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Effects of Alpha Lipoic Acid on Multiple Cytokines and Biomarkers and Recurrence of Atrial Fibrillation Within 1 Year of Catheter Ablation
- Source :
- The American journal of cardiology. 119(9)
- Publication Year :
- 2016
-
Abstract
- Catheter ablation (CA) is a procedure commonly used to restore sinus rhythm in patients with atrial fibrillation (AF). However, AF recurrence after CA remains a relevant clinical issue. We tested the effects of an oral anti-oxidant treatment (α-lipoic acid, ALA) on AF recurrence post-CA. Patients with paroxysmal AF have been enrolled in a randomized, prospective, double blind, controlled placebo trial. Following CA, patients have been randomly assigned to receive ALA oral supplementation (ALA group) or placebo (control group), and evaluated at baseline and after a 12-month follow-up: 73 patients completed the 12-month follow-up (ALA: 33; control: 40). No significant difference has been detected between the two groups at baseline. Strikingly, one year after CA, ALA therapy significantly reduced serum markers of inflammation. However, there was no significant difference in AF recurrence events at follow-up when comparing ALA to placebo group. Multivariate analysis revealed that the only independent prognostic risk factor for AF recurrence post-CA is age. In conclusion, ALA therapy reduces serum levels of common markers of inflammation in ablated patients. Nevertheless, ALA does not prevent AF recurrence after an ablative treatment.
- Subjects :
- Blood Glucose
Male
medicine.medical_treatment
030204 cardiovascular system & hematology
Triglyceride
Gastroenterology
Antioxidants
law.invention
chemistry.chemical_compound
0302 clinical medicine
Peptide Fragment
Randomized controlled trial
law
Recurrence
Atrial Fibrillation
Natriuretic Peptide, Brain
Natriuretic peptide
Medicine
Sinus rhythm
Thioctic Acid
Atrial fibrillation
Middle Aged
Interleukin-10
C-Reactive Protein
Treatment Outcome
030220 oncology & carcinogenesis
Anesthesia
Cardiology
Catheter Ablation
Cytokines
Female
Antioxidant
Cardiology and Cardiovascular Medicine
Human
medicine.medical_specialty
medicine.drug_class
Catheter ablation
Placebo
Article
03 medical and health sciences
Double-Blind Method
Internal medicine
Peroxynitrous Acid
Humans
Risk factor
Cytokine
Triglycerides
Aged
Postoperative Care
Cholesterol
business.industry
Interleukin-6
Tumor Necrosis Factor-alpha
Cholesterol, HDL
Interleukin-8
Biomarker
Cholesterol, LDL
medicine.disease
Peptide Fragments
chemistry
Tyrosine
business
Biomarkers
Subjects
Details
- ISSN :
- 18791913
- Volume :
- 119
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- The American journal of cardiology
- Accession number :
- edsair.doi.dedup.....15e6c2d2f06344a7d36362c51d2c2fb1