1. Assessing the Impact of Acute Respiratory Illnesses on the Risk of Subsequent Respiratory Illness
- Author
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Dandan Liu, John V Willams, Kathryn M. Edwards, Ana I. Gil, Yuwei Zhu, Leigh M Howard, Claudio F. Lanata, Yuhan Liu, Marie R. Griffin, and Carlos G. Grijalva
- Subjects
Male ,medicine.medical_specialty ,Respiratory System ,Lower risk ,Asymptomatic ,Cohort Studies ,Major Articles and Brief Reports ,Internal medicine ,Peru ,Viral Interference ,medicine ,Humans ,Immunology and Allergy ,Prospective Studies ,Respiratory system ,Child ,Prospective cohort study ,Respiratory Tract Infections ,Respiratory illness ,business.industry ,Infant ,respiratory tract diseases ,Virus detection ,Infectious Diseases ,Virus Diseases ,Child, Preschool ,Acute Disease ,Viruses ,Female ,Conditional logistic regression ,medicine.symptom ,business - Abstract
Background Whether acute respiratory illnesses (ARIs), often associated with virus detection, are associated with lower risk for subsequent ARI remains unclear. We assessed the association between symptomatic ARI and subsequent ARI in young children. Methods In a prospective cohort of Peruvian children Results Among 983 index ARI, 339 (34%) had an ARI event during follow-up, compared with 876/2826 (31%) matched asymptomatic observations. We found no significant association of index ARI and subsequent ARI risk during follow-up overall (adjusted odds ratio [aOR], 1.10; 95% confidence interval [CI], .98–1.23) or when limited to index ARI with respiratory viruses detected (aOR, 1.03; 95% CI, .86–1.24). Similarly, when the outcome was limited to ARI in which viruses were detected, no significant association was seen (aOR, 1.05; 95% CI, .87–1.27). Conclusions ARIs were not associated with short-term protection against subsequent ARI in these children. Additional longitudinal studies are needed to understand drivers of recurrent ARI in young children.
- Published
- 2021