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BACKGROUND AND PURPOSE The rate at which the chance of a good outcome of endovascular stroke therapy (EVT) decays with time when eligible patients are selected by baseline diffusion-weighted magnetic resonance imaging (DWI-MRI) and whether ischaemic core size affects this rate remain to be investigated. METHODS This study analyses a prospective multicentre registry of stroke patients treated with EVT based on pretreatment DWI-MRI that was categorized into three groups: small [Diffusion-Weighted Imaging Alberta Stroke Program Early Computed Tomography Score (DWI-ASPECTS)] (8-10), moderate (5-7) and large (

This paper proposes a compact high-voltage pulse electron gun power supply (EGPS) consisted of interleaved capacitor-charging power supply (CCPS) with a series-resonant converter (SRC) to drive the electron tube. Requirement specifications are −40 kV, −7 A (280 kW), and continuous output lower than ±1% ripple stability lasted few seconds with

Background Robot-assisted gastrectomy (RAG) has been developed in the hope of improving surgical quality and overcoming the limitations of conventional laparoscopically assisted gastrectomy (LAG) and open gastrectomy (OG) for gastric cancer. The aim of this study was to determine the extent of evidence in support of these ideals. Methods A systematic review of the three operation types (RAG, LAG and OG) was carried out to evaluate short-term outcomes including duration of operation, retrieved lymph nodes, estimated blood loss, resection margin status, technical postoperative complications and hospital stay. Results Nine non-randomized observational clinical studies involving 7200 patients satisfied the eligibility criteria. RAG was associated with longer operating times than LAG and OG (weighted mean difference 61·99 and 65·73 min respectively; P ≤ 0·001). The number of retrieved lymph nodes and the resection margin length in RAG were comparable with those of LAG and OG. Estimated blood loss was significantly less in RAG than in OG (P = 0·002), but not LAG. Mean hospital stay for RAG was similar to that for LAG (P = 0·14). In contrast, hospital stay was significantly shorter, by a mean of 2·18 days, for RAG compared with OG (P < 0·001). Postoperative complications were similar for all three operative approaches. Conclusion Short-term oncological outcomes of RAG were comparable with those of the other approaches. LAG was a shorter procedure and less expensive than RAG. Future studies involving RAG should focus on minimizing duration of operation and reducing cost.

Objective To determine the diagnostic accuracy of the Xpert® MTB/RIF assay using samples obtained through bronchoscopy in patients with suspected pulmonary tuberculosis (PTB). Design We retrospectively reviewed the records of patients with suspected PTB for whom the Xpert MTB/RIF assay was performed on bronchoscopy specimens. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) for the diagnosis of active PTB were calculated for acid-fast bacilli (AFB) smear microscopy and the Xpert assay using culture of Mycobacterium tuberculosis from sputum or bronchoscopy specimens as a reference standard. Results A total of 132 patients were included in the final analysis. Of these, 38 had culture-confirmed PTB. The sensitivity of the Xpert assay using bronchial washing or bronchoalveolar lavage (BAL) fluid for the diagnosis of PTB was 81.6%, and specificity was 100%. The PPV and NPV were 100% and 92.1%, respectively. The sensitivity and specificity of AFB smear microscopy were respectively 13.2% and 98.8%. Conclusion The Xpert assay on bronchoscopy specimens provided an accurate diagnosis of PTB in patients who had a negative AFB smear or who could not produce sputum.

AimsChildren treated for osteosarcoma around the knee often have a substantial leg-length discrepancy at skeletal maturity. The aim of this study was to investigate the results of staged skeletal reconstruction after a leg lengthening procedure using an external fixator in these patients.Patients and MethodsWe reviewed 11 patients who underwent staged reconstruction with either an arthroplasty (n = 6) or an arthrodesis (n = 5). A control group of 11 patients who had undergone wide excision and concurrent reconstruction with an arthroplasty were matched for gender, location, and size of tumour. We investigated the change in leg-length discrepancy, function as assessed by the Musculoskeletal Tumor Society Scale (MSTS) score and complications.ResultsA mean 5.2 cm (1.7 to 8.9) of lengthening was achieved. The mean MSTS scores significantly improved after staged reconstruction (p = 0.003) but were still worse than those of the control group (p = 0.049). However, the MSTS scores of the arthroplasty subgroup were comparable with those of the controls, although the extensor lag was greater and the range of movement was less. The patient group experienced more complications, but all of these resolved.ConclusionApproximately 5 cm of lengthening and significant functional improvement can be achieved by staged reconstruction and lengthening, without major complications. Although it has limitations, this method of treatment seems to be a satisfactory surgical option for growing children with a significant leg-length discrepancy after excision of an osteosarcoma around the knee. Cite this article: Bone Joint J 2017;99-B:401–8.

We reviewed the outcome of distal chevron metatarsal osteotomy without tendon transfer in 19 consecutive patients (19 feet) with a hallux varus deformity following surgery for hallux valgus. All patients underwent distal chevron metatarsal osteotomy with medial displacement and a medial closing wedge osteotomy along with a medial capsular release. The mean hallux valgus angle improved from −11.6° pre-operatively to 4.7° postoperatively, the mean first-second intermetatarsal angle improved from −0.3° to 3.3° and the distal metatarsal articular angle from 9.5° to 2.3° and the first metatarsophalangeal joints became congruent post-operatively in all 19 feet. The mean relative length ratio of the metatarsus decreased from 1.01 to 0.99 and the mean American Orthopaedic Foot and Ankle Society score improved from 77 to 95 points. In two patients the hallux varus recurred. One was symptom-free but the other remained symptomatic after a repeat distal chevron osteotomy. There were no other complications. We consider that distal chevron metatarsal osteotomy with a medial wedge osteotomy and medial capsular release is a useful procedure for the correction of hallux varus after surgery for hallux valgus.

Objectives The use of umbilical cord blood (CB) that is genetically resistant to HIV infection has been proposed as a novel stem cell therapy for the treatment of patients with AIDS. These genetically unique CB units (CBUs) should be present in public CB banks at a predicted frequency. Methods The chemokine (C-C motif) receptor 5 (CCR5) genotypes of CBUs donated to the M. D. Anderson CB Bank by four Houston area hospitals were determined by polymerase chain reaction (PCR) and DNA sequencing. Results The frequency of CCR5Δ32/Δ32 CBUs was consistent with the frequency of the CCR5Δ32 allele in human populations, and was apparently dependent on the ethnic population of the parents of the newborns from whom the CBUs were collected. Conclusions Routine genotyping to identify HIV-resistant CBUs could create a bank of CB-derived stem/progenitor cells with which to treat HIV infection.

Careful internal defect coverage is important for a well vascularised internal base for the transplant in reconstructive nasal surgery. Secondary healing of intranasal wounds often results in nostril contracture and scar stenosis. The choice of methods for surgical coverage depends on the location of the defect and the condition of surrounding elements. For example, the double-stemmed "pot handle" flap is suitable for small defects of the internal lining of the nasal lobule. The septal mucosa flap can be used for larger and more complex defects of the internal nasal lining. Using composite skin and cartilage grafts from the ear, three-layered nasal defects can be treated in a variety of ways. The turn-in flap is a tilt flap and is very versatile for the treatment of inner defects of the lower nasal half.

Capecitabine, a prodrug of 5-FU, has been reported to generate maximal tumour activity at tumour sites and/or to improve drug tolerability as compared with 5-FU infusion, and it has also been demonstrated to act synergistically with irinotecan against some solid cancers. A previous study concluded that dose-intensified biweekly capecitabine seems to be more effective at increasing both response rate and progression-free survival time than conventional dose and schedule of capecitabine in colon cancer. We conducted this study to ascertain the efficacy and toxicity of dose-intensified biweekly capecitabine and irinotecan combination chemotherapy in chemotherapy-naïve advanced or metastatic gastric cancer patients. Patients were treated with irinotecan 130 mg m(-2) intravenously for 90 min on days 1 and 15. Capecitabine at 3500 mg m(-2) day(-1), divided into two sessions per day, was administered for seven consecutive days from days 1 and 15, and followed by a 7-day drug-free period, respectively. Fifty-five eligible patients were enrolled in this study from November 2003 to April 2006. There were 22 women and 33 men: median patient age was 54 years (range: 27-81). A total of 200 treatment cycles were administered at a median number of four per patient (range: 1-9). Intent-to-treatment analysis showed that one patient achieved complete response (1.8%), 23 partial response (41.8%), 15 stable disease (27.3%), 10 progressive disease (18.2%) and 6 were non-evaluable (10.9%). The overall response rate was 43.6% (95% confidence interval: 30.2-56.9). The common grade 3-4 toxicities were neutropenia in 12 (21.8%), nausea/vomiting in 3 (5.4%) and diarrhea in 4 (7.2%) patients. Median time to progression was 5 months (range: 0.5-11 months), median survival duration was 11 months (range: 0.5-45 months) and median response duration was 6 months (range: 0.5-9 months). Biweekly dose-intensified capecitabine and irinotecan combination chemotherapy was active for the treatment of advanced or metastatic gastric cancers with a tolerable safety profile.

Whether indoor painting aggravates preexisting allergic diseases remains unclear. We aimed to evaluate the impact of new classroom painting on aggravation of asthma, allergic rhinitis (AR), and atopic dermatitis (AD) in children. Studied school was previously painted with conventional water-based paint 20 years ago and had natural ventilation system. We identified a total of 172 children aged 10-12 years with allergic diseases in 17 classrooms, which were allocated to newly painted rooms with low-volatile organic compounds (VOC), water-based paint, or existing rooms. After painting, there was no intervention or internal airflow to influence indoor air environment in both classrooms. We prospectively assessed the symptom severity and serious events of allergic diseases between both classrooms at baseline and after one and eight weeks after painting. At one and eight weeks, there were no significant changes in the Childhood Asthma Control Test scores, the fractional nitric oxide levels, lung function in asthmatic children in either classroom. There were also no significant changes in the severity score of AR or AD, or serious events in all allergic diseases. These findings suggest classroom painting with this new paint at the levels encountered in this study might not be a major aggravating factor for school-aged children with allergic diseases.

This study deals with the cold forging process design for shaft in the main part of automobile motors with rectangular deep groove. In forging process, the accuracy and die lift is very important because it have influence on reduction of the production cost and the increase of the production rate. Therefore, it is necessary to develop the manufacturing process of shaft by cold forging., process variables are the cropped face angle of billet and the eccentric load of punch. The former is derived from cropping test, the latter is occurred by clearance between container and preform. Also, grooved preform select the process variable for decrease in punch deflection. We investigate that a deflection of punch and a deformation of preform to every process variables. Through this investigation, we suggest the optimal preform and process design, expect to be improved the tool life in forging process.

The Pohang Accelerator Laboratory (PAL) had started the 10 GeV PAL-XFEL project from 2011. The PAL-XFEL needs a highly stable electron beam. The very stable beam voltage of a klystron- modulator is essential to provide the stable acceleration field for an electron beam. Thus, the modulator system for the XFEL requires less than 50 ppm PFN voltage stability. To get this high stability on the modulator system, the inverter type HVPS is a pivot component. And the modulator needs lower noise and smart. We discuss the measurement of the stability and the test results of the pulse modulator system.

In this paper, we present the results of an experimental study focused on understanding the strain concentrations arising due to nonlinear phenomena associated with polarization switching. A moire interferometry technique is used to measure the normal and shear strains of a PZT-5H piezoceramic undergoing 180 and 90 deg switching. These results include the strain concentrations measured between polarized regions oriented 180 and 90 deg apart. The results show that very large strain mismatches (e.g., as large as 4500 microstrains) occur along the boundary of dissimilar oriented domains, suggesting a source of microcrack initiation and fatigue degradation.

Mechanical circulatory support emerged for the pediatric population in the late 1980s as a bridge to cardiac transplantation. The Total Artificial Heart (TAH-t) (SynCardia Systems Inc., Tuscon, AZ) has been approved for compassionate use by the Food and Drug Administration for patients with end-stage biventricular heart failure as a bridge to heart transplantation since 1985 and has had FDA approval since 2004. However, of the 1,061 patients placed on the TAH-t, only 21 (2%) were under the age 18. SynCardia Systems, Inc. recommends a minimum patient body surface area (BSA) of 1.7 m2, thus, limiting pediatric application of this device. This unique case report shares this pediatric institution’s first experience with the TAH-t. A 14-year-old male was admitted with dilated cardiomyopathy and severe biventricular heart failure. The patient rapidly decompensated, requiring extracorporeal life support. An echocardiogram revealed severe biventricular dysfunction and diffuse clot formation in the left ventricle and outflow tract. The decision was made to transition to biventricular assist device. The biventricular failure and clot formation helped guide the team to the TAH-t, in spite of a BSA (1.5 m2) below the recommendation of 1.7m2. A computed tomography (CT) scan of the thorax, in conjunction with a novel three-dimensional (3D) modeling system and team, assisted in determining appropriate fit. Chest CT and 3D modeling following implantation were utilized to determine all major vascular structures were unobstructed and the bronchi were open. The virtual 3D model confirmed appropriate device fit with no evidence of compression to the left pulmonary veins. The postoperative course was complicated by a left lung opacification. The left lung anomalies proved to be atelectasis and improved with aggressive recruitment maneuvers. The patient was supported for 11 days prior to transplantation. Chest CT and 3D modeling were crucial in assessing whether the device would fit, as well as postoperative complications in this smaller pediatric patient.

The Fontan procedure represents the final stage of the transition to single ventricle physiology. Conversion of very complex congenital heart anatomy, such as hypoplastic left heart syndrome, double-outlet right ventricle or double-inlet left ventricle, to a single ventricle has grown in popularity as morbidity and mortality have improved. As these patients grow, survivors are at risk for impaired ventricular dysfunction, plastic bronchitis, protein-losing enteropathy and late failure. Late failing Fontan patients represent a particularly vexing scenario for clinicians, as the only durable treatment option is cardiac transplantation. However, in the short-term, some of these patients require support beyond medical management, with mechanical circulatory support via extracorporeal life support or a ventricular assist device. We report the successful bridge of an adolescent female post-Fontan conversion with late severe cardiac failure. The patient was initially resuscitated with extracorporeal life support, transitioned to a single Berlin Heart EXCOR® ventricular assist device and, subsequently, underwent successful cardiac transplantation.

SETTING A central hospital laboratory in South Korea. OBJECTIVE To evaluate the usefulness of the Xpert® MTB/RIF assay in a country with an intermediate tuberculosis burden. DESIGN A total of 71 real-time polymerase chain reaction-positive sputum sediments were tested within 24 h by the Xpert MTB/RIF assay. Mycobacterium tuberculosis detection was compared with smear microscopy and culture. Rifampicin (RMP) resistance was compared with a culture-based method and rpoB gene sequencing. We also assessed the limit of detection for mutant proportions and time savings in diagnosis. RESULTS The Xpert MTB/RIF assay detected M. tuberculosis in 71 (100%) specimens (32 smear-positive, 39 smear-negative). This assay showed 100% (62/62) concordance with drug resistance confirmed by culture and 98.4% (61/62) concordance with sequencing. A specimen containing approximately 50% of mutant p.His526Tyr was falsely interpreted as wild-type bacilli by this assay. The minimal detection ratio was 5:1 of mutant vs. wild-type cells. The median time saved was 18.5 days (range 9-30) for the diagnosis of M. tuberculosis and 81.5 days (65-136) for RMP susceptibility in smear-negative, culture-positive patients. CONCLUSIONS The Xpert MTB/RIF assay showed high sensitivity in detecting M. tuberculosis with information on RMP resistance, and had a more rapid time to diagnosis compared to conventional tests; however, the location and amount of mutation may affect test sensitivity.

From 2011, the Pohang Accelerator Laboratory (PAL) had started the 10 GeV PAL-XFEL project. The PAL-XFEL needs a highly stable electron beam. The very stable beam voltage of a klystron- modulator is essential to provide the stable acceleration field for an electron beam[1]. Thus, the modulator system for the XFEL requires less than 50 ppm PFN voltage stability. To get this high stability on the modulator system, the inverter type HVPS is a pivot component. The requested specification of the inverter power supply is being developed the 50 kV, 5 kJ/sec 1 sets and 30 kJ/sec 4 sets at the PAL. In this paper, we will discuss the development and the test results of the inverter power supply for pulse modulator system for obtaining machine stability.

High-quality free-standing GaN was obtained by hydride vapor-phase epitaxy (HVPE) growth and the subsequent removal of the sapphire substrates. In the photoluminescence (PL) spectra of the as-grown HVPE-GaN, we observed a strong phonon replica peak for temperatures higher than 80 K. Both the near-band-edge emission and the yellow emission in the cathodoluminescence spectra were inhomogeneous, and correlated with the crystalline structure. With the homoepitaxial regrowth by metal–organic chemical-vapor deposition (MOCVD) in the GaN substrates, these unusual optical properties were no longer observed and the PL peak became sharper than GaN grown by MOCVD on sapphire substrates, indicating that the free-standing GaN is suitable as substrates for the growth of device structures.

Ring rolling process is usually used to fabricate large‐sized ring, such as, tower flange for wind power electric generator. Many kinds of seamless ring are used in wind power electric generator and manufactured by ring rolling process. In general, final part is machined after forming with shape of plain square section. Since interests for near net shaping of seamless ring have been increased gradually because of green energy, it is necessary to develop the technology for shape ring rolling with respect to the market demands and cost. Therefore, we studied the process and die design for shape ring rolling of large sized ring over 3,500 mm out diameter by experiment and FEM simulation. Ring rolling process is very difficult to solve by FEM method because of equilibrium state and size effect, etc. Moreover, shape ring rolling is more difficult to solve the problem that two plastic deformation zones are different each other, that is main roll and conical roll. Also since conical roll has a shape, deformation velocity field is very much complex and the deformed section passed axial roll is different section and velocity field. The FE simulations are performed to analyze process variables affected in forming of profiled ring. Therefore, the main features of used FE model are: (1) it adopts a transient or unsteady state full ring mesh to model the deformation processes and shape development; (2) the mandrel and conical rolls are modeled using coupled heat‐transfer elements; (3) the model involves the full process from blank through perform to final profiled ring. From these calculated results, we have proposed the mechanisms of various tools, such as mandrel and conical roll. The calculated results are compared experimental results. Calculated results can predict the tilting of profiled ring and then process variables to form large sized ring.

We reviewed the results of a selective à la carte soft-tissue release operation for recurrent or residual deformity after initial conservative treatment for idiopathic clubfoot by the Ponseti method. Recurrent or residual deformity occurred in 13 (19 feet) of 33 patients (48 feet; 40%). The mean age at surgery was 2.3 years (1.3 to 4) and the mean follow-up was 3.6 years (2 to 5.3). The mean Pirani score had improved from 2.8 to 1.1 points, and the clinical and radiological results were satisfactory in all patients. However, six of the 13 patients (9 of 19 feet) had required further surgery in the form of tibial derotation osteotomy, split anterior tibialis tendon transfer, split posterior tibialis transfer or a combination of these for recurrent deformity. We concluded that selective soft-tissue release can provide satisfactory early results after failure of initial treatment of clubfoot by the Ponseti method, but long-term follow-up to skeletal maturity will be necessary.

We designed a fast capacitive high voltage probe for a Marx generator. Since the capacitive probe works on differential mode, we designed also a fast passive integrator to integrate the signals. We tested the probe's performance by using a simple pulse generator to simulate the Marx generator signals. We calibrated the probe using a calibrated water load which act as a resistive voltage divider. We present and discuss the results of the experiments.

Summary form only given. A high voltage resonant pulser is designed by using an air core transformer. Triple resonant circuit is used to step up the primary voltage. The voltage step-up ratio is designed as about eleven at the charging stage. A distributed PFN is used to form a squre waveform. The output has an overvolted sparkgap switch that transfers energy to a matched resistive load with the PFN. The pulser is positioned in a cylindrical transformer oil tank. The height and diameter of the tank are respectively 1.06 m and 1.28 m. A dummy water load will be used to test the pulser. Design procedures and preliminary test results will be presented.

Summary form only given. We designed a compact repetitive Marx generator. The Marx generator contains 25 stages consisted with capactor banks and spark gap switches. We used door knob ceramic capacitors. The capacitors are charged through inductors by a capacitor charging power supply. The length and the diameter of the Marx generator are about 150 cm and 60 cm, respectively. We conducted a preliminary test at the condiction of low charging voltage using helium gas. We present the characteristic of the Marx generator and discuss the design issues such as the insulation of a high voltage feedthrough.

The Onsan copper smelter of LG Metals Corporation started operation in 1979 with an installed copper smelting capacity of 80,000 t/y. Utilizing Outokumpu flash-smelting technology, the smelter has expanded capacity since its start-up; in 1997, it is expected that the tonnage of smelted concentrate will be more than twice the original design capacity. Furthermore, a new smelting line based on the Mitsubishi continuous process will be commissioned in early 1998 with a capacity of 160,000 t/y of copper. This article describes the modifications and improvements made to increase the smelting capacity.

In their Comment on our publication [Phys. Rev. B 66, 245317 (2002)], Freitas et al. criticize our identification of donor-bound exciton transitions and the analysis of two-electron satellite emission lines. We show that some arguments given in the Comment are in conflict with our time-resolved and magneto-optical data. We present a discussion of the intradonor transition energies and donor chemical shifts to avoid misunderstanding.

We have developed a synchronously switched cyclic capillary electrophoresis (CE) separator that is fabricated on a silicon substrate and glass containing reservoirs, Au electrode, and isolated channels. The advantage of a cyclic separator is the high resolution and ability to separate each sample to the designated reservoir from mixed samples. This approach makes it possible to reduce the supplied voltage and the total chip size. Another goal of this work is to introduce the methodology of electroosmosis flow (EOF) to silicon substrate and to separate DNA samples using a modified double-T injector.

After 14 years of successful operation, the Pohang Light Source (PLS) has completed PLS-II upgrade to meet the increasing demand from the growing user community. The PLS-II upgrade has increased the beam energy from 2.5 GeV to 3 GeV; the number of insertion devices has been increased by a factor of two (20 IDs); and the beam current has been increased to 400 mA from 200 mA. The beam emittance has been reduced to below 10 nm while retaining the existing PLS tunnel as well as the existing injection system. During the six months of commissioning in the latter half of 2011, we have successfully achieved 14 insertion device operations and top-up operations with 100 mA beam current and 5.8 nm beam emittance. In this paper, we report the experimental results obtained from the PLS-II commissioning.

An iterative type impedance analysis method for an impedance network is presented. The whole impedance network is divided into several sub-networks and each sub-network is analysed in a form of the linear voltage-current relation. The analysed voltage-current relation is iteratively applied to obtain the whole impedance. An illustrated example is given to show that the proposed method is simple and effective to analyse the impedance of a network which has a very large number of impedance elements.

InGaAsP/InGaAsP multiple-quantum-well (MQW) double-channel planar-buried heterostructure (DCPBH) lasers emitting at λ∼ 1.57 μm were fabricated by optimizing the epitaxial growth with material characterization. At 25 °C (85 °C), a 1.8-μm-wide and 300-μm-long antireflectivity/high reflectivity coated laser exhibits a threshold current of 8 mA (23 mA) and a slope efficiency of 0.34 mW/mA (0.24 mW/mA) in continuous-wave mode (cw) as a result of the optimized thickness of the p-InP filling layer in the PBH structure with p-n-p-n current blocking layers. The maximum cw output power was approximately 20 mW at 25 °C, which was reduced to 17 mW at 85 °C. The peak wavelength varied from 1572 nm at 25 °C to 1602 nm at 100 °C for a fixed output power of 5 mW, indicating a temperature coefficient of ∼ 0.4 nm/K. The resonance frequency in the small-signal modulation response of devices depends on the etching depth of the U-shaped double channel; it increases from 0.4 GHz without channel etching to 4.3 GHz with 7-μm-thick etching. The full-width at half maximum values in the horizontal and vertical far-field patterns were approximately 24.5° (25.2°) and 29.4° (30.1°), respectively, at 25 °C (85 °C).

Thyratrons have been used as switching tubes in power conditioning systems, primarily for radar and accelerator applications. Their function are to control power pulses to high-frequency oscillators in high-power radar sets, lasers, and other communications equipment. However, it is difficult to diagnose the switching characteristics of the thyratron. From a convection heat transfer, we have discovered the diagnostic factor of the thyratron, where the variation of the heater current occurs according to the variation of the internal gas pressure. By this diagnostic factor, thyratron ranging and diagnosis are possible. We have verified the theoretical propriety of the diagnostic factor and confirmed that the assumption used in the theory is applicable to the thyratron.

One of the aims of artificial intelligence has been to make machines behave intelligently as humans do. Thus the study of artificial intelligence includes the study of how humans acquire and apply knowledge, reason under uncertainty and in complex environments, and how they do planning and solve problems. Knowledge-based automation deals with the application of artificial intelligence to a production environment in order to reduce the involvement of human beings to a minimum.