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1. Alcohol consumption and pancreatic cancer: a pooled analysis in the International Pancreatic Cancer Case–Control Consortium (PanC4)

Author

Manal M. Hassan, Anthony B. Miller, E. A. Holly, Paolo Boffetta, Parviz Ghadirian, William R. Bamlet, Jerry Polesel, Ersilia Lucenteforte, C. La Vecchia, Michelle Cotterchio, Elizabeth T. H. Fontham, Steve Gallinger, Eric J. Duell, J. Su, Donghui Li, Bu Tian Ji, Debra T. Silverman, Paige M. Bracci, Witold Zatonski, R. Talamini, Eva Negri, Yu-Tang Gao, Patrick Maisonneuve, Cristina Bosetti, H. B. Bueno-de-Mesquita, Gloria M. Petersen, Peter A. Baghurst, Lucenteforte, E., La Vecchia, C., Silverman, D., Petersen, G.M., Bracci, P.M., Ji, B.T., Bosetti, C., Li, D., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Bamlet, W.R., Holly, E.A., Gao, Y.T., Negri, E., Hassan, M., Cotterchio, M., Su, J., Maisonneuve, P., Boffetta, P., Duell, E.J., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, and Icahn School of Medicine at Mount Sinai [New York] (MSSM)

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Pathology, alcohol drinking, case–control, studies, ethanol, pancreatic cancer, pooled analysis, risk factors, Alcohol, chemistry.chemical_compound, Internal medicine, Pancreatic cancer, Odds Ratio, medicine, Adult Aged Alcohol Drinking/*adverse effects Case-Control Studies Confounding Factors (Epidemiology) Female Humans Logistic Models Male Middle Aged Odds Ratio Pancreatic Neoplasms/*epidemiology/etiology Pancreatitis/complications Risk Factors Smoking/adverse effects, Humans, risk of pancreatic cancer, Aged, business.industry, Smoking, Confounding Factors, Epidemiologic, Original Articles, Hematology, Middle Aged, medicine.disease, Pancreatic Neoplasms, Logistic Models, Pooled analysis, Pancreatitis, chemistry, Case-Control Studies, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Female, business, Alcohol consumption, heavy alcohol consumptio
Abstract

Lucenteforte, E La Vecchia, C Silverman, D Petersen, G M Bracci, P M Ji, B T Bosetti, C Li, D Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Gao, Y T Negri, E Hassan, M Cotterchio, M Su, J Maisonneuve, P Boffetta, P Duell, E J eng CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ Meta-Analysis Research Support, N.I.H., Extramural Research Support, N.I.H., Intramural Research Support, Non-U.S. Gov't England 2011/05/04 06:00 Ann Oncol. 2012 Feb;23(2):374-82. doi: 10.1093/annonc/mdr120. Epub 2011 May 2.; International audience; BACKGROUND: Heavy alcohol drinking has been related to pancreatic cancer, but the issue is still unsolved. METHODS: To evaluate the role of alcohol consumption in relation to pancreatic cancer, we conducted a pooled analysis of 10 case-control studies (5585 cases and 11,827 controls) participating in the International Pancreatic Cancer Case-Control Consortium. We computed pooled odds ratios (ORs) by estimating study-specific ORs adjusted for selected covariates and pooling them using random effects models. RESULTS: Compared with abstainers and occasional drinkers (< 1 drink per day), we observed no association for light-to-moderate alcohol consumption (/= 9 drinks per day). Results did not change substantially when we evaluated associations by tobacco smoking status, or when we excluded participants who reported a history of pancreatitis, or participants whose data were based upon proxy responses. Further, no notable differences in pooled risk estimates emerged across strata of sex, age, race, study type, and study area. CONCLUSION: This collaborative-pooled analysis provides additional evidence for a positive association between heavy alcohol consumption and the risk of pancreatic cancer.

Published
2012

2. Past Medical History and Pancreatic Cancer Risk: Results From a Multicenter Case-Control Study

Author

Peter Boyle, Albert B. Lowenfels, Peter A. Baghurst, Witold Zatonski, H. Bas Bueno-de-Mesquita, Eric J. Duell, Paolo Boffetta, Parviz Ghadirian, Anthony B. Miller, Patrick Maisonneuve, Maisonneuve, P., Lowenfels, A.B., Bueno-de-Mesquita, H.B., Ghadirian, P., Baghurst, P.A., Zatonski, W.A., Miller, A.B., Duell, E.J., Boffetta, P., and Boyle, P.

Subjects
Adult, Male, Canada, medicine.medical_specialty, Epidemiology, Population, Diabete, Allergie, Risk Factors, Internal medicine, Pancreatic cancer, Diabetes Mellitus, Humans, Medicine, Pancreas Cancer, education, Aged, Netherlands, Aged, 80 and over, education.field_of_study, Past medical history, Pancreatiti, business.industry, Smoking, Australia, Past Medical History, Case-control study, Cancer, Odds ratio, Middle Aged, medicine.disease, Multicenter Case-Control Study, Surgery, Pancreatic Neoplasms, Pancreatitis, Case-Control Studies, Female, Poland, business, Risk assessment
Abstract

Purpose: To investigate risk factors that may be linked to pancreatic cancer. Methods: We designed a multicenter population-based case-control (823 cases, 1679 control patients) study with data collection by using a common protocol and questionnaire. Participating centers were located in Australia, Canada, the Netherlands, and Poland. Results: After adjustment for confounding factors, a positive history of pancreatitis was associated with pancreatic cancer (odds ratio [OR], 4.68; 95% confidence interval [95% CI], 2.23 - 9.84). The risk was especially high in heavy smokers (OR, 15.4; 95% CI, 3.18 - 74.9). Patients with diabetes had an increased risk of developing pancreatic cancer (OR, 2.16; 95% CI, 1.60 - 2.91). The risk was highest in the first year after the development of diabetes (OR, 6.68; 95% CI, 3.56 - 12.6) and decreased over time. A history of allergy was associated with a reduced risk of pancreas cancer (OR, 0.64; 95% CI, 0.50 - 0.82). Conclusions: Patients with newly diagnosed diabetes and patients with pancreatitis, particularly in heavy smokers, have an increased risk for developing pancreatic cancer. In addition to being risk factors, these conditions could be early manifestations of underlying pancreatic cancer. A history of allergy decreases the risk of pancreatic cancer. © 2010 Elsevier Inc. All rights reserved.

Published
2010

3. Diabetes, antidiabetic medications, and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium

Author

C. La Vecchia, Robert C. Kurtz, Michelle Cotterchio, Anna E. Prizment, Ghislaine Scelo, Sean P. Cleary, Gloria M. Petersen, Joshua E. Muscat, Sara H. Olson, E. Fabianova, Paige M. Bracci, Manal M. Hassan, P. Ghadirian, William R. Bamlet, Anthony B. Miller, Steve Gallinger, Pagona Lagiou, Witold Zatonski, Donghui Li, H. Bas Bueno-de-Mesquita, Vladimir Janout, Eva Negri, Valentina Rosato, Peter A. Baghurst, Eric J. Duell, Patrick Maisonneuve, Cristina Bosetti, Diego Serraino, Rachel E. Neale, E. A. Holly, Ivana Holcatova, Dimitrios Trichopoulos, Elizabeth T. H. Fontham, Debra T. Silverman, Kristin E. Anderson, Paolo Boffetta, Lenka Foretova, Jerry Polesel, Ersilia Lucenteforte, Bosetti, C., Rosato, V., Li, D., Silverman, D., Petersen, G.M., Bracci, P.M., Neale, R.E., Muscat, J., Anderson, K., Gallinger, S., Olson, S.H., Miller, A.B., Bas Bueno-de-Mesquita, H., Scelo, G., Janout, V., Holcatova, I., Lagiou, P., Serraino, D., Lucenteforte, E., Fabianova, E., Ghadirian, P., Baghurst, P.A., Zatonski, W., Foretova, L., Fontham, E., Bamlet, W.R., Holly, E.A., Negri, E., Hassan, M., Prizment, A., Cotterchio, M., Cleary, S., Kurtz, R.C., Maisonneuve, P., Trichopoulos, D., Polesel, J., Duell, E.J., Boffetta, P., and La Vecchia, C.

Subjects
Adult, Male, medicine.medical_specialty, insulin, pancreatic cancer, oral antidiabetics, pancreatic cance r, Risk Factors, Diabetes mellitus, Internal medicine, Pancreatic cancer, medicine, Humans, Hypoglycemic Agents, Aged, Aged, 80 and over, 2. Zero hunger, diabetes, business.industry, Smoking, Absolute risk reduction, Cancer, Type 2 Diabetes Mellitus, case–control study, Hematology, Odds ratio, Original Articles, Middle Aged, medicine.disease, Confidence interval, pooled analysis, 3. Good health, Pancreatic Neoplasms, Logistic Models, Endocrinology, Diabetes Mellitus, Type 2, Oncology, diabete, Case-Control Studies, oral antidiabetic, Female, business, Body mass index
Abstract

BACKGROUND: Type 2 diabetes mellitus has been associated with an excess risk of pancreatic cancer, but the magnitude of the risk and the time-risk relationship are unclear, and there is limited information on the role of antidiabetic medications. PATIENTS AND METHODS: We analyzed individual-level data from 15 case-control studies within the Pancreatic Cancer Case-Control Consortium, including 8305 cases and 13 987 controls. Pooled odds ratios (ORs) were estimated from multiple logistic regression models, adjusted for relevant covariates. RESULTS: Overall, 1155 (15%) cases and 1087 (8%) controls reported a diagnosis of diabetes 2 or more years before cancer diagnosis (or interview, for controls), corresponding to an OR of 1.90 (95% confidence interval, CI, 1.72-2.09). Consistent risk estimates were observed across strata of selected covariates, including body mass index and tobacco smoking. Pancreatic cancer risk decreased with duration of diabetes, but a significant excess risk was still evident 20 or more years after diabetes diagnosis (OR 1.30, 95% CI 1.03-1.63). Among diabetics, long duration of oral antidiabetic use was associated with a decreased pancreatic cancer risk (OR 0.31, 95% CI 0.14-0.69, for =15 years). Conversely, insulin use was associated with a pancreatic cancer risk in the short term (OR 5.60, 95% CI 3.75-8.35, for

Published
2014

4. Ulcer, gastric surgery and pancreatic cancer risk: an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author

Maurice P. Zeegers, Herbert Yu, Michelle Cotterchio, Harvey A. Risch, Sara H. Olson, Jerry Polesel, Elizabeth T. H. Fontham, Robert C. Kurtz, Eric J. Duell, Ersilia Lucenteforte, Anthony B. Miller, Witold Zatonski, Steven Gallinger, Rachel E. Neale, Eva Negri, Paige M. Bracci, E. A. Holly, Patrick Maisonneuve, Cristina Bosetti, Paolo Boffetta, C. La Vecchia, Parviz Ghadirian, Yu-Tang Gao, H. B. Bueno-de-Mesquita, R. Talamini, Peter A. Baghurst, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Complexe Genetica, RS: NUTRIM - R4 - Gene-environment interaction, Bosetti, C., Lucenteforte, E., Bracci, P.M., Negri, E., Neale, R.E., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Holly, E.A., Gao, Y.T., Yu, H., Kurtz, R.C., Cotterchio, M., Maisonneuve, P., Zeegers, M.P., Duell, E.J., Boffetta, P., and La Vecchia, C.

Subjects
medicine.medical_specialty, Gastrointestinal Diseases, medicine.medical_treatment, Peptic, pancreatic cancer, Gastroenterology, Risk Factors, Internal medicine, Pancreatic cancer, medicine, Humans, Ulcer, peptic ulcer, Aged, business.industry, Absolute risk reduction, Case-control study, Cancer, case–control study, Original Articles, Hematology, Odds ratio, Middle Aged, anti-ulcer drugs, medicine.disease, Confidence interval, gastrectomy, digestive system diseases, Surgery, Pancreatic Neoplasms, Logistic Models, Oncology, Case-Control Studies, Female, Gastrectomy, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, anti-ulcer drugs, case–control study, gastrectomy, pancreatic cancer, peptic ulcer, pooled analysis, pooled analysis, business
Abstract

Bosetti, C Lucenteforte, E Bracci, P M Negri, E Neale, R E Risch, H A Olson, S H Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Holly, E A Gao, Y T Yu, H Kurtz, R C Cotterchio, M Maisonneuve, P Zeegers, M P Duell, E J Boffetta, P La Vecchia, C eng 5R01-CA098870/CA/NCI NIH HHS/ CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ R01 CA97075/CA/NCI NIH HHS/ U01 CA074783/CA/NCI NIH HHS/ U01-CA74783/CA/NCI NIH HHS/ U24 CA074783/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2013/08/24 06:00 Ann Oncol. 2013 Nov;24(11):2903-10. doi: 10.1093/annonc/mdt336. Epub 2013 Aug 22.; International audience; BACKGROUND: Peptic ulcer and its treatments have been associated to pancreatic cancer risk, although the evidence is inconsistent. METHODS: We pooled 10 case-control studies within the Pancreatic Cancer Case-control Consortium (PanC4), including 4717 pancreatic cancer cases and 9374 controls, and estimated summary odds ratios (OR) using multivariable logistic regression models. RESULTS: The OR for pancreatic cancer was 1.10 [95% confidence interval (CI) 0.98-1.23] for history of ulcer (OR = 1.08 for gastric and 0.97 for duodenal ulcer). The association was stronger for a diagnosis within 2 years before cancer diagnosis (OR = 2.43 for peptic, 1.75 for gastric, and 1.98 for duodenal ulcer). The OR was 1.53 (95% CI 1.15-2.03) for history of gastrectomy; however, the excess risk was limited to a gastrectomy within 2 years before cancer diagnosis (OR = 6.18, 95% CI 1.82-20.96), while no significant increased risk was observed for longer time since gastrectomy. No associations were observed for pharmacological treatments for ulcer, such as antacids, H2-receptor antagonists, or proton-pump inhibitors. CONCLUSIONS: This uniquely large collaborative study does not support the hypothesis that peptic ulcer and its treatment materially affect pancreatic cancer risk. The increased risk for short-term history of ulcer and gastrectomy suggests that any such association is due to increased cancer surveillance.

Published
2013

5. Cigarette smoking and pancreatic cancer : an analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author

Yu-Tang Gao, Parviz Ghadirian, E. A. Holly, Michelle Cotterchio, C. La Vecchia, Gloria M. Petersen, Steven Gallinger, Donghui Li, Patrick Maisonneuve, Cristina Bosetti, Elizabeth T. H. Fontham, R. Talamini, H. B. Bueno-de-Mesquita, Sara H. Olson, Paola Bertuccio, Paige M. Bracci, Jerry Polesel, Bu Tian Ji, Ersilia Lucenteforte, Debra T. Silverman, William R. Bamlet, J. Su, Witold Zatonski, Paolo Boffetta, Eva Negri, Peter A. Baghurst, Robert C. Kurtz, Manal M. Hassan, Anthony B. Miller, Herbert Yu, Harvey A. Risch, Eric J. Duell, International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM), Bosetti, C., Lucenteforte, E., Silverman, D.T., Petersen, G., Bracci, P.M., Ji, B.T., Negri, E., Li, D., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E., Bamlet, W.R., Holly, E.A., Bertuccio, P., Gao, Y.T., Hassan, M., Yu, H., Kurtz, R.C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E.J., Boffetta, P., and La Vecchia, C.

Subjects
medicine.medical_specialty, Multivariate analysis, analysi, pancreatic cancer, cigarette smoking, cancer, Sensitivity and Specificity, PANC4, Cigarette smoking, Internal medicine, Pancreatic cancer, Odds Ratio, medicine, case–control study, pooled analysis, Humans, and pancreatic, Case-Control Studies Humans Logistic Models Multivariate Analysis Odds Ratio Pancreatic Neoplasms/*etiology Sensitivity and Specificity Smoking/*adverse effects, Cigarette, Cancer, Pancreatic, business.industry, Smoking, Case-control study, Original Articles, Hematology, Odds ratio, medicine.disease, Former Smoker, Confidence interval, Surgery, Pancreatic Neoplasms, Case-Control, Logistic Models, Oncology, International, Case-Control Studies, Meta-analysis, Multivariate Analysis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Corrigendum, business, Consortium
Abstract

Bosetti, C Lucenteforte, E Silverman, D T Petersen, G Bracci, P M Ji, B T Negri, E Li, D Risch, H A Olson, S H Gallinger, S Miller, A B Bueno-de-Mesquita, H B Talamini, R Polesel, J Ghadirian, P Baghurst, P A Zatonski, W Fontham, E Bamlet, W R Holly, E A Bertuccio, P Gao, Y T Hassan, M Yu, H Kurtz, R C Cotterchio, M Su, J Maisonneuve, P Duell, E J Boffetta, P La Vecchia, C eng 5R01-CA098870/CA/NCI NIH HHS/ CA098889/CA/NCI NIH HHS/ CA108370/CA/NCI NIH HHS/ CA109767/CA/NCI NIH HHS/ CA59706/CA/NCI NIH HHS/ CA89726/CA/NCI NIH HHS/ N01-CP-05225/CP/NCI NIH HHS/ N01-CP-05227/CP/NCI NIH HHS/ N01-CP-31022/CP/NCI NIH HHS/ N01-CP-51089/CP/NCI NIH HHS/ N01-CP-51090/CP/NCI NIH HHS/ N01-CP-51092/CP/NCI NIH HHS/ N01-PC-35136/PC/NCI NIH HHS/ P50 CA102701/CA/NCI NIH HHS/ R01 CA97075/CA/NCI NIH HHS/ Canadian Institutes of Health Research/Canada Meta-Analysis Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2011/11/23 06:00 Ann Oncol. 2012 Jul;23(7):1880-8. doi: 10.1093/annonc/mdr541. Epub 2011 Nov 21.; International audience; BACKGROUND: To evaluate the dose-response relationship between cigarette smoking and pancreatic cancer and to examine the effects of temporal variables. METHODS: We analyzed data from 12 case-control studies within the International Pancreatic Cancer Case-Control Consortium (PanC4), including 6507 pancreatic cases and 12 890 controls. We estimated summary odds ratios (ORs) by pooling study-specific ORs using random-effects models. RESULTS: Compared with never smokers, the OR was 1.2 (95% confidence interval [CI] 1.0-1.3) for former smokers and 2.2 (95% CI 1.7-2.8) for current cigarette smokers, with a significant increasing trend in risk with increasing number of cigarettes among current smokers (OR=3.4 for >/=35 cigarettes per day, P for trend

Published
2012

6. Cigar and pipe smoking, smokeless tobacco use and pancreatic cancer: An analysis from the International Pancreatic Cancer Case-Control Consortium (PanC4)

Author

Witold Zatonski, Eva Negri, Elizabeth T. H. Fontham, Debra T. Silverman, Donghui Li, Eric J. Duell, Sara H. Olson, Michelle Cotterchio, H. B. Bueno-de-Mesquita, Steve Gallinger, Paige M. Bracci, Herbert Yu, Paolo Boffetta, E. A. Holly, Harvey A. Risch, Paola Bertuccio, William R. Bamlet, J. Su, C. La Vecchia, Jerry Polesel, Ersilia Lucenteforte, Gloria M. Petersen, Robert C. Kurtz, Peter A. Baghurst, Patrick Maisonneuve, Cristina Bosetti, Parviz Ghadirian, Manal M. Hassan, Anthony B. Miller, R. Talamini, Bertuccio, P., La Vecchia, C., Silverman, D.T., Petersen, G.M., Bracci, P.M., Negri, E., Li, D., Risch, H.A., Olson, S.H., Gallinger, S., Miller, A.B., Bueno-de-Mesquita, H.B., Talamini, R., Polesel, J., Ghadirian, P., Baghurst, P.A., Zatonski, W., Fontham, E.T., Bamlet, W.R., Holly, E.A., Lucenteforte, E., Hassan, M., Yu, H., Kurtz, R.C., Cotterchio, M., Su, J., Maisonneuve, P., Duell, E.J., Bosetti, C., and Boffetta, P.

Subjects
Oncology, Adult, Male, Risk, medicine.medical_specialty, Cigar Smoking, Pancreatic disease, Tobacco, Smokeless, pancreatic cancer, tobacco, smoking, cigar, pancreatic cancer, pooled analysis, smokeless tobacco, tobacco, pipe, Pancreatic cancer, Internal medicine, Epidemiology, medicine, Humans, cancer, education, Aged, Aged, 80 and over, Smoking pipe, education.field_of_study, business.industry, Cigar, technology, industry, and agriculture, Cancer, Hematology, Tobacco Use Disorder, Original Articles, smokeless tobacco, Middle Aged, medicine.disease, Surgery, Pancreatic Neoplasms, stomatognathic diseases, pipe, Smokeless tobacco, Case-Control Studies, pancreatic, Female, Biostatistics, pooled analysis, business
Abstract

Background: Cigarette smoking is the best-characterized risk factor for pancreatic cancer. However, data are limited for other tobacco smoking products and smokeless tobacco. Materials and methods: We conducted a pooled analysis of cigar and pipe smoking and smokeless tobacco use and risk of pancreatic cancer using data from 11 case-control studies (6056 cases and 11 338 controls) within the International Pancreatic Cancer Case-Control Consortium (PanC4). Pooled odds ratios (OR) and the corresponding 95% confidence intervals (CI) were estimated by unconditional multiple logistic regression models adjusted for study center and selected covariates. Results: Compared with never tobacco users, the OR for cigar-only smokers was 1.6 (95% CI: 1.2-2.3), i.e. comparable to that of cigarette-only smokers (OR 1.5; 95% CI 1.4-1.6). The OR was 1.1 (95% CI 0.69-1.6) for pipeonly smokers. There was some evidence of increasing risk with increasing amount of cigar smoked per day (OR 1.82 for = 10 grams of tobacco), although not with duration. The OR for ever smokeless tobacco users as compared with never tobacco users was 0.98 (95% CI 0.75-1.3). Conclusion: This collaborative analysis provides evidence that cigar smoking is associated with an excess risk of pancreatic cancer, while no significant association emerged for pipe smoking and smokeless tobacco use. © The Author 2011. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved.

Published
2011

7. Menstrual and reproductive factors and pancreatic cancer in the search program of the IARC

Author

Witold Zatonski, Parviz Ghadirian, H. Bas Bueno-de-Mesquita, Eric J. Duell, Anthony B. Miller, Paolo Boffetta, Peter Boyle, Alina Vrieling, Peter A. Baghurst, Patrick Maisonneuve, Duell, E.J., Maisonneuve, P., Baghurst, P.A., Bueno-De-Mesquita, H.B., Ghadirian, P., Miller, A.B., Zatonski, W., Vrieling, A., Boffetta, P., and Boyle, P.

Subjects
Adult, Cancer Research, medicine.medical_specialty, Adolescent, media_common.quotation_subject, Population, Young Adult, Risk Factors, Pancreatic cancer, Epidemiology, medicine, Humans, Child, education, Prospective cohort study, Reproductive History, Menstrual Cycle, Menstrual cycle, media_common, Menarche, Gynecology, education.field_of_study, Obstetrics, business.industry, Menstrual reproductive factors pancreatic cancer search program IARC, Middle Aged, medicine.disease, Pancreatic Neoplasms, medicine.anatomical_structure, Oncology, Case-Control Studies, Female, Menopause, Pancreas, business, Risk assessment, Carcinoma, Pancreatic Ductal
Abstract

We conducted a population-based case-control study on the relation of menstrual and reproductive factors and hormone use with pancreatic cancer risk among female participants of the SEARCH program study. We evaluated 367 cases of ductal adenocarcinoma and 821 controls for associations between pancreatic cancer and age at menarche, age at menopause, number of pregnancies, exogenous hormone use, and history of gynaecologic surgery. Among directly interviewed and proxy participants, we found a statistically significant association for having age of menarche at 11 years or younger compared with menarche at ages 12-13 years (OR = 1.8, 95% CI = 1.1-3.1). This result was consistent, but not statistically significant, among three of the four studies analyzed, and when the data were analyzed separately by response status (direct vs. proxy interviews). No other menstrual or reproductive factors were associated with pancreatic cancer risk in this study. In conclusion, earlier age at menarche may be weakly associated with pancreatic cancer, but it seems unlikely that menstrual and reproductive factors play more than only a minor role in pancreatic cancer. Additional analyses in large prospective study populations and in pooled studies may help to clarify remaining inconsistencies.

Published
2009

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