1. Metabolic syndrome is associated with a poor outcome in patients affected by outflow tract premature ventricular contractions treated by catheter ablation
- Author
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Sardu, Celestino, Carreras, Giovanni, Katsanos, Spyridon, Kamperidis, Vasileios, Pace, Maria Caterina, Passavanti, Maria Beatrice, Fava, Ilaria, Paolisso, Pasquale, Pieretti, Gorizio, Nicoletti, Giovanni Francesco, Paolisso, Giuseppe Marfella, Raffaele, SANTULLI, GAETANO, Sardu, Celestino, Carreras, Giovanni, Katsanos, Spyridon, Kamperidis, Vasileio, Pace, Maria Caterina, Passavanti, Maria Beatrice, Fava, Ilaria, Paolisso, Pasquale, Pieretti, Gorizio, Nicoletti, Giovanni Francesco, Santulli, Gaetano, Paolisso, Giuseppe, Marfella, Raffaele, Sardu, C, Carreras, G, Katsanos, S, Kamperidis, V, Pace, Mc, Passavanti, Mb, Fava, I, Paolisso, P, Pieretti, G, Nicoletti, Gf, Santulli, G, Paolisso, G, and Marfella, R.
- Subjects
medicine.medical_specialty ,Heart disease ,medicine.medical_treatment ,Biophysics ,Catheter ablation ,Recurrence ,Internal medicine ,medicine ,Humans ,Ventricular outflow tract ,Prospective Studies ,cardiovascular diseases ,Prospective cohort study ,Angiology ,Metabolic Syndrome ,business.industry ,Proportional hazards model ,Metabolic Syndrome X ,medicine.disease ,Ventricular Premature Complexes ,Ventricular Premature Complexe ,Cardiac surgery ,Prospective Studie ,Treatment Outcome ,Catheter Ablation ,cardiovascular system ,Cardiology ,Medicine ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Research Article ,Human - Abstract
Background The purpose of this study was to investigate the impact of metabolic syndrome (MS) on outcome of catheter ablation (CA) for treatment of frequent premature ventricular contraction beats (PVCs) originating from right ventricular outflow tract (RVOT), left ventricular outflow tract (LVOT) or coronary cusps (CUSPs), in patients with normal ventricular systolic function and absence of cardiac structural disease. Methods In this multicentre prospective study we evaluated 90 patients with frequent PVCs originating from RVOT (n = 68), LVOT (n = 19) or CUSPs (n = 3), treated with CA. According to baseline diagnosis they were divided in patients with MS (n = 24) or without MS (n = 66). The study endpoint was a composite of recurrence of acute or delayed outflow tract ventricular arrhythmia: acute spontaneous or inducible outflow tract ventricular arrhythmia recurrence or recurrence of outflow tract PVCs in holter monitoring at follow up. Results Patients with MS compared to patients without MS showed a higher acute post-procedural recurrence of outflow tract PVCs (n = 8, 66.6%, vs. n = 6, 9.0%, p = 0.005). At a mean follow up of 35 (17-43) months survival free of recurrence of outflow tract PVCs was lower in patients with baseline MS compared to patients without MS diagnosis (log-rank test, p
- Published
- 2014