1. A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis
- Author
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Christoph Riethmüller, B. van't Land, D.P. Hack, Q.C.J. Hasnoe, Bianca Dontje, Alida Sprikkelman, M.A. Middelkamp‐Hup, W.M.C. van Aalderen, Lies Hulshof, Sanja Kezic, Ivone Jakasa, Whi McLean, Groningen Research Institute for Asthma and COPD (GRIAC), Paediatric Pulmonology, AII - Inflammatory diseases, Coronel Institute of Occupational Health, APH - Personalized Medicine, APH - Societal Participation & Health, General Paediatrics, Dermatology, APH - Quality of Care, CCA - Cancer Treatment and Quality of Life, and APH - Methodology
- Subjects
Male ,Chemokine ,atopic dermatitis, stratum corneum analysis, biomarkers, children, natural moisturizing factor, skin barrier, skin type differences ,Light skin ,Dark skin ,Skin Pigmentation ,Dermatology ,Filaggrin Proteins ,Permeability ,Dermatitis, Atopic ,030207 dermatology & venereal diseases ,03 medical and health sciences ,0302 clinical medicine ,Medicine ,CCL17 ,CXCL10 ,Humans ,Child ,Corneocyte ,biology ,integumentary system ,business.industry ,S100 Proteins ,Infant ,Atopic dermatitis ,medicine.disease ,Case-Control Studies ,Child, Preschool ,Immunology ,Mutation ,biology.protein ,Feasibility Studies ,Female ,Chemokines ,Epidermis ,business ,CCL22 ,Biomarkers - Abstract
Background: Atopic dermatitis (AD) affects children of all skin types. Most research has focused on light skin types. Studies investigating biomarkers in people with AD with dark skin types are lacking. Objectives: To explore skin barrier and immune response biomarkers in stratum corneum (SC) tape strips from children with AD with different skin types. Methods: Tape strips were collected from lesional and nonlesional forearm skin of 53 children with AD and 50 controls. We analysed 28 immunomodulatory mediators, and natural moisturizing factors (NMF) and corneocyte morphology. Results: Interleukin (IL)-1β, IL-18, C-X-C motif chemokine (CXCL) 8 (CXCL8), C-C motif chemokine ligand (CCL) 22 (CCL22), CCL17, CXCL10 and CCL2 were significantly higher (P
- Published
- 2019
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