A minimally invasive tool to study immune response and skin barrier in children with atopic dermatitis

Authors :: Christoph Riethmüller
B. van't Land
D.P. Hack
Q.C.J. Hasnoe
Bianca Dontje
Alida Sprikkelman
M.A. Middelkamp‐Hup
W.M.C. van Aalderen
Lies Hulshof
Sanja Kezic
Ivone Jakasa
Whi McLean
Groningen Research Institute for Asthma and COPD (GRIAC)
Paediatric Pulmonology
AII - Inflammatory diseases
Coronel Institute of Occupational Health
APH - Personalized Medicine
APH - Societal Participation & Health
General Paediatrics
Dermatology
APH - Quality of Care
CCA - Cancer Treatment and Quality of Life
APH - Methodology
Source :: Br J Dermatol, 180(3), 621-630. Wiley, British journal of dermatology, 180(3), 621-630. Wiley-Blackwell
Publication Year :: 2019
Publisher :: Wiley, 2019.
Abstract: Background: Atopic dermatitis (AD) affects children of all skin types. Most research has focused on light skin types. Studies investigating biomarkers in people with AD with dark skin types are lacking. Objectives: To explore skin barrier and immune response biomarkers in stratum corneum (SC) tape strips from children with AD with different skin types. Methods: Tape strips were collected from lesional and nonlesional forearm skin of 53 children with AD and 50 controls. We analysed 28 immunomodulatory mediators, and natural moisturizing factors (NMF) and corneocyte morphology. Results: Interleukin (IL)-1β, IL-18, C-X-C motif chemokine (CXCL) 8 (CXCL8), C-C motif chemokine ligand (CCL) 22 (CCL22), CCL17, CXCL10 and CCL2 were significantly higher (P

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