Back to Search
Start Over
Clinical Features of Human Metapneumovirus-Associated Community-acquired Pneumonia Hospitalizations
- Source :
- Clin Infect Dis
- Publication Year :
- 2019
-
Abstract
- Background Human metapneumovirus (HMPV) is a leading cause of respiratory tract infections. Few studies have compared the clinical characteristics and severity of HMPV-associated pneumonia with other pathogens. Methods Active, population-based surveillance was previously conducted for radiographically confirmed, community-acquired pneumonia hospitalizations among children and adults in 8 United States hospitals. Clinical data and specimens for pathogen detection were systematically collected. We described clinical features of all HMPV-associated pneumonia and, after excluding codetections with other pathogen types, we compared features of HMPV-associated pneumonia with other viral, atypical, and bacterial pneumonia and modeled the severity (mild, moderate, and severe) and length of stay using multivariable proportional odds regression. Results HMPV was detected in 298/2358 (12.6%) children and 88/2320 (3.8%) adults hospitalized with pneumonia and was commonly codetected with other pathogens (125/298 [42%] children and 21/88 [24%] adults). Fever and cough were the most common presenting symptoms of HMPV-associated pneumonia and were also common symptoms of other pathogens. After excluding codetections in children (n = 1778), compared to HMPV (reference), bacterial pneumonia exhibited increased severity (odds ratio [OR], 3.66; 95% confidence interval [CI], 1.43–9.40), respiratory syncytial virus (RSV; OR, 0.76; 95% CI, .59–.99) and atypical (OR, 0.39; 95% CI, .19–.81) infections exhibited decreased severity, and other viral pneumonia exhibited similar severity (OR, 0.88; 95% CI, .55–1.39). In adults (n = 2145), bacterial (OR, 3.74; 95% CI, 1.87–7.47) and RSV pneumonia (OR, 1.82; 95% CI, 1.32–2.50) were more severe than HMPV (reference), but all other pathogens had similar severity. Conclusions Clinical features did not reliably distinguish HMPV-associated pneumonia from other pathogens. HMPV-associated pneumonia was less severe than bacterial and adult RSV pneumonia, but was otherwise as or more severe than other common pathogens.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Adult
medicine.medical_specialty
viruses
030106 microbiology
Population
Pneumonia, Viral
Respiratory Syncytial Virus Infections
03 medical and health sciences
0302 clinical medicine
Human metapneumovirus
Community-acquired pneumonia
Internal medicine
medicine
Humans
030212 general & internal medicine
education
Child
Articles and Commentaries
Respiratory Tract Infections
education.field_of_study
Paramyxoviridae Infections
Respiratory tract infections
biology
business.industry
Bacterial pneumonia
virus diseases
Infant
Odds ratio
medicine.disease
biology.organism_classification
respiratory tract diseases
Community-Acquired Infections
Hospitalization
Pneumonia
Infectious Diseases
Viral pneumonia
Respiratory Syncytial Virus, Human
Metapneumovirus
business
Subjects
Details
- ISSN :
- 15376591
- Volume :
- 72
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
- Accession number :
- edsair.doi.dedup.....f56647d1431278b52512dce7c331eb5a