1. Neuroimaging studies within Cognitive Genetics Collaborative Research Organization aiming to replicate and extend works of ENIGMA
- Author
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Kenichiro Miura, Junya Matsumoto, Masaki Fukunaga, Ryota Hashimoto, Daisuke Koshiyama, Naohiro Okada, and Kiyotaka Nemoto
- Subjects
magnetic resonance imaging (MRI) ,Review Article ,050105 experimental psychology ,White matter ,03 medical and health sciences ,0302 clinical medicine ,Meta-Analysis as Topic ,Neuroimaging ,Genetics ,medicine ,Humans ,Multicenter Studies as Topic ,0501 psychology and cognitive sciences ,Radiology, Nuclear Medicine and imaging ,Bipolar disorder ,Gray Matter ,mega‐analysis ,Review Articles ,reproducibility ,neuroimaging ,Radiological and Ultrasound Technology ,business.industry ,Mental Disorders ,05 social sciences ,Cognition ,medicine.disease ,Magnetic Resonance Imaging ,White Matter ,schizophrenia ,psychiatric disorders ,medicine.anatomical_structure ,Neurology ,meta‐analysis ,Schizophrenia ,Autism spectrum disorder ,Meta-analysis ,Major depressive disorder ,Neurology (clinical) ,Anatomy ,business ,030217 neurology & neurosurgery - Abstract
Reproducibility is one of the most important issues for generalizing the results of clinical research; however, low reproducibility in neuroimaging studies is well known. To overcome this problem, the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) consortium, an international neuroimaging consortium, established standard protocols for imaging analysis and employs either meta‐ and mega‐analyses of psychiatric disorders with large sample sizes. The Cognitive Genetics Collaborative Research Organization (COCORO) in Japan promotes neurobiological studies in psychiatry and has successfully replicated and extended works of ENIGMA especially for neuroimaging studies. For example, (a) the ENIGMA consortium showed subcortical regional volume alterations in patients with schizophrenia (n = 2,028) compared to controls (n = 2,540) across 15 cohorts using meta‐analysis. COCORO replicated the volumetric changes in patients with schizophrenia (n = 884) compared to controls (n = 1,680) using the ENIGMA imaging analysis protocol and mega‐analysis. Furthermore, a schizophrenia‐specific leftward asymmetry for the pallidum volume was demonstrated; and (b) the ENIGMA consortium identified white matter microstructural alterations in patients with schizophrenia (n = 1,963) compared to controls (n = 2,359) across 29 cohorts. Using the ENIGMA protocol, a study from COCORO showed similar results in patients with schizophrenia (n = 696) compared to controls (n = 1,506) from 12 sites using mega‐analysis. Moreover, the COCORO study found that schizophrenia, bipolar disorder (n = 211) and autism spectrum disorder (n = 126), but not major depressive disorder (n = 398), share similar white matter microstructural alterations, compared to controls. Further replication and harmonization of the ENIGMA consortium and COCORO will contribute to the generalization of their research findings., The Cognitive Genetics Collaborative Research Organization (COCORO), which is a Japanese consortium established to elucidate psychiatric disorders and brain functions, replicated the results of the ENIGMA consortium, such as subcortical volume abnormalities and white matter microstructural abnormalities in schizophrenia, using the mega‐analysis method. These replication studies strengthened the reliability and generalization of the results of the ENIGMA consortium based on common and different methods in both consortiums. Further replication and harmonization of large consortia will contribute to the generalization of their research findings.
- Published
- 2022