Back to Search
Start Over
Degree of foot process effacement in patients with genetic focal segmental glomerulosclerosis: a single-center analysis and review of the literature
- Source :
- Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021), Scientific Reports
- Publication Year :
- 2021
- Publisher :
- Springer Science and Business Media LLC, 2021.
-
Abstract
- Determining the cause of focal segmental glomerulosclerosis (FSGS) has crucial implications for evaluating the risk of posttransplant recurrence. The degree of foot process effacement (FPE) on electron micrographs (EM) of native kidney biopsies can reportedly differentiate primary FSGS from secondary FSGS. However, no systematic evaluation of FPE in genetic FSGS has been performed. In this study, percentage of FPE and foot process width (FPW) in native kidney biopsies were analyzed in eight genetic FSGS patients and nine primary FSGS patients. All genetic FSGS patients showed segmental FPE up to 38% and FPW below 2000 nm, while all primary FSGS patients showed diffuse FPE above 88% and FPW above 3000 nm. We reviewed the literature which described the degree of FPE in genetic FSGS patients and identified 38 patients with a description of the degree of FPE. The degree of FPE in patients with mutations in the genes encoding proteins associated with slit diaphragm and cytoskeletal proteins was varied, while almost all patients with mutations in other FSGS genes showed segmental FPE. In conclusion, the present study suggests that the degree of FPE in native kidney biopsies may be useful for differentiating some genetic FSGS patients from primary FSGS patients.
- Subjects :
- Male
Nephrology
medicine.medical_specialty
Pathology
Science
030232 urology & nephrology
Diseases
030204 cardiovascular system & hematology
urologic and male genital diseases
Single Center
Article
Primary FSGS
03 medical and health sciences
0302 clinical medicine
Focal segmental glomerulosclerosis
Internal medicine
Genetics
medicine
Humans
Native kidney
In patient
Child
Kidney diseases
Multidisciplinary
Glomerulosclerosis, Focal Segmental
urogenital system
business.industry
Foot process effacement
medicine.disease
Kidney Transplantation
female genital diseases and pregnancy complications
Child, Preschool
Slit diaphragm
Medicine
Female
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....253b13a5c42fe011b6e30cfca0f09528