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667 results on '"PUDDU A."'

1. A contested financial frontier: banking and empire building in Eritrea, c.1952–73

Author

Luca Puddu and Puddu L.

Subjects
Finance, Government, economic history, business.industry, media_common.quotation_subject, Corporate governance, Geography, Planning and Development, Tribute, Eritrea, National bank, Banking, Frontier, Empire-building, Italy, Arts and Humanities (miscellaneous), Anthropology, Political science, Elite, Institution, decolonization, Ethiopia, business, media_common
Abstract

This article provides an account of the relationship between imperial Ethiopia and Eritrea in the realm of banking governance from the start of the federation to the last years of the imperial regime. It looks in particular at the relationship between the Ethiopian administrations and an Italian bank, Banco di Roma, which had its headquarters in Eritrea from 1948 to 1967 before moving to Addis Ababa. The struggle for control of the economic flows generated by the Italian bank is an index of the changes in centre–periphery linkages between Addis Ababa and the sub-regional centre of Asmara. Archival evidence highlights the multifaced nature of Ethiopian governance and the role performed by the Italian institution in providing alternative sources of diplomatic leverage and wealth accumulation to the Eritrean elite. It is argued that the extraterritorial status enjoyed by Banco di Roma until 1967 was actively tolerated by a section of the Ethiopian establishment, which resorted to an established pattern of imperial governance based on flexibility in return for tribute. This centre–periphery arrangement was harshly opposed by prominent Ethiopian officials from the Ministry of Finance and the National Bank of Ethiopia, who struggled to enforce tighter government control over capital flows within and across the country's borders. The National Bank's final success in the quest for financial centralization drained significant resources out of Eritrea, with adverse effects on the preservation of the pax aethiopica in the former Italian colony.

Published
2021

2. Congenital Cardiac Defects, Such as Eustachian Valve, May Increase the Risk of Cryptogenic Stroke: A Case Report

Author

Giampaolo Bianchi, Marco Zoli, Chiara Bandinelli, Anna Balducci, Giovanni M. Puddu, Bandinelli, Chiara, Puddu, Giovanni Maria, Balducci, Anna, Bianchi, Giampaolo, and Zoli, Marco

Subjects
medicine.medical_specialty, business.industry, Eustachian Valve, Cryptogenic Stroke, Patent Foramen Ovale, PFO, Endocarditis, Staphylococcus aureus, Transesophageal Echocardiography, Migraine, medicine.disease, Pathophysiology, Transcranial Doppler, Shunt (medical), Eustachian Valve, Migraine, Internal medicine, otorhinolaryngologic diseases, Patent foramen ovale, medicine, Cardiology, Endocarditis, business, Stroke
Abstract

Eustachian valve is an embryonic endocardial heart structure; after birth it becomes an embryogenic residue and its persistance in adult life is unusual.The literature reports some cases of association between Eustachian valve and PFO and is known that the prominent Eustachian valve can represent a way facilitating systemic embolism. Several studies also investigated the role of Eustachian valve in the pathophysiology of both migraine and cerebral em-bolism.In addiction is known how Eustachian valve may increase the risk of endocarditis, which mostly affects intravenous drug abusers or those withimplanted medical devices or central venous catheters. The most commonly identified organism is Staphylococcus aureus(approximately 53% of cases).We present a case of a 46-year-old woman with known migraine. She was hos-pitalized in Stroke Unit for a cryptogenic stroke with a right-to -left shunt de-tected with transcranial doppler ultrasound with “bubble test” and a patent foramen ovale with right-to-left shunt with a fenestration of atrial septumand a voluminous Eustachian valve detected with transesophageal echocardiogra-phy; she developed fever with a blood cultures positive for methicillin-resis-tant Staphylococcus aureus(MRSA), even if without evidence of endocarditis vegetations. In summary, the objective of our paper is to present an example of a correlation between the persistence of the Eustachian valve with bothcryptogenetic stroke, possible valve infection and migraine

Published
2020

3. Simple versus complex carbohydrates and health: A frequently neglected problem

Author

Paolo Emilio Puddu and Alessandro Menotti

Subjects
Nutrition and Dietetics, business.industry, Endocrinology, Diabetes and Metabolism, Data synthesis, Medicine (miscellaneous), 030209 endocrinology & metabolism, Protective Factors, 030204 cardiovascular system & hematology, Cvd mortality, Bioinformatics, Risk Assessment, Coronary heart disease, 03 medical and health sciences, 0302 clinical medicine, Cardiovascular Diseases, Heart Disease Risk Factors, Terminology as Topic, Dietary Carbohydrates, Humans, Medicine, Cardiology and Cardiovascular Medicine, business, Nutritive Value, Dietary fat, Simple (philosophy)
Abstract

Aims For several decades, there has been a notion that dietary fat is made of different components (at least SAFA, MUFA, and PUFA) that exhibit different and sometimes contrasting effects when associated with health and diseases: coronary heart disease (CHD) and cardiovascular diseases (CVD) in general. A similar fact is not noticed in carbohydrates and their components considering that even some major recent studies on the issue did not segregate simple carbohydrates from complex carbohydrates. In this study, we aimed to stress this need. Data synthesis A small number of selected studies are presented and commented where segregation of simple from complex carbohydrates was either performed or disregarded to address the inconsistency of not disentangling them. Conclusions If only total fats were considered in investigations where fat was studied, the present notion and attitude toward different roles of the various classes of fats, at least SAFA versus unsaturated (MUFA and PUFA) would be missing. Therefore, there is a need to disentangle simple from complex carbohydrates, and this should be systematically applied when addressing CHD or CVD mortality risks and their preventive measures.

Published
2021

4. Lifestyle as determinant of all-cause mortality and age at death. A middle-aged male population followed-up 60 years until the survivors were aged 100 years

Author

Alessandro Menotti, Paolo Emilio Puddu, and Giovina Catasta

Subjects
Male, Aging, Mediterranean diet, media_common.quotation_subject, Population, Diet, Mediterranean, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Humans, Medicine, Survivors, 030212 general & internal medicine, Mortality, education, Exercise, Life Style, Survival analysis, Proportional Hazards Models, media_common, education.field_of_study, business.industry, Proportional hazards model, Mortality rate, Smoking, Hazard ratio, Longevity, Middle Aged, Confidence interval, Geriatrics and Gerontology, business, 030217 neurology & neurosurgery, Demography
Abstract

To relate major lifestyle habits with all-cause mortality in an almost extinct male middle-aged population. A 40–59 aged male population of 1712 subjects was enrolled and examined in 1960 and then followed-up for 60 years. Baseline smoking habits, working physical activity and dietary habits, each subdivided into 3 classes, were related to 60-year mortality, by Kaplan–Meier survival curves, Cox proportional hazards model and to age at death during 60 years by multiple linear regression. Death rate in 60 years was of 99.7% with only 5 survivors and 2 lost to follow-up after 50 years. Two out of three classes of each behavior were significantly protective versus the third class in all the statistical approaches. Cox hazard ratios (and their 95% confidence limits) of never smokers versus smokers was 0.71 (0.63–0.79); that of vigorous physical activity versus sedentary activity was 0.75 (0.64–0.89); that of Mediterranean diet versus Not Mediterranean diet was 0.74 (0.66–0.84). The gain of age at death for never smokers versus smokers was 3.32 years (2.05–4.54); of vigorous physical activity versus sedentary activity was 3.53 years (1.68–5.37); that of Mediterranean diet versus Not Mediterranean diet was 3.67 years (2.32–5.02). Age at death was more than 10 years longer for men with the 3 best behaviors than for those with the 3 worst behaviors. Some lifestyle habits are strongly related to lifetime mortality and longevity.

Published
2021

5. Ischemic Stroke Due to Paradoxical Embolism in a Patient with Patent Foramen Ovale, Bilateral Distal Deep Vein Thrombosis and Platypnea-Orthodeoxia Syndrome: A Case Report

Author

Viola Tallarico, Paola Forti, Silvia Gianstefani, Giovanni M. Puddu, Marco Zoli, and Rossella Loiacono

Subjects
medicine.medical_specialty, business.industry, Heart malformation, medicine.medical_treatment, Deep vein, medicine.disease, Thrombosis, Stenosis, medicine.anatomical_structure, Paradoxical embolism, Respiratory failure, Internal medicine, medicine, Cardiology, Patent foramen ovale, cardiovascular diseases, business, Endarterectomy
Abstract

Patent foramen ovale (PFO) is a common congenital cardiac defect. It is usually asymptomatic, but it can be associated with relevant clinical manifestations such as cryptogenic stroke and platypnea-orthodeoxia syndrome. We present the case of a patient with hemodynamically significant carotid artery stenosis who underwent endarterectomy for a transient ischemic attack (TIA). After surgery, the patient presented an ischemic stroke due to M2 occlusion treated with mechanical thrombectomy. During hospitalization, a distal bilateral deep vein thrombosis was found. The patient developed respiratory failure due to a massive right-to-left shunt through a large PFO (platypnea-orthodeoxia syndrome). These findings are consistent with the hypothesis that the TIA and the subsequential ischemic stroke were related to paradoxical embolism rather than atherothromboembolism. The aim of our case report is to raise awareness of the possible complications of such a common finding as PFO.

Published
2021

6. The QUBIC instrument for CMB polarization measurements

Author

A. Bottani, E. Jules, A. Zullo, Federico Nati, V. Gilles, A. Baù, L. Mousset, Giampaolo Pisano, C. Perbost, C. Oriol, Damien Rambaud, G. Amico, D. Buzi, Emory F. Bunn, M. Tomasi, L. H. Arnaldi, A. Etchegoyen, S. Azzoni, F. Wicek, Marco Bersanelli, Mark McCulloch, Alejandro Almela, Mario Zannoni, M. Perciballi, Peter A. R. Ade, A. Pelosi, Maria Salatino, D. Auguste, S. Scully, M. Gómez Berisso, F. Piacentini, Andrea Tartari, M. Platino, Martin Giard, P. Chanial, Jonathan Aumont, C. Scóccola, M.-A. Bigot-Sazy, Alessandro Paiella, Lucio Piccirillo, C. Kristukat, Federico Pezzotta, Carole Tucker, A. Passerini, Sophie Henrot-Versille, J.-Ch. Hamilton, Nicola Vittorio, M. De Leo, M. Tristram, J. G. Alberro, G. D' Alessandro, L. M. Mundo, Cristian Franceschet, Massimo Gervasi, B. Maffei, L. Grandsire, M. De Petris, K. Ganga, Francesco Cavaliere, S. Marnieros, S. Loucatos, Michel Piat, D. Fracchia, J. Bonaparte, Créidhe O'Sullivan, Laurent Bergé, N. Bleurvacq, A. Mattei, J. Bonis, Gianluca Polenta, L. Mele, J.-P. Bernard, W. Marty, E. Olivieri, H. Pastoriza, Peter Timbie, D. Harari, A. Mennella, D. L. Burke, F. Columbro, Steve Torchinsky, S. Melhuish, Bruce Rafael Mellado Garcia, L.P. Ferreyro, M. Stolpovskiy, Gustavo E. Romero, M. M. Gamboa Lerena, D. T. Hoang, R. Puddu, F. Incardona, D. Bennett, Alessandro Coppolecchia, M. González, S. Spinelli, T. Louis, C. Chapron, P. de Bernardis, P. Ringegni, Marcin Gradziel, François Pajot, A. Fasciszewski, G. Stankowiak, D. Viganò, Luca Lamagna, Alessandro Schillaci, R. Charlassier, L. Dumoulin, J.-P. Thermeau, Andrew May, G. de Gasperis, S. Banfi, Y. Giraud-Heraud, Silvia Masi, J. Kaplan, M. E. García Redondo, J.D. Murphy, B. Bélier, J.M. Salum, S. Dheilly, J. A. Murphy, M. Gaspard, L. A. Montier, Elia S. Battistelli, D. Gayer, F. Voisin, D. Prêle, Gregory S. Tucker, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Centre National de la Recherche Scientifique (CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)-Université Fédérale Toulouse Midi-Pyrénées-Centre National d'Études Spatiales [Toulouse] (CNES)-Météo France-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Institut national des sciences de l'Univers (INSU - CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Spectrométrie Nucléaire et de Spectrométrie de Masse (CSNSM), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Mele, L, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battistelli, E, Ba, A, B lier, B, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppolecchia, A, D'Alessandro, G, Bernardis, P, Gasperis, G, Leo, M, Petris, M, Dheilly, S, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Lerena, M, Ganga, K, Garcia, B, Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Henrot-Versille, S, Hoang, D, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marnieros, S, Marty, W, Masi, S, Mattei, A, May, A, Mcculloch, M, Melhuish, S, Mennella, A, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, O'Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Pr le, D, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Salatino, M, Salum, J, Schillaci, A, Scoccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Torchinsky, S, Tristram, M, Tucker, G, Tucker, C, Vigan, D, Vittorio, N, Voisin, F, Wicek, F, Zannoni, M, and Zullo, A

Subjects
History, [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], interferometer, Cosmic microwave background, Polarimetry, cosmic background radiation: polarization, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, Cosmology, Education, law.invention, qubic, polarimetry, bolometric interferometry, cmb, b modes, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, bolometer, law, 0103 physical sciences, Astronomical interferometer, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, 010303 astronomy & astrophysics, detector: design, ComputingMilieux_MISCELLANEOUS, Physics, polarization, business.industry, Gravitational wave, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Polarization (waves), calibration, polarization: monitoring, Computer Science Applications, Bolometers, Cosmology, Interferometers, Inflation, Cosmic microwave background, Polarization, Interferometry, modulation, business, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], performance
Abstract

Measurements of cosmic microwave background (CMB) polarization may reveal the presence of a background of gravitational waves produced during cosmic inflation, providing thus a test of inflationary models. The Q&U Bolometric Interferometer for Cosmology (QUBIC) is an experiment designed to measure the CMB polarization. It is based on the novel concept of bolometric interferometry, which combines the sensitivity of bolometric detectors with the properties of beam synthesis and control of calibration offered by interferometers. To modulate and extract the input polarized signal of the CMB, QUBIC exploits Stokes polarimetry based on a rotating half-wave plate (HWP). In this work, we illustrate the design of the QUBIC instrument, focusing on the polarization modulation system, and we present preliminary results of beam calibrations and the performance of the HWP rotator at 300 K.

Published
2021

7. Second asymptomatic carotid surgery trial (ACST-2): a randomised comparison of carotid artery stenting versus carotid endarterectomy

Author

Alison Halliday, Richard Bulbulia, Leo H Bonati, Johanna Chester, Andrea Cradduck-Bamford, Richard Peto, Hongchao Pan, John Potter, Hans Henning Eckstein, Barbara Farrell, Marcus Flather, Averil Mansfield, Boby Mihaylova, Kazim Rahimi, David Simpson, Dafydd Thomas, Peter Sandercock, Richard Gray, Andrew Molyneux, Cliff P Shearman, Peter Rothwell, Anna Belli, Will Herrington, Parminder Judge, Peter Leopold, Marion Mafham, Michael Gough, Piergiorgio Cao, Sumaira MacDonald, Vasha Bari, Clive Berry, S Bradshaw, Wojciech Brudlo, Alison Clarke, Robin Cox, Susan Fathers, Kamran Gaba, Mo Gray, Elizabeth Hayter, Constance Holliday, Rijo Kurien, Michael Lay, Steffi le Conte, Jessica McManus, Zahra Madgwick, Dylan Morris, Andrew Munday, Sandra Pickworth, Wiktor Ostasz, Michiel Poorthuis, Sue Richards, Louisa Teixeira, Sergey Tochlin, Lynda Tully, Carol Wallis, Monique Willet, Alan Young, Renato Casana, Chiara Malloggi, Andrea Odero Jr, Vincenzo Silani, Gianfranco Parati, Giuseppe Malchiodi, Giovanni Malferrari, Francesco Strozzi, Nicola Tusini, Enrico Vecchiati, Gioacchino Coppi, Antonio Lauricella, Roberto Moratto, Roberto Silingardi, Jessica Veronesi, Andrea Zini, Emanuele Ferrero, Michelangelo Ferri, Andrea Gaggiano, Carmelo Labate, Franco Nessi, Daniele Psacharopulo, Andrea Viazzo, Giovanni Malacrida, Daniela Mazzaccaro, Giovanni Meola, Alfredo Modafferi, Giovanni Nano, Maria Teresa Occhiuto, Paolo Righini, Silvia Stegher, Stefano Chiarandini, Filippo Griselli, Sandro Lepidi, Fabio Pozzi Mucelli, Marcello Naccarato, Mario D'Oria, Barbara Ziani, Andrea Stella, Mortalla Dieng, Gianluca Faggioli, Mauro Gargiulo, Sergio Palermo, Rodolfo Pini, Giovanni Maria Puddu, Andrea Vacirca, Domenico Angiletta, Claudio Desantis, Davide Marinazzo, Giovanni Mastrangelo, Guido Regina, Raffaele Pulli, Paolo Bianchi, Lea Cireni, Elisabetta Coppi, Rocco Pizzirusso, Filippo Scalise, Giovanni Sorropago, Valerio Tolva, Valeria Caso, Enrico Cieri, Paola DeRango, Luca Farchioni, Giacomo Isernia, Massimo Lenti, Gian Battista Parlani, Guglielmo Pupo, Grazia Pula, Gioele Simonte, Fabio Verzini, Federico Carimati, Maria Luisa Delodovici, Federico Fontana, Gabriele Piffaretti, Matteo Tozzi, Efrem Civilini, Giorgio Poletto, Bernhard Reimers, Barbara Praquin, Sonia Ronchey, Laura Capoccia, Wassim Mansour, Enrico Sbarigia, Francesco Speziale, Pasqualino Sirignano, Danilo Toni, Roberto Galeotti, Vincenzo Gasbarro, Francesco Mascoli, Tiberio Rocca, Elpiniki Tsolaki, Giulia Bernardini, Ester DeMarco, Alessia Giaquinta, Francesco Patti, Massimiliano Veroux, Pierfrancesco Veroux, Carla Virgilio, Nicola Mangialardi, Matteo Orrico, Vincenzo Di Lazzaro, Nunzio Montelione, Francesco Spinelli, Francesco Stilo, Carlo Cernetti, Sandro Irsara, Giuseppe Maccarrone, Diego Tonello, Adriana Visonà, Beniamino Zalunardo, Emiliano Chisci, Stefano Michelagnoli, Nicola Troisi, Maela Masato, Massimo Dei Negri, Andrea Pacchioni, Salvatore Saccà, Giovanni Amatucci, Alfredo Cannizzaro, Federico Accrocca, Cesare Ambrogi, Renzo Barbazza, Giustino Marcucci, Andrea Siani, Guido Bajardi, Giovanni Savettieri, Angelo Argentieri, Riccardo Corbetta, Attilio Odero, Pietro Quaretti, Federico Z Thyrion, Alessandro Cappelli, Domenico Benevento, Gianmarco De Donato, Maria Agnese Mele, Giancarlo Palasciano, Daniela Pieragalli, Alessandro Rossi, Carlo Setacci, Francesco Setacci, Domenico Palombo, Maria Cecilia Perfumo, Edoardo Martelli, Aldo Paolucci, Santi Trimarchi, Viviana Grassi, Luigi Grimaldi, Giuliana La Rosa, Domenico Mirabella, Matteo Scialabba, Leonildo Sichel, Costantino L D'Angelo, Gian Franco Fadda, Holta Kasemi, Mario Marino, Francesco Burzotta, Francesco Alberto Codispoti, Angela Ferrante, Giovanni Tinelli, Yamume Tshomba, Claudio Vincenzoni, Deborah Amis, Dawn Anderson, Martin Catterson, Mike Clarke, Michelle Davis, Anand Dixit, Alexander Dyker, Gary Ford, Ralph Jackson, Sreevalsan Kappadath, David Lambert, Tim Lees, Stephen Louw, James McCaslin, Noala Parr, Rebecca Robson, Gerard Stansby, Lucy Wales, Vera Wealleans, Lesley Wilson, Michael Wyatt, Hardeep Baht, Ibrahim Balogun, Ilse Burger, Tracy Cosier, Linda Cowie, Gunaratnam Gunathilagan, David Hargroves, Robert Insall, Sally Jones, Hannah Rudenko, Natasha Schumacher, Jawaharlal Senaratne, George Thomas, Audrey Thomson, Tom Webb, Ellen Brown, Bernard Esisi, Ali Mehrzad, Shane MacSweeney, Norman McConachie, Alison Southam, Wayne Sunman, Ahmed Abdul-Hamiq, Jenny Bryce, Ian Chetter, Duncan Ettles, Raghuram Lakshminarayan, Kim Mitchelson, Christopher Rhymes, Graham Robinson, Paul Scott, Alison Vickers, Ray Ashleigh, Stephen Butterfield, Ed Gamble, Jonathan Ghosh, Charles N McCollum, Mark Welch, Sarah Welsh, Leszek Wolowczyk, Mary Donnelly, Stephen D'Souza, Anselm A Egun, Bindu Gregary, Thomas Joseph, Christine Kelly, Shuja Punekar, M Asad Rahi, Sonia Raj, Dare Seriki, George Thomson, James Brown, Ragunath Durairajan, Iris Grunwald, Paul Guyler, Paula Harman, Matthew Jakeways, Christopher Khuoge, Ashish Kundu, Thayalini Loganathan, Nisha Menon, Raji O Prabakaran, Devesh Sinha, Vicky Thompson, Sharon Tysoe, Dennis Briley, Chris Darby, Linda Hands, Dominic Howard, Wilhelm Kuker, Ursula Schulz, Rachel Teal, David Barer, Andrew Brown, Susan Crawford, Paul Dunlop, Ramesh Krishnamurthy, Nikhil Majmudar, Duncan Mitchell, Min P Myint, Richard O'Brien, Janice O'Connell, Naweed Sattar, Shanmugam Vetrivel, Jonathan Beard, Trevor Cleveland, Peter Gaines, John Humphreys, Alison Jenkins, Craig King, Daniel Kusuma, Ralph Lindert, Robbie Lonsdale, Raj Nair, Shah Nawaz, Faith Okhuoya, Douglas Turner, Graham Venables, Paul Dorman, Andrea Hughes, Deborah Jones, David Mendelow, Helen Rodgers, Aidas Raudoniitis, Peter Enevoldson, Hans Nahser, Imelda O'Brien, Francesco Torella, Dave Watling, Richard White, Pauline Brown, Dipankar Dutta, Lorraine Emerson, Paula Hilltout, Sachin Kulkarni, Jackie Morrison, Keith Poskitt, Fiona Slim, Sarah Smith, Amanda Tyler, Joanne Waldron, Mark Whyman, Milda Bajoriene, Lucy Baker, Amanda Colston, Bekky Eliot-Jones, Gita Gramizadeh, Catherine Lewis-Clarke, Laura McCafferty, Deborah Oliver, Debbie Palmer, Abhijeet Patil, Suzannah Pegler, Gopi Ramadurai, Aisling Roberts, Tracey Sargent, Shivaprasad Siddegowda, Ravi Singh-Ranger, Akintunde Williams, Lucy Williams, Steve Windebank, Tadas Zuromskis, Lanka Alwis, Jane Angus, Asaipillai Asokanathan, Caroline Fornolles, Diana Hardy, Sophy Hunte, Frances Justin, Duke Phiri, Marie Mitabouana-Kibou, Lakshmanan Sekaran, Sakthivel Sethuraman, Margaret L Tate, Joyce Akyea-Mensah, Stephen Ball, Angela Chrisopoulou, Elizabeth Keene, Alison Phair, Steven Rogers, John V Smyth, Colin Bicknell, Jeremy Chataway, Nicholas Cheshire, Andrew Clifton, Caroline Eley, Richard Gibbs, Mohammad Hamady, Beth Hazel, Alex James, Michael Jenkins, Nyma Khanom, Austin Lacey, Maz Mireskandari, Joanna O'Reilly, Antony Pereira, Tina Sachs, John Wolfe, Philip Davey, Gill Rogers, Gemma Smith, Gareth Tervit, Ian Nichol, Andrew Parry, Gavin Young, Simon Ashley, James Barwell, Francis Dix, Azlisham M Nor, Chris Parry, Angela Birt, Paul Davies, Jim George, Anne Graham, Leon Jonker, Nicci Kelsall, Caroline Potts, Toni Wilson, Jamie Crinnion, Larissa Cuenoud, Nikola Aleksic, Srdan Babic, Nenad Ilijevski, Đorde Radak, Dragan Sagic, Slobodan Tanaskovic, Momcilo Colic, Vladimir Cvetic, Lazar Davidovic, Dejana R Jovanovic, Igor Koncar, Perica Mutavdžic, Miloš Sladojevic, Ivan Tomic, Eike S Debus, Ulrich Grzyska, Dagmar Otto, Götz Thomalla, Jessica Barlinn, Johannes Gerber, Kathrin Haase, Christian Hartmann, Stefan Ludwig, Volker Pütz, Christian Reeps, Christine Schmidt, Norbert Weiss, Sebastian Werth, Simon Winzer, Janine Gemper, Albrecht Günther, Bianka Heiling, Elisabeth Jochmann, Panagiota Karvouniari, Carsten Klingner, Thomas Mayer, Julia Schubert, Friederike Schulze-Hartung, Jürgen Zanow, Yvonne Bausback, Franka Borger, Spiridon Botsios, Daniela Branzan, Sven Bräunlich, Henryk Hölzer, Janin Lenzer, Christopher Piorkowski, Nadine Richter, Johannes Schuster, Dierk Scheinert, Andrej Schmidt, Holger Staab, Matthias Ulrich, Martin Werner, Hermann Berger, Gábor Biró, Hans-Henning Eckstein, Michael Kallmayer, Kornelia Kreiser, Alexander Zimmermann, Bärbel Berekoven, Klaus Frerker, Vera Gordon, Giovanni Torsello, Sebastian Arnold, Cora Dienel, Martin Storck, Bernhard Biermaier, Hans Martin Gissler, Christof Klötzsch, Tomas Pfeiffer, Ralph Schneider, Leander Söhl, Michael Wennrich, Angelika Alonso, Michael Keese, Christoph Groden, Andreas Cöster, Andreas Engelhardt, Christoph-Maria Ratusinski, Bengt Berg, Martin Delle, Johan Formgren, Peter Gillgren, Lotta Jarl, Torbjörn B Kall, Peter Konrad, Niklas Nyman, Claes Skiöldebrand, Johnny Steuer, Rabbe Takolander, Jonas Malmstedt, Stefan Acosta, Katarina Björses, Kerstin Brandt, Nuno Dias, Anders Gottsäter, Jan Holst, Thorarinn Kristmundsson, Tobias Kühme, Tilo Kölbel, Bengt Lindblad, Mats Lindh, Martin Malina, Tomas Ohrlander, Tim Resch, Viola Rönnle, Björn Sonesson, Margareta Warvsten, Zbigniew Zdanowski, Erik Campbell, Per Kjellin, Hans Lindgren, Johan Nyberg, Björn Petersen, Gunnar Plate, Håkan Pärsson, Peter Qvarfordt, Pavel Ignatenko, Andrey Karpenko, Vladimir Starodubtsev, Mikhail A Chernyavsky, Maria S Golovkova, Boris B Komakha, Nikolay N Zherdev, Andrey Belyasnik, Pavel Chechulov, Dmitry Kandyba, Igor Stepanishchev, Csaba Csobay-Novák, Edit Dósa, László Entz, Balázs Nemes, Zoltán Szeberin, Pál Barzó, Mihaly Bodosi, Eniko Fákó, Béla Fülöp, Tamás Németh, Szilárd Pazdernyik, Krisztina Skoba, Erika Vörös, Eleni Chatzinikou, Athanasios Giannoukas, Christos Karathanos, Stylianos Koutsias, Georgios Kouvelos, Miltiadis Matsagkas, Styliani Ralli, Christos Rountas, Nikolaos Rousas, Konstantinos Spanos, Elias Brountzos, John D Kakisis, Andreas Lazaris, Konstantinos G Moulakakis, Leonidas Stefanis, Georgios Tsivgoulis, Spyros Vasdekis, Constantine N Antonopoulos, Ion Bellenis, Dimitrios Maras, Antonios Polydorou, Victoria Polydorou, Antonios Tavernarakis, Nikolaos Ioannou, Maria Terzoudi, Miltos Lazarides, Michalis Mantatzis, Kostas Vadikolias, Lukasz Dzieciuchowicz, Marcin Gabriel, Zbigniew Krasinski, Grzegorz Oszkinis, Fryderyk Pukacki, Maciej Slowinski, Michal-Goran Stanišic, Ryszard Staniszewski, Jolanta Tomczak, Maciej Zielinski, Piotr Myrcha, Dorota Rózanski, Stanislaw Drelichowski, Wojciech Iwanowski, Katarzyna Koncewicz, Pawel Bialek, Zbigniew Biejat, Wojciech Czepel, Anna Czlonkowska, Anatol Dowzenko, Julia Jedrzejewska, Adam Kobayashi, Jerzy Leszczynski, Andrzej Malek, Jerzy Polanski, Robert Proczka, Maciej Skorski, Mieczyslaw Szostek, Piotr Andziak, Maciej Dratwicki, Robert Gil, Miroslaw Nowicki, Jaroslaw Pniewski, Jaroslaw Rzezak, Piotr Seweryniak, Pawel Dabek, Michal Juszynski, Grzegorz Madycki, Bartosz Pacewski, Witold Raciborski, Piotr Slowinski, Walerian Staszkiewicz, Martin Bombic, Vladimír Chlouba, Jirí Fiedler, Karel Hes, Petr Koštál, Jindrich Sova, Zdenek Kríž, Mojmír Prívara, Michal Reif, Robert 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Callaert, Koen Deloose, Estrella Blanco Cañibano, Beatriz García Fresnillo, Mercedes Guerra Requena, Pilar C Morata Barrado, Miguel Muela Méndez, Antonio Yusta Izquierdo, Fernando Aparici Robles, Paula Blanes Orti, Luis García Dominguez, Rafael Martínez López, Manuel Miralles Hernández, José I Tembl Ferrairo, Ángel Chamorro, Juan Macho, Víctor Obach, Vincent Riambau, Luis San Román, Frank J Ahlhelm, Kristine Blackham, Stefan Engelter, Thomas Eugster, Henrik Gensicke, Lorenz Gürke, Philippe Lyrer, Luigi Mariani, Marina Maurer, Edin Mujagic, Mandy Müller, Marios Psychogios, Peter Stierli, Christoph Stippich, Christopher Traenka, Thomas Wolff, Benjamin Wagner, Martina M Wiegert, Sandra Clarke, Michael Diepers, Ernst Gröchenig, Philipp Gruber, Andrej Isaak, Timo Kahles, Regula Marti, Krassen Nedeltchev, Luca Remonda, Nadir Tissira, Martina Valença Falcão, Gert J de Borst, Rob H Lo, Frans L Moll, Raechel Toorop, Bart H van der Worp, Evert J Vonken, Jaap L Kappelle, Ommid Jahrome, Floris 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Golovkova M.S., Komakha B.B., Zherdev N.N., Belyasnik A., Chechulov P., Kandyba D., Stepanishchev I., Csobay-Novak C., Dosa E., Entz L., Nemes B., Szeberin Z., Barzo P., Bodosi M., Fako E., Fulop B., Nemeth T., Pazdernyik S., Skoba K., Voros E., Chatzinikou E., Giannoukas A., Karathanos C., Koutsias S., Kouvelos G., Matsagkas M., Ralli S., Rountas C., Rousas N., Spanos K., Brountzos E., Kakisis J.D., Lazaris A., Moulakakis K.G., Stefanis L., Tsivgoulis G., Vasdekis S., Antonopoulos C.N., Bellenis I., Maras D., Polydorou A., Polydorou V., Tavernarakis A., Ioannou N., Terzoudi M., Lazarides M., Mantatzis M., Vadikolias K., Dzieciuchowicz L., Gabriel M., Krasinski Z., Oszkinis G., Pukacki F., Slowinski M., Stanisic M.-G., Staniszewski R., Tomczak J., Zielinski M., Myrcha P., Rozanski D., Drelichowski S., Iwanowski W., Koncewicz K., Bialek P., Biejat Z., Czepel W., Czlonkowska A., Dowzenko A., Jedrzejewska J., Kobayashi A., Leszczynski J., Malek A., Polanski J., Proczka R., Skorski M., Szostek M., Andziak P., Dratwicki M., Gil R., Nowicki M., Pniewski J., Rzezak J., Seweryniak P., Dabek P., Juszynski M., Madycki G., Pacewski B., Raciborski W., Slowinski P., Staszkiewicz W., Bombic M., Chlouba V., Fiedler J., Hes K., Kostal P., Sova J., Kriz Z., Privara M., Reif M., Staffa R., Vlachovsky R., Vojtisek B., Hrbac T., Kuliha M., Prochazka V., Roubec M., Skoloudik D., Netuka D., Steklacova A., Benes III V., Buchvald P., Endrych L., Sercl M., Campos W., Casella I.B., de Luccia N., Estenssoro A.E.V., Presti C., Puech-Leao P., Neves C.R.B., da Silva E.S., Sitrangulo C.J., Monteiro J.A.T., Tinone G., Bellini Dalio M., Joviliano E.E., Pontes Neto O.M., Serra Ribeiro M., Cras P., Hendriks J.M.H., Hoppenbrouwers M., Lauwers P., Loos C., Yperzeele L., Geenens M., Hemelsoet D., van Herzeele I., Vermassen F., Astarci P., Hammer F., Lacroix V., Peeters A., Verhelst R., Cirelli S., Dormal P., Grimonprez A., Lambrecht B., Lerut P., Thues E., De Koster G., Desiron Q., Maertens de Noordhout A., Malmendier D., Massoz M., Saad G., Bosiers M., Callaert J., Deloose K., Blanco Canibano E., Garcia Fresnillo B., Guerra Requena M., Morata Barrado P.C., Muela Mendez M., Yusta Izquierdo A., Aparici Robles F., Blanes Orti P., Garcia Dominguez L., Martinez Lopez R., Miralles Hernandez M., Tembl Ferrairo J.I., Chamorro A., Macho J., Obach V., Riambau V., San Roman L., Ahlhelm F.J., Blackham K., Engelter S., Eugster T., Gensicke H., Gurke L., Lyrer P., Mariani L., Maurer M., Mujagic E., Muller M., Psychogios M., Stierli P., Stippich C., Traenka C., Wolff T., Wagner B., Wiegert M.M., Clarke S., Diepers M., Grochenig E., Gruber P., Isaak A., Kahles T., Marti R., Nedeltchev K., Remonda L., Tissira N., Valenca Falcao M., de Borst G.J., Lo R.H., Moll F.L., Toorop R., van der Worp B.H., Vonken E.J., Kappelle J.L., Jahrome O., Vos F., Schuiling W., van Overhagen H., Keunen R.W.M., Knippenberg B., Wever J.J., Lardenoije J.W., Reijnen M., Smeets L., van Sterkenburg S., Fraedrich G., Gizewski E., Gruber I., Knoflach M., Kiechl S., Rantner B., Abdulamit T., Bergeron P., Padovani R., Trastour J.-C., Cardon J.-M., Le Gallou-Wittenberg A., Allaire E., Becquemin J.-P., Cochennec-Paliwoda F., Desgranges P., Hosseini H., Kobeiter H., Marzelle J., Almekhlafi M.A., Bal S., Barber P.A., Coutts S.B., Demchuk A.M., Eesa M., Gillies M., Goyal M., Hill M.D., Hudon M.E., Jambula A., Kenney C., Klein G., McClelland M., Mitha A., Menon B.K., Morrish W.F., Peters S., Ryckborst K.J., Samis G., Save S., Smith E.E., Stys P., Subramaniam S., Sutherland G.R., Watson T., Wong J.H., Zimmel L., Flis V., Matela J., Miksic K., Milotic F., Mrdja B., Stirn B., Tetickovic E., Gasparini M., Grad A., Kompara I., Milosevic Z., Palmiste V., Toomsoo T., Aidashova B., Kospanov N., Lyssenko R., Mussagaliev D., Beyar R., Hoffman A., Karram T., Kerner A., Nikolsky E., Nitecki S., Andonova S., Bachvarov C., Petrov V., Cvjetko I., Vidjak V., Haluzan D., Petrunic M., Liu B., Liu C.-W., Bartko D., Beno P., Rusnak F., Zelenak K., Ezura M., Inoue T., Kimura N., Kondo R., Matsumoto Y., Shimizu H., Endo H., Furui E., Bakke S., Krohg-Sorensen K., Nome T., Skjelland M., Tennoe B., Albuquerque e Castro J., Alves G., Bastos Goncalves F., de Aragao Morais J., Garcia A.C., Valentim H., Vasconcelos L., Belcastro F., Cura F., Zaefferer P., Abd-Allah F., Eldessoki M.H., Heshmat Kassem H., Soliman Gharieb H., Colgan M.P., Haider S.N., Harbison J., Madhavan P., Moore D., Shanik G., Kazan V., Nazzal M., Ramsey-Williams V., and Gargiulo M

Subjects
Male, medicine.medical_specialty, Time Factors, Time Factor, medicine.medical_treatment, Carotid Stenosi, MEDLINE, Carotid endarterectomy, Rate ratio, Risk Assessment, Asymptomatic, law.invention, Randomized controlled trial, law, Risk Factors, carotid artery stenting (CAS), carotid endarterectomy (CEA), Stent, medicine, Humans, Carotid Stenosis, Stroke, Endarterectomy, Aged, Endarterectomy, Carotid, business.industry, carotid artery, Risk Factor, Articles, General Medicine, trial, medicine.disease, Settore MED/22 - CHIRURGIA VASCOLARE, Surgery, Stenosis, Treatment Outcome, Settore MED/11 - MALATTIE DELL'APPARATO CARDIOVASCOLARE, Female, Stents, Human medicine, medicine.symptom, business, Human
Abstract

Summary Background Among asymptomatic patients with severe carotid artery stenosis but no recent stroke or transient cerebral ischaemia, either carotid artery stenting (CAS) or carotid endarterectomy (CEA) can restore patency and reduce long-term stroke risks. However, from recent national registry data, each option causes about 1% procedural risk of disabling stroke or death. Comparison of their long-term protective effects requires large-scale randomised evidence. Methods ACST-2 is an international multicentre randomised trial of CAS versus CEA among asymptomatic patients with severe stenosis thought to require intervention, interpreted with all other relevant trials. Patients were eligible if they had severe unilateral or bilateral carotid artery stenosis and both doctor and patient agreed that a carotid procedure should be undertaken, but they were substantially uncertain which one to choose. Patients were randomly allocated to CAS or CEA and followed up at 1 month and then annually, for a mean 5 years. Procedural events were those within 30 days of the intervention. Intention-to-treat analyses are provided. Analyses including procedural hazards use tabular methods. Analyses and meta-analyses of non-procedural strokes use Kaplan-Meier and log-rank methods. The trial is registered with the ISRCTN registry, ISRCTN21144362. Findings Between Jan 15, 2008, and Dec 31, 2020, 3625 patients in 130 centres were randomly allocated, 1811 to CAS and 1814 to CEA, with good compliance, good medical therapy and a mean 5 years of follow-up. Overall, 1% had disabling stroke or death procedurally (15 allocated to CAS and 18 to CEA) and 2% had non-disabling procedural stroke (48 allocated to CAS and 29 to CEA). Kaplan-Meier estimates of 5-year non-procedural stroke were 2·5% in each group for fatal or disabling stroke, and 5·3% with CAS versus 4·5% with CEA for any stroke (rate ratio [RR] 1·16, 95% CI 0·86–1·57; p=0·33). Combining RRs for any non-procedural stroke in all CAS versus CEA trials, the RR was similar in symptomatic and asymptomatic patients (overall RR 1·11, 95% CI 0·91–1·32; p=0·21). Interpretation Serious complications are similarly uncommon after competent CAS and CEA, and the long-term effects of these two carotid artery procedures on fatal or disabling stroke are comparable. Funding UK Medical Research Council and Health Technology Assessment Programme.

Published
2021

8. Experiencing Homelessness in the Time of COVID-19

Author

Cynthia Puddu

Subjects
2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Medicine, business, Virology
Published
2020

9. Association of serum cholesterol with coronary heart disease mortality during 50-year follow-up in ten cohorts of the seven countries study

Author

Anthony Kafatos, Alessandro Menotti, Paolo Emilio Puddu, Hanna Tolonen, and Hisashi Adachi

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, Endocrinology, Diabetes and Metabolism, Medicine (miscellaneous), Coronary Disease, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, chemistry.chemical_compound, Chd mortality, 0302 clinical medicine, Japan, Risk Factors, Seven Countries Study, Internal medicine, Humans, Medicine, Serum cholesterol, Dyslipidemias, Nutrition and Dietetics, Cholesterol Measurement, Proportional hazards model, business.industry, Cholesterol, Middle Aged, Prognosis, Individual level, United States, Coronary heart disease, Europe, chemistry, Cardiology and Cardiovascular Medicine, business, Biomarkers, Follow-Up Studies
Abstract

Background and aim The association of serum cholesterol levels with the occurrence of coronary heart disease (CHD) mortality during a follow-up of 50 years was rarely investigated previously. Thus, we took advantage of results at hand in 10 pooled cohorts of men aged 40–59 years from the Seven Countries Study (9063 individuals and 2057 CHD fatal events) and we assessed this. Methods and results Cox proportional hazards models were run with CHD fatal events (as dependent variable) and cholesterol levels (as independent variables) at years 0, 10, and 25 (in 5 cohorts). Cumulative events during subsequent decades (cumulative approach: CA) and separately in each subsequent decade (partitioned approach: PA) were analyzed. The ecological correlation of average baseline serum cholesterol levels with CHD mortality was very high (R = 0.97). Serum cholesterol and CHD mortality for 50 years were associated at the individual level, and the association estimated by the Cox's coefficients (and related hazards ratios) was initially strong in both CA and PA, but slightly declined during later decades. Hazards ratios (for a difference of 40 mg/dl) ranged from 1.39 to 1.20 for CA and from 1.39 to 0.80 for PA. Coefficients were larger for CA than for PA and the decline was more evident for the latter. Partitioned coefficient became negative and significant in the last decade (from year 40–50). Coefficients derived from cholesterol levels measured at year 10 of follow-up showed similar trends but their magnitude was smaller. Conclusion Thus, the relationship of serum cholesterol levels with CHD mortality remained relatively stable during at least 40 years after a single cholesterol measurement at baseline in middle-aged men.

Published
2020

10. The Human Breast Milk Metabolome in Preeclampsia, Gestational Diabetes, and Intrauterine Growth Restriction: Implications for Child Growth and Development

Author

Vassilios Fanos, Melania Puddu, and Flaminia Bardanzellu

Subjects
medicine.medical_specialty, Breastfeeding, MEDLINE, Intrauterine growth restriction, Preeclampsia, Child Development, Metabolomics, Pre-Eclampsia, Pregnancy, Metabolome, Humans, Medicine, Child growth, Fetal Growth Retardation, Milk, Human, business.industry, Obstetrics, Infant, medicine.disease, Gestational diabetes, Diabetes, Gestational, Breast Feeding, Pediatrics, Perinatology and Child Health, Female, business
Published
2020

11. Association of patient-reported outcomes and heart rate trends in heart failure: a report from the Chiron project

Author

Paolo Emilio Puddu, Pietro Fedele Calvisi, Michele Schiariti, Luca Monzo, Mitja Luštrek, and Silvio Bonfiglio

Subjects
Male, medicine.medical_specialty, education, lcsh:Medicine, 030204 cardiovascular system & hematology, QT interval, Article, 03 medical and health sciences, QRS complex, Electrocardiography, 0302 clinical medicine, Heart Rate, Internal medicine, Heart rate, medicine, Humans, 030212 general & internal medicine, Patient Reported Outcome Measures, lcsh:Science, Aged, Cardiac device therapy, Heart Failure, Multidisciplinary, medicine.diagnostic_test, business.industry, aged, electrocardiography, female, heart failure, heart rate, humans, male, middle aged, prognosis, reproducibility of results, stroke volume, patient reported outcome measures, lcsh:R, Reproducibility of Results, Stroke Volume, Stroke volume, Middle Aged, medicine.disease, Prognosis, humanities, 3. Good health, Heart failure, Etiology, Cardiology, Observational study, Female, lcsh:Q, business, Biotechnology
Abstract

Patient-reported outcomes (PROs) have been previously considered “soft” end-points because of the lack of association of the reported outcome to measurable biological parameters. The present study aimed to assess whether electrocardiographic measures are associated to PROs changes. We evaluated the association between heart rate (HR), QRS and QT/QTc durations and PROs, classified as “good” or “bad” according to the patients’ overall feeling of health, in patients from the Chiron project. Twenty-four chronic heart failure (HF) patients were enrolled in the study (71% male, mean age 62.9 ± 9.4 years, 42% ischemic etiology, 15 NYHA class II and 9 class III) providing 1086 days of usable physiological recordings (4 hours/day). The mean HR was significantly higher in the “bad” than in the “good” PROs class (74.0 ± 6.4 bpm vs 68.0 ± 7.2 bpm; p

Published
2020

12. Of Capital and Power Italian Late-Colonial Policies in Eritrea at the Onset of the Federation with Ethiopia

Author

Puddu, Luca and Puddu, Luca

Subjects
Italy, decolonization, Ethiopia, Eritrea, business
Abstract

Scholars of African history have often inquired into the relationship between government and business in the making of North-South relations after decolonization. The neo-colonial thesis maintained that the metropolitan governments undertook overt and covert actions to preserve the dominant position of their own multinational corporations in the newly independent African nations. Historians of British Africa have partially revisited this thesis, suggesting a more nuanced understanding of the relationship between political and economic actors. This article seeks to test these arguments in relation to the Italian case, looking at the early process of decolonization in Eritrea. In 1952, the former Italian colony passed from British to Ethiopian rule, but Italian companies maintained the dominant position they had enjoyed for decades. The analysis of the relationship between the Italian authorities, Italian companies and African administrations in Ethiopia and Eritrea suggests that government intervention was crucial to support the positions of Italian capital in the former colonies, at least in the first few years of the Federation of Eritrea with Ethiopia. But it also shows that this alliance was possible only thanks to the subjugation of the needs of capital to those of raison d’état. Methodologically, the article is based on material from the historical archives of the Bank of Italy, those of the Italian Ministry of Foreign Affairs, the national archives of the United Kingdom, and the historical archives of the Italian bank Banco di Roma

Published
2021

13. The Simons Observatory: modeling optical systematics in the Large Aperture Telescope

Author

Rolando Dünner, John Orlowski-Scherer, Adrian T. Lee, Kavilan Moodley, Aamir Ali, Philip Daniel Mauskopf, Giuseppe Puglisi, Patricio A. Gallardo, Sara M. Simon, Carlos Sierra, Michael D. Niemack, Grace E. Chesmore, Giulio Fabbian, Alexandre E. Adler, Nicholas F. Cothard, Lyman A. Page, Gabriele Coppi, Ningfeng Zhu, Nicholas Galitzki, Edward J. Wollack, Federico Nati, Shuay-Pwu Patty Ho, Nadia Dachlythra, Bruce Partridge, Michele Limon, Zhilei Xu, Christian L. Reichardt, A. M. Kofman, Jon E. Gudmundsson, Simon Dicker, Peter Charles Hargrave, Joseph E. Golec, Andrew Bazarko, Roberto Puddu, Frederick Matsuda, Carole Tucker, Mark J. Devlin, Grant Teply, Gudmundsson, J, Gallardo, P, Puddu, R, Dicker, S, Adler, A, Ali, A, Bazarko, A, Chesmore, G, Coppi, G, Cothard, N, Dachlythra, N, Devlin, M, Dünner, R, Fabbian, G, Galitzki, N, Golec, J, Patty Ho, S, Hargrave, P, Kofman, A, Lee, A, Limon, M, Matsuda, F, Mauskopf, P, Moodley, K, Nati, F, Niemack, M, Orlowski-Scherer, J, Page, L, Partridge, B, Puglisi, G, Reichardt, C, Sierra, C, Simon, S, Teply, G, Tucker, C, Wollack, E, Xu, Z, and Zhu, N

Subjects
FOS: Physical sciences, 01 natural sciences, law.invention, 010309 optics, Telescope, Optics, Observatory, law, 0103 physical sciences, Light beam, Electrical and Electronic Engineering, Instrumentation and Methods for Astrophysics (astro-ph.IM), Engineering (miscellaneous), Physics, Geometrical optics, business.industry, Stray light, Settore FIS/05, Optical Design, Telescope, Simons Observatory, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Physical optics, Atomic and Molecular Physics, and Optics, Ray tracing (graphics), Astrophysics - Instrumentation and Methods for Astrophysics, business
Abstract

We present geometrical and physical optics simulation results for the Simons Observatory Large Aperture Telescope. This work was developed as part of the general design process for the telescope; allowing us to evaluate the impact of various design choices on performance metrics and potential systematic effects. The primary goal of the simulations was to evaluate the final design of the reflectors and the cold optics which are now being built. We describe non-sequential ray tracing used to inform the design of the cold optics, including absorbers internal to each optics tube. We discuss ray tracing simulations of the telescope structure that allow us to determine geometries that minimize detector loading and mitigate spurious near-field effects that have not been resolved by the internal baffling. We also describe physical optics simulations, performed over a range of frequencies and field locations, that produce estimates of monochromatic far field beam patterns which in turn are used to gauge general optical performance. Finally, we describe simulations that shed light on beam sidelobes from panel gap diffraction., 15 pages, 13 figures

Published
2021

14. Innesto di cellule mesenchimali su membrana nel trattamento delle patologie cartilaginee della tibio-tarsica

Author

Domenico Mercurio, Leonardo Puddu, Alessandro Santandrea, and Fabrizio Cortese

Subjects
030222 orthopedics, medicine.medical_specialty, business.industry, 030229 sport sciences, Iliac crest, Hyperintensity, Rheumatology, Lesion, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Subchondral bone, Internal medicine, Orthopedic surgery, medicine, Implant, Ankle, medicine.symptom, business, Nuclear medicine
Abstract

Osteochondral lesions of the ankle are very common, the talus being the second most frequent site after the knee, and their treatment depends on the lesion site, width and depth. According to the Giannini classification as lesion type II (width larger than 1.5 cm2 and depth lower than 15 mm), the suggested treatment is through mesenchymal stem cell implant on collagen membrane. The surgical technique consists in arthroscopic assessment of the lesion, mesenchymal stem cell harvesting from the iliac crest, processing of the cells on the lesion site and implant on collagen membrane (IOR G1 technique), which may be performed arthroscopically or through the mini-open technique. The authors report their experience with this procedure on 36 cases over four years. All patients have been evaluated pre- and postoperatively using the AOFAS and VAS scales. MRI was performed preoperatively and at 6, 12 and 24 months postoperatively, using T1 and T2-weighted FSE sequences. Eighteen cases were evaluated with a minimum follow-up of 24 months both clinically and through MRI; in three cases, an arthroscopic second look was performed. In all cases, AOFAS and VAS scores improved significantly, MRI scans showed filling of chondral defects in 83% of cases at 24-month follow-up, although in 30% of MRI scans subchondral bone hyperintensity was still present. In spite of these findings, the technique proved to be effective in improving the clinical and radiological outcomes in most cases.

Published
2019

15. Composite Enclaves: Towards Disaggregated Trusted Execution

Author

Moritz Schneider, Srdjan Capkun, Kari Kostiainen, Aritra Dhar, and Ivan Puddu

Subjects
FOS: Computer and information sciences, Hardware security module, Computer engineering. Computer hardware, Computer Science - Cryptography and Security, Trusted execution environments, RISC-V security, Computer science, Overhead (engineering), Information technology, computer.software_genre, TK7885-7895, Software, Trusted computing base, Hardware Architecture (cs.AR), Code (cryptography), Field-programmable gate array, Computer Science - Hardware Architecture, business.industry, T58.5-58.64, Operating system, Central processing unit, business, computer, Cryptography and Security (cs.CR), Context switch
Abstract

The ever-rising computation demand is forcing the move from the CPU to heterogeneous specialized hardware, which is readily available across modern datacenters through disaggregated infrastructure. On the other hand, trusted execution environments (TEEs), one of the most promising recent developments in hardware security, can only protect code confined in the CPU, limiting TEEs’ potential and applicability to a handful of applications. We observe that the TEEs’ hardware trusted computing base (TCB) is fixed at design time, which in practice leads to using untrusted software to employ peripherals in TEEs. Based on this observation, we propose composite enclaves with a configurable hardware and software TCB, allowing enclaves access to multiple computing and IO resources. Finally, we present two case studies of composite enclaves: i) an FPGA platform based on RISC-V Keystone connected to emulated peripherals and sensors, and ii) a large-scale accelerator. These case studies showcase a flexible but small TCB (2.5 KLoC for IO peripherals and drivers), with a low-performance overhead (only around 220 additional cycles for a context switch), thus demonstrating the feasibility of our approach and showing that it can work with a wide range of specialized hardware., IACR Transactions on Cryptographic Hardware and Embedded Systems, 2022 (1), ISSN:2569-2925

Published
2021

16. Repeatability and reproducibility of deep-learning-based liver volume and Couinaud segment volume measurement tool

Author

Anthony Puddu, Hildo J. Lamb, Angela Barone, Ged Ridgway, Rajarshi Banerjee, Matt Kelly, Amirkasra Mojtahed, Carlos Ferreira, John Connell, Zobair Arya, J. Michael Brady, Luis Núñez, Mariana Marieiro, Rowan C. Nicholls, Alessandro Fichera, and Felipe Caseiro-Alves

Subjects
Accuracy and precision, Cirrhosis, Urology, medicine.medical_treatment, Liver volume, Deep Learning, Couinaud Segment, medicine, Humans, Hepatectomy, Radiology, Nuclear Medicine and imaging, Observer Variation, Reproducibility, Radiological and Ultrasound Technology, Liver resection, business.industry, Gastroenterology, Reproducibility of Results, Repeatability, Hepatic function, medicine.disease, Magnetic Resonance Imaging, Liver, Hepatobiliary, business, Nuclear medicine, Couinaud, Volume (compression), Post-hepatectomy liver failure
Abstract

Purpose Volumetric and health assessment of the liver is crucial to avoid poor post-operative outcomes following liver resection surgery. No current methods allow for concurrent and accurate measurement of both Couinaud segmental volumes for future liver remnant estimation and liver health using non-invasive imaging. In this study, we demonstrate the accuracy and precision of segmental volume measurements using new medical software, Hepatica™. Methods MRI scans from 48 volunteers from three previous studies were used in this analysis. Measurements obtained from Hepatica™ were compared with OsiriX. Time required per case with each software was also compared. The performance of technicians and experienced radiologists as well as the repeatability and reproducibility were compared using Bland–Altman plots and limits of agreement. Results High levels of agreement and lower inter-operator variability for liver volume measurements were shown between Hepatica™ and existing methods for liver volumetry (mean Dice score 0.947 ± 0.010). A high consistency between technicians and experienced radiologists using the device for volumetry was shown (± 3.5% of total liver volume) as well as low inter-observer and intra-observer variability. Tight limits of agreement were shown between repeated Couinaud segment volume (+ 3.4% of whole liver), segmental liver fibroinflammation and segmental liver fat measurements in the same participant on the same scanner and between different scanners. An underestimation of whole-liver volume was observed between three non-reference scanners. Conclusion Hepatica™ produces accurate and precise whole-liver and Couinaud segment volume and liver tissue characteristic measurements. Measurements are consistent between trained technicians and experienced radiologists. Graphic abstract

Published
2021

17. Detection chain and electronic readout of the QUBIC instrument

Author

L. M. Mundo, S. Marnieros, D. Fracchia, A. Mattei, R. Puddu, S. Spinelli, A. Passerini, Federico Nati, V. Gilles, K. Ganga, B. García, Giuseppe D'Alessandro, F. Wicek, P. A. R. Ade, Diego Harari, J. Bonaparte, F. Pezzotta, Massimo Gervasi, F. Incardona, M. E. García Redondo, M. Platino, L. Grandsire, J. D. Murphy, Damien Rambaud, E. Jules, M. Wright, C. Kristukat, L. Dumoulin, E. Olivieri, B. Maffei, Alessandro Paiella, J. Bonis, J.-P. Thermeau, D. Prêle, H. Pastoriza, Michel Piat, M. Gómez Berisso, M. Perciballi, F. Piacentini, D. Burke, Mark McCulloch, A. Zullo, L. H. Arnaldi, Giampaolo Pisano, A. Baù, L.P. Ferreyro, C. Perbost, C. Duca, C. Franceschet, L. Mousset, J. A. Murphy, D. Viganò, Gustavo E. Romero, Martin Giard, Emory F. Bunn, Alessandro Schillaci, Gregory S. Tucker, P. Chanial, L. A. Montier, M.-A. Bigot-Sazy, Alejandro Almela, A. Etchegoyen, Marco Bersanelli, E. Rasztocky, M. Gaspard, Nicola Vittorio, Mario Zannoni, A. Pelosi, S. Azzoni, P. de Bernardis, T. D. Hoang, S. Banfi, W. Marty, A. Mennella, S. Scully, M. M. Gamboa Lerena, Elia S. Battistelli, Andrea Tartari, J.G. Alberro, D. Gayer, Alessandro Coppolecchia, C. Oriol, J.M. Salum, J. Aumont, D. Bennett, S. Loucatos, Silvia Masi, Marcin Gradziel, S. Dheilly, François Pajot, A.C. Cobos Cerutti, C. Chapron, A. Fasciszewski, J.-Ch. Hamilton, M. González, M. Tomasi, Créidhe O'Sullivan, Laurent Bergé, G. Amico, D. Buzi, A.D. Supanitsky, D. Auguste, Gianluca Polenta, Francesco Cavaliere, P. Ringegni, G. Stankowiak, Luca Lamagna, Steve Torchinsky, L. Mele, Andrew May, Peter Timbie, F. Columbro, F. Voisin, C. Tucker, J. Kaplan, B. Bélier, R. Charlassier, M. R. Hampel, G. de Gasperis, C. Scóccola, Lucio Piccirillo, Thibaut Louis, Sophie Henrot-Versille, D. Melo, J.-Ph. Bernard, M. Stolpovskiy, Y. Giraud-Héraud, M. De Leo, M. De Petris, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Zmuidzinas, Jonas, Gao, Jian-Rong, Stankowiak, G, Piat, M, Battistelli, E, D'Alessandro, G, de Bernardis, P, De Petris, M, González, M, Grandsire, L, Hamilton, J, Hoang, T, Masi, S, Marnieros, S, Mennella, A, Mousset, L, O'Sullivan, C, Prêle, D, Tartari, A, Thermeau, J, Torchinsky, S, Voisin, F, Zannoni, M, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Bélier, B, Baù, A, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, de Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Héraud, Y, Gómez Berisso, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Montier, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Rasztocky, E, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Supanitsky, A, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Wicek, F, Wright, M, and Zullo, A

Subjects
QUBIC, Cosmic microwave background, 02 engineering and technology, CMB, SQUID, 7. Clean energy, Superconducting QUantum Interference Device, 030218 nuclear medicine & medical imaging, law.invention, TDM, FIS/05 - ASTRONOMIA E ASTROFISICA, 03 medical and health sciences, 020210 optoelectronics & photonics, 0302 clinical medicine, Optics, Application-specific integrated circuit, law, Cosmic Microwave Background, B-modes, 0202 electrical engineering, electronic engineering, information engineering, Noise-equivalent power, [PHYS]Physics [physics], Physics, TES, business.industry, Bolometer, Time constant, CMB instrumentation, bolometric interferometry, Transition Edge Sensor, Interferometry, Transition edge sensor, business
Abstract

International audience; The Q and U Bolometric Interferometer for Cosmology (QUBIC) Technical Demonstrator (TD) aiming to shows the feasibility of the combination of interferometry and bolometric detection. The electronic readout system is based on an array of 128 NbSi Transition Edge Sensors cooled at 350mK readout with 128 SQUIDs at 1K controlled and amplified by an Application Specific Integrated Circuit at 40K. This readout design allows a 128:1 Time Domain Multiplexing. We report the design and the performance of the detection chain in this paper. The technological demonstrator unwent a campaign of test in the lab. Evaluation of the QUBIC bolometers and readout electronics includes the measurement of I-V curves, time constant and the Noise Equivalent Power. Currently the mean Noise Equivalent Power is ~ 2 x 10-16W= p √Hz

Published
2020

18. Managing Accessible Tourist Services in a Social Manner

Author

Roberto Puddu, Maurizio Murroni, Mauro Fadda, and Vlad Popescu

Subjects
Structure (mathematical logic), Knowledge management, business.industry, Order (business), Travel experience, Business, Social strategies, Internet of Things, Accessible tourism, Tourism
Abstract

The demand for accessible tourism is growing, thus the tourism industry has recently stepped up its efforts to guarantee opportunities and services also to tourists with disabilities. The Social IoT (SIoT) paradigm can extend the advantages to contextualize heterogeneous objects in a social structure that includes also services, in order to accomplish an extended applicability in social strategy for sustainable tourist services. This paper proposes a SIoT-based system developed to provide dedicated services to tourists with disabilities, facilitating and improving their travel experience. The proposed system can also allow tourist facilities and structures such as airports, train stations, museums, etc., to guarantee suitable accessibility providing dedicated itineraries or simply establishing a direct relationship with users with disabilities.

Published
2021

19. TES Bolometer Arrays for the QUBIC B-Mode CMB Experiment

Author

F. Piacentini, S. Loucatos, A. Zullo, C. Oriol, J.-Ch. Hamilton, Silvia Masi, Peter Timbie, F. Columbro, P. A. R. Ade, Francesco Cavaliere, S. Azzoni, M. Gómez Berisso, G. Amico, J. G. Alberro, D. Buzi, A. Bottani, A. Passerini, J. Bonis, Steve Torchinsky, V. Gilles, A. Pelosi, J. Aumont, Nicola Vittorio, B. Maffei, C. Chapron, Michel Piat, J. Bonaparte, Bruce Rafael Mellado Garcia, E. Olivieri, Alessandro Coppolecchia, Giampaolo Pisano, François Pajot, A. Fasciszewski, Luca Lamagna, Emory F. Bunn, Alejandro Almela, M. E. García Redondo, M. Platino, L. M. Mundo, W. Marty, R. Charlassier, J.-P. Thermeau, C. Kristukat, Federico Pezzotta, S. Marnieros, J. Kaplan, D. Fracchia, Andrea Tartari, A. Mattei, G. de Gasperis, M. De Leo, D. T. Hoang, Y. Giraud-Heraud, B. Bélier, P. Ringegni, M. De Petris, N. Bleurvacq, Massimo Gervasi, Cristian Franceschet, G. Stankowiak, E. Jules, Andrew May, Gustavo E. Romero, F. Incardona, Marcin Gradziel, J.M. Salum, S. Dheilly, L. Mele, P. de Bernardis, H. Pastoriza, D. Harari, F. Voisin, P. Battaglia, Alessandro Schillaci, S. Spinelli, L.P. Ferreyro, M. Gaspard, M. Tomasi, A. Etchegoyen, Marco Bersanelli, D. Viganò, Mario Zannoni, D. Prêle, S. Scully, A. Mennella, M. M. Gamboa Lerena, Créidhe O'Sullivan, Laurent Bergé, Gianluca Polenta, D. Bennett, J. D. Murphy, M. González, Alessandro Paiella, Damien Rambaud, F. Wicek, Mark McCulloch, Lucio Piccirillo, Thibaut Louis, Sophie Henrot-Versille, J.-Ph. Bernard, M. Stolpovskiy, D. Burke, C. Perbost, J. A. Murphy, P. Chanial, L. A. Montier, Roberto Puddu, Elia S. Battistelli, D. Gayer, S. Banfi, Gregory S. Tucker, L. Grandsire, Giuseppe D'Alessandro, Martin Giard, M.-A. Bigot-Sazy, Federico Nati, M. Perciballi, L. Dumoulin, L. H. Arnaldi, Simon J. Melhuish, A. Baù, L. Mousset, Maria Salatino, D. Auguste, C. Scóccola, Carole Tucker, K. Ganga, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Marnieros, S, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battaglia, P, Battistelli, E, Bau, A, Belier, B, Bennett, D, Berge, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bleurvacq, N, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Columbro, F, Coppolecchia, A, D'Alessandro, G, de Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Dheilly, S, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, Garcia, B, Garcia Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gomez Berisso, M, Gonzalez, M, Gradziel, M, Grandsire, L, Hamilton, J, Harari, D, Henrot-Versille, S, Hoang, D, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Masi, S, Mattei, A, May, A, Mcculloch, M, Mele, L, Melhuish, S, Mennella, A, Montier, L, Mousset, L, Mundo, L, Murphy, J, Nati, F, Olivieri, E, Oriol, C, O'Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piat, M, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prele, D, Puddu, R, Rambaud, D, Ringegni, P, Romero, G, Salatino, M, Salum, J, Schillaci, A, Scoccola, C, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Torchinsky, S, Tucker, G, Tucker, C, Vigano, D, Vittorio, N, Voisin, F, Wicek, F, Zannoni, M, and Zullo, A

Subjects
Fabrication, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Cosmic microwave background, Cryogenic detector, Astrophysics::Cosmology and Extragalactic Astrophysics, 01 natural sciences, 010305 fluids & plasmas, law.invention, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, law, 0103 physical sciences, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, ComputingMilieux_MISCELLANEOUS, Physics, business.industry, Settore FIS/05, Transition edge sensors, Bolometer, Detector, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Polarization (waves), Atomic and Molecular Physics, and Optics, Interferometry, Cryogenic detectors, business
Abstract

International audience; QUBIC is a ground-based experiment aiming to measure the B-mode polarization of the cosmic microwave background. The developed instrument is an innovative two-frequency band bolometric interferometer that will operate at 300 mK with NbSi TES arrays. In this paper, we describe the fabrication process of the detectors.

Published
2020

20. Statin Treatment May Play a Key Role in the Prevention of Dementia: A Review of the Literature

Author

Giovanni M. Puddu, Chiara Bandinelli, Marco Zoli, Luca Spinardi, Giampaolo Bianchi, and Chiara Bandinelli, Giovanni Maria Puddu, Luca Spinardi, Giampaolo Bianchi, Marco Zoli

Subjects
medicine.medical_specialty, business.industry, mental disorders, medicine, Key (cryptography), Statin treatment, Intensive care medicine, business, Prevention of dementia, statin prevention dementia
Abstract

Dementiais characterized by cognitive decline and deterioration of daily function, often with behavioral disturbances. Degenerative dementia includes many sub groups like Alzheimer's disease (AD), frontotemporal dementia, etc, and nondegenerative dementia mainly encompasses vascular dementia, traumatic brain dementia, and so on. Alzheimer's disease is the most common dementia in the elderly, accounting for 60% of cases(1). There is n't specific therapy for degenerative dementia, only symptomatic treatment.

Published
2020

21. Usefulness of the ACTEL Score to Predict Atrial Fibrillation in Patients with Cryptogenic Stroke

Author

Marco Pastore Trossello, Antonio Muscari, Pietro Barone, Marco Ghinelli, Luca Spinardi, Marco Zoli, Giovanni M. Puddu, Luca Faccioli, Muscari A., Barone P., Faccioli L., Ghinelli M., Pastore Trossello M., Puddu G.M., Spinardi L., and Zoli M.

Subjects
Male, medicine.medical_specialty, Logistic Model, Echocardiogram, Context (language use), Predictive Value of Test, Cryptogenic stroke, 030204 cardiovascular system & hematology, Risk Assessment, Severity of Illness Index, Brain Ischemia, Diagnosis, Differential, 03 medical and health sciences, Electrocardiography, 0302 clinical medicine, Predictive Value of Tests, Risk Factors, Retrospective Studie, Internal medicine, Severity of illness, medicine, Humans, Pharmacology (medical), Stroke, Retrospective Studies, Aged, Aged, 80 and over, medicine.diagnostic_test, Receiver operating characteristic, business.industry, Risk Factor, Score, Atrial fibrillation, Retrospective cohort study, Middle Aged, medicine.disease, Logistic Models, ROC Curve, Echocardiography, Predictive value of tests, Cardiology, Female, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery, Human
Abstract

Introduction: To assess the probability of undetected atrial fibrillation (AF) in patients with ischemic stroke, we previously compared patients who were first diagnosed with AF with patients with large or small artery disease and obtained the MrWALLETS 8-item scoring system. In the present study, we utilized cryptogenic strokes (CS) as the control group, as AF is normally sought among CS patients. Methods: We retrospectively examined 191 ischemic stroke patients (72.5 ± 12.6 years), 68 with first diagnosed AF and 123 with CS, who had undergone 2 brain CT scans, echocardiography, carotid/vertebral ultrasound, continuous electrocardiogram monitoring and anamnestic/laboratory search for cardiovascular risk factors. Results: In logistic regression, 5 variables were independently associated with AF, forming the “ACTEL” score: Age ≥75 years (OR 2.42, 95% CI 1.18–4.96, p = 0.02; +1 point); hyperCholesterolemia (OR 0.38, 95% CI 0.18–0.78, p = 0.009; –1 point); Tricuspid regurgitation ≥ mild-to-moderate (OR 4.99, 95% CI 1.63–15.27, p = 0.005; +1 point); left ventricular End-diastolic volume p = 0.0004; +1 point); Left atrium ≥4 cm (OR 4.57, 95% CI 1.97–10.62, p = 0.0004; +1 point). The algebraic sum of these points may range from –1 to +4. For AF identification, the area under the receiver operating characteristic curve was 0.80 (95% CI 0.73–0.87). With a cutoff of ≥2, positive predictive value was 80.8%, specificity 92.7% and sensitivity 55.9%. Conclusions: The ACTEL score, a simplified and improved version of the MrWALLETS score, allows the identification of patients with first diagnosed AF, in the context of CSs, with a high positive predictive value.

Published
2020

22. Venous thromboembolism prevention with low molecular weight heparin may reduce hemorrhagic transformation in acute ischemic stroke

Author

Luca Faccioli, Giovanni M. Puddu, Elena Franchi, Luca Spinardi, Antonio Muscari, Elena Bartoli, Marco Pastore Trossello, Marco Zoli, Muscari A., Bartoli E., Faccioli L., Franchi E., Pastore Trossello M., Puddu G.M., Spinardi L., and Zoli M.

Subjects
medicine.medical_specialty, Neurology, medicine.drug_class, Low molecular weight heparin, Dermatology, Brain Ischemia, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Risk Factors, law, Internal medicine, medicine, Humans, 030212 general & internal medicine, Enoxaparin, Stroke, Brain CT scan, Aged, Cerebral Hemorrhage, Retrospective Studies, Aged, 80 and over, Ischemic stroke, business.industry, Hemorrhagic transformation, Hazard ratio, Retrospective cohort study, Venous Thromboembolism, General Medicine, Odds ratio, Heparin, Low-Molecular-Weight, Middle Aged, medicine.disease, Discontinuation, Psychiatry and Mental health, Cardiology, Neurology (clinical), Low-dose heparin, business, 030217 neurology & neurosurgery
Abstract

Background: Subcutaneous heparin at a prophylactic dose (SHPD) is a rather common treatment in ischemic stroke, but whether it confers an increased risk of hemorrhagic transformation of cerebral infarct (HT) and whether its reduction or discontinuation favors HT regression are presently poorly understood. Methods: Two samples of ischemic stroke patients with a cerebral lesion diameter ≥ 3cm on brain CT scan, admitted over 7years to our stroke unit, were retrospectively examined: (1) patients treated or not treated with SHPD (enoxaparin 4000U/day), with subsequent assessment of possible HT appearance (N = 267, mean age 75.9 ± 12.8years) and (2) patients treated with SHPD, with HT and subsequent reduction/discontinuation or maintenance of the initial dose, and subsequent assessment of HT evolution (N = 116, mean age 75.7 ± 11.1years). HT severity was quantified according to the ECASS study (HT score). Results: In the first sample, after adjustment for age, sex, stroke severity, cerebral lesion diameter, and other possible confounders, SHPD was inversely associated with HT appearance (hazard ratio 0.62, 95% CI 0.39–0.98, P = 0.04). In the second sample, after adjustment for age, sex, stroke severity, cerebral lesion diameter, and initial HT severity, SHPD reduction/discontinuation had an inverse effect on both HT score improvement (odds ratio 0.42, 95% CI 0.18–0.99, P = 0.049) and HT improvement according to neuroradiological reports (odds ratio 0.34, 95% CI 0.14–0.82, P = 0.015). Conclusions: This retrospective study suggests that SHPD may play a protective role in HT appearance and evolution, which requires verification by a randomized clinical trial.

Published
2020

23. Calibration of QUBIC: The Q and U bolometric interferometer for cosmology

Author

D. Melo, Peter T. Timbie, G. Polenta, L. Mele, S. Loucatos, K. Ganga, Alejandro Almela, Luca Lamagna, W. Marty, Gustavo E. Romero, Giuseppe D'Alessandro, D. Burke, Emory F. Bunn, H. Pastoriza, D. Harari, L. Montier, E. Rasztocky, F. Piacentini, C. Duca, L.P. Ferreyro, L. M. Mundo, D. Prêle, Andrew May, C. Perbost, J.-Ph. Bernard, M. Stolpovskiy, P. de Bernardis, Francesco Cavaliere, J. A. Murphy, P. A. R. Ade, M. Platino, Federico Nati, Créidhe O'Sullivan, M. Wright, Cristian Franceschet, M. Gómez Berisso, M. Giard, M. Gaspard, P. Chanial, E. Olivieri, Alessandro Schillaci, D. Fracchia, C. Kristukat, Y. Giraud-Héraud, A. Baù, L. Mousset, J. Kaplan, C. Oriol, A. Mattei, F. Columbro, J. Bonaparte, M. E. García Redondo, B. Bélier, Nicola Vittorio, L. Grandsire, Silvia Masi, J. Bonis, C. Tucker, G. Amico, Federico Pezzotta, M. Piat, J.-P. Thermeau, F. Incardona, D. Buzi, A. Mennella, Marcin Gradziel, A.D. Supanitsky, J. D. Murphy, Gregory S. Tucker, E. Jules, A. Passerini, V. Gilles, J.M. Salum, S. Dheilly, M. Perciballi, M. M. Gamboa Lerena, F. Voisin, S. A. Torchinsky, Alessandro Paiella, Damien Rambaud, Bruno Maffei, J.G. Alberro, A.C. Cobos Cerutti, C. Chapron, L. Bergé, Mark McCulloch, S. Marnieros, S. Azzoni, D. Auguste, Giampaolo Pisano, F. Pajot, F. Wicek, R. Puddu, Elia S. Battistelli, D. Gayer, S. Banfi, L. H. Arnaldi, J. Aumont, Massimo Gervasi, M. De Leo, D. Bennett, A. Zullo, S. Spinelli, M. Tomasi, Lucio Piccirillo, C. Scóccola, M. De Petris, A. Etchegoyen, Thibaut Louis, Marco Bersanelli, Sophie Henrot-Versille, Mario Zannoni, M.-A. Bigot-Sazy, M. González, A. Pelosi, S. Scully, P. Ringegni, G. Stankowiak, J.-Ch. Hamilton, L. Dumoulin, A. Tartari, D. Viganò, R. Charlassier, M. R. Hampel, G. de Gasperis, Bruce Rafael Mellado Garcia, Alessandro Coppolecchia, A. Fasciszewski, Zmuidzinas, Jonas, Murphy, J, Burke, D, Gamboa Lerena, M, Hamilton, J, Mousset, L, De Petris, M, O'Sullivan, C, Torchinsky, S, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Bélier, B, Battistelli, E, Baù, A, Bennett, D, Bergé, L, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bunn, E, Buzi, D, Cavaliere, F, Chanial, P, Chapron, C, Charlassier, R, Cobos Cerutti, A, Columbro, F, Coppolecchia, A, D'Alessandro, G, De Gasperis, G, De Leo, M, Dheilly, S, Duca, C, Dumoulin, L, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Grandsire, L, Gómez Berisso, M, González, M, Gradziel, M, Hampel, M, Harari, D, Henrot-Versillé, S, Incardona, F, Jules, E, Kaplan, J, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Maffei, B, Marty, W, Mattei, A, May, A, Mcculloch, M, Mele, L, Melo, D, Mennella, A, Montier, L, Mundo, L, Nati, F, Olivieri, E, Oriol, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perbost, C, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Prêle, D, Puddu, R, Rambaud, D, Rasztocky, E, Ringegni, P, Romero, G, Salum, J, Scóccola, C, Schillaci, A, Scully, S, Spinelli, S, Stankowiak, G, Stolpovskiy, M, Supanitsky, A, Tartari, A, Thermeau, J, Timbie, P, Tomasi, M, Tucker, G, Tucker, C, Viganò, D, Vittorio, N, Voisin, F, Wicek, F, Wright, M, Zannoni, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Observatoire de Paris - Site de Paris (OP), Centre National de la Recherche Scientifique (CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut national des sciences de l'Univers (INSU - CNRS), Laboratoire de Physique des 2 Infinis Irène Joliot-Curie (IJCLab), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), and Gao, Jian-Rong

Subjects
QUBIC, Instrumentation, interferometer, Cosmic microwave background, measurement methods, CDM, cosmic background radiation: polarization, 02 engineering and technology, Astrophysics::Cosmology and Extragalactic Astrophysics, CMB, 7. Clean energy, 01 natural sciences, Cosmology, law.invention, 010309 optics, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, bolometer, B-mode polarisation, law, 0103 physical sciences, Cosmic Microwave Background, Calibration, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], measure: spectral, detector: design, data-analysis, Physics, instrumentation, calibration, TES, business.industry, Instrument Data, Bolometer, transition edge sensor, Astrophysics::Instrumentation and Methods for Astrophysics, 021001 nanoscience & nanotechnology, sensitivity, Interferometry, B-mode, Transition edge sensor, 0210 nano-technology, business
Abstract

International audience; QUBIC (a Q and U Bolometric Interferometer for Cosmology) is a next generation cosmology experiment designed to detect the B-mode polarisation of the Cosmic Microwave Background (CMB). A B-mode detection is hard evidence of Inflation in the ΛCDM model. QUBIC aims to accomplish this by combining novel technologies to achieve the sensitivity required to detect the faint B-mode signal. QUBIC uses technologies such as a rotating half-wave plate, cryogenics, interferometric horns with self-calibration switches and transition edge sensor bolometers. A Technical Demonstrator (TD) is currently being calibrated in APC in Paris before observations in Argentina in 2021. As part of the calibration campaign, the spectral response of the TD is measured to test and validate QUBIC's spectro-imaging capability. This poster gives an overview of the methods used to measure the spectral response and a comparison of the instrument data with theoretical predictions and optical simulations.

Published
2020

24. Predicting hemorrhagic transformation and its timing from maximum cerebral lesion diameter in nonlacunar ischemic strokes

Author

Maria Vittoria Lega, Luca Faccioli, Antonio Muscari, Marco Masetti, Marco Pastore Trossello, Marco Zoli, Andrea Lorusso, Luca Spinardi, Giovanni M. Puddu, Muscari A., Faccioli L., Lega M.V., Lorusso A., Masetti M., Pastore Trossello M., Puddu G.M., Spinardi L., and Zoli M.

Subjects
Male, medicine.medical_specialty, Prognosi, cerebral lesion diameter, determinant, 050105 experimental psychology, Time-to-Treatment, lcsh:RC321-571, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Hematoma, Cerebral lesion, Retrospective Studie, Edema, Internal medicine, ischemic stroke, medicine, Humans, 0501 psychology and cognitive sciences, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, Retrospective Studies, Aged, Cerebral Hemorrhage, oral anticoagulation, business.industry, Proportional hazards model, Ischemic strokes, 05 social sciences, Hazard ratio, Anticoagulant, Anticoagulants, determinants, Retrospective cohort study, hemoglobin, Prognosis, medicine.disease, Confidence interval, hemorrhagic transformation, Disease Progression, Cardiology, Female, medicine.symptom, Tomography, X-Ray Computed, business, 030217 neurology & neurosurgery, Human
Abstract

Objectives We performed this retrospective cohort study to establish which factors are mostly indicative of the appearance of hemorrhagic transformation (HT) and of its time course in a sample of nonlacunar ischemic strokes. Materials and Methods In 402 patients with nonlacunar ischemic stroke (75.0 ± 12.7 years, 192 male), clinical, laboratory, and neuroimaging variables obtained during the first 3 days of hospitalization were compared between patients with and without HT at computer tomography scan. Results HT was documented in 129 patients (32.1%), including 36 with parenchymal hematoma (PH), after a median time of 6 days (range 1–27). Many variables were univariately associated with HT, but only 5 of them were confirmed in Cox regression (Hazard Ratio, 95% Confidence Interval): maximum cerebral lesion diameter (CLD) in cm (1.12, 1.06–1.18; p = .0001), hemoglobin in g/dl (1.16, 1.06–1.27; p = .002), blood glucose in mmol/L (1.10, 1.03–1.18; p = .007), prior anticoagulant therapy (1.82, 1.10–3.03; p = .02), and edema with mass effect (1.72, 1.08–2.75; p = .02). Thus, the most significant predictor was CLD. The overall risk of HT was minimum for CLD, In our sample of 402 nonlacunar ischemic strokes, the main predictors of hemorrhagic transformation were as follows: (a) cerebral lesion diameter, (b) blood glucose, (c) prior anticoagulant therapy, (d) cerebral edema with mass effect, (e) hemoglobin concentration. A simple relationship between cerebral lesion diameter and the timing of hemorrhagic transformation has been found, which could be considered in deciding when starting anticoagulation after a cardioembolic stroke.

Published
2019

25. The clinical impact of maternal weight on offspring health: lights and shadows in breast milk metabolome

Author

Vassilios Fanos, Melania Puddu, Flaminia Bardanzellu, and Diego Peroni

Subjects
Milk, Human, Offspring, business.industry, Intrauterine growth restriction, Physiology, Overweight, medicine.disease, Biochemistry, Obesity, Gestational diabetes, Insulin resistance, Breast Feeding, Pregnancy, medicine, Metabolome, Glucose homeostasis, Humans, Female, medicine.symptom, business, Molecular Biology
Abstract

Introduction Pre-pregnancy overweight and obesity, depending on maternal nutrition and metabolic state, can influence fetal, neonatal and long-term offspring health, regarding cardio-metabolic, respiratory, immunological and cognitive outcomes. Thus, maternal weight can act, through mechanisms that are not full understood, on the physiology and metabolism of some fetal organs and tissues, to adapt themselves to the intrauterine environment and nutritional reserves. These effects could occur by modulating gene expression, neonatal microbiome, and through breastfeeding. Areas covered In this paper, we investigated the potential effects of metabolites found altered in breast milk (BM) of overweight/obese mothers, through an extensive review of metabolomics studies, and the potential short- and long-term clinical effects in the offspring, especially regarding overweight, glucose homeostasis, insulin resistance, oxidative stress, infections, immune processes, and neurodevelopment. Expert opinion Metabolomics seems the ideal tool to investigate BM variation depending on maternal or fetal/neonatal factors. In particular, BM metabolome alterations according to maternal conditions were recently pointed out in cases of gestational diabetes, preeclampsia, intrauterine growth restriction and maternal overweight/obesity. In our opinion, even if BM is the food of choice in neonatal nutrition, the deepest comprehension of its composition in overweight/obese mothers could allow targeted supplementation, to improve offspring health and metabolic homeostasis.

Published
2021

26. IChannels: Exploiting Current Management Mechanisms to Create Covert Channels in Modern Processors

Author

Lois Orosa, Jawad Haj-Yahya, A. Giray Yaglikci, Juan Gómez Luna, Mohammed Alser, Jeremie S. Kim, Onur Mutlu, and Ivan Puddu

Subjects
FOS: Computer and information sciences, Power management, Computer Science - Cryptography and Security, business.industry, Computer science, Covert channel, Context (language use), Voltage regulator, Instruction set, Channel capacity, Software, Computer Science - Distributed, Parallel, and Cluster Computing, Embedded system, Hardware Architecture (cs.AR), Distributed, Parallel, and Cluster Computing (cs.DC), Communication source, Computer Science - Hardware Architecture, business, Cryptography and Security (cs.CR)
Abstract

To operate efficiently across a wide range of workloads with varying power requirements, a modern processor applies different current management mechanisms, which briefly throttle instruction execution while they adjust voltage and frequency to accommodate for power-hungry instructions (PHIs) in the instruction stream. Doing so 1) reduces the power consumption of non-PHI instructions in typical workloads and 2) optimizes system voltage regulators' cost and area for the common use case while limiting current consumption when executing PHIs. However, these mechanisms may compromise a system's confidentiality guarantees. In particular, we observe that multilevel side-effects of throttling mechanisms, due to PHI-related current management mechanisms, can be detected by two different software contexts (i.e., sender and receiver) running on 1) the same hardware thread, 2) co-located Simultaneous Multi-Threading (SMT) threads, and 3) different physical cores. Based on these new observations on current management mechanisms, we develop a new set of covert channels, IChannels, and demonstrate them in real modern Intel processors (which span more than 70% of the entire client and server processor market). Our analysis shows that IChannels provides more than 24x the channel capacity of state-of-the-art power management covert channels. We propose practical and effective mitigations to each covert channel in IChannels by leveraging the insights we gain through a rigorous characterization of real systems., Comment: To appear in ISCA 2021

Published
2021

27. Quantitative MRI T2 Mapping is Able to Assess Tissue Quality After Reparative and Regenerative Treatments of Osteochondral Lesions of the Talus

Author

Leonardo Puddu, Giulio Rizzo, Alessandro Cristoforetti, Francesco Tessarolo, Giandomenico Nollo, Marta Rigoni, Fabrizio Cortese, Sabino Walter Della Sala, and Alessandro Marinetti

Subjects
Cartilage, Articular, Population, 030218 nuclear medicine & medical imaging, Talus, Lesion, 03 medical and health sciences, Arthroscopy, 0302 clinical medicine, ankle, medicine, Humans, Radiology, Nuclear Medicine and imaging, articular cartilage, Prospective Studies, T2 relaxation time, education, Prospective cohort study, Research Articles, education.field_of_study, business.industry, Cartilage, Magnetic Resonance Imaging, Transplantation, Exact test, medicine.anatomical_structure, Musculoskeletal, Fibrocartilage, Ankle, medicine.symptom, Nuclear medicine, business, Research Article
Abstract

Background Quantitative MRI has potential for tissue characterization after reparative and regenerative surgical treatment of osteochondral lesions of the talus (OCLTs). However available data is inconclusive and quantitative sequences can be difficult to implement in real‐time clinical application. Purpose To assess the potential of T2 mapping in discriminating articular tissue characteristics after reparative and regenerative surgery of OCLTs in real‐world clinical settings. Study Type Observational and prospective cohort study. Population 15 OCLT patients who had received either reparative treatment with arthroscopic microfracture surgery (MFS) for a grade I lesion or regenerative treatment with bone marrow derived cell transplantation (BMDCT) for a grade II lesion. Field Strength/Sequence 1.5 T, proton density weighted TSE, T2‐weighted true fast imaging with steady‐state‐free precession and multi‐echo T2 mapping sequences. Assessment Patients were evaluated at a minimum postoperative follow‐up of 24 months. T2 maps of the ankle were generated and the distribution of T2 values was analyzed in manually identified volumes of interest (VOIs) for both treated lesions (TX) and healthy cartilage (CTRL). The amount of fibrocartilage, hyaline‐like and remodeling tissue in TX VOIs was obtained, based on T2 thresholds from CTRL VOIs. Statistical Tests Fisher's exact test for categorical data, nonparametric Mann–Whitney U test for continuous data. The statistical significance level was P 45 msec were considered as representative for fibrocartilage, hyaline‐like and remodeling tissue, respectively. Tissue composition of the two treatment groups was different, with significantly more fibrocartilage (+28%) and less hyaline‐like tissue (−15%) in MFS than in BMDCT treated lesions. No difference in healthy tissue composition was found between the two groups (P = 0.75). Data Conclusions T2 mapping of surgically treated OCLTs can provide quantitative information about the type and amount of newly formed tissue at the lesion site, thereby facilitating surgical follow‐up in a real‐word clinical setting. Level of Evidence 2 Technical Efficacy Stage 3

Published
2021

28. Breast Milk and COVID-19: From Conventional Data to 'Omics' Technologies to Investigate Changes Occurring in SARS-CoV-2 Positive Mothers

Author

Melania Puddu, Vassilios Fanos, and Flaminia Bardanzellu

Subjects
breastfeeding, Health, Toxicology and Mutagenesis, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Breastfeeding, Mothers, Context (language use), Review, SARS-COV-2, Breast milk, Bioinformatics, Antibodies, Viral, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Medicine, Humans, antibodies, Pregnancy Complications, Infectious, skin and connective tissue diseases, Pandemics, innate immunity, 030304 developmental biology, 0303 health sciences, Maternal Transmission, Milk, Human, business.industry, Transmission (medicine), Public Health, Environmental and Occupational Health, Infant, COVID-19, medicine.disease, metabolomics, Infectious Disease Transmission, Vertical, Breast Feeding, breast milk, Female, business, Breast feeding, microbiomics, 030217 neurology & neurosurgery
Abstract

In this context of COVID-19 pandemic, great interest has been aroused by the potential maternal transmission of SARS-CoV-2 by transplacental route, during delivery, and, subsequently, through breastfeeding. Some open questions still remain, especially regarding the possibility of finding viable SARS-CoV-2 in breast milk (BM), although this is not considered a worrying route of transmission. However, in BM, it was pointed out the presence of antibodies against SARS-CoV-2 and other bioactive components that could protect the infant from infection. The aim of our narrative review is to report and discuss the available literature on the detection of anti-SARS-CoV-2 antibodies in BM of COVID-19 positive mothers, and we discussed the unique existing study investigating BM of SARS-CoV-2 positive mothers through metabolomics, and the evidence regarding microbiomics BM variation in COVID-19. Moreover, we tried to correlate metabolomics and microbiomics findings in BM of positive mothers with potential effects on breastfed infants metabolism and health. To our knowledge, this is the first review summarizing the current knowledge on SARS-CoV-2 effects on BM, resuming both “conventional data” (antibodies) and “omics technologies” (metabolomics and microbiomics).

Published
2021

29. Association of Left Ventricular Hypertrophy and Atrial Fibrillation with Hemorrhagic Evolution of Small Vessel Disease

Author

Marco Pastore Trossello, Marco Ghinelli, Antonio Muscari, Giovanni Masetti, Luca Faccioli, Giovanni M. Puddu, Luca Spinardi, and Marco Zoli

Subjects
Male, medicine.medical_specialty, Lacunar stroke, Disease, Left ventricular hypertrophy, Risk Assessment, Ventricular Function, Left, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Leukoencephalopathies, Predictive Value of Tests, Risk Factors, Internal medicine, Atrial Fibrillation, medicine, Diabetes Mellitus, Prevalence, Humans, cardiovascular diseases, Aged, Cerebral Hemorrhage, Retrospective Studies, Intracerebral hemorrhage, Aged, 80 and over, Ventricular Remodeling, business.industry, Rehabilitation, Smoking, Atrial fibrillation, Retrospective cohort study, Middle Aged, medicine.disease, Prognosis, Hyperintensity, nervous system diseases, Italy, Hypertension, Stroke, Lacunar, Cardiology, Disease Progression, Surgery, Female, Hypertrophy, Left Ventricular, Neurology (clinical), Small vessel, Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Cerebral small vessel disease (SVD) is often associated with hypertension and may evolve towards intracerebral hemorrhage (ICH) or lacunar ischemic stroke. However, the factors favoring the evolution towards ICH or lacunar stroke are not well understood.This retrospective study included 326 consecutive patients (71.1±13.2 years, 38% women): 143 with deep ICH and 183 with lacunar lesions (LL)2 cm, which were visible in a deep location on brain CT scan. Among LL patients, 143 had a small-artery occlusion (SAO) stroke according to the TOAST classification. Clinical characteristics plus laboratory and neuroradiological variables of these patients had been prospectively collected and a subgroup underwent echocardiography.In multivariate analysis, ICH patients (97% hypertensive), compared to SAO patients (89% hypertensive), had greater left ventricular wall thickness (LVWT; OR 4.15, 95%CI 1.64-10.53, for those with LVWT ≥ 1.4 cm, 70% of whom were hemorrhagic) and lower prevalence of white matter lesions (OR 0.30, 95%CI 0.13-0.70), ever smokers (OR 0.39, 95%CI 0.18-0.82) and diabetics (OR 0.29, 95% CI 0.10-0.84). Moreover, ICH patients had a greater prevalence of atrial fibrillation than LL patients (OR 3.14, 95%CI 1.11-8.93), and so they were more often anticoagulated.Most SVD patients were hypertensive, but those evolving towards ICH were characterized by organ damage at the cardiac level (increase in LVWT and atrial fibrillation), while those evolving towards lacunar stroke were characterized by a higher prevalence of smokers and diabetics, and by organ damage at the cerebral level (white matter lesions).

Published
2021

31. Sistemi di scarico articolare extra-capsulari del ginocchio: stato dell’arte

Author

Francesco Uboldi, Leonardo Puddu, Federica Denti, Sebastiano Cudoni, and Pietro Zedde

Subjects
musculoskeletal diseases, Orthodontics, 030222 orthopedics, medicine.medical_specialty, Joint compartment, business.industry, medicine.medical_treatment, Biomechanics, 030229 sport sciences, musculoskeletal system, 03 medical and health sciences, 0302 clinical medicine, Angular stability, Orthopedic surgery, medicine, Femur, Tibia, business, Reduction (orthopedic surgery), Early osteoarthritis
Abstract

The treatment of early osteoarthritis of the knee can also be addressed with the use of different techniques that provide for the discharge of the affected joint compartment. Internal extra-articular devices consist of metal or polycarbonate-urethane shock absorbers fixed to the femur and tibia by angular stability plates. Their purpose is to unload the joint and allow for reduction of the intra-articular compressive strength in the first degrees of flexion without modifying its anatomy and biomechanics and, therefore, being reversible. The literature is lacking in medium- and long-term clinical results with the presence of limited case series or case reports with contrasting results that do not provide significant conclusions on their efficacy but highlight some complications. Further studies are needed, as the theory is very promising.

Published
2019

32. Changes in left ventricular repolarization after short-term testosterone replacement therapy in hypogonadal males

Author

Andrea M. Isidori, Gianfranco Piccirillo, Marianna Minnetti, Antonio Aversa, Damiano Magrì, Joachim Alexandre, Riccardo Pofi, Davide Francomano, Gaetana D'Alessandro, Andrea Lenzi, Paolo-Emilio Puddu, and Federica Moscucci

Subjects
androgen, ghypogonadism, QT, sudden cardiac death, testosterone, ventricular repolarization, Male, medicine.medical_specialty, Ventricular Repolarization, Hormone Replacement Therapy, medicine.drug_class, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, QT interval, Ventricular Function, Left, Androgen, Sudden cardiac death, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Heart Rate, Internal medicine, Androgen deficiency, Humans, Medicine, Repolarization, Testosterone, Testosterone replacement, business.industry, Hypogonadism, Arrhythmias, Cardiac, Middle Aged, Prognosis, medicine.disease, Ventricular repolarization, Case-Control Studies, 030220 oncology & carcinogenesis, Exercise Test, Cardiology, Original Article, business, Follow-Up Studies
Abstract

Background and aim Evidences suggest that androgen deficiency is associated with sudden cardiac death (SCD). Our purpose was to analyse some electrocardiographic (ECG) markers of repolarization phase in hypogonadal patients either at baseline or after testosterone replacement therapy (TRT). Patients and Methods Baseline and after 6 months of testosterone replacement therapy, 14 hypogonadal patients and 10 age-matched controls underwent a short-term ECG recordings at rest and immediately after a maximal exercise test. The following ECG parameters have been collected: QTe (the interval between the q wave the end of T wave), QTp (the interval between the q wave and the peak of T wave), and Te (the interval between the peak and the end of T wave). Results At baseline, in the hypogonadal patients, corrected QTe and QTp values were longer at rest than in the controls at rest (p < 0.05), whereas, during the recovery phase, only the QTp remained significantly longer (p < 0.05). After TRT, hypogonadal patients showed an improvement only in Te (p < 0.05). Conversely, any difference between hypogonadal patients and control subjects was found with respect to the markers of temporal dispersion of repolarization phases, except for a worse QTp → Te coherence (p = 0.001) obtained during the recovery phase. Conclusions In conclusion, at rest, hypogonadal patients suffer from a stable increase in the myocardial repolarization phase without an increase in its temporal dispersion and, hence, the SCD risk seems to be low.

Published
2019

33. Age at death of major cardiovascular diseases in 13 cohorts

Author

Hisashi Adachi, Alessandro Menotti, Paolo Emilio Puddu, Daan Kromhout, Hanna Tolonen, and Anthony Kafatos

Subjects
Male, Heart disease, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Japan, Cause of Death, Medicine, risk factors, ARTERY-DISEASE, 030212 general & internal medicine, Stroke, CHOLESTEROL, Age at death, Age Factors, General Medicine, Middle Aged, COMPETING RISKS, Europe, Survival Rate, Cardiovascular Diseases, Female, Cardiology and Cardiovascular Medicine, Adult, EUROPEAN COHORTS, Risk Assessment, 03 medical and health sciences, Age Distribution, longevity, Seven Countries Study, Humans, CORONARY-HEART-DISEASE, MYOCARDIAL LESIONS, Retrospective Studies, long-term, business.industry, Cholesterol, Proportional hazards model, MORTALITY, prediction, medicine.disease, TRENDS, Blood pressure, chemistry, seven countries study, Etiology, business, Demography, Follow-Up Studies, Forecasting
Abstract

Objectives: To explore age at death (AD) for major cardiovascular diseases (CVD) and their risk factors in originally middle-aged men followed nearly to extinction in the Seven Countries Study.Materials and methods: Thirteen cohorts of men aged 40-59 years (N= 10,628) in seven countries (USA, Finland, the Netherlands, Italy, Serbia, Greece, Japan) were enrolled in late 1950s and early 1960s and were followed 45 years for mortality. AD was computed for coronary heart disease (CHD), stroke (STR), heart disease of uncertain aetiology (HDUE) and for all-causes. AD was compared across CHD-HDUE-STR. Cox models were computed for each end-point using baseline age, cigarettes smoking, systolic blood pressure and serum cholesterol.Results: After 45 years 92.9% of men had died. The most common CVD death was CHD in most cohorts except some Mediterranean and Japanese cohorts where STR or HDUE were most prevalent. In 13 cohorts mean AD was 74.5, 73.5, 75.7 and 79.1 years, respectively, for all-cause, CHD, STR and HDUE mortality (all possible differences were significant). The difference, across cohorts, between the highest and the lowest mean AD was 12.9, 9.0 and 4.7 years for CHD, HDUE and STR mortality, respectively. Risk factors explored were significant predictors of all three CVD end-points, except serum cholesterol, specific to CHD mortality.Conclusions: AD is a useful indicator of previous health and aging populations. STR and HDUE are diseases appearing later in life, thus being associated with a higher AD compared with CHD mortality.

Published
2019

34. Hypertension induced by serotonin reuptake inhibitors: analysis of two pharmacovigilance databases

Author

Sophie Fedrizzi, Marion Sassier, Sandrine Combret, François Le Bas, Haleh Bagheri, Milou-Daniel Drici, Paolo Emilio Puddu, Joachim Alexandre, Basile Chrétien, and Xavier Humbert

Subjects
Adult, Male, Time Factors, Adolescent, Databases, Factual, Fluvoxamine, Citalopram, computer.software_genre, 030226 pharmacology & pharmacy, Pharmacovigilance, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Odds Ratio, medicine, Adverse Drug Reaction Reporting Systems, Humans, Escitalopram, Pharmacology (medical), Child, Aged, Aged, 80 and over, Pharmacology, Sertraline, Fluoxetine, Database, business.industry, Infant, Newborn, Infant, Odds ratio, Middle Aged, Paroxetine, Child, Preschool, Hypertension, Female, France, business, computer, Selective Serotonin Reuptake Inhibitors, 030217 neurology & neurosurgery, medicine.drug
Abstract

Drug-induced hypertension was described with several pharmacological classes, especially with serotonin reuptake inhibitors (SRIs). However, this link has remained controversial: the French summary of product characteristics specify a risk of hypertension only with paroxetine and sertraline. To identify a possible class effect common to all SRIs, our study investigated the reports of hypertension associated with SRIs in two pharmacovigilance databases. Two different types of investigations were performed: (i) a comparative study in VigiBase® , which is the World Health Organization (WHO) pharmacovigilance database (PVDB), from where notifications of hypertension with six SRIs (citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, sertraline) were extracted. The relationship between the suspected SRIs and the occurrence of hypertension was assessed by calculating reporting odds ratio (ROR) in a case/non-case design; (ii) a descriptive study of hypertension reports associated with SRIs in the French pharmacovigilance database (FPVDB). In VigiBase® , 14 824 notifications of SRI-induced hypertension (2.5%) were identified (mean age 54.3 years, mainly women 69.1%). Among them, 3 879 (26.2%) were associated to sertraline; 3 118 (21.0%) to fluoxetine; 2 725 (18.4%) to paroxetine; 2 570 (17.3%) to citalopram; 2 295 (15.5%) to escitalopram; and 237 (1.6%) to fluvoxamine. A significant ROR value was found with all six SRIs (ROR range from 1.16 to 1.92). In the FPVDB, 24 reports of hypertension were found with all six SRIs used at standard doses, mainly in women (66.7%) with a mean age of 57.8 years and a median time of onset of 6 days. In 10 cases (42%), patients had a history of hypertension. This study, performed in real conditions of life, shows a significant pharmacovigilance safety signal between the use of SRIs and the development or worsening of hypertension.

Published
2019

35. Coronary heart disease mortality trends during 50 years as explained by risk factor changes: The European cohorts of the Seven Countries Study

Author

Daan Kromhout, Hanna Tolonen, Alessandro Menotti, Paolo Emilio Puddu, and Anthony Kafatos

Subjects
Adult, Male, Time Factors, Epidemiology, Blood Pressure, Coronary Artery Disease, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Seven Countries Study, Cause of Death, Humans, Medicine, 030212 general & internal medicine, Risk factor, Mortality trends, business.industry, Smoking, Middle Aged, Coronary heart disease, Europe, Serum cholesterol measurement, Cholesterol, Heart Disease Risk Factors, Smoking Cessation, Cardiology and Cardiovascular Medicine, business, Biomarkers, Demography
Abstract

Objectives The purpose of this study was to relate risk factor changes during decades with 50-year coronary heart disease mortality in European cohorts of middle-aged men of the Seven Countries Study. Material and methods In the 1950s–early 1960s, nine cohorts of 6518 men aged 40–59 years were examined in five European countries. Smoking habits, systolic blood pressure and serum cholesterol were measured at entry and five times during the next 35 years and a comprehensive Risk Factor Change Score was created. Coronary heart disease mortality data was collected during a 50-year follow-up, modelled by the Weibull distribution, whose shape (Weibull shape) was related to the Risk Factor Change Score by linear regression. Results The Risk Factor Change Score showed slight declines in the Finnish and Dutch cohorts, moderate or large increases in the other cohorts. These effects were related to a decrease of smoking habits in all cohorts, an increase of blood pressure in all cohorts except East Finland, a decrease of serum cholesterol in Finland and the Netherlands, whereas serum cholesterol increases were slight in Italy and large in Serbia and Greece. Weibull distribution shape for coronary heart disease mortality showed slight deceleration in one Finnish and the Dutch cohorts, large acceleration in the Serbian and Greek cohorts. The correlation coefficient of the Risk Factor Change Score versus Weibull shape for the nine cohorts was 0.78 ( R2 = 0.60; p = 0.0132). Conclusions Spontaneous long-term changes of major coronary risk factor levels were associated with changes in the same direction of coronary heart disease mortality risk modelled by the Weibull distribution, expressing a kind of ‘natural experiment’ with an outcome that matches those of controlled preventive trials.

Published
2019

36. Self - Configurable IoT Satellite Gateway with QoS Traffic Management

Author

Cristinel Gavrila, Roberto Puddu, Vlad Popescu, Maurizio Murroni, and Claudio Sacchi

Subjects
business.industry, Gateway (telecommunications), Computer science, Quality of service, 05 social sciences, 050801 communication & media studies, 020206 networking & telecommunications, Context (language use), 02 engineering and technology, 0508 media and communications, Logic gate, 0202 electrical engineering, electronic engineering, information engineering, Satellite, Architecture, business, Internet of Things, Computer network
Abstract

Internet-of- Things (IoT) represents a breakthrough for the current ICI market. In many IoT applications, sensors and actuators are distributed over very wide areas, sometimes not reached by terrestrial networks. In such scenarios, called Internet-of-Remote- Things (IoRT) the satellite can play a significant role. This paper presents the hardware implementation and functional test of a gateway for IoRT, along with its operational characteristics. In particular, it focuses on the self-configurability of the proposed gateway and on the QoS-based traffic management in the context of IoRT. The functional analysis of the proposed architecture is performed at “proof-of-concept” level, without open-field testing that would require the presence of an operational satellite link.

Published
2021

37. A Personal Health System for Self-Management of Congestive Heart Failure (HeartMan)

Author

Erik Dovgan, Mitja Luštrek, Karin Slegers, Aljoša Vodopija, Marko Bohanec, Els Clays, Paolo Emilio Puddu, Carlos Cavero Barca, Miha Mlakar, Jan Derboven, Flavia Marino, Jakob Valič, Gennaro Tartarisco, Juan Mario Rodríguez, Giovanni Pioggia, Amos Adeyemo Dawodu, Jure Lampe, Gašper Slapničar, Michele Schiariti, Maria Costanza Ciancarelli, Delphine De Smedt, and Language, Communication and Cognition

Subjects
medicine.medical_specialty, Decision support system, Technology and Engineering, Remote patient monitoring, Computer applications to medicine. Medical informatics, R858-859.7, Health Informatics, human centered design, 030204 cardiovascular system & hematology, Unified theory of acceptance and use of technology, law.invention, 03 medical and health sciences, 0302 clinical medicine, Health Information Management, Randomized controlled trial, law, medicine, Medicine and Health Sciences, wearable electronic devices, Original Paper, mobile phone, Self-management, decision support techniques, business.industry, mobile application, 030227 psychiatry, Clinical trial, personal health system, Blood pressure, congestive heart failure, Physical therapy, Anxiety, medicine.symptom, business, psychological support
Abstract

BackgroundCongestive heart failure (CHF) is a disease that requires complex management involving multiple medications, exercise, and lifestyle changes. It mainly affects older patients with depression and anxiety, who commonly find management difficult. Existing mobile apps supporting the self-management of CHF have limited features and are inadequately validated.ObjectiveThe HeartMan project aims to develop a personal health system that would comprehensively address CHF self-management by using sensing devices and artificial intelligence methods. This paper presents the design of the system and reports on the accuracy of its patient-monitoring methods, overall effectiveness, and patient perceptions.MethodsA mobile app was developed as the core of the HeartMan system, and the app was connected to a custom wristband and cloud services. The system features machine learning methods for patient monitoring: continuous blood pressure (BP) estimation, physical activity monitoring, and psychological profile recognition. These methods feed a decision support system that provides recommendations on physical health and psychological support. The system was designed using a human-centered methodology involving the patients throughout development. It was evaluated in a proof-of-concept trial with 56 patients.ResultsFairly high accuracy of the patient-monitoring methods was observed. The mean absolute error of BP estimation was 9.0 mm Hg for systolic BP and 7.0 mm Hg for diastolic BP. The accuracy of psychological profile detection was 88.6%. The F-measure for physical activity recognition was 71%. The proof-of-concept clinical trial in 56 patients showed that the HeartMan system significantly improved self-care behavior (P=.02), whereas depression and anxiety rates were significantly reduced (PConclusionsThe HeartMan project combined a range of advanced technologies with human-centered design to develop a complex system that was shown to help patients with CHF. More psychological than physical benefits were observed.Trial RegistrationClinicalTrials.gov NCT03497871; https://clinicaltrials.gov/ct2/history/NCT03497871.International Registered Report Identifier (IRRID)RR2-10.1186/s12872-018-0921-2

Published
2021

38. Melanoma Prevention: Comparison of Different Screening Methods for the Selection of a High Risk Population

Author

Pietro Massei, Grazia Salimbeni, Andrea Nannipieri, Nevio Dubbini, Maurizia Ghilardi, Marco Celli, Stefano Malloggi, Giovanni Menchini, Laura Ricci, Tommaso Rubino, Antonella Romanini, Roberto Gianfaldoni, Giuseppe Ferraùto, Antonella Puddu, Daniele Gandini, and Serena Gianfaldoni

Subjects
Adult, Male, medicine.medical_specialty, Skin Neoplasms, Health, Toxicology and Mutagenesis, Population, lcsh:Medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Screening method, melanoma, Medicine, Humans, Mass Screening, 030212 general & internal medicine, Family history, education, Physical Examination, Selection (genetic algorithm), Secondary prevention, education.field_of_study, business.industry, Melanoma, screening, lcsh:R, Public Health, Environmental and Occupational Health, Limiting, medicine.disease, Risk evaluation, 030220 oncology & carcinogenesis, Female, business, secondary prevention
Abstract

Background: Guidelines recommend limiting melanoma screening in a population with known risk factors, but none indicates methods for efficient recruitment. The purpose of this study is to compare three different methods of recruiting subjects to be screened for melanoma to detect which, if any, is the most efficient. Methods: From 2010 to 2019, subjects were recruited as follows: (1) regular skin examinations (RS), mainly conducted through the Associazione Contro il Melanoma network, (2) occasional melanoma screening (OS), during annual public campaigns, (3) and selective screening (SS), where people were invited to undergo a skin check after filling in a risk evaluation questionnaire, in cases where the assigned outcome was intermediate/high risk. Melanoma risk factors were compared across different screening methods. Generalized Linear Mixed Models were used for multivariable analysis. Results: A total of 2238 subjects (62.7% women) were recruited, median age 44 years (2–85), and 1094 (48.9 %) records were collected through RS, 826 (36.9 %) through OS, and 318 (14.2 %) through SS. A total of 131 suspicious non-melanoma skin cancers were clinically diagnosed, 20 pathologically confirmed, and 2 melanomas detected. SS performed significantly better at selecting subjects with a family history of melanoma and I-II phototypes compared to OS. Conclusions: Prior evaluation of melanoma known risk factors allowed for effective selection of a population to screen at higher risk of developing a melanoma.

Published
2021

39. HeartMan DSS: A decision support system for self-management of congestive heart failure

Author

Aljoša Vodopija, Marko Bohanec, Michele Schiariti, Els Clays, Paolo Emilio Puddu, Sofie Pardaens, Flavia Marino, Giovanni Pioggia, Anneleen Baert, Gennaro Tartarisco, and Mitja Luštrek

Subjects
Congestive heart failure, Decision support system, Personal health system, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Artificial Intelligence, medicine, Web application, 030212 general & internal medicine, Disease management (health), Self-management, business.industry, General Engineering, Physical exercise, medicine.disease, 3. Good health, Computer Science Applications, Variety (cybernetics), Workflow, Anxiety, Decision models, Medical emergency, medicine.symptom, business, Decision model
Abstract

Congestive heart failure is a chronic medical condition that affects about 2 % of the adult population. Even though it cannot be cured, it can be relieved by a proper, long-term, complex and personalized disease management. In this paper we present the HeartMan Decision Support System (DSS), aimed at supporting individual patients in their uptake of well-established clinical guidelines (i.e., both medication and behaviour based) for disease management. The HeartMan DSS is a central component of the wider HeartMan mobile-health platform that employs mobile phones, wristband sensors and a web application for communication with patients, their physicians and caregivers. The DSS itself provides recommendations for (1) managing patient’s physical health in terms of exercise, nutrition, medications and self-monitoring, (2) psychological support, and (3) managing environmental parameters. The DSS employs a variety of methods: rule-based decision models and adaptable workflows developed using literature and in collaboration with medical experts, classification models developed by machine learning from data, and optimization algorithms. Taken together, they provide a comprehensive, personalized and user-friendly disease management platform. The system was evaluated in a clinical proof-or-concept trial, involving 56 patients in four hospitals. The results confirmed that the system was successful in improving self-care behaviour, decreased patients' levels of depression and anxiety, and improved the overall predicted 1-year mortality risk.

Published
2021
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40. CODIC: A Low-Cost Substrate for Enabling Custom In-DRAM Functionalities and Optimizations

Author

Ivan Puddu, Saugata Ghose, Yaohua Wang, Kaveh Razavi, Juan Gómez-Luna, Nika Mansouri-Ghiasi, Lois Orosa, Mohammad Sadrosadati, Haocong Luo, Jeremie S. Kim, Onur Mutlu, Hasan Hassan, and Minesh Patel

Subjects
FOS: Computer and information sciences, Computer Science - Cryptography and Security, Hardware_MEMORYSTRUCTURES, business.industry, Computer science, B.3, K.6.5, Reliability (computer networking), Interface (computing), Physical unclonable function, Cold boot attack, Memory controller, Embedded system, Hardware Architecture (cs.AR), Key (cryptography), business, Computer Science - Hardware Architecture, Throughput (business), Cryptography and Security (cs.CR), Dram
Abstract

DRAM is the dominant main memory technology used in modern computing systems. Computing systems implement a memory controller that interfaces with DRAM via DRAM commands. DRAM executes the given commands using internal components (e.g., access transistors, sense amplifiers) that are orchestrated by DRAM internal timings, which are fixed foreach DRAM command. Unfortunately, the use of fixed internal timings limits the types of operations that DRAM can perform and hinders the implementation of new functionalities and custom mechanisms that improve DRAM reliability, performance and energy. To overcome these limitations, we propose enabling programmable DRAM internal timings for controlling in-DRAM components. To this end, we design CODIC, a new low-cost DRAM substrate that enables fine-grained control over four previously fixed internal DRAM timings that are key to many DRAM operations. We implement CODIC with only minimal changes to the DRAM chip and the DDRx interface. To demonstrate the potential of CODIC, we propose two new CODIC-based security mechanisms that outperform state-of-the-art mechanisms in several ways: (1) a new DRAM Physical Unclonable Function (PUF) that is more robust and has significantly higher throughput than state-of-the-art DRAM PUFs, and (2) the first cold boot attack prevention mechanism that does not introduce any performance or energy overheads at runtime., Comment: Extended version of an ISCA 2021 paper

Published
2021
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42. In vitro evaluation of bioburden, three-dimensional stability, and accuracy of surgical templates without metallic sleeves after routinely infection control activities

Author

Franco Sanseverino, Chang Joo Park, Antonio Puddu, Rocco Amarena, Marco Tallarico, Aurea Immacolata Lumbau, and Silvio Mario Meloni

Subjects
business.industry, 0206 medical engineering, Dentistry, 030206 dentistry, 02 engineering and technology, Surgical procedures, 020601 biomedical engineering, Steam sterilization, Bioburden, Implant placement, Disinfection, 03 medical and health sciences, 0302 clinical medicine, Template, Surgery, Computer-Assisted, Chlorhexidine gluconate, Infection control, Medicine, Computer-Aided Design, Implant, Oral Surgery, business, General Dentistry, Software
Abstract

BACKGROUND Surgical templates are classified as noncritical devices, and they do not need to be sterile. AIM Primary aim of this study was to assess the microbiological burden present on the surgical templates without metallic sleeves after disinfection. Furthermore, to evaluate trueness after disinfection and steam sterilization at 121°C/15 min, and over a 8-week storage period. Finally, to assess their accuracy after in vitro implant placement simulation. MATERIALS AND METHODS Forty surgical templates were printed and divided in five groups of eight templates each. Groups A to C were disinfected with 0.5% Chlorhexidine Gluconate and 70% ethyl alcohol base solution for 15 min. Templates in the group D were steam sterilized at 121°C for 15 min, while, the templates in the group E were used as control. Implant simulation was performed in the group A. Outcome measures were determination of bioburden, trueness assessment using GOM Inspect Professional software, and accuracy evaluated thought the mean angular deviation of simulated implants. RESULTS Total microbic charge measured as colony forming units (CFU) for sample, was 24.40 in the control group (group E; n = 8), and

Published
2020

43. Homeostatic Left Heart integration and disintegration links atrio-ventricular covariation’s dyshomeostasis in Hypertrophic Cardiomyopathy

Author

Michele Schiariti, Valerio Varano, Luciano Teresi, Concetta Torromeo, Paola Nardinocchi, Stefano Gabriele, Antonietta Evangelista, Giuseppe Esposito, Paolo Piras, Paolo Emilio Puddu, Andrea Madeo, Piras, Paolo, Torromeo, Concetta, Evangelista, Antonietta, Gabriele, Stefano, Esposito, Giuseppe, Nardinocchi, Paola, Teresi, Luciano, Madeo, Andrea, Schiariti, Michele, Varano, Valerio, and Puddu, Paolo Emilio

Subjects
Adult, Male, medicine.medical_specialty, Heartbeat, Heart Ventricles, Science, Left atrium, Cardiomyopathy, 030204 cardiovascular system & hematology, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Heart Rate, Left atrial, Internal medicine, Heart rate, Homeostasis, Humans, Medicine, Heart Atria, Orientation, Spatial, Multidisciplinary, business.industry, Hypertrophic cardiomyopathy, Anatomy, Cardiomyopathy, Hypertrophic, Middle Aged, medicine.disease, medicine.anatomical_structure, Ventricle, Case-Control Studies, Atrioventricular Node, Cardiology, Female, business, speckle-tracking echocardiography, acute myocardial-infarction, ejection fraction, ventricular-function, failure, strain, shape, deformation, mechanics, doppler
Abstract

Left ventricle and left atrium are and have been practically always analyzed separately in common clinically and non-clinically oriented cardiovascular investigations. Both classic and speckle tracking echocardiographic data contributed to the knowledge about deformational impairments occurring in systo-diastolic differences. Recently new trajectory based approaches allowed a greater awareness about the entire left ventricle or left atrium revolution and on their deficiencies that take place in presence of hypertrophic cardiomyopathy. However, surprisingly, the concomitant function of the two left heart chambers has not been analyzed for their geometrical/mechanical relationship. For the first time we study here, by acquiring left ventricle and left atrial geometries on the same heartbeat, the trajectory attributes of the entire left heart treated as a whole shape and the shape covariation of its two subunits. We contrasted healthy subjects with patients affected by hypertrophic cardiomyopathy. We found impaired left heart trajectory mainly in terms of orientation and size. More importantly, we found profound differences in the direction of morphological covariation of left ventricle and left atrium. These findings open to new perspectives in pathophysiological evaluation of different diseases by allowing the appreciation of concomitant functioning of both left heart whole geometry and of its two chambers.

Published
2017

44. Major adverse cardiovascular events in non-valvular atrial fibrillation with chronic obstructive pulmonary disease: the ARAPACIS study

Author

Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, Alessandri, C., Serviddio, G., Palange, P., Greco, E., Bruno, G., Averna, M., Giammanco, A., Sposito, P., de Cristofaro, R., Carulli, L., de Gennaro, L., Pellegrini, E., Cominacini, L., Mozzini, C., Pasini, A. F., Sprovieri, M., Spagnuolo, V., Cerqua, G., Cerasola, G., Mulé, G., Barbagallo, M., Lo Sciuto, S., Monteverde, A., Saitta, A., Lo Gullo, A., Malatino, L., Cilia, C., Terranova, V., Pisano, M., Pinto, A., Di Raimondo, D., Tuttolomondo, A., Conigliaro, R., Signorelli, S., de Palma, D., Galderisi, M., Cudemo, G., Galletti, F., Fazio, V., de Luca, N., Meccariello, A., Caputo, D., de Donato, M. T., Iannuzi, A., Bresciani, A., Giunta, R., Utili, R., Iorio, V., Adinolfi, L. E., Sellitto, C., Iuliano, N., Bellis, P., Tirelli, P., Sacerdoti, D., Vanni, D., Iuliano, L., Ciacciarelli, M., Pacelli, A., Palazzuoli, A., Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., Verrusio, W., Nobili, L., Tarquinio, N., Pellegrini, F., Vincentelli, G. M., Ravallese, F., Santini, C., Letizia, C., Petramala, L., Zinnamosca, L., Minisola, S., Cilli, M., Colangelo, L., Falaschi, P., Martocchia, A., Pastore, F., Bertazzoni, G., Attalla El Halabieh, E., Paradiso, M., Lizzi, E. M., Timmi, S., Battisti, P., Cerci, S., Ciavolella, M., Di Veroli, C., Malci, F., de Ciocchis, A., Abate, D., Castellino, P., Zanoli, L., Fidone, F., Mannarino, E., Pasqualini, L., Oliverio, G., Pende, A., Artom, N., Ricchio, R., Fimognari, F. L., Alletto, M., Messina, S., Sesti, G., Arturi, F., Succurro, E., Fiorentino, T. V., Pedace, E., Scarpino, P. E., Carullo, G., Maio, R., Sciacqua, A., Frugiuele, P., Battaglia, G., Atzori, S., Delitala, G., Angelucci, E., Sestili, S., Traisci, G., de Feudis, L., Di Michele, D., Fava, A., Balsano, C., de Ciantis, P., Desideri, G., Camerota, A., Mezzetti, M., Gresele, P., Vedovati, C., Fierro, T., Puccetti, L., Bertolotti, M., Mussi, C., Boddi, M., Savino, A., Contri, S., Degl’Innocenti, G., Saller, A., Fabris, F., Pesavento, R., Filippi, L., Vedovetto, V., Puato, M., Treleani, M., de Luca, E., de Zaiacomo, F., Giantin, V., Semplicini, A., Minuz, P., Romano, S., Fantin, F., Manica, A., Stockner, I., Pattis, P., Gutmann, B., Catena, C., Colussi, G., Sechi, L. A., Annoni, G., Bruni, A. A., Castagna, A., Spinelli, D., Miceli, E., Padula, D., Schinco, G., Spreafico, S., Secchi, B., Vanoli, M., Casella, G., Pulixi, E. A., Sansone, L., Serra, M. G., Longo, S., Antonaci, S., Belfiore, A., Frualdo, M., Palasciano, G., Ricci, L., Ventrella, F., Bianco, C., Santovito, D., Cipollone, F., Nicolai, S., Salvati, F., Rini, G. B., Scozzari, F., Muiesan, M. L., Salvetti, M., Bazza, A., Picardi, A., Vespasiani-Gentilucci, U., de Vincentis, A., Cosio, P., Terzolo, M., Madaffari, B., Parasporo, B., Fenoglio, L., Bracco, C., Melchio, R., Gentili, T., Salvi, A., Nitti, C., Gabrielli, A., Martino, G. P., Capucci, A., Brambatti, M., Sparagna, A., Tirotta, D., Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., Musumeci, M., Delfino, M., Giorgi, A., Glorioso, N., Melis, G., Marras, G., Matta, M., Sacco, A., Stellitano, E., Scordo, A., Russo, F., Caruso, A. A., Porreca, E., Tana, M., Ferri, C., Cheli, P., Portincasa, P., Muscianisi, G., Giordani, S., Stanghellini, V., Sabbà, C., Mancuso, G., Bartone, M., Calipari, D., Arcidiacono, G., Bellanuova, I., Ferraro, M., Marigliano, G., Cozzolino, D., Lampitella, A., Acri, V., Galasso, D., Mazzei, F., Buratti, A., Galasso, S., Porta, M., Brizzi, M. F., Fattorini, A., Sampietro, F., D’Angelo, A., Manfredini, R., Pala, M., Fabbian, F., Moroni, C., Valente, L., Lopreiato, F., Parente, F., Granata, M., Moia, M., Braham, S., Rossi, M., Pesce, M., Gentile, A., Catozzo, V., Baciarello, G., Cosimati, A., Ageno, W., Rancan, E., Guasti, L., Ciccaglioni, A., Negri, S., Polselli, M., Prisco, D., Marcucci, R., Ferro, D., Perri, L., Cangemi, R., Saliola, M., Del Ben, M., Angelico, F., Baratta, F., Migliacci, R., Porciello, G., Corrao, S., Proietti, M., Raparelli, V., Napoleone, L., Talerico, G., Amoroso, D., Romiti, G. F., Ruscio, E., Toriello, F., Sperduti, N., Todisco, T., Di Tanna, G., Sacchetti, M. L., Puddu, P. E., Farcomeni, A., Anzaldi, M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., de Giorgi, A., de Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., ARAPACIS Study Collaborators, Raparelli, V, Pastori, D, Pignataro, S, Vestri, A, Pignatelli, P, Cangemi, R, Proietti, M, Davi, G, Hiatt, W, Lip, G, Corazza, G, Perticone, F, Violi, F, Basili, S, Alessandri, C, Serviddio, G, Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, Decristofaro, R, Carulli, L, Degennaro, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, A, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mule, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Diraimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, Depalma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, Deluca, N, Meccariello, A, Caputo, D, Dedonato, M, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, L, Sellitto, C, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L, Tarquinio, N, Pellegrini, F, Vincentelli, G, Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S, Cilli, M, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F, Bertazzoni, G, Attalla El Halabieh, E, Paradiso, M, Lizzi, E, Timmi, S, Battisti, P, Cerci, S, Ciavolella, M, Diveroli, C, Malci, F, Deciocchis, A, Abate, D, Castellino, P, Zanoli, L, Fidone, F, Mannarino, E, Pasqualini, L, Oliverio, G, Pende, A, Artom, N, Ricchio, R, Fimognari, F, Alletto, M, Messina, S, Sesti, G, Arturi, F, Succurro, E, Fiorentino, T, Pedace, E, Scarpino, P, Carullo, G, Maio, R, Sciacqua, A, Frugiuele, P, Battaglia, G, Atzori, S, Delitala, G, Angelucci, E, Sestili, S, Traisci, G, Defeudis, L, Dimichele, D, Fava, A, Balsano, C, Deciantis, P, Desideri, G, Camerota, A, Mezzetti, M, Gresele, P, Vedovati, C, Fierro, T, Puccetti, L, Bertolotti, M, Mussi, C, Boddi, M, Savino, A, Contri, S, Degl'Innocenti, G, Saller, A, Fabris, F, Pesavento, R, Filippi, L, Vedovetto, V, Puato, M, Treleani, M, Deluca, E, Dezaiacomo, F, Giantin, V, Semplicini, A, Minuz, P, Romano, S, Fantin, F, Manica, A, Stockner, I, Pattis, P, Gutmann, B, Catena, C, Colussi, G, Sechi, L, Annoni, G, Bruni, A, Castagna, A, Spinelli, D, Miceli, E, Padula, D, Schinco, G, Spreafico, S, Secchi, B, Vanoli, M, Casella, G, Pulixi, E, Sansone, L, Serra, M, Longo, S, Antonaci, S, Belfiore, A, Frualdo, M, Palasciano, G, Ricci, L, Ventrella, F, Bianco, C, Santovito, D, Cipollone, F, Nicolai, S, Salvati, F, Rini, G, Scozzari, F, Muiesan, M, Salvetti, M, Bazza, A, Picardi, A, Vespasiani-Gentilucci, U, Devincentis, A, Cosio, P, Terzolo, M, Madaffari, B, Parasporo, B, Fenoglio, L, Bracco, C, Melchio, R, Gentili, T, Salvi, A, Nitti, C, Gabrielli, A, Martino, G, Capucci, A, Brambatti, M, Sparagna, A, Tirotta, D, Andreozzi, P, Ettorre, E, Viscogliosi, G, Servello, A, Musumeci, M, Delfino, M, Giorgi, A, Glorioso, N, Melis, G, Marras, G, Matta, M, Sacco, A, Stellitano, E, Scordo, A, Russo, F, Caruso, A, Porreca, E, Tana, M, Ferri, C, Cheli, P, Portincasa, P, Muscianisi, G, Giordani, S, Stanghellini, V, Sabba, C, Mancuso, G, Bartone, M, Calipari, D, Arcidiacono, G, Bellanuova, I, Ferraro, M, Marigliano, G, Cozzolino, D, Lampitella, A, Acri, V, Galasso, D, Mazzei, F, Buratti, A, Galasso, S, Porta, M, Brizzi, M, Fattorini, A, Sampietro, F, D'Angelo, A, Manfredini, R, Pala, M, Fabbian, F, Moroni, C, Valente, L, Lopreiato, F, Parente, F, Granata, M, Moia, M, Braham, S, Rossi, M, Pesce, M, Gentile, A, Catozzo, V, Baciarello, G, Cosimati, A, Ageno, W, Rancan, E, Guasti, L, Ciccaglioni, A, Negri, S, Polselli, M, Prisco, D, Marcucci, R, Ferro, D, Perri, L, Saliola, M, Delben, M, Angelico, F, Baratta, F, Migliacci, R, Porciello, G, Corrao, S, Napoleone, L, Talerico, G, Amoroso, D, Romiti, G, Ruscio, E, Toriello, F, Sperduti, N, Todisco, T, Ditanna, G, Sacchetti, M, Puddu, P, Farcomeni, A, Anzaldi, M, Bazzini, C, Bianchi, P, Boari, B, Buonauro, A, Butta, C, Buzzetti, E, Calabria, S, Capeci, W, Caradio, F, Carleo, P, Carrabba, M, Castorani, L, Cecchetto, L, Cicco, S, Cimini, C, Colombo, B, De Giorgi, A, Devuono, S, Delcorso, L, Denegri, A, Digiosia, P, Durante Mangoni, E, Falsetti, L, Forgione, A, Giorgini, P, Grassi, D, Grembiale, A, Hijazi, D, Iamele, L, Lorusso, G, Marchese, A, Marra, A, Masala, M, Miceli, G, Montebianco Abenavoli, L, Murgia, G, Naccarato, P, Pattoneri, P, Perego, F, Pesce, P, Piano, S, Pinna, M, Pinto, D, Pretti, V, Pucci, G, Salinaro, F, Salzano, A, Santilli, F, Scarpini, F, Scicali, R, Sirico, D, Suppressa, P, Talia, M, Tassone, E, Torres, D, Vazzana, N, Vecchio, C, Vidili, G, Vitale, F, Zaccone, V, Raparelli, V1, Pastori, D1, Pignataro, Sf1, Vestri, Ar2, Pignatelli, P1, Cangemi, R1, Proietti, M3, Davì, G4, Hiatt, Wr5, Lip, Gyh3, Corazza, Gr6, Perticone, F7, Violi, F8, Basili, S1, De Cristofaro, R, De Gennaro, L, Pasini, Af, Mulé, G, Di Raimondo, D, De Palma, D, De Luca, N, De Donato, Mt, Adinolfi, Le, Vincentelli, Gm, Lizzi, Em, Di Veroli, C, De Ciocchis, A, Fimognari, Fl, Fiorentino, Tv, Scarpino, Pe, De Feudis, L, Di Michele, D, De Ciantis, P, De Luca, E, De Zaiacomo, F, Sechi, La, Bruni, Aa, Pulixi, Ea, Serra, Mg, Rini, Gb, Muiesan, Ml, De Vincentis, A, Martino, Gp, Caruso, Aa, Sabbà, C, Brizzi, Mf, Del Ben, M, Romiti, Gf, Di Tanna, G, Sacchetti, Ml, Puddu, Pe, Bianchi, Pi, Buttà, C, Carrabba, Md, Colombo, Bm, De Vuono, S, Del Corso, L, Di Giosia, P, Marra, Am, Tassone, Ej, Vecchio, Cr, Zaccone, V., Pignataro, Sf, Vestri, Ar, Davì, G, Hiatt, Wr, Lip, Gyh, Corazza, Gr, Raparelli, Valeria, Pastori, Daniele, Pignataro, Serena Francesca, Vestri, Anna Rita, Pignatelli, Pasquale, Cangemi, Roberto, Proietti, Marco, Davì, Giovanni, Hiatt, William Robert, Lip, Gregory Yoke Hong, Corazza, Gino Roberto, Perticone, Francesco, Violi, Francesco, Basili, Stefania, Alessandri C., Serviddio G., Palange P., Greco E., Bruno G., Averna M., Giammanco A., Sposito P., De Cristofaro R., Carulli L., De Gennaro L., Pellegrini E. Cominacini L., Mozzini C., Pasini A.F., Sprovieri M., Spagnuolo V., Cerqua G., Cerasola G., Mulé G., Barbagallo M., Lo Sciuto S., Monteverde A., Saitta A., Lo Gullo A., Malatino L., Cilia C., Terranova V., Pisano M., Pinto A., Di Raimondo D., Tuttolomondo A., Conigliaro R., Signorelli S., De Palma D., Galderisi M., Cudemo G., Galletti F., Fazio V., De Luca N., Meccariello A., Caputo D., De Donato M. T., Iannuzi A., Bresciani A., Giunta R., Utili R., Iorio V., Adinolfi L.E., Sellitto C., Iuliano N., Bellis P., Tirelli P., Sacerdoti D., Vanni D., Iuliano L., Ciacciarelli M., Pacelli A., Palazzuoli A., Cacciafesta M., Gueli N., Lo Iacono C., Brusco S., Verrusio W., Nobili L., Tarquinio N., Pellegrini F., Vincentelli G.M., Ravallese F., Santini C., Letizia C., Petramala L., Zinnamosca L., Minisola S., Cilli M., Colangelo L., Falaschi P., Martocchia A., Pastore F., Bertazzoni G., Attalla El Halabieh E., Paradiso M., Lizzi E.M., Timmi S., Battisti P., Cerci S., Ciavolella M., Di Veroli C., Malci F., De Ciocchis A., Abate D., Castellino P., Zanoli L., Fidone F., Mannarino E., Pasqualini L., Oliverio G., Pende A., Artom N., Ricchio R., Fimognari F.L., Alletto M., Messina S., Sesti G., Arturi F., Succurro E, Fiorentino T.V., Pedace E., Scarpino P.E., Carullo G., Maio R., Sciacqua A., Frugiuele P., Spagnuolo V., Battaglia G., Atzori S., Delitala G., Angelucci E., Sestili S., Traisci G., De Feudis L., Di Michele D., Fava A., Balsano C., De Ciantis P., Desideri G., Camerota A., Mezzetti M., Gresele P., Vedovati C., Fierro T., Puccetti L., Bertolotti M., Mussi C., Boddi M., Savino A., Contri S., Degl’Innocenti G., Saller A., Fabris F., Pesavento R., Filippi L., Vedovetto V., Puato M., Fabris F., Treleani M., De Luca E., De Zaiacomo F., Giantin V., Semplicini A., Minuz P., Romano S., Fantin F., Manica A., Stockner I., Pattis P., Gutmann B., Catena C., Colussi G., Sechi L.A., Annoni G., Bruni A.A., Castagna A., Spinelli D., Miceli E., Padula D., Schinco G., Spreafico S., Secchi B., Vanoli M., Casella G., Pulixi E.A., Sansone L., Serra M.G., Longo S., Antonaci S., Belfiore A., Frualdo M., Palasciano G., Ricci L., Ventrella F., Bianco C., Santovito D., Cipollone F., Nicolai S., Salvati F., Rini G. B., Scozzari F., Muiesan M.L., Salvetti M., Bazza A., Picardi A., Vespasiani-Gentilucci U., De Vincentis A., Cosio P., Terzolo M., Madaffari B., Parasporo B., Fenoglio L., Bracco C., Melchio R., Gentili T., Salvi A., Nitti C., Gabrielli A., Martino G.P., Capucci A., Brambatti M., Sparagna A., Tirotta D., Andreozzi P., Ettorre E., Viscogliosi G., Servello A., Musumeci M., Delfino M., Giorgi A., Glorioso N., Melis G., Marras G., Matta M., Sacco A., Stellitano E., Scordo A., Russo F., Caruso A.A., Porreca E., Tana M., Ferri C., Cheli P., Portincasa P., Muscianisi G., Giordani S., Stanghellini V., Sabbà C., Mancuso G., Bartone M., Calipari D., Arcidiacono G., Bellanuova I., Ferraro M., Marigliano G., Cozzolino D., Lampitella A., Acri V., Galasso D., Mazzei F., Buratti A., Galasso S., Porta M., Brizzi M.F., Fattorini A., Sampietro F., D’Angelo A., Manfredini R., Pala M., Fabbian F., Moroni C., Valente L., Lopreiato F., Parente F., Granata M., Moia M., Braham S., Rossi M., Pesce M., Gentile A., Catozzo V., Baciarello G., Cosimati A., Ageno W., Rancan E., Guasti L., Ciccaglioni A., Negri S., Polselli M., Prisco D., Marcucci R., Ferro D., Perri L., Cangemi R., Saliola M., Del Ben M., Angelico F., Baratta F., Migliacci R., Porciello G., Corrao S. Data entry and Safety Monitoring Board: Proietti M., Raparelli V., Napoleone L., Talerico G., Amoroso D., Romiti G.F., Ruscio E., Toriello F., Sperduti N., Todisco T., Di Tanna G., Sacchetti M.L., Puddu P.E., Farcomeni A. Simi Young Internists Group: Anzaldi M., Bazzini C., Bianchi P.I., Boari B., Bracco C., Buonauro A., Buttà C., Buzzetti E., Calabria S., Capeci W., Caradio F., Carleo P., Carrabba M.D., Castorani L., Cecchetto L., Cicco S., Cimini C., Colombo B.M., De Giorgi A., De Vuono S., Del Corso L., Denegri A., Di Giosia P., Durante Mangoni E., Falsetti L., Forgione A., Giorgini P., Grassi D., Grembiale A., Hijazi D., Iamele L., Lorusso G., Marchese A., Marra A.M., Masala M., Miceli G., Montebianco Abenavoli L., Murgia G., Naccarato P., Padula D., Pattoneri P., Perego F., Pesce P., Piano S., Pinna M., Pinto D., Pretti V., Pucci G., Salinaro F., Salzano A., Santilli F., Scarpini F., Scicali R., Sirico D., Suppressa P., Talia M., Tassone E.J., Torres D., Vazzana N., Vecchio C.R., Vidili G., Vitale F., Zaccone V., Raparelli Valeria, Pastori Daniele, Pignataro Serena Francesca, Vestri Anna Rita, Pignatelli Pasquale, Cangemi Roberto, Proietti Marco, Davì Giovanni, Hiatt William Robert, Lip Gregory Yoke Hong, Corazza Gino Roberto, Perticone Francesco, Violi Francesco, Basili Stefania, Alessandri C, Serviddio G, Palange P, Greco E, Bruno G, Averna M, Giammanco A, Sposito P, De Cristofaro R, Carulli L, De Gennaro L, Pellegrini E, Cominacini L, Mozzini C, Pasini AF, Sprovieri M, Spagnuolo V, Cerqua G, Cerasola G, Mulé G, Barbagallo M, Lo Sciuto S, Monteverde A, Saitta A, Lo Gullo A, Malatino L, Cilia C, Terranova V, Pisano M, Pinto A, Di Raimondo D, Tuttolomondo A, Conigliaro R, Signorelli S, De Palma D, Galderisi M, Cudemo G, Galletti F, Fazio V, De Luca N, Meccariello A, Caputo D, De Donato MT, Iannuzi A, Bresciani A, Giunta R, Utili R, Iorio V, Adinolfi LE, Sellitto C, Iuliano N, Bellis P, Tirelli P, Sacerdoti D, Vanni D, Iuliano L, Ciacciarelli M, Pacelli A, Palazzuoli A, Cacciafesta M, Gueli N, Lo Iacono C, Brusco S, Verrusio W, Nobili L, Tarquinio N, Pellegrini F, Vincentelli GM, Ravallese F, Santini C, Letizia C, Petramala L, Zinnamosca L, Minisola S, Cilli M, Colangelo L, Falaschi P, Martocchia A, Pastore F, Bertazzoni G, Attalla El Halabieh E, Paradiso M, Lizzi EM, Timmi S, Battisti P, Cerci S, Ciavolella M, Di Veroli C, Malci F, De Ciocchis A, Abate D, Castellino P, Zanoli L, Fidone F, Mannarino E, Pasqualini L, Oliverio G, Pende A, Artom N, Ricchio R, Fimognari FL, Alletto M, Messina S, Sesti G, Arturi F, Succurro E, Fiorentino TV, Pedace E, Scarpino PE, Carullo G, Maio R, Sciacqua A, Frugiuele P, Battaglia G, Atzori S, Delitala G, Angelucci E, Sestili S, Traisci G, De Feudis L, Di Michele D, Fava A, Balsano C, De Ciantis P, Desideri G, Camerota A, Mezzetti M, Gresele P, Vedovati C, Fierro T, Puccetti L, Bertolotti M, Mussi C, Boddi M, Savino A, Contri S, Degl’Innocenti G, Saller A, Fabris F, Pesavento R, Filippi L, Vedovetto V, Puato M, Treleani M, De Luca E, De Zaiacomo F, Giantin V, Semplicini A, Minuz P, Romano S, Fantin F, Manica A, Stockner I, Pattis P, Gutmann B, Catena C, Colussi G, Sechi LA, Annoni G, Bruni AA, Castagna A, Spinelli D, Miceli E, Padula D, Schinco G, Spreafico S, Secchi B, Vanoli M, Casella G, Pulixi EA, Sansone L, Serra MG, Longo S, Antonaci S, Belfiore A, Frualdo M, Palasciano G, Ricci L, Ventrella F, Bianco C, Santovito D, Cipollone F, Nicolai S, Salvati F, Rini GB, Scozzari F, Muiesan ML, Salvetti M, Bazza A, Picardi A, Vespasiani-Gentilucci U, De Vincentis A, Cosio P, Terzolo M, Madaffari B, Parasporo B, Fenoglio L, Bracco C, Melchio R, Gentili T, Salvi A, Nitti C, Gabrielli A, Martino GP, Capucci A, Brambatti M, Sparagna A, Tirotta D, Andreozzi P, Ettorre E, Viscogliosi G, Servello A, Musumeci M, Delfino M, Giorgi A, Glorioso N, Melis G, Marras G, Matta M, Sacco A, Stellitano E, Scordo A, Russo F, Caruso AA, Porreca E, Tana M, Ferri C, Cheli P, Portincasa P, Muscianisi G, Giordani S, Stanghellini V, Sabbà C, Mancuso G, Bartone M, Calipari D, Arcidiacono G, Bellanuova I, Ferraro M, Marigliano G, Cozzolino D, Lampitella A, Acri V, Galasso D, Mazzei F, Buratti A, Galasso S, Porta M, Brizzi MF, Fattorini A, Sampietro F, D’Angelo A, Manfredini R, Pala M, Fabbian F, Moroni C, Valente L, Lopreiato F, Parente F, Granata M, Moia M, Braham S, Rossi M, Pesce M, Gentile A, Catozzo V, Baciarello G, Cosimati A, Ageno W, Rancan E, Guasti L, Ciccaglioni A, Negri S, Polselli M, Prisco D, Marcucci R, Ferro D, Perri L, Cangemi R, Saliola M, Del Ben M, Angelico F, Baratta F, Migliacci R, Porciello G, Corrao S, Proietti M, Raparelli V, Napoleone L, Talerico G, Amoroso D, Romiti GF, Ruscio E, Toriello F, Sperduti N, Todisco T, Di Tanna G, Sacchetti ML, Puddu PE, Farcomeni A, Anzaldi M, Bazzini C, Bianchi PI, Boari B, Buonauro A, Buttà C, Buzzetti E, Calabria S, Capeci W, Caradio F, Carleo P, Carrabba MD, Castorani L, Cecchetto L, Cicco S, Cimini C, Colombo BM, De Giorgi A, De Vuono S, Del Corso L, Denegri A, Di Giosia P, Durante Mangoni E, Falsetti L, Forgione A, Giorgini P, Grassi D, Grembiale A, Hijazi D, Iamele L, Lorusso G, Marchese A, Marra AM, Masala M, Miceli G, Montebianco Abenavoli L, Murgia G, Naccarato P, Pattoneri P, Perego F, Pesce P, Piano S, Pinna M, Pinto D, Pretti V, Pucci G, Salinaro F, Salzano A, Santilli F, Scarpini F, Scicali R, Sirico D, Suppressa P, Talia M, Tassone EJ, Torres D, Vazzana N, Vecchio CR, Vidili G, Vitale F, and Zaccone V

Subjects
Male, Settore MED/09 - Medicina Interna, 030204 cardiovascular system & hematology, Pulmonary Disease, Chronic Obstructive, 0302 clinical medicine, Risk Factors, Major cardiovascular event, Cause of Death, Risk of mortality, Prevalence, Medicine, 030212 general & internal medicine, Prospective Studies, Registries, Prospective cohort study, Stroke, Cause of death, COPD, Chronic obstructive pulmonary disease, Incidence, Hazard ratio, Atrial fibrillation, Cardiovascular mortality, Major cardiovascular events, Aged, Atrial Fibrillation, Cardiovascular Diseases, Endpoint Determination, Female, Follow-Up Studies, Humans, Italy, Predictive Value of Tests, Internal Medicine, Emergency Medicine, Atrial fibrillation, Cardiovascular mortality, Chronic obstructive pulmonary disease, Major cardiovascular events, Cardiology, Settore SECS-S/01 - Statistica, medicine.medical_specialty, Chronic Obstructive, Socio-culturale, Pulmonary Disease, 03 medical and health sciences, Internal medicine, cardiovascular diseases, business.industry, medicine.disease, business, Mace
Abstract

Chronic obstructive pulmonary disease (COPD) increases the risk of mortality in non-valvular atrial fibrillation (NVAF) patients. Data on the relationship of COPD to major cardiovascular events (MACE) in AF have not been defined. The aim of the study is to assess the predictive value of COPD on incident MACE in NVAF patients over a 3-year follow-up. In the Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study (ARAPACIS) cohort, we evaluate the impact of COPD on the following clinical endpoints: MACE (including vascular death, fatal/non-fatal MI and stroke/TIA), cardiovascular (CV) death and all-cause mortality. Among 2027 NVAF patients, patients with COPD (9%) are more commonly male, elderly and at higher thromboembolic risk. During a median 36.0months follow-up, 186 patients experienced MACE: vascular death (n = 72), MI (n = 57), stroke/TIA (n = 57). All major outcomes (including stroke/TIA, MI, vascular death, and all-cause death) are centrally adjudicated. Kaplan–Meier curves show that NVAF patients with COPD are at higher risk for MACE (p < 0.001), CV death (p < 0.001) and all-cause death (p < 0.001). On Cox proportional hazard analysis, COPD is an independent predictor of MACE (Hazard ratio [HR] 1.77, 95% Confidence Intervals [CI] 1.20–2.61; p = 0.004), CV death (HR 2.73, 95% CI 1.76–4.23; p < 0.0001) and all-cause death (HR 2.16, 95% CI 1.48–3.16; p < 0.0001). COPD is an independent predictor of MACE, CV death and all-cause death during a long-term follow-up of NVAF patients.

Published
2018

45. Premorbid academic and social functioning in patients with schizophrenia and its associations with negative symptoms and cognition

Author

Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, M., Cuomo, A., Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., Vita, A., Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Bucci P., Galderisi S., Mucci A., Rossi A., Rocca P., Bertolino A., Aguglia E., Amore M., Andriola I., Bellomo A., Biondi M., Cuomo A., dell'Osso L., Favaro A., Gambi F., Giordano G.M., Girardi P., Marchesi C., Monteleone P., Montemagni C., Niolu C., Oldani L., Pacitti F., Pinna F., Roncone R., Vita A., Zeppegno P., Maj M., Patriarca S., Pietrafesa D., Aiello C., Longo L., Barone M., Romano R., Atti A.R., Barlati S., Deste G., Valsecchi P., Carpiniello B., Tusconi M., Puddu L., Signorelli M.S., Cannavo D., Minutolo G., Corbo M., Montemitro C., Baroni G., Altamura M., La Montagna M., Carnevale R., Murri M.B., Calcagno P., Bugliani M., Pizziconi G., Logozzo F., Rossi R., Giusti L., Salza A., Malavolta M., Orsenigo G., Grassi S., De Bartolomeis A., Gramaglia C., Gattoni E., Gambaro E., Tenconi E., Ferronato L., Collantoni E., Tonna M., Ossola P., Gerra M.L., Carmassi C., Cremone I.M., Carpita B., Buzzanca A., Girardi N., Frascarelli M., Del Casale A., Comparelli A., Corigliano V., Siracusano A., Di Lorenzo G., Ribolsi M., Corrivetti G., Bartoli L., Del Buono G., Fagiolini A., Bolognesi S., Goracci A., Mancini I., Bava I., Cardillo S., Bucci, P., Galderisi, S., Mucci, A., Rossi, A., Rocca, P., Bertolino, A., Aguglia, E., Amore, M., Andriola, I., Bellomo, A., Biondi, Maria, Cuomo, Anna, Dell'Osso, L., Favaro, A., Gambi, F., Giordano, G. M., Girardi, P., Marchesi, C., Monteleone, P., Montemagni, C., Niolu, C., Oldani, L., Pacitti, F., Pinna, F., Roncone, R., DE VITA, Anna, Zeppegno, P., Maj, M., Patriarca, Sara, Pietrafesa, Daria, Aiello, Carmen, Longo, Luisa, Barone, Marina, Romano, Raffaella, Atti, Anna Rita, Barlati, Stefano, Deste, Giacomo, Valsecchi, Paolo, Carpiniello, Bernardo, Tusconi, Massimo, Puddu, Laura, Signorelli, Maria Salvina, Cannavò, Dario, Minutolo, Giuseppe, Corbo, Mariangela, Montemitro, Chiara, Baroni, Gaia, Altamura, Mario, La Montagna, Maddalena, Carnevale, Raffaella, Murri, Martino Belvederi, Calcagno, Pietro, Bugliani, Michele, Pizziconi, Giulia, Logozzo, Francesca, Rossi, Rodolfo, Giusti, Laura, Salza, Anna, Malavolta, Maurizio, Orsenigo, Giulia, Grassi, Silvia, De Bartolomeis, Andrea, Gramaglia, Carla, Gattoni, Eleonora, Gambaro, Eleonora, Tenconi, Elena, Ferronato, Luisa, Collantoni, Enrico, Tonna, Matteo, Ossola, Paolo, Gerra, Maria Lidia, Carmassi, Claudia, Cremone, Ivan Mirko, Carpita, Barbara, Buzzanca, Antonio, Girardi, Nicoletta, Frascarelli, Marianna, Del Casale, Antonio, Comparelli, Anna, Corigliano, Valentina, Siracusano, Alberto, Di Lorenzo, Giorgio, Ribolsi, Michele, Corrivetti, Giulio, Bartoli, Luca, Del Buono, Gianfranco, Fagiolini, Andrea, Bolognesi, Simone, Goracci, Arianna, Mancini, Irene, Bava, Irene, Cardillo, Simona, Biondi, M., Cuomo, A., Vita, A., and Casale, Antonio

Subjects
Male, avolition, Severity of Illness Index, cognitive functioning, 0302 clinical medicine, Cognition, Academic Performance, Medicine, Psychopathology, Depression, primary negative symptoms, Middle Aged, Psychiatric Status Rating Scale, avolition, cognitive functioning, poor emotion expression, premorbid adjustment, primary negative symptoms, poor emotion expression, premorbid adjustment, Psychiatry and Mental Health, Memory, Short-Term, Schizophrenia, Female, Schizophrenic Psychology, medicine.symptom, Psychosocial, Social Adjustment, Clinical psychology, Human, Adult, primary negative symptom, 03 medical and health sciences, Cognition Disorder, Memory, Social cognition, Humans, Cognitive Dysfunction, Cognitive skill, Social Behavior, Aged, Cognition Disorders, Motivation, Psychiatric Status Rating Scales, Settore MED/25 - Psichiatria, Avolition, business.industry, medicine.disease, 030227 psychiatry, Short-Term, business, Neurocognitive, 030217 neurology & neurosurgery
Abstract

Objective The study aimed to explore premorbid academic and social functioning in patients with schizophrenia, and its associations with the severity of negative symptoms and neurocognitive impairment. Method Premorbid adjustment (PA) in patients with schizophrenia was compared to early adjustment in unaffected first-degree relatives and healthy controls. Its associations with psychopathology, cognition, and real-life functioning were investigated. The associations of PA with primary negative symptoms and their two factors were explored. Results We found an impairment of academic and social PA in patients (P ≤ 0.000001) and an impairment of academic aspects of early adjustment in relatives (P ≤ 0.01). Patients with poor PA showed greater severity of negative symptoms (limited to avolition after excluding the effect of depression/parkinsonism), working memory, social cognition, and real-life functioning (P ≤ 0.01 to ≤0.000001). Worse academic and social PA were associated with greater severity of psychopathology, cognitive impairment, and real-life functioning impairment (P ≤ 0.000001). Regression analyses showed that worse PA in the academic domain was mainly associated to the impairment of working memory, whereas worse PA in the social domain to avolition (P ≤ 0.000001). Conclusion Our findings suggest that poor early adjustment may represent a marker of vulnerability to schizophrenia and highlight the need for preventive/early interventions based on psychosocial and/or cognitive programs.

Published
2018

46. The role of Glycoprotein IIb/IIIa inhibitors in acute coronary syndromes and the interference with anemia

Author

Michele Schiariti, Olivia Manfrini, Loredana Iannetta, Domenico Cuturello, Attilio Placanica, Paolo Emilio Puddu, Puddu, Paolo Emilio, Iannetta, Loredana, Placanica, Attilio, Cuturello, Domenico, Schiariti, Michele, and Manfrini, Olivia

Subjects
medicine.medical_specialty, Anemia, medicine.drug_class, gp iib/iiia inhibitors, high risk patients, acute coronary syndromes, acute ischemia, pci, elderly, anemia, Platelet Glycoprotein GPIIb-IIIa Complex, 030204 cardiovascular system & hematology, GP IIb/IIIa inhibitor, Bioinformatics, Risk profile, 03 medical and health sciences, 0302 clinical medicine, Acute ischemia, Risk Factors, medicine, Humans, 030212 general & internal medicine, business.industry, Medicine (all), Anticoagulant, PCI, medicine.disease, High risk patient, Surgery, Red blood cell, Treatment Outcome, medicine.anatomical_structure, Glycoprotein IIb/IIIa inhibitors, Pharmacogenomics, Conventional PCI, Acute coronary syndrome, Hemoglobin, Elderly, anemia, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors, medicine.drug
Abstract

The role played by glycoprotein (GP) IIb/IIIa inhibitors (GPI) has continuously evolved until the most recent Guidelines whereby they were stepped down from class I to class II recommendation for treating acute coronary syndromes (ACS). GPI compete with a wider use of ADP inhibitors and novel anticoagulant drugs although GPI use has greatly narrowed. However, GPI may still have a role. Several criteria were proposed to define post-PCI anemia which is strictly related to bleeding and transfusion. In ACS, it should be important to define anemia in comparative terms versus baseline levels: ≥ 15% of red blood cell decrease should be a practical cut-off value. If one wishes to concentrate on hemoglobin (Hb), a ≥ 2 g/dl Hb decrease from baseline should be considered. It is important to recognize post-PCI anemia in the setting of ACS. There are sub-populations exposed to short-term hemorrhagic and/or long-term ischemic risks. Ischemic and hemorrhagic risks need to be carefully evaluated along with thrombocytopenia and its prognostic significance in order to put all these blood and rheological parameters into a clinically oriented perspective on which therapeutical decisions should be based. Definition of high risk procedures (complexity, angiographic characteristics and patient's risk profile, regardless whether STEMI or NSTEMI) may help selecting GPI. There are positive elements in GPI use: efficacy, rapid onset and reversibility of action, absence of pharmacogenomic variability, pharmacoeconomic considerations and the possibility of intracoronary administration. All these elements should be evaluated when selecting these agents for therapeutics.

Published
2016

47. Predicting cerebral edema in ischemic stroke patients

Author

Luca Faccioli, Marco Zoli, Marco Pastore Trossello, Maria Vittoria Lega, Antonio Muscari, Andrea Lorusso, Giovanni M. Puddu, Luca Spinardi, Muscari A., Faccioli L., Lega M.V., Lorusso A., Trossello M.P., Puddu G.M., Spinardi L., and Zoli Marco

Subjects
Male, medicine.medical_specialty, Neurology, Prognosi, Determinant, Brain Edema, Dermatology, Severity of Illness Index, Cerebral edema, Brain Ischemia, Brain ischemia, 03 medical and health sciences, 0302 clinical medicine, Retrospective Studie, medicine.artery, Internal medicine, Edema, medicine, Humans, 030212 general & internal medicine, Stroke, Brain CT scan, Retrospective Studies, Neuroradiology, Aged, Aged, 80 and over, Ischemic stroke, business.industry, General Medicine, Middle Aged, Prognosis, medicine.disease, Hyperintensity, Psychiatry and Mental health, Middle cerebral artery, Cardiology, Female, Neurology (clinical), medicine.symptom, business, Tomography, X-Ray Computed, 030217 neurology & neurosurgery, Predictor, Human
Abstract

Objectives: To produce a scoring system for predicting the development of edema in ischemic stroke patients without edema on admission. Methods: This retrospective study included 572 ischemic stroke patients (73.3 ± 13.0years, 300 male) without signs of cerebral edema on the first CT scan, which was performed on admission. Another scan was normally performed 3days later, and subsequently whenever needed. Edema was defined as cerebral hypodensity with compression of lateral ventricles. The main clinical, laboratory, and instrumental variables obtained during the first 24h were related to the appearance of edema on the CT scans performed after the first one. Results: Cerebral edema occurred in 158 patients (27.6%) after a median time of 4days. The variables independently associated with edema development were (odds ratio, 95% CI) the following: (1) total anterior circulation syndrome (4.20, 2.55–6.93; P < 0.0001), (2) hyperdense appearance of middle cerebral artery (4.12, 2.03–8.36; P = 0.0001), (3) closed eyes (2.53, 1.39–4.60; P = 0.002), (4) vomiting (3.53, 1.45–8.60; P = 0.006), (5) lacunar cerebral syndrome (0.36, 0.17–0.77; P = 0.008); and (6) white matter lesions (0.53, 0.33–0.86; P = 0.01). Counting one positive point for the first four variables and one negative point for the last two variables, a scoring system (E-score) was built. Cerebral edema could be predicted when the score was ≥ 1 (positive predictive value 61.6%, specificity 85.3%, sensitivity 62.0%). The area under the receiver operating characteristic curve was 0.78. Conclusions: In ischemic stroke patients, six variables obtained during the first 24h of hospitalization were predictive of subsequent cerebral edema development.

Published
2019

48. QUBIC: using NbSi TESs with a bolometric interferometer to characterize the polarisation of the CMB

Author

Alejandro Almela, L. H. Arnaldi, W. Marty, S. Loucatos, Andrea Tartari, A. Pelosi, J. Aumont, Massimo Gervasi, K. Ganga, Emory F. Bunn, L. Grandsire, Giuseppe D'Alessandro, L. M. Mundo, E. Jules, Victor Haynes, S. Marnieros, C. Chapron, L. Mele, M. Platino, C. Kristukat, D. Fracchia, M. C. Medina, F. Piacentini, A. Gault, D. Prêle, D. T. Hoang, Andrei Korotkov, A. Mattei, M. Gaspard, Damien Rambaud, P. A. R. Ade, Gustavo E. Romero, M. Tomasi, Federico Pezzotta, Y. Giraud-Heraud, S. Vanneste, S. Banfi, J. Bonaparte, A. Etchegoyen, Martin Giard, Marco Bersanelli, Elia S. Battistelli, J.-Ph. Bernard, M. Stolpovskiy, D. Gayer, P. de Bernardis, Marcin Gradziel, F. Wicek, J. Kaplan, M. Gómez Berisso, R. Charlassier, J.G. Alberro, Mark McCulloch, F. Incardona, Asdrúbal Enrique Bottani, Mario Zannoni, Peter Timbie, B. Bélier, V. Gilles, F. Columbro, Luca Lamagna, M. E. García Redondo, M.-A. Bigot-Sazy, A. Zullo, Giampaolo Pisano, S. Scully, Nicola Vittorio, N. Bleurvacq, J.M. Salum, S. Dheilly, Lucio Piccirillo, D. Burke, F. Suarez, A. Passerini, J. Bonis, G. de Gasperis, Maria Salatino, D. Auguste, R. Luterstein, Thibaut Louis, Sophie Henrot-Versille, J. D. Murphy, Gregory S. Tucker, C. Perbost, J. A. Murphy, B. Maffei, P. Chanial, L. A. Montier, Michel Piat, F. Voisin, Alessandro Schillaci, Alessandro Paiella, Roberto Puddu, E. Olivieri, C. Scóccola, Carole Tucker, Andrew May, Bruce Rafael Mellado Garcia, Alessandro Coppolecchia, H. Pastoriza, D. Harari, L. Dumoulin, G. Amico, J.-P. Thermeau, D. Buzi, François Pajot, C. Oriol, M. De Leo, L.P. Ferreyro, Cristian Franceschet, A. Fasciszewski, Alessandro Buzzelli, M. De Petris, S. Spinelli, J.-Ch. Hamilton, Federico Nati, B. Watson, Francesco Cavaliere, M. Perciballi, S. Azzoni, Silvia Masi, A. Di Donato, Créidhe O'Sullivan, Laurent Bergé, D. Viganò, Gabriele Coppi, Steve Torchinsky, Gianluca Polenta, Simon J. Melhuish, A. Baù, L. Mousset, P. Ringegni, G. Stankowiak, A. Mennella, M. M. Gamboa Lerena, D. Bennett, M. González, P. Battaglia, Piat, M, Bélier, B, Bergé, L, Bleurvacq, N, Chapron, C, Dheilly, S, Dumoulin, L, González, M, Grandsire, L, Hamilton, J, Henrot-Versillé, S, Hoang, D, Marnieros, S, Marty, W, Montier, L, Olivieri, E, Oriol, C, Perbost, C, Prêle, D, Rambaud, D, Salatino, M, Stankowiak, G, Thermeau, J, Torchinsky, S, Voisin, F, Ade, P, Alberro, J, Almela, A, Amico, G, Arnaldi, L, Auguste, D, Aumont, J, Azzoni, S, Banfi, S, Battaglia, P, Battistelli, E, Baù, A, Bennett, D, Bernard, J, Bersanelli, M, Bigot-Sazy, M, Bonaparte, J, Bonis, J, Bottani, A, Bunn, E, Burke, D, Buzi, D, Buzzelli, A, Cavaliere, F, Chanial, P, Charlassier, R, Columbro, F, Coppi, G, Coppolecchia, A, D’Alessandro, G, de Bernardis, P, De Gasperis, G, De Leo, M, De Petris, M, Di Donato, A, Etchegoyen, A, Fasciszewski, A, Ferreyro, L, Fracchia, D, Franceschet, C, Gamboa Lerena, M, Ganga, K, García, B, García Redondo, M, Gaspard, M, Gault, A, Gayer, D, Gervasi, M, Giard, M, Gilles, V, Giraud-Heraud, Y, Gómez Berisso, M, Gradziel, M, Harari, D, Haynes, V, Incardona, F, Jules, E, Kaplan, J, Korotkov, A, Kristukat, C, Lamagna, L, Loucatos, S, Louis, T, Luterstein, R, Maffei, B, Masi, S, Mattei, A, May, A, Mcculloch, M, Medina, M, Mele, L, Melhuish, S, Mennella, A, Mousset, L, Mundo, L, Murphy, J, Nati, F, O’Sullivan, C, Paiella, A, Pajot, F, Passerini, A, Pastoriza, H, Pelosi, A, Perciballi, M, Pezzotta, F, Piacentini, F, Piccirillo, L, Pisano, G, Platino, M, Polenta, G, Puddu, R, Ringegni, P, Romero, G, Salum, J, Schillaci, A, Scóccola, C, Scully, S, Spinelli, S, Stolpovskiy, M, Suarez, F, Tartari, A, Timbie, P, Tomasi, M, Tucker, C, Tucker, G, Vanneste, S, Viganò, D, Vittorio, N, Watson, B, Wicek, F, Zannoni, M, Zullo, A, AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre de Nanosciences et de Nanotechnologies [Orsay] (C2N), Université Paris-Sud - Paris 11 (UP11)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Institut de recherche en astrophysique et planétologie (IRAP), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Institut d'astrophysique spatiale (IAS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Saclay, Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Centre National d’Études Spatiales [Paris] (CNES), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
Cosmology and Nongalactic Astrophysics (astro-ph.CO), TESs, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Physics::Instrumentation and Detectors, Cosmic microwave background, FOS: Physical sciences, Integrated circuit, CMB, TDM, 01 natural sciences, Multiplexing, Cosmology, 010305 fluids & plasmas, law.invention, FIS/05 - ASTRONOMIA E ASTROFISICA, Optics, law, 0103 physical sciences, General Materials Science, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], 010306 general physics, Instrumentation and Methods for Astrophysics (astro-ph.IM), ComputingMilieux_MISCELLANEOUS, [PHYS]Physics [physics], Physics, business.industry, Cosmology, Instrumentation, Polarization, Cosmic Microwave Background, Cryogenics, Bolometers, Detector, Bolometer, Astrophysics::Instrumentation and Methods for Astrophysics, Condensed Matter Physics, Polarization (waves), Atomic and Molecular Physics, and Optics, Interferometry, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Astrophysics - Instrumentation and Methods for Astrophysics, business, TES, Astrophysics - Cosmology and Nongalactic Astrophysics
Abstract

QUBIC (Q \& U Bolometric Interferometer for Cosmology) is an international ground-based experiment dedicated in the measurement of the polarized fluctuations of the Cosmic Microwave Background (CMB). It is based on bolometric interferometry, an original detection technique which combine the immunity to systematic effects of an interferometer with the sensitivity of low temperature incoherent detectors. QUBIC will be deployed in Argentina, at the Alto Chorrillos mountain site near San Antonio de los Cobres, in the Salta province. The QUBIC detection chain consists in 2048 NbSi Transition Edge Sensors (TESs) cooled to 350mK.The voltage-biased TESs are read out with Time Domain Multiplexing based on Superconducting QUantum Interference Devices (SQUIDs) at 1 K and a novel SiGe Application-Specific Integrated Circuit (ASIC) at 60 K allowing to reach an unprecedented multiplexing (MUX) factor equal to 128. The QUBIC experiment is currently being characterized in the lab with a reduced number of detectors before upgrading to the full instrument. I will present the last results of this characterization phase with a focus on the detectors and readout system., Conference proceedings submitted to the Journal of Low Temperature Physics for LTD18

Published
2019
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49. Non-invasive prediction of genotype positive–phenotype negative in hypertrophic cardiomyopathy by 3D modern shape analysis

Author

Concetta Torromeo, Andrea Madeo, Paola Nardinocchi, Antonietta Evangelista, Claudia Chialastri, Michele Schiariti, Luciano Teresi, Federica Re, Paolo Piras, Paolo Emilio Puddu, Valerio Varano, Giuseppe Esposito, Piras, P., Torromeo, C., Evangelista, A., Esposito, G., Nardinocchi, P., Teresi, L., Madeo, A., Re, F., Chialastri, C., Schiariti, M., Varano, V., and Puddu, P. E.

Subjects
Adult, Male, medicine.medical_specialty, Genotype, Physiology, Heart Ventricles, Speckle tracking echocardiography, 030204 cardiovascular system & hematology, Muscle hypertrophy, 03 medical and health sciences, Ventricular Dysfunction, Left, 0302 clinical medicine, Physiology (medical), Internal medicine, Medicine, Humans, cardiovascular diseases, Nutrition and Dietetics, 3D echocardiography, Receiver operating characteristic, business.industry, Hypertrophic cardiomyopathy, General Medicine, Cardiomyopathy, Hypertrophic, Middle Aged, medicine.disease, hypertrophic cardiomyopathy, Phenotype, 3D echocardiography, genetics, genotype positive, hypertrophic cardiomyopathy, modern shape analysis, medicine.anatomical_structure, ROC Curve, genotype positive, modern shape analysis, Ventricle, Echocardiography, Cardiology, Female, Hypertrophy, Left Ventricular, genetic, business, 030217 neurology & neurosurgery, Shape analysis (digital geometry)
Abstract

New findings What is the central question of this study? Can impaired deformational indicators for genotype positive for hypertrophic cardiomyopathy in subjects that do not exhibit a left-ventricular wall hypertrophy condition (G+LVH-) be determined using non-invasive 3D echocardiography? What is the main finding and its importance? Using 3D-STE and modern shape analysis, peculiar deformational impairments can be detected in G+LVH- subjects that can be classified with good accuracy. Moreover, the patterns of impairment are located mainly on the apical region in agreement with other evidence coming from previous biomechanical investigations. Abstract We propose a non-invasive procedure for predicting genotype positive for hypertrophic cardiomyopathy (HCM) in subjects that do not exhibit a left-ventricular wall hypertrophy condition (G+LVH-); the procedure is based on the enhanced analysis of medical imaging from 3D speckle tracking echocardiography (3D-STE). 3D-STE, due to its low quality images, has not been used so far to detect effectively the G+LVH- condition. Here, we post-processed echocardiographic images exploiting the tools of modern shape analysis, and we studied the motion of the left ventricle (LV) during an entire cycle. We enrolled 82 controls, 21 HCM patients and 11 G+LVH- subjects. We followed two steps: (i) we selected the most impaired regions of the LV by analysing its strains; and (ii) we used shape analysis on these regions to classify the subjects. The G+LVH- subjects showed different trajectories and deformational attributes. We found high classification performance in terms of area under the receiver operating characteristic curve (∼90), sensitivity (∼78) and specificity (∼79). Our results showed that (i) G+LVH- subjects present important deformational impairments relative to healthy controls and (ii) modern shape analysis can efficiently predict genotype by means of a non-invasive and inexpensive technique such as 3D-STE.

Published
2019

50. The Human Breast Milk Metabolome in Overweight and Obese Mothers

Author

Flaminia Bardanzellu, Vassilios Fanos, Melania Puddu, and Diego Peroni

Subjects
lcsh:Immunologic diseases. Allergy, 0301 basic medicine, obesity, breastfeeding, Offspring, Immunology, Breastfeeding, Physiology, Review, Breast milk, Overweight, 03 medical and health sciences, 0302 clinical medicine, Pregnancy, Polyamines, Metabolome, Humans, overweight, Immunology and Allergy, Medicine, Amino Acids, Milk, Human, diabetes, Nucleotides, business.industry, medicine.disease, metabolomics, Lipids, Obesity, gestational diabetes mellitus, 030104 developmental biology, Alcohols, breast milk, Female, medicine.symptom, Sugars, lcsh:RC581-607, business, Body mass index, 030215 immunology
Abstract

Pre-pregnancy body mass index (BMI) is a major relevance factor, since maternal overweight and obesity can impair the pregnancy outcome and represent risk factors for several neonatal, childhood, and adult conditions, including excessive weight gain, cardiovascular disease, diabetes mellitus, and even behavioral disorders. Currently, breast milk (BM) composition in such category of mothers was not completely defined. In this field, metabolomics represents the ideal technology, able to detect the whole profile of low molecular weight molecules in BM. Limited information is available on human BM metabolites differences in overweight or obese compared to lean mothers. Analyzing all the metabolomics studies published on Medline in English language, this review evaluated the effects that 8 specific types of metabolites found altered by maternal overweight and obesity (nucleotide derivatives, 5-methylthioadenosine, sugar-alcohols, acylcarnitine and amino acids, polyamines, mono-and oligosaccharides, lipids) can exert on the risk of offspring obesity development and other potentially associated health outcomes and complications. However, metabolites variations in samples collected from overweight and obese mothers and the potentially correlated effects highlighted below still need further investigations and should be confirmed in future metabolomics studies on larger samples. Finally, the positive or negative influence of maternal overweight and obesity on the offspring, potentially exerted by breastfeeding, should be analyzed in close correlation with maternal age, genetic and environmental factors, including diet, and taking into account the interactions occurring between BM metabolites and lactobiome. The evaluation of all the factors affecting BM metabolites in overweight and obese mothers can lead to the comprehensive description of such biofluid and the related effects on breastfed subjects, potentially highlighting personalized needs of BM supplementation or short- and long-term prevention strategies to optimize offspring health.

Published
2020

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