmonic generation of continuous-wave lasers in coupled-cavity configuration
- Author
-
Taro Hasegawa
- Subjects
Physics ,business.industry ,Physics::Optics ,Resonance ,Laser ,medicine.disease_cause ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,law.invention ,Power (physics) ,Optics ,law ,Modulation ,Optical cavity ,medicine ,Physics::Accelerator Physics ,Continuous wave ,Optoelectronics ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,business ,Beam (structure) ,Ultraviolet - Abstract
Frequency quadrupling of a continuous-wave laser is carried out in coupled cavities with the stabilization to the resonance. The fourth harmonic generation in the coupled cavities is expected to be more efficient than in the two build-up cavity configuration in tandem, because input couplers, which increase the optical loss of the cavity, are not required. The cavity length is stabilized by the feedback of the error signal obtained by the cavity length modulation. In the present demonstration, the ultraviolet beam of 6 μ W at 238 nm is obtained by the fourth harmonic generation of the near infrared laser of 180 mW at 952 nm. This output power is expected to become higher ( ∼ 1.7 mW ) when the cavity setup is optimized.
- Published
- 2012
10. Direct comb spectroscopy by heterodyne detection with a continuous-wave laser for high spectral resolution
- Author
-
Hiroyuki Sasada and Taro Hasegawa
- Subjects
Materials science ,business.industry ,Physics::Optics ,Laser ,law.invention ,Optics ,law ,Optoelectronics ,Continuous wave ,Physics::Atomic Physics ,Heterodyne detection ,Spectral resolution ,business ,Spectroscopy - Abstract
A scheme to resolve individual comb modes by heterodyne detection with a continuous-wave laser for direct comb spectroscopy is proposed and demonstrated. This is simple and suitable for application to high-resolution spectroscopy.
- Published
- 2016
11. Modulation-free laser frequency stabilization to a saturated sub-Doppler spectral line in a transversal magnetic field
- Author
-
Kana Iwakuni, Sho Okubo, and Taro Hasegawa
- Subjects
Materials science ,Laser diode ,business.industry ,Physics::Optics ,chemistry.chemical_element ,Dichroic glass ,Laser ,Atomic and Molecular Physics, and Optics ,Spectral line ,Electronic, Optical and Magnetic Materials ,law.invention ,Magnetic field ,symbols.namesake ,Optics ,chemistry ,Modulation ,law ,symbols ,Physics::Atomic Physics ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,business ,Doppler effect ,Helium - Abstract
We demonstrate frequency stabilization of a modulation-free laser to a saturated absorption spectral line of atoms in a transversal magnetic field. This stabilization scheme has been proposed for wide capture range in comparison with the dichroic atomic vapor laser lock (DAVLL) scheme and demonstrated for a Doppler-broadened spectral line in J. Opt. Soc. Am. B, 26, 1216 (2009). In this paper, a 1083-nm external-cavity laser diode is frequency-stabilized to the sub-Doppler spectral line of helium transition ( 2 3 S 1 , m J = 0 ↔ 2 3 P 0 ). Even though the error signal shape strongly depends on the pump beam polarization, the stabilized frequency is expected to be insensitive to the pump beam polarization.
- Published
- 2012
12. Diagnosis of the subtype and affected ear of benign paroxysmal positional vertigo using a questionnaire
- Author
-
Yumi Ohta, Arata Horii, Tadashi Kitahara, Hidenori Inohara, Takao Imai, Taro Hasegawa, Kayoko Higashi-Shingai, Takayuki Kawashima, Suetaka Nishiike, and Atsuhiko Uno
- Subjects
Male ,medicine.medical_specialty ,Benign paroxysmal positional vertigo ,Supine position ,Posture ,Nystagmus ,Audiology ,Nystagmus, Pathologic ,Surveys and Questionnaires ,Vertigo ,otorhinolaryngologic diseases ,medicine ,Humans ,Medical diagnosis ,Paroxysmal vertigo ,biology ,business.industry ,General Medicine ,medicine.disease ,biology.organism_classification ,Otorhinolaryngology ,Head Movements ,Head movements ,Female ,sense organs ,Positional nystagmus test ,medicine.symptom ,business - Abstract
Conclusion: The prediction of subtype and the affected ear of benign paroxysmal positional vertigo (BPPV) derived from the answers to our questionnaire can support the definitive diagnosis of BPPV. Objectives: We examined to what extent the diagnosis of subtype and the affected ear of BPPV judged from answers to a questionnaire agreed with the diagnosis decided by the results of the positional nystagmus test. Methods: We asked the following questions: ‘What kind of head movements induce vertigo?’ and ‘How long does the vertigo continue?’. As for the affected ear, we asked which ear was lower during stronger vertigo when induced in a supine position or during sleep. Results: The percentages of correct diagnosis speculated by the combined answers were 69% in posterior canal-type BPPV, 48% in BPPV with geotropic nystagmus, and 39% in BPPV with apogeotropic nystagmus. The percentage of correct diagnoses of the affected ear was more than 80%.
- Published
- 2011
13. A Case of Nasal Septum Chondrosarcoma
- Author
-
Hidenori Inohara, Takashi Shikina, Suetaka Nishiike, Junji Miyabe, Atsuhiko Uno, Yumi Ota, and Taro Hasegawa
- Subjects
medicine.anatomical_structure ,business.industry ,medicine ,Nasal septum ,Anatomy ,Chondrosarcoma ,medicine.disease ,business - Published
- 2011
14. Mode density multiplication of an optical frequency comb by N2 with phase modulation
- Author
-
Taro Hasegawa
- Subjects
Optical amplifier ,Physics ,business.industry ,Physics::Optics ,02 engineering and technology ,021001 nanoscience & nanotechnology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,Square (algebra) ,010309 optics ,Optics ,Fiber laser ,0103 physical sciences ,Multiplication ,Spectral resolution ,0210 nano-technology ,Spectroscopy ,business ,Phase modulation ,Integer (computer science) - Abstract
We introduce a simple scheme for mode-density multiplication of an optical frequency comb (OFC) by a factor of square of an arbitrary integer N using phase modulation. This scheme is employed to multiply the mode density of an erbium-doped fiber laser OFC (repetition rate of 66.87 MHz) by factors of 42, 82, and 3 · 42 using an electro-optic phase modulator. The OFC multiplied by 42 is applied to direct-comb spectroscopy of methane with a spectral resolution of 4.18 MHz.
- Published
- 2018
15. The Effect of Tamsulosin Treatment on Erectile Functions in Patients with Lower Urinary Tract Symptoms (LUTS) due to Benign Prostate Hyperplasia: Correlation between Improvement of LUTS and Erectile Function
- Author
-
Teruaki Iwamoto, Taro Hasegawa, Masaru Nakano, Tomohiko Matsushita, and Toshiaki Tanaka
- Subjects
Gynecology ,medicine.medical_specialty ,business.industry ,Urology ,Hyperplasia ,medicine.disease ,Correlation ,Erectile dysfunction ,medicine.anatomical_structure ,Urine flow rate ,Neurology ,Prostate ,Lower urinary tract symptoms ,Tamsulosin ,Medicine ,In patient ,business ,medicine.drug - Abstract
Objectives: To evaluate the impact of tamsulosin treatment on erectile function in patients with lower urinary tract symptoms (LUTS). Methods: Seventy-five patients with LUTS received tamsulosin 0.2 mg once daily for 3 months. Subjective efficacy was assessed by International Prostatic Symptom Score (IPSS) for LUTS and International Index for Erectile Function 5 (IIEF5) for erectile dysfunction (ED). Objective efficacy was assessed by prostate volume and urine flow rate. All measurements were performed at baseline and month 3. On the basis of IPSS ratio (month 3/baseline), the patients were classified into good responders (≤0.75) and poor responders (>0.75). Good responders to ED were defined as the patients who improved IIEF5 score 3 or more. Results: Seventy-four subjects completed the study. IPSS score showed significant improvement, but IIEF5 score showed no significant change. Forty-three patients (58%) were classified into good responders to LUTS. The baseline score of IIEF5 in the good responders was significantly higher than that in the poor responders. Negative correlation was recognized between IPSS ratio and baseline score of IIEF5. Nine patients (13%) were able to classify into good responders to ED, who had significantly smaller prostate volume and showed significantly lower IPSS ratio. Conclusions: The tamsulosin therapy for LUTS patients showed a significant improvement of LUTS, but no significant change of erectile functions. The better response to LUTS was seen in the milder ED patient. Tamsulosin therapy may be effective not only on LUTS but also on ED in the patients who have small prostate.
- Published
- 2010
16. Axisymmetrical Stress and Strength Analyses of Epoxy-Steel Composite Cylinders under Push-off Loads
- Author
-
Taro Hasegawa, Lijuan Liao, and Toshiyuki Sawa
- Subjects
Materials science ,business.industry ,Modulus ,Structural engineering ,Elasticity (physics) ,Cylinder (engine) ,law.invention ,Physics::Fluid Dynamics ,Shear (sheet metal) ,Stress (mechanics) ,law ,Shear stress ,Cylinder stress ,Composite material ,business ,Stress concentration - Abstract
The interface stress distributions in composite cylinders of steel (solid cylinder) and epoxy (hollow cylinder) under push-off loads are analyzed using axisymmetrical theory of elasticity as a three-body contact problem. In the numerical calculations, the effects of Young’s modulus and the diameter of solid cylinder on the interface stress distribution are examined. In addition, the effects of the diameter of supported hollow cylinder and the stress distribution due to the applied push-off loads are also examined. It is found that the normal stress at the interfaces increases as Young’s modulus of solid cylinder decreases, the diameter of solid cylinder and the diameter of supported hollow cylinder increase. It is also found that the shear stress at the interfaces increases as the diameter of supported hollow cylinder increases, Young’s modulus and the diameter of solid cylinder decrease. Singular stresses occur at the edges of the interfaces. A valid method for estimating the singularity is proposed and the discussion is made. Using the interfaces stresses obtained from the numerical analysis and analogous tests, the push-off strength of composite cylinders is estimated. The experiments to measure composite cylinders strength are carried out. It is seen that a rupture initiates at the lower edge of the interface area when the push-off loads are applied to the upper end of solid cylinder. For verification of the present analysis of the interface stress distributions, finite-element method (FEM) is also carried out. The numerical results of the interface stress distributions and the strength are in fairly good agreement with the experimental results and the FEM results. The axisymmetrical theory of elasticity is more rational compared to the shear lag theory in examining the stress singularity and considering the normal stress and shear stress at the interfaces at the same time. Finally, as an example, it is observed that the weight of composite cylinders is lighter by 48.1% than that of the structure with the same of steel material for obtaining the same strength.
- Published
- 2010
17. Fasudil administration combined with a steroid for the treatment of idiopathic sudden sensorineural hearing loss.-effect of Rho-kinase inhibitor on cochlear ischemia
- Author
-
Tomoyuki Shimizu, Hidenori Boku, Katsumi Doi, Takeshi Kubo, Takayuki Kawashima, Yasuhiro Osaki, Taro Hasegawa, Hiroshi Nishimura, and Osamu Senba
- Subjects
medicine.medical_specialty ,Endocrinology ,business.industry ,Internal medicine ,Anesthesia ,Sudden sensorineural hearing loss ,medicine.medical_treatment ,medicine ,Fasudil ,General Medicine ,business ,Steroid - Abstract
Rhoキナーゼ阻害剤の塩酸ファスジルは, 1) 血管拡張・血流改善作用, 2) 神経・シナプス再生作用を有し, 突発性難聴の主たる病態の1つとされる内耳血流障害を改善させ, 同時に, ラセン神経節細胞―有毛細胞間のシナプス結合の修復を促すことで, 突発性難聴に対して優れた治療効果を示すことが期待される薬剤である。塩酸ファスジル併用ステロイド治療を突発性難聴10症例に対して行い, 完全回復が9例と極めて良好な治療効果が得られた。血管収縮物質エンドセリンによる内耳微小血管の収縮は, 突発性難聴の内耳病態, 分子機構の一つと示唆されている。エンドセリンによる砂ネズミ蝸牛軸動脈の収縮は, Rhoキナーゼ阻害薬により濃度依存性に抑制される。塩酸ファスジル併用ステロイド治療は, エンドセリンによる内耳循環障害を軽減し, ステロイド単剤治療の効果をより高め, 突発性難聴の治療成績を著明に向上させ得る新規治療法となる可能性が示唆された。
- Published
- 2007
18. Fatal Septic Shock Caused by Transrectal Needle Biopsy of the Prostate; A Case Report
- Author
-
Yukihiko Oishi, Taro Hasegawa, Kouji Asano, Hiroki Yamada, Hiroyuki Ito, Norio Hasegawa, Tatuya Shimomura, Shouichi Onodera, Nobuki Kato, Hiroshi Kiyota, and Isao Ikemoto
- Subjects
Male ,medicine.medical_specialty ,Urology ,Bacteremia ,Fatal Outcome ,Prostate ,Biopsy ,Escherichia coli ,medicine ,Carcinoma ,Humans ,medicine.diagnostic_test ,business.industry ,Septic shock ,Biopsy, Needle ,Prostatic Neoplasms ,Hemospermia ,General Medicine ,Rectal examination ,Middle Aged ,medicine.disease ,Shock, Septic ,medicine.anatomical_structure ,Adenocarcinoma ,Chills ,Radiology ,medicine.symptom ,business - Abstract
A 46-year-old man refer to us because of hemospermia. The prostatic gland was normal in size and consistency at rectal examination. Serum prostate specific antigen was 7.04 ng/ml. Magnetic resonance imaging showed an area of low signal intensity on T2-weighted images in the left peripheral gland, possibly indicative of carcinoma. Transrectal prostate biopsy was performed after intravenous administration of piperacillin. He developed chills and fever (39 degrees C) the next morning following biopsy. He was taken unconscious into the hospital where a diagnosis of septic shock caused by Escherichia coli was made. Five days later, he died. His general condition deteriorated notwithstanding intensive treatment. Postmortem blood cultures were positive for a piperacillin resistant Escherichia coli. Histological examination of the biopsies showed a benign prostatic hyperplasia. Autopsy showed diffuse tissue damage in the heart, lung, liver and kidneys. The prostate had numerous microabscesses. Currently, transrectal prostate biopsy is considered a generally reliable procedure to detect adenocarcinoma of the prostate. Our case seems to the sixth case report of fatal complications.
- Published
- 2002
19. Direct-comb molecular spectroscopy by heterodyne detection with continuous-wave laser for high sensitivity
- Author
-
Hiroyuki Sasada and Taro Hasegawa
- Subjects
Materials science ,Tunable diode laser absorption spectroscopy ,Laser diode ,business.industry ,Physics::Optics ,Atomic spectroscopy ,Laser ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,law.invention ,010309 optics ,Optics ,law ,Fiber laser ,0103 physical sciences ,Continuous wave ,Physics::Atomic Physics ,Heterodyne detection ,010306 general physics ,business ,Absorption (electromagnetic radiation) - Abstract
We have demonstrated direct-comb molecular spectroscopy in which an individual-comb mode is resolved by heterodyne detection with a continuous-wave (cw) laser. This simple, fast, and sensitive technique was demonstrated for atomic spectroscopy in [ Appl. Phys. Lett.101, 051105 ( 2012)], but is more suitable for molecular spectroscopy. Four rotation-vibration transitions of methane have simultaneously been recorded in a Doppler-limited resolution using a spectrally broadened comb based on an Er-doped fiber laser and a cw 1651-nm distributed-feedback laser diode. Even though the power level of the comb modes and the sample absorption are weaker than those of the previous studies, in this work the cw laser frequency is stabilized to one of the comb modes, and the data are thereby averaged for extended periods of time, resulting an improvement in sensitivity.
- Published
- 2017
20. Optical bistability induced by Gouy phase shift
- Author
-
Taro Hasegawa
- Subjects
Materials science ,High power lasers ,business.industry ,Physics::Optics ,Statistical and Nonlinear Physics ,Molecular spectroscopy ,01 natural sciences ,Molecular physics ,eye diseases ,Atomic and Molecular Physics, and Optics ,Optical bistability ,010309 optics ,Nonlinear system ,Optics ,0103 physical sciences ,Molecule ,010306 general physics ,business ,Refractive index ,Gaussian beam - Abstract
Optical bistability in a passive ring cavity with no designed nonlinear materials is experimentally observed in the near-infrared region. The nonlinear material that induces the optical bistability is considered to be water molecules in atmosphere. In the model calculation, it is found that the optical bistability is induced by transversal distribution of optical power-dependent refractive index of water in the Gaussian beam, which causes the power-dependent Gouy phase shift in the cavity. The model calculation agrees qualitatively with the experimental results. This result suggests that the Gouy phase shift has an effect on cavity-enhanced molecular spectroscopy.
- Published
- 2017
21. Retroperitoneoscopic ureterolithotomy for impacted ureteral stone
- Author
-
Koji Asano, Hiroshi Kiyota, Kenta Miki, Yasumasa Yoshino, Jun Madarame, Isao Ikemoto, Taro Hasegawa, and Yukihiko Ohishi
- Subjects
Male ,Retroperitoneoscopic ureterolithotomy ,medicine.medical_specialty ,Ureteral Calculi ,Urology ,medicine.medical_treatment ,Ureteral stone ,Balloon ,Catheterization ,Ureter ,medicine ,Humans ,Retroperitoneal space ,Retroperitoneal Space ,Abscess ,Aged ,business.industry ,Stent ,Urography ,Middle Aged ,Surgical Instruments ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Laparoscopy ,Splint (medicine) ,business - Abstract
Retroperitoneoscopic ureterolithotomy was successfully performed in two patients with impacted upper ureteral stone. The retroperitoneal space was extended using a balloon dissector and four ports were established into the retroperitoneal space according to Gaur's procedure (1993). The impacted ureteral stone was removed after the ureter was incised using a hook electrode. An indwelling splint or stent was placed in the ureter. The incised ureter was not sutured and an indwelling drain was placed in the retroperitoneal space. Urine leakage ceased within 3 days postoperatively. With regard to complications, the first patient developed wound infection caused by methicillin-resistant Staphylococcus aureus and the second patient had abscess formation in the psoas muscle. Retroperitoneoscopic ureterolithotomy should be useful as an alternative treatment for impacted ureteral stones because it involves minimal postoperative pain.
- Published
- 2001
22. Nodal Gamma/Delta T Cell Lymphoma in Complete Remission following Allogeneic Bone Marrow Transplantation from an HLA-Matched Unrelated Donor
- Author
-
Ki-Ryang Koh, Yasutaka Aoyama, Hirohisa Nakamae, Chikahiko Sakamoto, Noriyuki Tatsumi, Takahisa Yamane, Takayuki Takubo, Ryousuke Yamamura, Kazuo Tsubaki, Taro Hasegawa, Kensuke Ota, Takeshi Inoue, and Masayuki Hino
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Biopsy ,Prednisolone ,Human leukocyte antigen ,Lymphoma, T-Cell ,Bone Marrow ,immune system diseases ,hemic and lymphatic diseases ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Asparaginase ,Humans ,Transplantation, Homologous ,T-cell lymphoma ,Gamma delta T cell ,Cyclophosphamide ,Bone Marrow Transplantation ,Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor ,business.industry ,Remission Induction ,T-cell receptor ,Cytarabine ,Receptors, Antigen, T-Cell, gamma-delta ,Hematology ,General Medicine ,medicine.disease ,Combined Modality Therapy ,Peripheral T-cell lymphoma ,Lymphoma ,medicine.anatomical_structure ,Doxorubicin ,Vincristine ,Bone marrow ,Stem cell ,business - Abstract
Gamma/delta T cell lymphoma is very rare, and usually occurs as an extranodal tumor. We describe the case of a 16-year-old Japanese man with an unusual nodal gamma/delta T cell lymphoma with generalized lymphadenopathy and bone marrow involvement. No tumor involvement was observed in the liver, spleen, or nasal cavity. Examination for surface antigens on lymphoma cells revealed a unique phenotype, positive for CD3 and T cell receptor (TCR) gamma/delta, but negative for CD2. Genotypic analysis revealed the tumor to be of monoclonal origin and characterized by TCR gamma-chain gene rearrangement, but there was no rearrangement of the TCR beta-chain gene. Our patient’s tumor responded to combination chemotherapy and subsequent allogeneic bone marrow transplantation from an HLA-matched unrelated donor. He has remained well and free of disease for 35 months.
- Published
- 2001
23. Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-γ in patients with acute graft-versus-host disease after allogeneic bone marrow transplantation
- Author
-
Hirofumi Teshima, Taro Hasegawa, Masako Ayaki, Hiroyuki Nakamura, Keiko Komatsu, Akira Hiraoka, Shinichiro Kawamoto, Takahiro Karasuno, Toshinari Yagi, Masaki Murakami, Tohru Masaoka, Nobuhiko Uoshima, and Masato Yasumi
- Subjects
Adult ,Male ,Interleukin 2 ,Adolescent ,Fever ,medicine.medical_treatment ,Immunology ,Graft vs Host Disease ,Pathogenesis ,Interferon-gamma ,Immunopathology ,medicine ,Humans ,Immunology and Allergy ,Interferon gamma ,IL-2 receptor ,Bone Marrow Transplantation ,business.industry ,Interleukin-18 ,Receptors, Interleukin-2 ,Th1 Cells ,Interleukin-12 ,medicine.anatomical_structure ,Cytokine ,Solubility ,Acute Disease ,Cytokines ,Female ,Interleukin 18 ,Bone marrow ,business ,medicine.drug - Abstract
Background: Acute graft-versus-host disease still represents the major factor that limits successful allogeneic bone marrow transplantation. Cytokines released by type 1 T-helper cells are thought to play a pivotal role in acute graft-versus-host disease. Objective: This study was performed to investigate whether the serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-γ were associated with the manifestation of acute graft-versus-host disease. Methods: Serum cytokine levels were measured by sandwich ELISA in 18 patients who underwent allogeneic bone marrow transplantation. Results: Serum levels of soluble IL-2 receptor, IL-12, IL-18, and IFN-γ were increased in patients in whom acute graft-versus-host disease developed. However, only serum soluble IL-2 receptor levels were significantly related to disease severity. Serum levels of IL-12 and IL-18, both of which are mainly produced by activated macrophages, were increased in different phases of acute graft-versus-host disease, especially grade I. Serum levels of soluble IL-2 receptor and IFN-γ were significantly elevated in patients with fever. Conclusion: Serum levels of soluble IL-2 receptor were more closely related to the severity of acute graft-versus-host disease than those of IL-12, IL-18, and IFN-γ. (J Allergy Clin Immunol 2000;106:S45-50.)
- Published
- 2000
24. Frequency-doubled Hermite–Gaussian beam and the mode conversion to the Laguerre–Gaussian beam
- Author
-
Taro Hasegawa and Tadao Shimizu
- Subjects
Physics ,Hermite polynomials ,business.industry ,Mathematics::Classical Analysis and ODEs ,Second-harmonic generation ,Nonlinear optics ,Atomic and Molecular Physics, and Optics ,Electronic, Optical and Magnetic Materials ,Optics ,Laguerre polynomials ,Physics::Accelerator Physics ,Ion trap ,Laser beam quality ,Electrical and Electronic Engineering ,Physical and Theoretical Chemistry ,business ,Beam (structure) ,Gaussian beam - Abstract
Frequency-doubled beam of the higher-order Laguerre–Gaussian mode is obtained with a high power (2 mW) aiming at an investigation of the interaction between the Laguerre–Gaussian beam and ions in a radio-frequency ion trap. For a sufficient beam power, the Hermite–Gaussian beam is obtained at first, frequency-doubled, and then mode-converted to the Laguerre–Gaussian mode. The beam profile is analyzed theoretically.
- Published
- 1999
25. Broadened optical spectrum of repetition-rate-multiplied erbium-doped fiber comb
- Author
-
Taro Hasegawa
- Subjects
Mode volume ,Multi-mode optical fiber ,Materials science ,business.industry ,Physics::Optics ,Statistical and Nonlinear Physics ,Optical power ,Polarization-maintaining optical fiber ,02 engineering and technology ,01 natural sciences ,Atomic and Molecular Physics, and Optics ,law.invention ,010309 optics ,020210 optoelectronics & photonics ,Optics ,law ,Fiber optic sensor ,Optical cavity ,0103 physical sciences ,0202 electrical engineering, electronic engineering, information engineering ,Optoelectronics ,Dispersion-shifted fiber ,business ,Optical attenuator - Abstract
The repetition rate of an erbium-doped fiber comb is multiplied by an optical cavity for filtering, and the optical spectral distribution is broadened in a highly nonlinear fiber. For erbium-doped fiber combs, filtering cavities are commonly used to obtain the high-repetition-rate combs by the repetition rate multiplication. After the multiplication, optical spectral broadening by a highly nonlinear fiber is necessary for applications to optical frequency measurements in broad bandwidth and astronomy. In this study, the broadened spectrum covers over the range from 1050 to 2250 nm, which is over an octave so that the determination of the filtered mode numbers is feasible. The optical power of the broadened beam within a narrow optical bandwidth is also measured in the time domain and in the frequency domain to examine the broadening property.
- Published
- 2016
26. Infliximab for the Treatment of Severe Steroid Refractory Acute Graft-versus-host Disease in Three Patients after Allogeneic Hematopoietic Transplantation
- Author
-
Mayasuki Hino, Yoshiki Terada, Takahisa Yamane, Genju Koh, Taro Hasegawa, Ryousuke Yamamura, Hirohisa Nakamae, Yasutaka Aoyama, Hisako Shibata, and Chikahiko Sakamoto
- Subjects
Adult ,Male ,Cancer Research ,medicine.medical_specialty ,Time Factors ,Adolescent ,Graft vs Host Disease ,Gastrointestinal Agents ,Refractory ,immune system diseases ,hemic and lymphatic diseases ,medicine ,Humans ,Transplantation, Homologous ,biology ,business.industry ,Lymphoma, Non-Hodgkin ,Hematopoietic Stem Cell Transplantation ,Antibodies, Monoclonal ,Hematology ,Middle Aged ,Precursor Cell Lymphoblastic Leukemia-Lymphoma ,Prognosis ,medicine.disease ,Infliximab ,Surgery ,Lymphoma ,Transplantation ,Haematopoiesis ,Diarrhea ,Treatment Outcome ,surgical procedures, operative ,Oncology ,Myelodysplastic Syndromes ,Acute Disease ,biology.protein ,Female ,Steroids ,Antibody ,medicine.symptom ,Complication ,business ,medicine.drug - Abstract
Acute graft-versus-host disease (aGVHD) is a serious complication of allogeneic peripheral blood stem cell transplantation (PBSCT). Patients with severe aGVHD not responding to treatment with steroids have a poor prognosis. We treated three patients with severe aGVHD refractory to steroids with infliximab. Patients (MDS 1, NHL 1, ALL 1) developed grade II-IV GVHD at a median of 13 days (range 9-17) after non-myeloablative PBSCT (HLA mismatched). All patients had received treatment with high-dose steroids for a median of 7 days (range 7-10) in addition to mycophenolate mofetil (MMF) (one). Infliximab was given in 3 weekly doses of 5 mg/kg. In one of three patients a partial resolution of diarrhea and minor improvement of skin were observed. One patient died with refractory GVHD. Infliximab is apparently an effective drug for the treatment of aGVHD, but can be more effective at doses of 5 mg/kg or higher and/or by administering it repeatedly every week.
- Published
- 2003
27. High reliability 1.3-μm buried heterostructure AlGaInAs-MQW DFB laser operated at 28-Gbit/s direct modulation
- Author
-
Katsumi Uesaka, Takuya Fujii, Yasuo Yamasaki, Nobumasa Okada, Noriaki Kaida, Taro Hasegawa, Kan Akiyama, Yutaka Onishi, Tatsuya Takeuchi, Takashi Nakabayashi, Nobuyuki Ikoma, and Gaishi Chifune
- Subjects
Optical amplifier ,Distributed feedback laser ,Materials science ,business.industry ,Optical modulation amplitude ,Laser ,law.invention ,Vertical-cavity surface-emitting laser ,Optics ,law ,Quantum dot laser ,Diode-pumped solid-state laser ,Optoelectronics ,Laser power scaling ,business - Abstract
Clear eye opening at 28-Gbit/s direct modulation up to 75°C is achieved with 1.3-μm buried heterostructure AlGaInAs-MQW DFB laser. No failure had occurred at high optical output power aging test over 7000 hours.
- Published
- 2012
28. Risk factor analysis for thrombotic microangiopathy after reduced-intensity or myeloablative allogeneic hematopoietic stem cell transplantation
- Author
-
Hirohisa Nakamae, Takahisa Yamane, Kensuke Ohta, Yoshiki Terada, Taro Hasegawa, Kiyoyuki Hagihara, Mika Nakamae, and Masayuki Hino
- Subjects
Adult ,Male ,medicine.medical_specialty ,Thrombotic microangiopathy ,Transplantation Conditioning ,Adolescent ,medicine.medical_treatment ,Graft vs Host Disease ,Hematopoietic stem cell transplantation ,Gastroenterology ,Disease-Free Survival ,Tacrolimus ,chemistry.chemical_compound ,immune system diseases ,Risk Factors ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,Transplantation, Homologous ,Busulfan ,Aged ,Retrospective Studies ,Hematology ,business.industry ,Hazard ratio ,Hematopoietic Stem Cell Transplantation ,Thrombosis ,Middle Aged ,Myeloablative Agonists ,medicine.disease ,Nitrogen mustard ,Surgery ,Transplantation ,surgical procedures, operative ,chemistry ,Evaluation Studies as Topic ,Hematologic Neoplasms ,Multivariate Analysis ,Female ,business ,Immunosuppressive Agents ,medicine.drug - Abstract
Thrombotic microangiopathy (TMA) impairs long-term survival after allogeneic hematopoietic stem cell transplantation (HSCT). As the allogeneic HSCT procedure has developed, addressing risk factors for TMA has become more complicated. The aim of this study was to investigate the impact of transplant-associated factors on TMA incidence in patients who have undergone HSCT in various settings. One hundred twenty-three consecutive allogeneic HSCT patients with hematologic diseases receiving myeloablative and reduced-intensity conditioning were evaluated retrospectively. Of 123 patients, 22 (17.9%) developed TMA after HSCT. Multivariate analysis showed the significance of GVHD grade II-IV, and the use of FK506 and the use of high-dose busulfan (Bu) (16 mg/kg) persisted. The hazard ratios of the use of FK506, the use of high-dose Bu (16 mg/kg), and GVHD grade II-IV for TMA were 8.7 (95% CI 2.0-37), 5.7 (95% CI 1.5-21), and 3.4 (95% CI 1.3-9.1), respectively. In the present study, reduced-intensity conditioning did not have an advantage over myeloablative conditioning in decreasing the incidence of TMA after HSCT. Our results also showed that high-dose Bu (16 mg/kg) for the conditioning and FK506 for the prophylaxis of GVHD might contribute more significantly to TMA onset after HSCT than other agents.
- Published
- 2006
29. T-lymphocyte subset analysis using the automated hematology analyser CELL-DYN 4000 for patients with hematological disorders
- Author
-
Masayuki Hino, Takahisa Yamane, Kiyoyuki Hagihara, Taro Hasegawa, and Hirohisa Nakamae
- Subjects
Subset Analysis ,Hematological disorders ,CD4-Positive T-Lymphocytes ,Cancer Research ,medicine.medical_specialty ,Pathology ,Analyser ,Human immunodeficiency virus (HIV) ,Biology ,CD8-Positive T-Lymphocytes ,medicine.disease_cause ,Sensitivity and Specificity ,T-Lymphocyte Subsets ,Internal medicine ,medicine ,Humans ,Lymphocyte Count ,Hematology ,Hematologic Tests ,business.industry ,T lymphocyte ,Equipment Design ,Flow Cytometry ,Hematologic Diseases ,Oncology ,Nuclear medicine ,business ,Automated method - Abstract
We evaluated the performance of a fully-automated hematology analyser CELL-DYN 4000 (CD4000; Abbott Laboratories, CA, USA) for T-lymphocyte subset analysis using the samples from 58 patients with hematological disorders. A flow cytometer (CytoronAbsolute; Ortho Diagnostics, NJ, USA) was used for comparison. Good correlations were shown between CD4000 and CytoronAbsolute for the of CD3(+), CD4(+), and CD8(+) T-lymphocyte counts (for each of correlations, r = 0.992, 0.992, and 0.969, respectively). This good correlation was sustained even in 24 cases in which the CD4(+) T-lymphocyte counts were less than 200/microl. In this group the correlation coefficients (r-values) for the comparisons between CD3(+), CD4(+), and CD8(+) T-lymphocytes measured by CD4000 and CytoronAbsolute were 0.991, 0.976, and 0.990, respectively. The CD4000 T-lymphocyte assay is a completely automated method, and does not require opening of the sample tube, which reduces exposure to any biohazards such as HIV. Furthermore, the method is rapid and requires only 7 min for completion of the analysis.
- Published
- 2006
30. Effective cw frequency tripling of cooling laser for magnesium ions
- Author
-
T. Shimizu and Taro Hasegawa
- Subjects
Distributed feedback laser ,Materials science ,Resolved sideband cooling ,Magnesium ,business.industry ,Physics::Optics ,Second-harmonic generation ,chemistry.chemical_element ,Laser ,law.invention ,Wavelength ,Optics ,chemistry ,law ,Laser cooling ,Physics::Atomic Physics ,business ,Magnesium ion - Abstract
Frequency tripling of cw 840 nm laser is obtained for laser cooling of magnesium ions. This beam at 280 nm is expected to improve the long-term and short-term stability of optical frequency standard by laser-cooled ions. Our frequency conversion system is essentially applicable to other wavelength.
- Published
- 2003
31. Excretion of granulocyte colony-stimulating factor into human breast milk
- Author
-
Yasutaka Aoyama, Hisako Shibata, Chikahiko Sakamoto, Hirohisa Nakamae, Genju Koh, Taro Hasegawa, Takahisa Yamane, Yoshiki Terada, and Masayuki Hino
- Subjects
Adult ,medicine.medical_specialty ,medicine.medical_treatment ,Enzyme-Linked Immunosorbent Assay ,Breast milk ,Lenograstim ,Excretion ,Internal medicine ,Granulocyte Colony-Stimulating Factor ,medicine ,Humans ,Human breast milk ,Hematology ,Milk, Human ,business.industry ,Siblings ,General Medicine ,Elisa assay ,Recombinant Proteins ,Granulocyte colony-stimulating factor ,Leukemia, Myeloid, Acute ,Cytokine ,Immunology ,Female ,business ,Stem Cell Transplantation - Published
- 2003
32. Renal metastasis of thyroid carcinoma
- Author
-
Shoichi Onodera, Taro Hasegawa, Masafumi Suzuki, Yukihiko Oishi, and Kazuhiro Abe
- Subjects
Oncology ,Adult ,Male ,medicine.medical_specialty ,Urology ,medicine.medical_treatment ,Metastasis ,Thyroid carcinoma ,Renal cell carcinoma ,Internal medicine ,medicine ,Carcinoma ,Humans ,Thyroid Neoplasms ,Kidney ,business.industry ,Ultrasound ,medicine.disease ,Renal metastasis ,Nephrectomy ,Carcinoma, Papillary ,Kidney Neoplasms ,medicine.anatomical_structure ,Radiology ,business ,Tomography, X-Ray Computed - Abstract
We report here the sixth known case of metastatic renal tumor of thyroid carcinoma. In 1999, a 37-year-old man was referred to us with a left renal mass found incidentally by ultrasound during an annual check-up. Computed tomography (CT) revealed a well-defined, hyperdense mass 3 cm in diameter in the middle of the left kidney. Left radical nephrectomy was performed under the preoperative diagnosis of renal cell carcinoma. Histologically, the tumor was metastatic of typical papillary thyroid carcinoma.
- Published
- 2003
33. Theoretical analysis of mid-infrared molecular spectral line profiles with transversal relaxation in an intense optical field
- Author
-
Taro Hasegawa
- Subjects
Physics ,Absorption spectroscopy ,business.industry ,Relaxation (NMR) ,Statistical and Nonlinear Physics ,Optical field ,Atomic and Molecular Physics, and Optics ,Spectral line ,Laser linewidth ,Optics ,business ,Absorption (electromagnetic radiation) ,Spectroscopy ,Astrophysics::Galaxy Astrophysics ,Beam (structure) - Abstract
Nonlinear effects by intense optical field on mid-infrared spectral lines (∼3 μm) are discussed. Recent development of intense mid-infrared coherent radiation makes nonlinear mid-infrared spectroscopy possible. In the mid-infrared region, the transversal relaxation process is important compared to the visible or near-infrared region. In the analysis, a two-energy-state system is discussed. The intense pump beam scattering spectral lines (Mollow triplet) and the absorption spectral lines of the probe beam with the intense pump beam are calculated.
- Published
- 2014
34. Squamous cell carcinoma of the renal pelvis with inferior vena caval extension
- Author
-
Hiroshi Kiyota, Yasumasa Yoshino, Takahiro Kimura, Kenta Miki, Yukihiko Ohishi, Koji Asano, Jun Madarame, Taro Hasegawa, and Kazuhiro Abe
- Subjects
Male ,medicine.medical_specialty ,Percutaneous ,Urology ,medicine.medical_treatment ,Vena Cava, Inferior ,Inferior vena cava ,Fatal Outcome ,Antineoplastic Combined Chemotherapy Protocols ,medicine ,Carcinoma ,Humans ,Kidney Pelvis ,cardiovascular diseases ,Venous Thrombosis ,Chemotherapy ,medicine.diagnostic_test ,business.industry ,Combination chemotherapy ,Middle Aged ,medicine.disease ,Extracorporeal shock wave lithotripsy ,Kidney Neoplasms ,Surgery ,Radiography ,medicine.anatomical_structure ,medicine.vein ,cardiovascular system ,Carcinoma, Squamous Cell ,Renal biopsy ,Radiology ,business ,Renal pelvis - Abstract
Background: We report here on a third case of squamous cell carcinoma (SCC) of the renal pelvis extending to the inferior vena cava. Methods/Results: A 48-year-old man was diagnosed with an advanced left renal pelvic tumor on computed tomography. He had undergone extracorporeal shock wave lithotripsy for left staghorn calculi 10 years ago. An inferior vena cavagram showed tumor thrombus extending to the inferior vena cava. Percutaneous left renal biopsy revealed SCC. The patient received three courses of combination chemotherapy with cisplatin, bleomycin and etoposide. However, 1 month after the last course of chemotherapy, he died of cancer progress. Conclusion: This is the third case of SCC of the renal pelvis extending to the inferior vena cava in the world.
- Published
- 2000
35. 605 Axisymmetrical Stress Analysis of Epoxy-Steel Laminated Circular Plates under Static Bending Moments
- Author
-
Taro Hasegawa and Toshiyuki Sawa
- Subjects
Stress (mechanics) ,Materials science ,Static bending ,business.industry ,visual_art ,visual_art.visual_art_medium ,Epoxy ,Structural engineering ,business - Published
- 2007
36. [Treatment of hepatosplenic candidiasis with liposomal amphotericin B in a patient with acute leukemia; a case report of the experience of use of liposomal amphotericin B]
- Author
-
Motofumi Hiyoshi, Chikahiko Sakamoto, Taro Hasegawa, Noriyuki Tatsumi, Kensuke Ohta, Yasutaka Aoyama, Masayuki Hino, and Takahisa Yamane
- Subjects
Adult ,Male ,medicine.medical_specialty ,Antifungal Agents ,Itraconazole ,Liver Abscess ,Gastroenterology ,Internal medicine ,Amphotericin B ,Medicine ,Humans ,Splenic Diseases ,Acute leukemia ,business.industry ,Clinical course ,Candidiasis ,General Medicine ,bacterial infections and mycoses ,Leukemia, Myeloid, Acute ,Male patient ,Liposomes ,Myelocytic leukemia ,Liposomal amphotericin ,business ,medicine.drug - Abstract
We report a 26-year-old male patient with acute myelocytic leukemia and hepatosplenic candidiasis during his clinical course. His hepatosplenic candidiasis was refractoty to itraconazole and fluconazol. He developed serious side-effect such as renal dysfunction, when conventional amphotericin B was given. Then he was treated with liposomal amphotericin B (Abelcet). This therapy was safe and effective for him. He was able to be treated with 3075 mg of a liposomal amphotericin B. This was ten times as much as the dose of conventional amphotericin B which was given earlier until amphotericin B was stopped because of renal dysfunction. Liposomal amphotericin B seems to be a safe and effective therapy for systemic fungal infectin and should be considered more in Japan.
- Published
- 1998
37. Laser frequency locking by dispersive response of atoms in transversal magnetic field
- Author
-
Taro Hasegawa and Mitsuyasu Deguchi
- Subjects
Distributed feedback laser ,Materials science ,Laser diode ,business.industry ,Physics::Optics ,Statistical and Nonlinear Physics ,Grating ,Dichroic glass ,Laser ,Atomic and Molecular Physics, and Optics ,law.invention ,Laser linewidth ,Optics ,law ,Dispersion (optics) ,Physics::Atomic Physics ,Laser power scaling ,business - Abstract
A robust laser-frequency-locking scheme to atomic transitions is proposed and demonstrated. In this scheme, dispersion of the Zeeman-shifted atoms instead of absorption in the dichroic atomic vapor laser lock (DAVLL) [Appl. Opt.37, 3295 (1998)] is measured and used as an error signal for stabilization feedback. The error signal of the proposed scheme can provide a wide locking range. Experimental demonstration with the transition between 5d 2D3/2 and 6p 2P1/2 of Ba+ is carried out for a grating feedback external-cavity laser diode at 650 nm.
- Published
- 2009
38. Significant and Morbid Changes in Heart Rate Variability Precedes and Complicates Symptomatic Hypotension in Peripheral Blood Stem Cell Apheresis
- Author
-
Takahiko Nakane, Hirohisa Nakamae, Kiyoyuki Hagihara, Taro Hasegawa, Kensuke Ohta, Yasunobu Takeoka, Yoshiki Terada, Masayuki Hino, Takahisa Yamane, and Mika Akahori
- Subjects
medicine.medical_specialty ,Diabetic neuropathy ,business.industry ,Immunology ,Hypertrophic cardiomyopathy ,Cell Biology ,Hematology ,medicine.disease ,Biochemistry ,Sudden death ,Surgery ,Transplantation ,Obstructive sleep apnea ,Heart failure ,Internal medicine ,medicine ,Cardiology ,Heart rate variability ,Myocardial infarction ,business - Abstract
Peripheral blood stem cell harvest (PBSCH) has been widely performed for rescue following high-dose chemotherapy or as an alternative to BMT for allogeneic stem cell transplantation. However, severe complications, which caused sudden death, were reported in PBSCH from healthy donors. Recent cumulative evidence shows that decrease in cardiovascular signal variability of the R-R period (heart rate variability, HRV) is strongly associated with sudden death and/or cardiac event after a myocardial infarction. Furthermore, usefulness of HRV as a clinical tool has been explored in numerous conditions such as hypertrophic cardiomyopathy, obstructive sleep apnea, diabetic neuropathy, and various neurological alterations. Two types, time domain and frequency domain, are included in HRV analysis. In this study, we investigated HRV during and after apheresis for PBSCH in 23 cases [8 autologous transplant patients, 15 allogeneic transplant donors; 8 men, 15 women; median age 47 years (27–55)]. Date from 24-hour ambulatory ECG recordings were analyzed with R-R data analysis software (MemCalc/CHIRAM version 1, Suwatrust, Tokyo, Japan). Acknowledged simple markers in time domain analysis are the standard deviation of all normal beats (SDNN) and the square root of the mean of the sum of squared differences between adjacent normal-to-normal intervals (r-MSSD). On the other hand, markers in frequency domain analysis include LH, low frequency power (0.04–0.15Hz); HF, high frequency power (0.15–0.4 Hz); LH/HF ratio; VLF, very low frequency power (0.003–0.04 Hz); and ULF, ultra low frequency power (
- Published
- 2004
39. Design of Two-layered Thin Absorber Using Dielectrics
- Author
-
Kazuo Kikuchi, Taro Hasegawa, and Masaru Chino
- Subjects
Materials science ,business.industry ,General Engineering ,Optoelectronics ,Dielectric ,business - Abstract
薄層電波吸収体を実現するために, 誘電体を利用する方法が考えられる.本文は厚さに対する完全整合波長 (2πl/λ0) と複素誘電率の関係を求め, 単層構造で整合し得ない材料に対しては, 2層目をtanδe補正することによって整合を得る方法を考察している.このtanδe補正とは, tanδeが適正値より小さい材料に対しては抵抗皮膜を, 適正値より大きい材料においては無損失誘電体と組み合わせて整合を得るものである.
- Published
- 1977
40. Polarization-Reflection Type Light Modulator Using Ferro Electrics
- Author
-
Heihachi Sato and Taro Hasegawa
- Subjects
Brewster's angle ,Materials science ,business.industry ,Cross-phase modulation ,General Engineering ,Physics::Optics ,Electro-optic modulator ,Optical polarization ,Condensed Matter Physics ,Polarization (waves) ,Laser ,Ferroelectricity ,Electronic, Optical and Magnetic Materials ,law.invention ,symbols.namesake ,Optics ,Optical modulator ,Modulation ,law ,symbols ,Optoelectronics ,business ,Refractive index - Abstract
A polarization-reflection type of light modulator is proposed to utilize the deviation of reflectance of polarized light incident on an electro-optical medium at an angle greater than the Brewster angle. Feasibility of this method is theoretically investigated for the cases of real as well as complex refractive index. From numerical calculations it is shown that the intensity of light changes linearly with applied voltage under a certain condition, and that this method is applicable to such a ferroelectric materials as BaTiO,, SBN and other crystals. The modulation of He-Ne laser or Arf laser is demonstrated experimentally at radio frequencies using a BaTiO, crystal. The merits of this type of light modulator are discussed and compared with crossed-polarizer tyoe of light modulator.
- Published
- 1972
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.