804 results on '"Jun Yuan"'
Search Results
2. Gail Model Improves the Diagnostic Performance of the Fifth Edition of Ultrasound BI-RADS for Predicting Breast Cancer: A Multicenter Prospective Study
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Chun-Song Kang, Bao-Ming Luo, Jia-Wei Tian, Man Chen, Chun-Quan Zhang, Qing Zhou, Yu-Hong Zhang, Jian-Jun Yuan, Ping Zhou, Luying Gao, Yuxin Jiang, Jie Li, Hongyan Wang, Jian-Feng Guo, Wu Chen, Haitao Ran, Weiwei Zhan, Ying Gu, Jianchu Li, Wei-Dong Ren, You-Bin Deng, Yang Gu, Qi Zhou, and Cai Chang
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medicine.medical_specialty ,Breast imaging ,Breast Neoplasms ,BI-RADS ,Malignancy ,Sensitivity and Specificity ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Prospective cohort study ,medicine.diagnostic_test ,business.industry ,medicine.disease ,Acoustic shadow ,030220 oncology & carcinogenesis ,Elasticity Imaging Techniques ,Female ,Ultrasonography, Mammary ,Radiology ,Elastography ,Microcalcification ,medicine.symptom ,business - Abstract
The sonographic appearance of benign and malignant breast nodules overlaps to some extent, and we aimed to assess the performance of the Gail model as an adjunctive tool to ultrasound (US) Breast Imaging Reporting and Data System (BI-RADS) for predicting the malignancy of nodules.From 2018 to 2019, 2607 patients were prospectively enrolled by 35 health care facilities. An individual breast cancer risk was assessed by the Gail model. Based on B-mode US, color Doppler, and elastography, all nodules were evaluated according to the fifth edition of BI-RADS, and these nodules were all confirmed later by pathology.We demonstrated that the Gail model, age, tumor size, tumor shape, growth orientation, margin, contour, acoustic shadowing, microcalcification, presence of duct ectasia, presence of architectural distortion, color Doppler flow, BI-RADS, and elastography score were significantly related to breast cancer (all p0.001). The sensitivity, specificity, positive predictive value, negative predictive value, accuracy, and area under the curve (AUC) for combining the Gail model with the BI-RADS category were 95.6%, 91.3%, 85.0%, 97.6%, 92.8%, and 0.98, respectively. Combining the Gail model with the BI-RADS showed better diagnostic efficiency than the BI-RADS and Gail model alone (AUC 0.98 vs 0.80, p0.001; AUC 0.98 vs 0.55, p0.001) and demonstrated a higher specificity than the BI-RADS (91.3% vs 59.4%, p0.001).The Gail model could be used to differentiate malignant and benign breast lesions. Combined with the BI-RADS category, the Gail model was adjunctive to US for predicting breast lesions for malignancy. For the diagnosis of malignancy, more attention should be paid to high-risk patients with breast lesions.
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- 2022
3. Design and HIL Realization of an Online Adaptive Dynamic Programming Approach for Real-Time Economic Operations of Household Energy Systems
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Chee Peng Lim, Hieu Trinh, Guidong Zhang, Jun Yuan, Yun Zhang, and Samson Shenglong Yu
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Dynamic programming ,General Computer Science ,Artificial neural network ,Computer science ,business.industry ,Energy management ,Convergence (routing) ,Control engineering ,DSPACE ,business ,Optimal control ,Energy (signal processing) ,Renewable energy - Abstract
Stochastic, nonlinear and time-varying factors bring great challenges to accurate modeling and design of real-time (RT) energy management systems (EMSs) for modern energy systems with intermittent renewable energy sources. In this paper, we propose a novel model-free RT-EMS based on the predictive adaptive dynamic programming (ADPredictive) algorithm for energy scheduling problems in a home EMS environment. The proposed RT-ADPreditive EMS can minimize the total cost of electricity, reduce battery life loss, and maximize the utilization of renewable energy generation. In the proposed RT-ADPredictive EMS, the gated recurrent unit (GRU) neural network (NN) is employed to perform online prediction of renewable energy generation and load consumption of the household based on RT data. The RT-ADPreditive algorithm can approximate the performance index function and the optimal control law based on the RT data and predicted data for the next time step. Convergence of the proposed method is mathematically proven, and a hardware-in-the-loop (HIL) experimental platform comprising dSPACE and RT-lab is built to verify the effectiveness of the proposed RT-ADPreditive home EMS.
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- 2022
4. Agomelatine might be more appropriate for elderly, depressed, type 2 diabetes mellitus patients than paroxetine/fluoxetine
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Lixia Hao, Jun Yuan, Bagen Tong, Yan-Bo Jia, Zi-Hong Liang, Pengfei Cui, Xuemei He, Run-Xiu Zhu, Fan Yang, and Lizhen Zhao
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Adult ,Male ,medicine.medical_specialty ,Aging ,Hamilton Anxiety Rating Scale ,endocrine system diseases ,type 2 diabetes mellitus ,Internal medicine ,Diabetes mellitus ,Acetamides ,medicine ,Agomelatine ,HARS ,Humans ,Hypnotics and Sedatives ,Aged ,Fluoxetine ,business.industry ,Depression ,fluoxetine ,nutritional and metabolic diseases ,Cell Biology ,Middle Aged ,medicine.disease ,Paroxetine ,Diabetes Mellitus, Type 2 ,Antidepressant ,Antidepressive Agents, Second-Generation ,Female ,business ,Body mass index ,agomelatine ,medicine.drug ,Research Paper - Abstract
Agomelatine was a novel and melatonergic antidepressant. The present study was conducted to find out whether age was an important factor for agomelatine in treating depressed type 2 diabetes mellitus (T2DM) patients. In total, 193 depressed T2DM patients were included. There were 84 patients ranged from 27 years old to 49 years old (age phase I) (n = 44 receiving agomelatine, n = 40 receiving paroxetine or fluoxetine), and 109 patients ranged from 50 years old to 70 years old (age phase II) (n = 56 receiving agomelatine, n = 53 receiving paroxetine or fluoxetine). The Hamilton Depression Rating Scale (HDRS) score, Hamilton Anxiety Rating Scale (HARS) score, fasting plasma glucose (FPG), hemoglobin A1c (HbA1c) level and body mass index (BMI) were assessed after 12 weeks treatment. After treatment, we found that among patients in age phase I, there were no significant differences in final average HDRS score, HARS score, FPG, HbA1c level, BMI, response rate and remission rate between the two groups. However, among patients in age phase II, compared to patients receiving paroxetine or fluoxetine, patients receiving agomelatine had the significantly lower average HDRS score, HARS score, HbA1c level and BMI, and significantly higher response rate and remission rate. The incidence of treatment-related adverse events was similar between the two groups in both age phases. These results suggested that age was an important factor for agomelatine in treating depressed T2DM patients. Compared to paroxetine/fluoxetine, agomelatine might be more appropriate for elderly depressed T2DM patients.
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- 2021
5. Stiffness and ultimate strength of tube-gusset plate joints with ring stiffener plate
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Songzhao Qu, Jun Yuan, and Qing Sun
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Materials science ,business.industry ,Tension (physics) ,Hinge ,Stiffness ,Building and Construction ,Structural engineering ,Gusset plate ,Joint stiffness ,Architecture ,medicine ,Limit state design ,medicine.symptom ,Safety, Risk, Reliability and Quality ,business ,Joint (geology) ,Beam (structure) ,Civil and Structural Engineering - Abstract
The stiffness of the stiffener plate of a tube-gusset plate joint (TGPJ) with a multi-ring stiffener plate is much larger than that in the chord wall. The load on the gusset plate will be concentrated in the area where the stiffener plate is located, and the joint will eventually fail in this area as a result of the ultimate state of the ring stiffener plate. This study investigated the stiffness and ultimate strength of a ring stiffener plate under an axial load. First, an experimental study was carried out on X-shaped TGPJs with double-ring stiffener plates. The failure mode of the joints was clarified, the variation law of the joint stiffness was revealed, and the rationality of using a 3% chord wall deformation as the criterion for determining the ultimate state of joints was verified. Then, based on the test results, finite element models (FEMs) of the X-type joint and ring stiffener plate were established, and their accuracy was verified. Numerical analysis results clarified the synergistic mechanism of the double-ring stiffener plate of an X-type joint, and the equivalence between the joint failure and the single-ring stiffener plate failure was revealed. Different nominal yield strength parameters (345 and 420 MPa), different dimensions (D/t = 32.3–55.9 and R/tr = 6–33.3), and different load conditions (tension and compression) for ring stiffener plates were analysed, and the accuracy of the calculation methods for the limit state of the ring stiffener plates proposed in this paper was verified. A comparison showed that the ‘four-hinged ring beam model’ proposed in this paper did not consider the changes in the curvature of the ring beam between plastic hinges. Thus, the calculation results of the model were obviously conservative, and the ‘deformation stiffness model’ was more accurate than the calculation results of other methods mentioned in this paper.
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- 2021
6. Imbalanced Th17/Treg in peripheral blood of adult patients with immunoglobulin A vasculitis nephritis
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Wen-cheng Xu, Xin-Rong Zou, Si-Ping Han, Jun Yuan, Huimin Zhou, Xiaoqin Wang, Qiang Liu, Xue Xue, and Xiangyan Meng
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Immunoglobulin A ,medicine.medical_specialty ,Immunology ,chemical and pharmacologic phenomena ,Gastroenterology ,Pathogenesis ,Internal medicine ,immunoglobulin a vasculitis nephritis ,medicine ,Immunology and Allergy ,biology ,treg ,business.industry ,immunoglobulin A vasculitis nephritis ,adult ,FOXP3 ,Interleukin ,Red blood cell distribution width ,hemic and immune systems ,medicine.disease ,Treg ,biology.protein ,Medicine ,Clinical Immunology ,Th17 ,Antibody ,red blood cell distribution width ,business ,Vasculitis ,Nephritis - Abstract
Introduction Adult immunoglobulin A vasculitis nephritis (IgAVN) was observed to be more severe than the disease in children because it tended to result in a poor prognosis. The present study analyzed the Th17/Treg cell axis in peripheral blood of adult IgAVN patients, aiming to provide new immunological viewpoints for the pathogenesis of adult IgAVN. Material and methods Th17 cell and Treg cell frequencies in peripheral blood of healthy subjects (n = 13) and adult IgAVN patients (n = 12) were analyzed by flow cytometry. Foxp3 mRNA in peripheral blood of healthy subjects and adult IgAVN patients was detected by RT-PCR. Interleukin (IL)-17 and IL-10 in peripheral blood serum of healthy subjects and adult IgAVN patients were examined by ELISA. Results The percentages of CD4+ Th17+ cells in peripheral blood of healthy subjects and adult IgAVN patients were 2.65 ±1.55% and 4.37 ±1.68% respectively. The percentages of Treg cells in peripheral blood of healthy subjects and adult IgAVN patients were 6.44 ±2.90% and 3.91 ±1.94% respectively. The ratio of Th17/Treg in adult IgAVN patients was significantly higher than that of healthy subjects (p = 0.0030). Meanwhile, the Foxp3 mRNA expression of adult IgAVN patients was significantly lower than that of healthy subjects. There was a significant difference in the ratio of IL-17/IL-10 between healthy subjects and adult IgAVN patients (p < 0.0001). A significant correlation between red blood cell distribution width (RDW) and the ratio of Th17/Treg in adult IgAVN patients was observed in Spearman correlation analysis (r = 0.6970, p = 0.0145). Conclusions Imbalanced Th17/Treg contributed to the complex pathogenesis of adult IgAVN.
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- 2021
7. Evaluation of Tourism Industry Efficiency in Pearl River Delta and its Influencing Factors in the Context of Happiness Industry
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Wenshi Liang, Jun Yuan, and Yanhong Liu
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Pearl river delta ,Index system ,Natural resource economics ,General Chemical Engineering ,media_common.quotation_subject ,Context (language use) ,engineering.material ,Livelihood ,Industrial and Manufacturing Engineering ,engineering ,Happiness ,General Materials Science ,Business ,Pearl ,Total factor productivity ,Tourism ,media_common - Abstract
In the context of happiness industry, this paper constructs the input-output index system of tourism industry efficiency, uses DEA model and Malmquist model to measure the tourism industry efficiency and its temporal-spatial evolution of nine cities in Pearl River Delta from 2010 to 2016, and uses Grey relational model to analyze the influencing factors.The results show that, the overall tourism industry efficiency in Pearl River Delta reaches a relatively high level; the overall efficiency and technical efficiency showed a descending trend from inside out with the Pearl River Estuary economic circle as the core. The scale efficiency of tourism industry in Pearl River Delta showed a good trend, and the tourism elements input could satisfy the livelihood needs to a great extent. The total factor productivity of most cities in Pearl River Delta shows a growing trend, but the change trend differs in different areas. Impact of influencing factors of tourism industry efficiency differs in cities of different development degree and the impact of social benefit and environmental benefit indicators on tourism industry efficiency increases significantly. Based on the construction of happiness industry, cities in Pearl River Delta should take effective measures to improve the tourism industry efficiency.
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- 2021
8. Compatibility between Solubility and Enhanced Crystallinity of Benzotriazole-Based Small Molecular Acceptors with Less Bulky Alkyl Chains for Organic Solar Cells
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Zhe Li, Xinxin Xia, Hui-lan Guan, Yongfang Li, Jun Yuan, Qingya Wei, Xiaosha Wang, Wei Liu, Can Zhu, Yingping Zou, Honggang Chen, and Xinhui Lu
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chemistry.chemical_classification ,Benzotriazole ,Materials science ,Organic solar cell ,business.industry ,Solar energy ,chemistry.chemical_compound ,Crystallinity ,Molecular geometry ,chemistry ,Chemical engineering ,General Materials Science ,Solubility ,business ,Low voltage ,Alkyl - Abstract
Optimizing the molecular structures of organic solar cell (OSC) materials and boosting the power conversion efficiencies are the eternal theme in the solar energy region. A series of fused benzotriazole (BTA)-based A-DA'D-A structures of nonfullerene acceptors (such as Y18) were developed for application in efficient OSCs, in which high quantum efficiencies and low voltage losses could be achieved because of the optimized electron-deficient core and specific molecular geometry. Here, based on the BTA core, the bulky alkyl chain on the BTA unit was further tailored to minimize the lateral alkyl chains and enhance the crystallinity while maintaining an adequate solubility. The resulting NFAs of BTA-C1, BTA-C5, and BTA-C6 are synthesized. Compared with the well-designed molecular Y18 (BTA-C8), we found that simply replacing the 2-ethylhexyl chain with a single methyl (BTA-C1) can easily improve the fill factor up to 77%, but its poor light absorption capacity and large domain size impeded further efficiency improvement. In particular, the BTA-C5, with a shortened branch alkyl chain of 2-methylbutyl, achieves suitable solubility and enhanced crystallinity. Significantly, owing to the balanced charge carrier mobility and suitable phase separation, the BTA-C5-based binary single-junction OSCs achieve a high efficiency of 17.11%, which is one of the top values in BTA-based OSCs.
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- 2021
9. Tool wear condition monitoring by combining spindle motor current signal analysis and machined surface image processing
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Bo Jingdong, Libing Liu, Zeqing Yang, Jun Yuan, and Yanrui Zhang
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business.product_category ,Computer science ,business.industry ,Mechanical Engineering ,Feature extraction ,Condition monitoring ,Image processing ,Industrial and Manufacturing Engineering ,Computer Science Applications ,Machine tool ,Control and Systems Engineering ,Numerical control ,Computer vision ,Current sensor ,Time domain ,Artificial intelligence ,Tool wear ,business ,Software - Abstract
For improving online tool condition monitoring (TCM) reliability and convenience, a novel TCM method based on current signal analysis and machined surface image processing is presented. In this paper, the correlation mechanism of spindle motor current, machined surface image, and the tool wear condition during cutting process was analyzed in detail. The theoretical analysis results show that the reliability of TCM can be improved by the fusion of the above two information. Cutting experiments in multiple conditions had been performed on the FANUC vertical computerized numerical control. The FANUC SERVO GUIDE software was used for obtaining the current data in built-in current sensor from machine tool, and an industrial CCD camera was used in the collection of machined surface image, which is convenient and feasible. Time domain analysis, frequency domain analysis, and variational mode decomposition (VMD) were performed on current signals for sensitive feature extraction closely related to tool wear; rotation-invariant uniform local binary patterns (RULBP) and_Gray-Level_o-occurrence Matrix (GLCM) were performed on machined surface image for sensitive feature extraction that was in close contact with tool wear. The obtained sensitive features were fed into random forest (RF) to establish the correlation between sensitive features and tool wear condition. According to the experimental result, in contrast to available TCM methods, the proposed method shows significantly better performance in improving the accuracy of tool wear condition recognition.
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- 2021
10. Neuraminidase 1 is a driver of experimental cardiac hypertrophy
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Lian-Wen Qi, Gaoxiang Ma, Shujun Jiang, An Pan, Lei Zhang, Jiangping Song, Yuan-Yuan Cai, Jun-Yuan Zhang, Qian-Qian Chen, Pingxi Xiao, Yibei Xiao, Ping Li, Jinfeng Liu, and Wei Tingting
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0301 basic medicine ,Neuraminidase ,Cardiomegaly ,030204 cardiovascular system & hematology ,Pharmacology ,Mice ,03 medical and health sciences ,NEU1 ,0302 clinical medicine ,medicine ,Animals ,Humans ,Myocytes, Cardiac ,Luciferase ,Heart Failure ,chemistry.chemical_classification ,biology ,GATA4 ,business.industry ,Hypertrophic cardiomyopathy ,Cardiomyopathy, Hypertrophic ,medicine.disease ,Rats ,030104 developmental biology ,Enzyme ,chemistry ,Heart failure ,biology.protein ,Cardiology and Cardiovascular Medicine ,business ,Chromatin immunoprecipitation - Abstract
Aims Despite considerable therapeutic advances, there is still a dearth of evidence on the molecular determinants of cardiac hypertrophy that culminate in heart failure. Neuraminidases are a family of enzymes that catalyze the cleavage of terminal sialic acids from glycoproteins or glycolipids. This study sought to characterize the role of neuraminidases in pathological cardiac hypertrophy and identify pharmacological inhibitors targeting mammalian neuraminidases. Methods and results Neuraminidase 1 (NEU1) was highly expressed in hypertrophic hearts of mice and rats, and this elevation was confirmed in patients with hypertrophic cardiomyopathy (n = 7) compared with healthy controls (n = 7). The increased NEU1 was mainly localized in cardiomyocytes by co-localization with cardiac troponin T. Cardiomyocyte-specific NEU1 deficiency alleviated hypertrophic phenotypes in response to transverse aortic constriction or isoproterenol hydrochloride infusion, while NEU1 overexpression exacerbated the development of cardiac hypertrophy. Mechanistically, co-immunoprecipitation coupled with mass spectrometry, chromatin immunoprecipitation, and luciferase assays demonstrated that NEU1 translocated into the nucleus and interacted with GATA4, leading to Foetal gene (Nppa and Nppb) expression. Virtual screening and experimental validation identified a novel compound C-09 from millions of compounds that showed favourable binding affinity to human NEU1 (KD = 0.38 μM) and effectively prevented the development of cardiac remodelling in cellular and animal models. Interestingly, anti-influenza drugs zanamivir and oseltamivir effectively inhibited mammalian NEU1 and showed new indications of cardio-protection. Conclusions This work identifies NEU1 as a critical driver of cardiac hypertrophy and inhibition of NEU1 opens up an entirely new field of treatment for cardiovascular diseases.
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- 2021
11. An Overview of High‐Performance Indoor Organic Photovoltaics
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Wei Liu, Xiang Xu, Yingping Zou, Hongbo Chen, Jun Yuan, Xiaoyan Luo, and Qingya Wei
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Led illumination ,Organic solar cell ,business.industry ,Computer science ,General Chemical Engineering ,Energy conversion efficiency ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Engineering physics ,0104 chemical sciences ,General Energy ,Photovoltaics ,Optimization methods ,Environmental Chemistry ,Microelectronics ,General Materials Science ,0210 nano-technology ,business ,Internet of Things - Abstract
In recent years, indoor organic photovoltaics (IOPVs) have attracted increasing attention because of their ability to power microelectronic devices and sensors, especially for the internet of things (IoT). In contrast with silicon-based indoor PV, the IOPVs exhibit better performance due to their tunable bandgap via molecular design, which could achieve a better spectrum matched with the lighting sources. Based on the simulated power conversion efficiency (PCE) in theory, the maximum value can achieve over 50 % under the white LED illumination, which is much higher than the practical top PCE of 31 %, indicating there is room further to improve the performance of IOPVs by various optimization methods. Based on these benefits, the recent progress in IOPVs with different methods was summarizes, and light was shed on the remaining challenges for achieving practical applications in the future. In the end, some guidelines for the development of IOPVs were proposed.
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- 2021
12. Solar‐Driven Lignocellulose‐to‐H 2 Conversion in Water using 2D‐2D MoS 2 /TiO 2 Photocatalysts
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Qing-Yu Liu, Quan Cheng, Zhi-Kai Shen, Yong-Jun Yuan, Zhigang Zou, Zhen-Tao Yu, and Pei Wang
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Aqueous solution ,Materials science ,Hydrogen ,Charge separation ,business.industry ,General Chemical Engineering ,Quantum yield ,chemistry.chemical_element ,Tio2 photocatalyst ,02 engineering and technology ,Generation rate ,010402 general chemistry ,021001 nanoscience & nanotechnology ,Solar energy ,01 natural sciences ,0104 chemical sciences ,General Energy ,chemistry ,Chemical engineering ,Photocatalysis ,Environmental Chemistry ,General Materials Science ,0210 nano-technology ,business - Abstract
As an alternative strategy for H2 production under ambient conditions, solar-driven lignocellulose-to-H2 conversion provides a very attractive approach to store and utilize solar energy sustainably. Exploiting efficient photocatalyst for photocatalytic lignocellulose-to-H2 conversion is of huge significance and remains the key challenge for development of solar H2 generation from lignocellulose. Herein, 2D-2D MoS2 /TiO2 photocatalysts with large 2D nanojunction were constructed for photocatalytic lignocellulose-to-H2 conversion. In this smart structure, the 2D nanojunctions acted as efficient channel for charge transfer from TiO2 to MoS2 to improve charge separation efficiency and thus enhance photocatalytic lignocellulose-to-H2 conversion activity. The 2 % MoS2 /TiO2 photocatalyst showed the highest photocatalytic lignocellulose-to-H2 conversion performance with the maximal H2 generation rate of 201 and 21.4 μmol h-1 g-1 in α-cellulose and poplar wood chip aqueous solution, respectively. The apparent quantum yield at 380 nm reached 1.45 % for 2 % 2D-2D TiO2 /MoS2 photocatalyst in α-cellulose aqueous solution. This work highlights the importance of optimizing the interface structures of photocatalyst for solar-driven lignocellulose-to-H2 conversion.
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- 2021
13. Anxiety disturbs the blood plasma metabolome in acute coronary syndrome patients
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Yimin Zhu, Bo-yu Tan, Nan Deng, Jing Wu, Jun-yuan Gu, Hong-yan Wei, Xueyao Jiang, and LianHong Zou
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Male ,Acute coronary syndrome ,Glucuronate ,Science ,Physiology ,Comorbidity ,Anxiety ,Acute coronary syndromes ,030204 cardiovascular system & hematology ,Pentose phosphate pathway ,Article ,03 medical and health sciences ,0302 clinical medicine ,Human behaviour ,Blood plasma ,Metabolome ,Humans ,Metabolomics ,Medicine ,Public Health Surveillance ,Acute Coronary Syndrome ,Chromatography, High Pressure Liquid ,Aged ,Pharmacology ,Multidisciplinary ,business.industry ,Metabolic disorder ,Middle Aged ,medicine.disease ,Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ,Female ,medicine.symptom ,business ,Biomarkers ,030217 neurology & neurosurgery - Abstract
Coronary heart disease (CHD) is the result of a complex metabolic disorder caused by various environmental and genetic factors, and often has anxiety as a comorbidity. Rupture of atherosclerotic plaque in CHD patients can lead to acute coronary syndrome (ACS). Anxiety is a known independent risk factor for the adverse cardiovascular events and mortality in ACS, but it remains unclear how stress-induced anxiety behavior impacts their blood plasma metabolome and contributes to worsening of CHD. The present study aimed to determine the effect of anxiety on the plasma metabolome in ACS patients. After receiving ethical approval 26 ACS patients comorbid anxiety were recruited and matched 26 ACS patients. Blood plasma samples were collected from the patients and stored at − 80 °C until metabolome profiling. Metabolome analysis was performed by liquid chromatography mass spectrometry (LC–MS), and the data were subjected to multivariate analysis. Disturbance of 39 plasma metabolites was noted in the ACS with comorbid anxiety group compared to the ACS group. These disturbed metabolites were mainly involved in tryptophan metabolism, pyrimidine metabolism, glycerophospholipid metabolism, pentose phosphate pathway, and pentose and glucuronate interconversions. The most significantly affected pathway was tryptophan metabolism including the down-regulation of tryptophan and serotonin. Glycerophospholipids metabolism, pentose and glucuronate interconversions, and pentose phosphate pathway were also greatly affected. These results suggest that anxiety can disturb three translation of material in ACS patients. Besides the above metabolism pathways pyrimidine metabolism was significantly disturbed. Based on the present findings the plasma metabolites monitoring can be recommended and may be conducive to early biomarkers detection for personalized treatment anxiety in CHD patients in future.
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- 2021
14. Double minute chromosomes in acute myeloid leukemia and myelodysplastic syndromes are associated with complex karyotype, monosomal karyotype, TP53 deletion, and TP53 mutations
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Li Yu, Keke Fan, Li-Jun Yuan, Li-Li Wang, Nan Wang, Yu Jing, Chao Lv, and Hongshi Jin
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Cancer Research ,Chromothripsis ,biology ,business.industry ,Anemia ,Myelodysplastic syndromes ,fungi ,Myeloid leukemia ,Karyotype ,Hematology ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,KMT2A ,Oncology ,hemic and lymphatic diseases ,030220 oncology & carcinogenesis ,Complex Karyotype ,Cancer research ,biology.protein ,Medicine ,Double minute ,business ,neoplasms ,030215 immunology - Abstract
Double minute chromosomes (DMs) are rare in hematologic malignancies. We presented the cytogenetic characteristics and clinical features of the largest single-center cohort of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) patients with DMs. A total of 2576 AML patients and 1642 MDS patients were investigated, and 30 patients (AML = 19; MDS = 11) who had DMs were followed up. DMs were more common in primary AML (94.7%) and MDS (90.9%). Monosomal karyotypes (MK) were also the main cytogenetic characteristics, like complex karyotypes (CK). AML with myelodysplasia-related changes (AML-MRC) and MDS-refractory anemia with excess blasts (MDS-RAEB) was common in this cohort. We conclude that DMs-positive AML and DMs-positive MDS are associated with older age, complex karyotypes, monosomal karyotypes, TP53 deletion and TP53 mutations. DMs are a type of chromothripsis, which can be observed by the karyotype analysis. MYC and KMT2A were the most commonly amplified genes in DMs. Most patients with DMs presented an extremely poor prognosis.
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- 2021
15. Urinary magnesium predicts risk of cardiovascular disease in Chronic Kidney Disease stage 1–4 patients
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Qiongjing Yuan, Yanyun Xie, Zhangzhe Peng, Jinwei Wang, Qiaoling Zhou, Xiangcheng Xiao, Wei Wang, Ling Huang, Wenbin Tang, Xiaozhao Li, Luxia Zhang, Fang Wang, Ming-Hui Zhao, Lijian Tao, Kevin He, Siyi Wanggou, Hui Xu, Xiaoqin Wang, Jun Yuan, Menghua Chen, Xiaoling Zhou, Shuxia Fu, Shaomei Li, Yan Zha, Rongsai Huang, Zhangsuo Liu, JunJun Zhang, Li Wang, Lei Pu, Jian Liu, Suhua Li, Zuying Xiong, Wei Liang, Jinghong Zhao, Jiao Mu, Xiyan Lian, Yunjuan Liao, Hua Gan, Liping Liao, Rong Wang, Zhimei Lv, Yunhua Liao, Ling Pan, Xiaoping Yang, Zhifeng Lin, Zongwu Tong, Yun Zhu, Qiang He, Fuquan Wu, Rong Li, Kai Rong, Caili Wang, Yanhui Zhang, Yue Wang, Wen Tang, Hua Wu, Ban Zhao, Rongshan Li, Lihua Wang, Detian Li, Feng Du, Yonggui Wu, Wei Zhang, Shan Lin, Pengcheng Xu, Hongli Lin, Zhao Hu, Fei Pei, Haisong Zhang, Yan Gao, Luying Sun, Xia Li, Wenke Wang, Fengling Lv, Deguang Wang, Xuerong Wang, Dongmei Xu, Lijun Tang, Yingchun Ma, Tingting Wang, Ping Fu, Tingli Wang, Changying Xing, Chengning Zhang, Xudong Xu, Haidong He, Xiaohui Liao, Shuqin Xie, Guicai Hu, and Lan Huang
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Male ,0301 basic medicine ,medicine.medical_specialty ,Urinary system ,Population ,030209 endocrinology & metabolism ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,medicine ,Humans ,Magnesium ,Prospective Studies ,Renal Insufficiency, Chronic ,education ,Survival analysis ,education.field_of_study ,030109 nutrition & dietetics ,Nutrition and Dietetics ,Proportional hazards model ,business.industry ,Incidence ,Middle Aged ,medicine.disease ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Cohort ,Kidney Failure, Chronic ,Female ,business ,Kidney disease ,Cohort study - Abstract
Summary Observational studies on dietary or circulating magnesium and risk of cardiovascular disease (CVD) in Chronic Kidney Disease (CKD) stage 1–4 have reported no-to-modest inverse associations. 24 h Urinary magnesium concentration (24 h UMg), an indicator of intestinal magnesium absorption, may provide better insight into the connection of CKD progression. We examined 3179 participants aged 18–74 years with CKD stage 1–4 in the Chinese Cohort Study of Chronic Kidney Disease (C-STRIDE) study, a prospective population-based cohort study. Data were analysed using Spearman rank-order correlation coefficients for all comparisons. We also performed a time-to-event analysis of the data using the Kaplan–Meier survival model, Cox proportional hazard model and competing risk Fine and Gray subdistribution hazard model. During a median follow-up of 4.19 years (interquartile range, 3.43–5.09 years), when modelling end-stage renal disease (ESRD), CVD and death, 24 h UMg was associated with risk of CVD (HR, 1.612 (95% CI, 1.056–2.460)), while no significant association with ESRD and death endpoints could be detected. 24 h UMg risk variants display a modest association with CVD in CKD stage 1–4 patients. Trial registration ClinicalTrials.gov Identifier NCT03041987. Registered January 1, 2012. (retrospectively registered) ( https://www.clinicaltrials.gov/ct2/show/NCT03041987?term=Chinese+Cohort+Study+of+Chronic+Kidney+Disease+%28C-STRIDE%29&rank=1 ).
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- 2021
16. The effect of cardiovascular disease and acute cardiac injury on fatal COVID-19: a meta-analysis
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Yefei Luo, Jun Yuan, Yuehong Wei, Chaojun Xie, and Jiali Long
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medicine.medical_specialty ,Coronavirus disease 2019 (COVID-19) ,Heart Diseases ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Disease ,Global Health ,Risk Assessment ,Severity of Illness Index ,Article ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,Pandemic ,Medicine ,Humans ,Mortality ,business.industry ,Routine laboratory ,COVID-19 ,030208 emergency & critical care medicine ,General Medicine ,Prognosis ,Cardiac injury ,Hospitalization ,Cardiovascular diseases ,Meta-analysis ,Emergency medicine ,Emergency Medicine ,business ,Hospital stay ,Meta analysis ,Systematic search - Abstract
Background With the continuance of the global COVID-19 pandemic, cardiovascular disease (CVD) and cardiac injury have been suggested to be risk factors for severe COVID-19. Objective The aim is to evaluate the mortality risks associated with CVD and cardiac injury among hospitalized COVID-19 patients, especially in subgroups of populations in different countries. Methods A comprehensive systematic literature search was performed using 9 databases from November 1, 2019 to November 9, 2020. Meta-analyses were performed for CVD and cardiac injury between non-survivors and survivors of COVID-19. Results Although the prevalence of CVD in different populations was different, hospitalized COVID-19 patients with CVD were at a higher risk of fatal outcomes (OR = 2.72; 95% CI 2.35–3.16) than those without CVD. Separate meta-analyses of populations in four different countries also reached a similar conclusion that CVD was associated with an increase in mortality. Cardiac injury was common among hospitalized COVID-19 patients. Patients with cardiac injury had a significantly higher mortality risk than those without cardiac injury (OR = 13.25; 95% CI: 8.56–20.52). Conclusions Patients' CVD history and biomarkers of cardiac injury should be taken into consideration during the hospital stay and incorporated into the routine laboratory panel for COVID-19.
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- 2021
17. Evaluating the Rail-Based Multimodal Freight Transportation after HSR Entry in Yangtze River Delta Economics Zone
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Jun Yuan, Hang Yu, Minghui Wei, Yanbing Chen, and Junliang He
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Delta ,050210 logistics & transportation ,Multimodal transport ,Index (economics) ,Article Subject ,Restructuring ,05 social sciences ,Transport network ,0211 other engineering and technologies ,Analytic hierarchy process ,021107 urban & regional planning ,02 engineering and technology ,Computer Science Applications ,Transport engineering ,QA76.75-76.765 ,0502 economics and business ,Sustainability ,Computer software ,Business ,China ,Software - Abstract
In recent years, China keeps working on restructuring the country’s multimodal transport and highly develops the high-speed rail (HSR) infrastructure to improve transport efficiency. As the economic engine of China, the Yangtze River Delta region keeps leading the HSR development and the transporting modal transformation within the whole country. The fast development of HSR on the one hand highly improves passengers’ travel efficiency and, on the other hand, releases the capacity of conventional rail infrastructures to support regional multimodal freight transport. This study applies a three-level AHP structure and constructs a comprehensive index to evaluate the development of a rail-based multimodal freight transport network including railway, rail-water, and rail-road. The comprehensive index contains 14 quantitative and 8 qualitative indexes, covering the rail-based infrastructures, multimodal transport capability, freight transport performance, and transport sustainability. The comprehensive index is then applied to analyze the rail-based multimodal freight transport for the Yangtze River Delta region. The operational data of 59 freight stations and more than 200 railway links of the Yangtze River Delta were recorded. About 172 valid questionnaires were collected to score the qualitative indexes, and all the quantitative indexes are scored based on the real-life freight data. The results reveal the impacts of HSR development on rail freight transportation and show that Zhejiang has led rail freight transportation while Shanghai mainly leads the waterway freight transportation. Meanwhile, Anhui performs very well on road-rail transportation and Jiangsu has made a great improvement on water-rail transportation.
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- 2021
18. Evaluation of Sampling Methods for Scatterplots
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Lingyun Yu, Jiazhi Xia, Jun Yuan, Shixia Liu, and Shouxing Xiang
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FOS: Computer and information sciences ,Computer science ,business.industry ,Computer Science - Human-Computer Interaction ,Sampling (statistics) ,020207 software engineering ,Pattern recognition ,02 engineering and technology ,Computer Graphics and Computer-Aided Design ,Human-Computer Interaction (cs.HC) ,Visualization ,Data visualization ,Colors of noise ,Signal Processing ,Outlier ,0202 electrical engineering, electronic engineering, information engineering ,Computer Vision and Pattern Recognition ,Artificial intelligence ,business ,Software ,Abstraction (linguistics) - Abstract
Given a scatterplot with tens of thousands of points or even more, a natural question is which sampling method should be used to create a small but "good" scatterplot for a better abstraction. We present the results of a user study that investigates the influence of different sampling strategies on multi-class scatterplots. The main goal of this study is to understand the capability of sampling methods in preserving the density, outliers, and overall shape of a scatterplot. To this end, we comprehensively review the literature and select seven typical sampling strategies as well as eight representative datasets. We then design four experiments to understand the performance of different strategies in maintaining: 1) region density; 2) class density; 3) outliers; and 4) overall shape in the sampling results. The results show that: 1) random sampling is preferred for preserving region density; 2) blue noise sampling and random sampling have comparable performance with the three multi-class sampling strategies in preserving class density; 3) outlier biased density based sampling, recursive subdivision based sampling, and blue noise sampling perform the best in keeping outliers; and 4) blue noise sampling outperforms the others in maintaining the overall shape of a scatterplot., 9 pages + 2 pages reference, 15 figures, IEEE VIS(VAST) 2020
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- 2021
19. Low-Bandgap Non-fullerene Acceptors Enabling High-Performance Organic Solar Cells
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Yongfang Li, Xiang Xu, Wei Liu, Yingping Zou, Jun Yuan, and Mario Leclerc
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Materials science ,Fullerene ,Organic solar cell ,Renewable Energy, Sustainability and the Environment ,Band gap ,business.industry ,Energy Engineering and Power Technology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,0104 chemical sciences ,Fuel Technology ,Chemistry (miscellaneous) ,Materials Chemistry ,Optoelectronics ,0210 nano-technology ,business - Abstract
Great progress in organic solar cells (OSCs) has been recently achieved owing to the advent of non-fullerene acceptors (NFAs). Indeed, low-bandgap NFAs ranging from 1.3 to 1.6 eV with broad absorpt...
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- 2021
20. Association of MTHFR C677T, MTHFR A1298C and MTRR A66G Polymorphisms with Birth Defects in Southern China
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Minmin Jiang, Lingyan Ren, Xingwei Ma, Zhaozhen Zhuo, Xiaoli Wu, Jun Yuan, Shengwen Huang, and Qian Jin
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medicine.medical_specialty ,Homocysteine ,biology ,business.industry ,Medicine (miscellaneous) ,Cell Biology ,Biochemistry ,Gastroenterology ,MTRR ,Biomaterials ,chemistry.chemical_compound ,chemistry ,Folic acid ,Southern china ,Internal medicine ,Methylenetetrahydrofolate reductase ,medicine ,biology.protein ,Mthfr c677t ,Orthopedics and Sports Medicine ,business ,General Dentistry - Published
- 2021
21. Disease-specific ACMG/AMP guidelines improve sequence variant interpretation for hearing loss
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Mayher J. Patel, Marina T. DiStefano, Andrea M. Oza, Madeline Y. Hughes, Emma H. Wilcox, Sarah E. Hemphill, Brandon J. Cushman, Andrew R. Grant, Rebecca K. Siegert, Jun Shen, Alex Chapin, Nicole J. Boczek, Lisa A. Schimmenti, Kiyomitsu Nara, Margaret Kenna, Hela Azaiez, Kevin T. Booth, Karen B. Avraham, Hannie Kremer, Andrew J. Griffith, Heidi L. Rehm, Sami S. Amr, Ahmad N. Abou Tayoun, Sonia Abdelhak, John Alexander, Zippora Brownstein, Rachel Burt, Byung Yoon Choi, Lilian Downie, Thomas Friedman, Anne Giersch, John Greinwald, Jeffrey Holt, Makoto Hosoya, Un-Kyung Kim, Ian Krantz, Suzanne Leal, Saber Masmoudi, Tatsuo Matsunaga, Matías Morín, Cynthia Morton, Hideki Mutai, Arti Pandya, Richard Smith, Mustafa Tekin, Shin-Ichi Usami, Guy Van Camp, Kazuki Yamazawa, Hui-Jun Yuan, Elizabeth Black-Zeigelbein, and Kejian Zhang
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Disease specific ,medicine.medical_specialty ,Hearing loss ,Molecular pathology ,business.industry ,Genome, Human ,Genetic Variation ,Computational biology ,Sensory disorders Donders Center for Medical Neuroscience [Radboudumc 12] ,Human genetics ,Article ,medicine ,Medical genetics ,Humans ,Genetic Testing ,medicine.symptom ,business ,Hearing Loss ,Uncertain significance ,Genetics (clinical) ,Likely pathogenic ,Sequence (medicine) - Abstract
Contains fulltext : 243959.pdf (Publisher’s version ) (Closed access) PURPOSE: The ClinGen Variant Curation Expert Panels (VCEPs) provide disease-specific rules for accurate variant interpretation. Using the hearing loss-specific American College of Medical Genetics and Genomics/Association for Molecular Pathology (ACMG/AMP) guidelines, the Hearing Loss VCEP (HL VCEP) illustrates the utility of expert specifications in variant interpretation. METHODS: A total of 157 variants across nine HL genes, previously submitted to ClinVar, were curated by the HL VCEP. The curation process involved collecting published and unpublished data for each variant by biocurators, followed by bimonthly meetings of an expert curation subgroup that reviewed all evidence and applied the HL-specific ACMG/AMP guidelines to reach a final classification. RESULTS: Before expert curation, 75% (117/157) of variants had single or multiple variants of uncertain significance (VUS) submissions (17/157) or had conflicting interpretations in ClinVar (100/157). After applying the HL-specific ACMG/AMP guidelines, 24% (4/17) of VUS and 69% (69/100) of discordant variants were resolved into benign (B), likely benign (LB), likely pathogenic (LP), or pathogenic (P). Overall, 70% (109/157) variants had unambiguous classifications (B, LB, LP, P). We quantify the contribution of the HL-specified ACMG/AMP codes to variant classification. CONCLUSION: Expert specification and application of the HL-specific ACMG/AMP guidelines effectively resolved discordant interpretations in ClinVar. This study highlights the utility of ClinGen VCEPs in supporting more consistent clinical variant interpretation.
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- 2021
22. Phenotype, molecular characterisation and risk factors for postoperative meningitis caused by ESBL-producing-Enterobacteriaceae: a six years multi-Centre comparative cohort study
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Chunhong Liu, Jun Yuan, Lingye Qian, Lv Hong, Lina Zhang, Miaomiao Cui, Guanghui Zheng, Huiting Sun, Yumeng Cai, Guojun Zhang, and Yanfei Cao
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0301 basic medicine ,Adult ,Male ,medicine.medical_specialty ,China ,medicine.medical_treatment ,030106 microbiology ,Logistic regression ,Malignancy ,Polymerase Chain Reaction ,beta-Lactamases ,Meningitis, Bacterial ,lcsh:Infectious and parasitic diseases ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Medical microbiology ,Postoperative Complications ,Enterobacteriaceae ,Risk Factors ,Internal medicine ,Medicine ,Humans ,Meningitis ,lcsh:RC109-216 ,030212 general & internal medicine ,Risk factor ,Craniotomy ,Retrospective Studies ,biology ,business.industry ,Enterobacteriaceae Infections ,medicine.disease ,biology.organism_classification ,Infectious Diseases ,Phenotype ,ESBL ,Molecular characterisation ,Female ,business ,Cohort study ,Research Article - Abstract
Background To determine the phenotype, molecular characterisation and risk factors of postoperative meningitis induced by Extended-spectrum β-lactamase (ESBL)-producing Enterobacteriaceae (EPE) in China. Methods We performed a multi-centre comparative cohort study of postoperative meningitis patients infected with Enterobacteriaceae in 4 neurosurgical centres in China from January 2014 to December 2019. Phenotype and molecular characteristics of the isolates were reviewed and tested, and independent risk factors of the EPE meningitis were evaluated by binary logistic regression. Results In total, 220 Enterobacteriaceae include 78 EPE were available in this study. 85.6% (67/78) ESBL-related genes were tested, and blaSHV (14.9%) and blaSHV + blaTEM + blaCTX-M-9 (20.9%) were found to be the most frequent mono and combined ESBL-related genes harboured by Enterobacteriaceae. On binary logistic analysis, craniotomy (OR. 2.583, 95% C.I. 1.274–5.235, P = 0.008) and malignancy (OR. 2.406, 95% C.I. 1.299–4.456, P = 0.005) were the associated independent risk factors to meningitis induced by EPE. Conclusions To the best of our knowledge, this is the largest series focusing on risk factors of EPE meningitis which has been conducted in China. Craniotomy and malignancy were independent risk factors for EPE meningitis. The risk factors identified may be further utilized in clinical practice and research to avoid and reduce the mortality in future.
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- 2021
23. Field Simulation of Aerosol Transmission of SARS-CoV-2 in a Special Building Layout — Guangdong Province, China, 2021
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Qin Wang, Sili Jiang, Zhuona Zhang, Jun Yuan, Shiqiang Liu, Xia Li, Wenru Feng, Dongqun Xu, Jin Xu, Jiayun Lyu, Ling Ye, and Qinqin Jiang
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Isolation (health care) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Airflow ,aerosol transmission ,respiratory system ,Civil engineering ,Aerosol ,law.invention ,airflow layout ,Transmission (mechanics) ,Preplanned Studies ,Air conditioning ,law ,Doors ,Environmental science ,simulations ,General Agricultural and Biological Sciences ,business ,China - Abstract
What is already known on this topic? Aerosol transmission was one route for the spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and usually occurred in confined spaces. What is added by this report? Aerosol transmission was found to exist between handshake buildings, i.e., buildings with extremely close proximity that formed relatively enclosed spaces. Transmission was mainly affected by the airflow layout caused by switching air conditioners on and off as well as opening and closing doors and windows. What are the implications for public health practice? Centralized isolation and home isolation in handshake buildings creates a risk of SARS-CoV-2 aerosol transmission under certain conditions. Attention should be paid to the influence of air distribution layout on aerosol diffusion in isolation wards, and disinfection of isolation venues should be strengthened.
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- 2021
24. Bionic optical physical unclonable functions for authentication and encryption
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Kun Chen, Pidong Wang, Jun Yuan, Jianbin Kang, Yongbiao Wan, Song Sun, Yao Yao, Taiping Zhang, Zhiguang Qiu, Qian Li, Dong Li, and Huang Feng
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FOS: Computer and information sciences ,Condensed Matter - Materials Science ,Authentication ,Computer Science - Cryptography and Security ,Cryptographic primitive ,Computer science ,Manufacturing process ,business.industry ,Physical unclonable function ,Materials Science (cond-mat.mtrl-sci) ,FOS: Physical sciences ,Cryptography ,General Chemistry ,Information security ,Encryption ,ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS ,Embedded system ,Materials Chemistry ,Entropy (information theory) ,business ,Cryptography and Security (cs.CR) ,Optics (physics.optics) ,Physics - Optics - Abstract
Information security is of great importance for modern society with all things connected. Physical unclonable function (PUF) as a promising hardware primitive has been intensively studied for information security. However, the widely investigated silicon PUF with low entropy is vulnerable to various attacks. Herein, we introduce a concept of bionic optical PUFs inspired from unique biological architectures, and fabricate four types of bionic PUFs by molding the surface micro-nano structures of natural plant tissues with a simple, low-cost, green and environmentally friendly manufacturing process. The laser speckle responses of all bionic PUFs are statistically demonstrated to be random, unique, unpredictable and robust enough for cryptographic applications, indicating the broad applicability of bionic PUFs. On this ground, the feasibility of implementing bionic PUFs as cryptographic primitives in entity authentication and encrypted communication is experimentally validated, which shows its promising potential in the application of future information security.
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- 2021
25. Precise fluorination of polymeric donors towards efficient non-fullerene organic solar cells with balanced open circuit voltage, short circuit current and fill factor
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Jun Huang, Xiaosha Wang, Jing Li, Honggang Chen, Yongfang Li, Qingya Wei, Yungui Li, Yingping Zou, Lihui Jiang, and Jun Yuan
- Subjects
Materials science ,Fullerene ,Organic solar cell ,Renewable Energy, Sustainability and the Environment ,business.industry ,Open-circuit voltage ,Energy conversion efficiency ,02 engineering and technology ,General Chemistry ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Acceptor ,0104 chemical sciences ,Optoelectronics ,General Materials Science ,Charge carrier ,0210 nano-technology ,business ,Ternary operation ,Short circuit - Abstract
Three polymer donors named Qx-8F, Qx-10F, and Qx-12F, with similar chemical structures, were synthesized. The energy level of these donors is manipulated by precisely controlling the fluorination sites. We demonstrate that the exciton dissociation efficiency is gradually enhanced from Qx-8F:Y6 to Qx-12F:Y6, leading to improved open circuit voltage VOC and short circuit current density JSC for donors with a higher degree of fluorination. Simultaneously, the trap-assisted recombination or bimolecular recombination intensity is reduced, while the extraction rate is enhanced because of increased charge carrier mobilities, leading to an increase in fill factor for donors with higher amount of fluorine atoms. The optimized device based on Qx-12F with the most fluorine atoms and the non-fullerene acceptor Y6 shows the highest power conversion efficiency of 15.21%, with a VOC of 0.85 V, JSC of 24.55 mA cm−2, and fill factor of 72.88%. It is further demonstrated that the optimized ternary device based on the Qx-12F:PM6:Y6 blend provides a power conversion efficiency of 16.32%.
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- 2021
26. Probable Evidence of Fecal Aerosol Transmission of SARS-CoV-2 in a High-Rise Building
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Jun Yuan, Xuguang Chen, Jianjian Wei, Yali Zhuang, Nanshan Zhong, Min Kang, Hua Qian, Tongxing Shi, Xin Peng, Jianfeng He, Jian Hang, Juxuan Guo, Yabin Qu, Jie Wu, Yuguo Li, Yingtao Zhang, Tie Song, and Jun Wang
- Subjects
Apartment ,Coronavirus disease 2019 (COVID-19) ,business.industry ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,010102 general mathematics ,Outbreak ,General Medicine ,01 natural sciences ,Aerosol ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Transmission (mechanics) ,law ,Drainage system (geomorphology) ,Environmental health ,Internal Medicine ,Medicine ,030212 general & internal medicine ,0101 mathematics ,business ,Feces - Abstract
BACKGROUND: The role of fecal aerosols in the transmission of severe acute respiratory syndrome coronavirus 2 has been suspected. OBJECTIVE: To investigate the temporal and spatial distributions of 3 infected families in a high-rise apartment building and examine the associated environment variables to verify the role of fecal aerosols. DESIGN: Epidemiologic survey and quantitative reverse transcriptase polymerase chain reaction analyses on throat swabs from the participants; 237 surface and air samples from 11 of the 83 flats in the building, public areas, and building drainage systems; and tracer gas released into bathrooms as a surrogate for virus-laden aerosols in the drainage system. SETTING: A high-rise apartment building in Guangzhou, China. PARTICIPANTS: 9 infected patients, 193 other residents of the building, and 24 members of the building's management staff. MEASUREMENTS: Locations of infected flats and positive environmental samples, and spread of virus-laden aerosols. RESULTS: 9 infected patients in 3 families were identified. The first family had a history of travel to the coronavirus disease 2019 (COVID-19) epicenter Wuhan, whereas the other 2 families had no travel history and a later onset of symptoms. No evidence was found for transmission via the elevator or elsewhere. The families lived in 3 vertically aligned flats connected by drainage pipes in the master bathrooms. Both the observed infections and the locations of positive environmental samples are consistent with the vertical spread of virus-laden aerosols via these stacks and vents. LIMITATION: Inability to determine whether the water seals were dried out in the flats of the infected families. CONCLUSION: On the basis of circumstantial evidence, fecal aerosol transmission may have caused the community outbreak of COVID-19 in this high-rise building. PRIMARY FUNDING SOURCE: Key-Area Research and Development Program of Guangdong Province and the Research Grants Council of Hong Kong.
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- 2020
27. Effects of cross-sectional geometry on flow characteristics in spiral separators
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Meng Lingguo, Zhenguo Song, Yanbai Shen, Jun Yuan, Dezhou Wei, Shuling Gao, and Baoyu Cui
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Gravity (chemistry) ,business.industry ,Chemistry ,Process Chemistry and Technology ,General Chemical Engineering ,Cross sectional geometry ,Filtration and Separation ,02 engineering and technology ,General Chemistry ,Mechanics ,010501 environmental sciences ,Computational fluid dynamics ,Secondary flow ,01 natural sciences ,020401 chemical engineering ,Flow (mathematics) ,0204 chemical engineering ,business ,Spiral ,0105 earth and related environmental sciences - Abstract
As flowing film gravity concentrators, spiral separators are extensively used in the processing of numerous minerals. Appropriate design of their cross-sectional geometries has been known as an eff...
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- 2020
28. Diflurobenzothiadiazole core-based noncovalently fused small molecule acceptor exhibiting over 12% efficiency and high fill factor
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Yunbin Hu, Fangfang Cai, Xuxian Xiao, Wei Liu, Jiefeng Hai, Yingping Zou, Honggang Chen, Qin Chang, Jun Yuan, and Juan Hong
- Subjects
chemistry.chemical_classification ,Materials science ,Organic solar cell ,Absorption spectroscopy ,business.industry ,Energy conversion efficiency ,Stacking ,Energy Engineering and Power Technology ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Small molecule ,Acceptor ,Planarity testing ,0104 chemical sciences ,Fuel Technology ,chemistry ,Electrochemistry ,Non-covalent interactions ,Optoelectronics ,0210 nano-technology ,business ,Energy (miscellaneous) - Abstract
The versatility and flexibility of organic photoelectric materials endow organic photovoltaic cells fine function modulation and huge commercial potential. In this work, a new noncovalent fused-ring small molecule acceptor (SMA) BID-4F has been synthesized for high-efficient organic solar cells (OSCs). BID-4F consists of a diflurobenzothiadiazole (DFBT) core, ladder-like indacenodithiophene (IDT) spacers, and dicyanoindanone electron-withdrawing end groups, which are supposed to be conformationally interlocked by noncovalent interactions, leading to good molecular planarity. In addition, compact solid state stacking was revealed by UV–vis–NIR absorption spectrum. The optimized PM6:BID-4F based device delivers an eminent power conversion efficiency (PCE) of 12.30% with a high open-circuit voltage (Voc) of 0.92 V and a high fill factor (FF) of 74.3%. Most importantly, the PCE and FF are among one of the highest values reported for the OSCs based on the unfused-ring SMAs. Overall, our work demonstrates that the unfused ring central framework with high molecular planarity through noncovalent interactions provides a good strategy to construct highly efficient SMAs.
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- 2020
29. Colistin for pneumonia involving multidrug-resistant Acinetobacter calcoaceticus-Acinetobacter baumannii complex
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Jung-Jr Ye, Shie-Shian Huang, Shu-Huan Huang, and Jun-Yuan Zheng
- Subjects
Acinetobacter baumannii ,Male ,0301 basic medicine ,Resistance ,lcsh:QR1-502 ,lcsh:Microbiology ,0302 clinical medicine ,Drug Resistance, Multiple, Bacterial ,polycyclic compounds ,Immunology and Allergy ,030212 general & internal medicine ,Acinetobacter calcoaceticus ,Acinetobacter ,biology ,Mortality rate ,General Medicine ,Anti-Bacterial Agents ,Treatment Outcome ,Infectious Diseases ,Administration, Intravenous ,Female ,lipids (amino acids, peptides, and proteins) ,Acinetobacter Infections ,medicine.drug ,Microbiology (medical) ,medicine.medical_specialty ,030106 microbiology ,Microbial Sensitivity Tests ,Nephrotoxicity ,03 medical and health sciences ,Internal medicine ,Administration, Inhalation ,medicine ,Humans ,Dosing ,Aged ,General Immunology and Microbiology ,Colistin ,business.industry ,Retrospective cohort study ,Pneumonia ,biochemical phenomena, metabolism, and nutrition ,bacterial infections and mycoses ,biology.organism_classification ,medicine.disease ,bacteria ,business - Abstract
Objectives To investigate clinical and microbiological response, and 30-day mortality of pneumonia involving multidrug-resistant (MDR) Acinetobacter calcoaceticus-Acinetobacter baumannii (Acb) complex treated with colistin, and identify associated factors of these outcomes. Methods A retrospective study of 183 adult patients with colistin treatment for at least 7 days between January 2014 and October 2017. Results The mean age was 76.8 years, and mean Acute Physiology and Chronic Health Evaluation II score was 17.7. Eighteen (9.8%) and 128 (69.9%) patients had intravenous (IV) colistin alone and inhaled (IH) colistin alone, respectively. Thirty-seven patients had both IV and IH colistin, including 5 (2.7%) with concurrent, and 32 (17.5%) with non-concurrent use of IV and IH colistin. The 30-day mortality rate was 19.1% and 131 (71.6%) patients had clinical response. In the 175 patients with available data, 126 (72%) had microbiological eradication. The multivariate analyses revealed that IH colistin alone was an independent predictor for 30-day survival, clinical response, and microbiological eradication, and IV colistin alone was an independent predictor for clinical failure. Patients with IV colistin alone had a significantly higher nephrotoxicity rate than IH colistin alone (37.5% vs 6.1%, P = 0.001). Sub-group analysis of 52 patients with IV colistin for ≧ 4 days revealed that 14 (26.9%) patients had inappropriate dose, and inappropriate dose was an independent predictor for 30-day mortality. Conclusions IH colistin provided good outcomes with few side effects, and appropriate dosing of IV colistin was important to avoid excess mortality.
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- 2020
30. A survey of visual analytics techniques for machine learning
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Shixia Liu, Jiazhi Xia, Mengchen Liu, Jun Yuan, Changjian Chen, and Weikai Yang
- Subjects
FOS: Computer and information sciences ,Visual analytics ,business.industry ,Computer science ,Computer Science - Human-Computer Interaction ,020207 software engineering ,02 engineering and technology ,Machine learning ,computer.software_genre ,Computer Graphics and Computer-Aided Design ,Field (computer science) ,Human-Computer Interaction (cs.HC) ,Visualization ,Task (project management) ,Computer graphics ,Artificial Intelligence ,Taxonomy (general) ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Computer Vision and Pattern Recognition ,Artificial intelligence ,Set (psychology) ,business ,computer ,Model building - Abstract
Visual analytics for machine learning has recently evolved as one of the most exciting areas in the field of visualization. To better identify which research topics are promising and to learn how to apply relevant techniques in visual analytics, we systematically review 259 papers published in the last ten years together with representative works before 2010. We build a taxonomy, which includes three first-level categories: techniques before model building, techniques during modeling building, and techniques after model building. Each category is further characterized by representative analysis tasks, and each task is exemplified by a set of recent influential works. We also discuss and highlight research challenges and promising potential future research opportunities useful for visual analytics researchers.
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- 2020
31. Visual Genealogy of Deep Neural Networks
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Jun Yuan, Huamin Qu, Shixia Liu, Qianwen Wang, Hang Su, and Shuxin Chen
- Subjects
Artificial neural network ,Computer science ,business.industry ,Deep learning ,020207 software engineering ,Context (language use) ,02 engineering and technology ,Computer Graphics and Computer-Aided Design ,Genealogy ,Visualization ,Information visualization ,Data visualization ,Signal Processing ,0202 electrical engineering, electronic engineering, information engineering ,Graph (abstract data type) ,Computer Vision and Pattern Recognition ,Artificial intelligence ,business ,Interactive visualization ,Software - Abstract
A comprehensive and comprehensible summary of existing deep neural networks (DNNs) helps practitioners understand the behaviour and evolution of DNNs, offers insights for architecture optimization, and sheds light on the working mechanisms of DNNs. However, this summary is hard to obtain because of the complexity and diversity of DNN architectures. To address this issue, we develop DNN Genealogy, an interactive visualization tool, to offer a visual summary of representative DNNs and their evolutionary relationships. DNN Genealogy enables users to learn DNNs from multiple aspects, including architecture, performance, and evolutionary relationships. Central to this tool is a systematic analysis and visualization of 66 representative DNNs based on our analysis of 140 papers. A directed acyclic graph is used to illustrate the evolutionary relationships among these DNNs and highlight the representative DNNs. A focus + context visualization is developed to orient users during their exploration. A set of network glyphs is used in the graph to facilitate the understanding and comparing of DNNs in the context of the evolution. Case studies demonstrate that DNN Genealogy provides helpful guidance in understanding, applying, and optimizing DNNs. DNN Genealogy is extensible and will continue to be updated to reflect future advances in DNNs.
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- 2020
32. Highly Emissive Perylene Diimide-Based Metallacages and Their Host–Guest Chemistry for Information Encryption
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Mingming Zhang, Shuai Lu, Jun Yuan, Kelong Zhu, Zeyuan Zhang, Wei-Peng Chen, Yali Hou, Qiangyu Zhu, Sanliang Ling, Xiaopeng Li, and Yan-Zhen Zheng
- Subjects
business.industry ,Triphenylene ,General Chemistry ,Photochemistry ,Encryption ,Biochemistry ,Fluorescence ,Catalysis ,chemistry.chemical_compound ,Colloid and Surface Chemistry ,chemistry ,Diimide ,Pyrene ,Acetonitrile ,Host–guest chemistry ,business ,Perylene - Abstract
Here we report two highly emissive perylene diimide (PDI)-based metallacages and explore their complexation with polycyclic aromatic hydrocarbons, such as pyrene, triphenylene, and perylene. The fluorescence quantum yields of metallacages exceed 90% and their binding constants with perylene can reach as high as 2.41 × 104 M-1 in acetonitrile. These features enable further tuning of the emission of the host-guest complexes to obtain white-light emission based on the complementary orange emission of the metallacages and the blue emission of perylene. Moreover, owing to the huge differences of their quantum yields in solution and in the solid state, the host-guest complexes are successfully employed for information encryption. This study offers a general approach for the construction of emissive metallacages and explores their application for information encryption.
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- 2020
33. Sewage as a Possible Transmission Vehicle During a Coronavirus Disease 2019 Outbreak in a Densely Populated Community: Guangzhou, China, April 2020
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Yi Zhong, Xi Chen, Qinlong Jing, Kuibiao Li, Zongqiu Chen, Pengzhe Qin, Chenghua Gong, Lijuan Huang, Zhicong Yang, Yufei Liu, Guocong Liu, Conghui Xu, Bao-Ping Zhu, Jun Yuan, Hui Liu, and Baisheng Li
- Subjects
disease outbreak ,Microbiology (medical) ,China ,Sanitation ,Attack rate ,Sewage ,010501 environmental sciences ,01 natural sciences ,Disease Outbreaks ,law.invention ,Feces ,03 medical and health sciences ,0302 clinical medicine ,law ,Environmental health ,Major Article ,Humans ,Medicine ,030212 general & internal medicine ,Retrospective Studies ,0105 earth and related environmental sciences ,Apartment ,SARS-CoV-2 ,business.industry ,COVID-19 ,Outbreak ,Retrospective cohort study ,infectious disease transmission ,sewage management ,Editorial Commentary ,AcademicSubjects/MED00290 ,Infectious Diseases ,Transmission (mechanics) ,risk factor ,Severe acute respiratory syndrome-related coronavirus ,epidemiology ,business - Abstract
Background SARS-CoV-2 has been identified in the fecal matter of COVID-19 patients. However, sewage transmission has never been shown. In April 2020, a COVID-19 outbreak occurred in a densely populated community in Guangzhou, China. We investigated this outbreak to identify the mode of transmission. Method A home quarantined order was issued in the community. We collected throat swab samples from the residents and environmental samples from the surfaces inside and around the houses, and conducted RT-PCR testing and genome sequencing. We defined a case as a resident in this community with a positive RT-PCR test, with or without symptoms. We conducted a retrospective cohort study of all residents living in the same buildings as the cases to identify exposure risk factors. Result We found eight cases (four couples) in this community of 2888 residents (attack rate=2.8/1000), with onset during April 5–21, 2020. During their incubation periods, Cases 1-2 frequented market T with an ongoing outbreak. Cases 3-8 never visited market T during incubation period, lived in separate buildings from, and never interacted with, Cases 1-2. Retrospective cohort study showed that working as cleaners or waste picker (RR=13, 95% CIexact: 2.3-180), not changing to clean shoes after returning home (RR=7.4, 95% CIexact: 1.8-34), collating and cleaning dirty shoes after returning home (RR=6.3, 95% CIexact: 1.4-30) were significant exposure risk factors. Of 63 samples collected from street-sewage puddles and sewage-pipe surfaces, 19% tested positive for SARS-CoV-2. Of 50 environmental samples taken from cases’ apartments, 24% tested positive. Viral genome sequencing showed that the viruses identified from the squat toilet and shoe-bottom dirt inside the apartment of Cases 1-2 were homologous with those from Cases 3-8 and those identified from sewage samples. The sewage pipe leading from the apartment of Cases 1-2 to the drainage had a large hole above ground. Rainfalls after the onset of Cases 1-2 flooded the streets. Conclusion Our investigation has for the first time pointed to the possibility that SARS-CoV-2 might spread by sewage. This finding highlighted the importance of sewage management, especially in densely-populated places with poor hygiene and sanitation measures, such as urban slums and other low-income communities in developing countries.
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- 2020
34. Effect of Wrist–Ankle Acupuncture on Propofol Dosage in Painless Gastroscopy of Elderly Patients: A Randomized Controlled Trial
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Dong Yajing, Jing Yang, Wei Hao, Jun Yuan, Dandan Wang, Xu Zhe, and Zhi Liang
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Pharmacology ,business.industry ,MEDLINE ,General Medicine ,Wrist ,law.invention ,medicine.anatomical_structure ,Randomized controlled trial ,law ,Anesthesia ,Acupuncture ,Medicine ,Pharmacology (medical) ,Ankle ,business ,Propofol ,medicine.drug - Published
- 2020
35. Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study
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Zhou Bin Zhang, Lei Luo, Ming Jin Liu, Ira M. Longini, Yang Yang, Li Qun Fang, Meng Meng Ma, Qin Long Jing, Natalie E. Dean, Eben Kenah, Jun Yuan, Yu Ma, Zhicong Yang, Ying Lu, An Ran Zhang, and Neda Jalali
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Adult ,Male ,0301 basic medicine ,China ,Middle East respiratory syndrome coronavirus ,Pneumonia, Viral ,Basic Reproduction Number ,medicine.disease_cause ,law.invention ,Betacoronavirus ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Risk Factors ,law ,Humans ,Medicine ,030212 general & internal medicine ,Transmission risks and rates ,Young adult ,Asymptomatic Infections ,Pandemics ,Retrospective Studies ,Family Characteristics ,SARS-CoV-2 ,business.industry ,Incidence ,Incidence (epidemiology) ,Comment ,COVID-19 ,Retrospective cohort study ,Middle Aged ,Models, Theoretical ,030104 developmental biology ,Infectious Diseases ,Transmission (mechanics) ,Quarantine ,Female ,Contact Tracing ,Coronavirus Infections ,business ,Basic reproduction number ,Contact tracing ,Demography - Abstract
As of June 8, 2020, the global reported number of COVID-19 cases had reached more than 7 million with over 400 000 deaths. The household transmissibility of the causative pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains unclear. We aimed to estimate the secondary attack rate of SARS-CoV-2 among household and non-household close contacts in Guangzhou, China, using a statistical transmission model.In this retrospective cohort study, we used a comprehensive contact tracing dataset from the Guangzhou Center for Disease Control and Prevention to estimate the secondary attack rate of COVID-19 (defined as the probability that an infected individual will transmit the disease to a susceptible individual) among household and non-household contacts, using a statistical transmission model. We considered two alternative definitions of household contacts in the analysis: individuals who were either family members or close relatives, such as parents and parents-in-law, regardless of residential address, and individuals living at the same address regardless of relationship. We assessed the demographic determinants of transmissibility and the infectivity of COVID-19 cases during their incubation period.Between Jan 7, 2020, and Feb 18, 2020, we traced 195 unrelated close contact groups (215 primary cases, 134 secondary or tertiary cases, and 1964 uninfected close contacts). By identifying households from these groups, assuming a mean incubation period of 5 days, a maximum infectious period of 13 days, and no case isolation, the estimated secondary attack rate among household contacts was 12·4% (95% CI 9·8-15·4) when household contacts were defined on the basis of close relatives and 17·1% (13·3-21·8) when household contacts were defined on the basis of residential address. Compared with the oldest age group (≥60 years), the risk of household infection was lower in the youngest age group (20 years; odds ratio [OR] 0·23 [95% CI 0·11-0·46]) and among adults aged 20-59 years (OR 0·64 [95% CI 0·43-0·97]). Our results suggest greater infectivity during the incubation period than during the symptomatic period, although differences were not statistically significant (OR 0·61 [95% CI 0·27-1·38]). The estimated local reproductive number (R) based on observed contact frequencies of primary cases was 0·5 (95% CI 0·41-0·62) in Guangzhou. The projected local R, had there been no isolation of cases or quarantine of their contacts, was 0·6 (95% CI 0·49-0·74) when household was defined on the basis of close relatives.SARS-CoV-2 is more transmissible in households than SARS-CoV and Middle East respiratory syndrome coronavirus. Older individuals (aged ≥60 years) are the most susceptible to household transmission of SARS-CoV-2. In addition to case finding and isolation, timely tracing and quarantine of close contacts should be implemented to prevent onward transmission during the viral incubation period.US National Institutes of Health, Science and Technology Plan Project of Guangzhou, Project for Key Medicine Discipline Construction of Guangzhou Municipality, Key Research and Development Program of China.
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- 2020
36. A Novel Visible‐Light‐Responsive Semiconductor ScTaO 4−x N x for Photocatalytic Oxygen and Hydrogen Evolution Reactions
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Shicheng Yan, Hao Jin, Lang Pei, Yong-Jun Yuan, Hong Cai, Heng Zhu, Jiasong Zhong, Zhigang Zou, and Taozhu Li
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Materials science ,business.industry ,Organic Chemistry ,Doping ,chemistry.chemical_element ,Photochemistry ,Oxygen ,Catalysis ,Inorganic Chemistry ,Semiconductor ,chemistry ,Photocatalysis ,Water splitting ,Hydrogen evolution ,Physical and Theoretical Chemistry ,business ,Visible spectrum - Published
- 2020
37. Effect of laparoscopic surgery for colorectal cancer with N. O. S. E. on recovery and prognosis of patients
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Shan He, Heng-Yi Deng, Man Hu, Nian Li, Chuan-Ming Zhang, Hong-Jun Yuan, Jing Wen, Xiao-Ting Wu, and Jun Bu
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Natural Orifice Endoscopic Surgery ,Laparoscopic surgery ,medicine.medical_specialty ,Colorectal cancer ,business.industry ,medicine.medical_treatment ,Length of Stay ,Prognosis ,medicine.disease ,Natural orifice ,Surgery ,Postoperative Complications ,Treatment Outcome ,medicine.anatomical_structure ,Quality of life ,Quality of Life ,medicine ,Humans ,Laparoscopy ,Colorectal Neoplasms ,business ,Nose - Abstract
To investigate the effect of laparoscopic surgery in colorectal cancer (CRC) patients with natural orifice specimen extraction (NOSE) on the recovery and quality of life (QOL) of patients.Ninety-two eligible patients were randomly assigned into two groups: the traditional laparoscopy group (L group,A total of 46 patients in each group were enrolled in this study. The general data and surgery-related indicators were comparable between the two groups (all
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- 2020
38. Reducing Voltage Losses in the A-DA′D-A Acceptor-Based Organic Solar Cells
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Feng Gao, Jianhui Hou, Yingping Zou, Mario Leclerc, Jun Yuan, Yongfang Li, Rui Zhang, Fei Huang, Huotian Zhang, Xiaowei Zhan, and Yuming Wang
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Materials science ,Organic solar cell ,business.industry ,General Chemical Engineering ,Biochemistry (medical) ,02 engineering and technology ,General Chemistry ,Condensed Matter Physics ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Biochemistry ,Acceptor ,0104 chemical sciences ,Materials Chemistry ,Environmental Chemistry ,Optoelectronics ,High current ,0210 nano-technology ,business ,Den kondenserade materiens fysik ,Low voltage ,Voltage - Abstract
Power conversion efficiencies (PCEs) of solution-processed organic solar cells (OSCs) have recently reached 17.4% (certified) for single-junction devices. Crucial to this advancement is the development of non-fullerene acceptors (NFAs) since 2015. The recent A-DAD-A NFAs have attracted widespread attention because of their ladder-type electron-deficient-core-based central fused ring with improved transport properties and optimum energy levels. With the synergistic effect of electron-deficient-core and specific molecular geometry, the A-DADA molecules could achieve low voltage losses and high current generation at the same time, reaching new regimes of device physics and photophysics. This perspective will discuss the voltage losses in state-of-the-art A-DAD-A NFA-based OSCs and propose new molecular design strategies to achieve PCEs over 20% in OSCs based on these new acceptors by further decreasing their total voltage losses. Funding Agencies|National Natural Science Foundation of China (NSFC)National Natural Science Foundation of China (NSFC) [21875286]; National Key Research & Development Projects of China [2017YFA0206600]; Science Fund for Distinguished Young Scholars of Hunan ProvinceNational Natural Science Foundation of China (NSFC)National Science Fund for Distinguished Young Scholars [2017JJ1029]; Swedish Research Council VRSwedish Research Council [2018-06048]; Swedish Energy Agency EnergimyndighetenSwedish Energy Agency [2016-010174]; Stiftelsen For Strategisk Forskning through a Future Research Leader program [FFL18-0322]; NSERCNatural Sciences and Engineering Research Council of Canada
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- 2020
39. Apache IoTDB
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Rong Kang, Huang Xiangdong, Julian Feinauer, Zhang Jinrui, Chen Wang, Qiao Jialin, Peng Wang, Lei Rui, Jun Yuan, Sun Jiaguang, Kevin A. McGrail, Jiang Tian, Diaohan Luo, and Jianmin Wang
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Database ,business.industry ,Computer science ,Data management ,General Engineering ,020206 networking & telecommunications ,Cloud computing ,02 engineering and technology ,computer.software_genre ,File format ,Analytics ,Spark (mathematics) ,Computer data storage ,0202 electrical engineering, electronic engineering, information engineering ,020201 artificial intelligence & image processing ,Latency (engineering) ,business ,computer ,Time series database - Abstract
The amount of time-series data that is generated has exploded due to the growing popularity of Internet of Things (IoT) devices and applications. These applications require efficient management of the time-series data on both the edge and cloud side that support high throughput ingestion, low latency query and advanced time series analysis. In this demonstration, we present Apache IoTDB managing time-series data to enable new classes of IoT applications. IoTDB has both edge and cloud versions, provides an optimized columnar file format for efficient time-series data storage, and time-series database with high ingestion rate, low latency queries and data analysis support. It is specially optimized for time-series oriented operations like aggregations query, down-sampling and sub-sequence similarity search. An edge-to-cloud time-series data management application is chosen to demonstrate how IoTDB handles time-series data in real-time and supports advanced analytics by integrating with Hadoop and Spark. An end-to-end IoT data management solution is shown by integrating IoTDB with PLC4x, Calcite, and Grafana.
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- 2020
40. The evidence of indirect transmission of SARS-CoV-2 reported in Guangzhou, China
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Kuibiao Li, Xiao Zhang, Jiachun Lu, Jin Chen, Chaojun Xie, Dahu Wang, Hongjun Zhao, Lin Zhang, Huide Peng, Xiaoxiao Lu, Jun Yuan, Di Wu, Yuzhou Gu, and Zhoubin Zhang
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Adult ,Male ,medicine.medical_specialty ,China ,Indirect Transmission ,Cross-sectional study ,Pneumonia, Viral ,030209 endocrinology & metabolism ,Snot-oral transmission ,Real-Time Polymerase Chain Reaction ,law.invention ,03 medical and health sciences ,Betacoronavirus ,0302 clinical medicine ,law ,Residence Characteristics ,Environmental health ,Pandemic ,Epidemiology ,medicine ,Environmental Microbiology ,Cluster Analysis ,Humans ,Severe acute respiratory syndrome coronavirus 2 ,Family ,030212 general & internal medicine ,Pandemics ,Aged ,Novel coronavirus disease ,business.industry ,SARS-CoV-2 ,Public health ,lcsh:Public aspects of medicine ,Public Health, Environmental and Occupational Health ,COVID-19 ,lcsh:RA1-1270 ,Middle Aged ,Transmission (mechanics) ,Cross-Sectional Studies ,Indirect transmission ,Female ,Biostatistics ,Contact Tracing ,business ,Coronavirus Infections ,Contact tracing ,Research Article - Abstract
Background More than 2 months have passed since the novel coronavirus disease 2019 (COVID-19) first emerged in Wuhan, China. With the migration of people, the epidemic has rapidly spread within China and throughout the world. Due to the severity of the epidemic, undiscovered transmission of COVID-19 deserves further investigation. The aim of our study hypothesized possible modes of SARS-CoV-2 transmission and how the virus may have spread between two family clusters within a residential building in Guangzhou, China. Methods In a cross-sectional study, we monitored and traced confirmed patients and their close contacts from January 11 to February 5, 2020 in Guangzhou, China, including 2 family cluster cases and 61 residents within one residential building. The environmental samples of the building and the throat swabs from the patients and from their related individuals were collected for SARS-CoV-2 and tested with real-time reverse transcriptase polymerase chain reaction (RT-PCR). The relevant information was collected and reported using big data tools. Results There were two notable family cluster cases in Guangzhou, which included 3 confirmed patients (family No.1: patient A, B, C) and 2 confirmed patients (family No.2: patient D, E), respectively. None of patients had contact with other confirmed patients before the onset of symptoms, and only patient A and patient B made a short stop in Wuhan by train. Home environment inspection results showed that the door handle of family No.1 was positive of SARS-CoV-2. The close contacts of the 5 patients all tested negative of SARS-CoV-2 and in good health, and therefore were released after the official medical observation period of 14-days. Finally, according to the traceability investigation through applying big data analysis, we found an epidemiological association between family No.1 and family No.2, in which patient D (family No.2) was infected through touching an elevator button contaminated by snot with virus from patient A (family No.1) on the same day. Conclusions Contaminants with virus from confirmed patients can pollute the environment of public places, and the virus can survive on the surface of objects for a short period of time. Therefore, in addition to the conventional droplet transmission, there is also indirect contact transmission such as snot-oral transmission that plays a crucial role in community spread of the virus.
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- 2020
41. Clinical outcomes of revision with retrograde intermedullary nailing for failed plating of distal femoral fractures: a retrospective study
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Jun Yuan, Zeng Zhijiang, Qu Gangbo, Jiafu Yang, Yi Yuan, Zu-Jian Xu, Bing Luo, Qi Hao, and Hao Pandeng
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030203 arthritis & rheumatology ,030222 orthopedics ,medicine.medical_specialty ,business.industry ,Deep vein ,Retrospective cohort study ,medicine.disease ,Thrombosis ,law.invention ,Surgery ,Intramedullary rod ,Vein thrombosis ,03 medical and health sciences ,Fixation (surgical) ,0302 clinical medicine ,medicine.anatomical_structure ,law ,Orthopedic surgery ,medicine ,Orthopedics and Sports Medicine ,Range of motion ,business - Abstract
To assess the feasibility and effectiveness of retrograde intramedullary nail (RIN) revision surgeries for locking compression plate (LCP) failure in distal femoral fractures. This retrospective study included 13 patients who suffered from metalwork failures after they initially underwent open reduction and LCP fixation. In patients who eventually underwent RIN revision from January 2014 to December 2016, range of motion (ROM) and Hospital for Special Surgery (HSS) scores obtained before surgery and at the final follow-up time were analysed. The average operative time was 155 minutes (range, 120–210 minutes), and the average blood loss volume was 650 ml (range, 200–1350 ml). There were two cases of complications (15.38%): one was calf muscle vein thrombosis, and the other was a superficial infection. No deep tissue infection or deep vein thrombosis was observed post-operatively. The average follow-up time was 16 months (range, 12–24 months). All fractures healed in a mean of 6.5 months (range, 4–12 months), and one patient underwent an additional bone graft surgery that did not involve a bone graft during the RIN revision operation (this eventually healed at 12 months post-operatively). The mean ROM before the operation was 86.92 ± 12.34°. At the final follow-up, the mean ROM was 112.69 ± 9.27°. There was a significant difference between pre-operative and post-operative ROM (P
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- 2020
42. Spin-coated 10.46% and blade-coated 9.52% of ternary semitransparent organic solar cells with 26.56% average visible transmittance
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Can Zhu, Jun Yuan, Zhanjun Zhang, Zhenrong Jia, Yingping Zou, Hongjian Peng, He Huang, Yongfang Li, Jing Li, Lei Meng, and Fangfang Cai
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Spin coating ,Materials science ,Opacity ,Organic solar cell ,Renewable Energy, Sustainability and the Environment ,business.industry ,020209 energy ,Energy conversion efficiency ,02 engineering and technology ,engineering.material ,021001 nanoscience & nanotechnology ,Coating ,0202 electrical engineering, electronic engineering, information engineering ,engineering ,Transmittance ,Optoelectronics ,General Materials Science ,Building-integrated photovoltaics ,0210 nano-technology ,Ternary operation ,business - Abstract
Semitransparent organic solar cells (ST-OSCs) have drawn great attention due to their wide application, such as smart windows, greenhouses and building integrated photovoltaics. The ternary strategy is often considered an useful way to enhance device performance due to improve the attracting or retracting morphology. Here, non-fullerene small molecule (Y8) with electron-deficient core as the center unit and a novel PBDTTT-type low-bandgap polymer (PCE10) were chosen to fabricate ST-OSCs according to the principle of more closely matched energy levels. With the introduction of indene-C60bisadduct (ICBA) as third component, opaque organic solar cells with a power conversion efficiency (PCE) of 12.86% and ST-OSCs with a PCE of 10.46% were obtained by using spin coating after optimization. The average visible transmittance of ST-OSCs is up to 26.56%. By the blade coating technique, 9.52% PCE is achieved for ST-OSCs, which is the highest value reported to date. These results show that it's higher efficiency to improve the performance of ST-OSCs through ternary strategy. And the blade coating technique has a promising application prospect for mass manufacturing ST-OSCs.
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- 2020
43. Forming a Reliable Hybrid Microgrid Using Electric Spring Coupled With Non-Sensitive Loads and ESS
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Samson Shenglong Yu, Hieu Trinh, Yun Zhang, Zhong Li, Jun Yuan, Chen Sizhe, and Guidong Zhang
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Wind power ,General Computer Science ,business.industry ,Computer science ,020209 energy ,020208 electrical & electronic engineering ,Photovoltaic system ,02 engineering and technology ,Power factor ,AC power ,Energy storage ,Electric power system ,Control theory ,Harmonics ,0202 electrical engineering, electronic engineering, information engineering ,Microgrid ,business - Abstract
The intermittency of renewable energy sources, i.e., photovoltaic cells and wind power causes problems such as unreliability, harmonic pollution, unpredictability and inefficiency, which pose a great challenge for constructing a reliable modern microgrid. To address these problems, in this paper, we propose a novel structure of microgrid, where sensitive loads, non-sensitive loads and the concept of “load follows demand” are adopted and incorporated. Within the designed microgrid, energy storage systems (ESSs) are coupled with the non-sensitive loads to achieve the supply/demand balance. In addition, a particle swarm optimization (PSO)-based collective load control is employed in this study to create pure resistiveness and piecewise constant active power features in the microgrid, in order to resolve harmonics and unpredictability problems. The proposed microgrid experimental platform is established based on real-time (RT)-lab and dSPACE in a hardware-in-the-loop (HIL) environment, where the efficacy of the proposed microgrid structure is verified in both islanded mode and grid-connected mode, which is able to achieve nearly 100% utilization rate of the intermittent solar energy, piecewise constant power and unity power factor. The proposed microgrid structure and established testing environment also have the potential to be scaled up to multi-microgrid power systems for advanced and wider applicability.
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- 2020
44. Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
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Qin Li, Jiang Gong, Jin Jing Li, Juan Chen, Wei Xu, Bo Wu, Hai Jun Deng, Kun Su, Xiaojun Tang, Xia Mao Liu, Ailong Huang, Yong Zhang, Fa Jin Lv, Fan Zhang, Jie Li Hu, Qiu Lin Shi, Quanxin Long, Jing Fu Qiu, and Jun Yuan
- Subjects
Adult ,Male ,0301 basic medicine ,China ,medicine.medical_specialty ,Adolescent ,Pneumonia, Viral ,Asymptomatic ,Gastroenterology ,General Biochemistry, Genetics and Molecular Biology ,Serology ,Betacoronavirus ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Interquartile range ,Internal medicine ,medicine ,Humans ,Young adult ,Viral shedding ,Child ,Neutralizing antibody ,Asymptomatic Infections ,Pandemics ,Aged ,biology ,SARS-CoV-2 ,business.industry ,COVID-19 ,General Medicine ,Middle Aged ,medicine.disease ,Immunity, Innate ,Hospitalization ,Pneumonia ,030104 developmental biology ,Immunoglobulin G ,030220 oncology & carcinogenesis ,biology.protein ,Cytokines ,Female ,medicine.symptom ,Antibody ,Coronavirus Infections ,business - Abstract
The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People's Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15-26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6-10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8-38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys.
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- 2020
45. Fine-Tuning Energy Levels via Asymmetric End Groups Enables Polymer Solar Cells with Efficiencies over 17%
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Ruijie Ma, Zhenghui Luo, Tao Liu, Guanshui Xie, Jie Min, Jian Zhang, Jun Yuan, Gaoda Chai, Yiqun Xiao, Chuluo Yang, Yuzhong Chen, Kai Chen, Xinhui Lu, He Yan, Feng Gao, Yingping Zou, Jianwei Yu, Rui Sun, and Huiliang Sun
- Subjects
Fine-tuning ,Materials science ,Open-circuit voltage ,business.industry ,Energy conversion efficiency ,02 engineering and technology ,010402 general chemistry ,021001 nanoscience & nanotechnology ,01 natural sciences ,Acceptor ,Polymer solar cell ,0104 chemical sciences ,General Energy ,Optoelectronics ,0210 nano-technology ,business ,HOMO/LUMO ,Energy (signal processing) ,Voltage - Abstract
Summary Generally, it is important to fine-tune the energy levels of donor and acceptor materials in the field of polymer solar cell (PSCs) to achieve a minimal highest occupied molecular orbital (HOMO) energy offset, which yet is still sufficient for charge separation. Based on the high-performance small-molecule acceptor (SMA) of BTP-4F, we modified the end groups of BTP-4F from IC-2F to CPTCN-Cl. It was found that when both end groups were substituted by CPTCN-Cl, the energy level upshift was too large that caused unfavorable energetic alignment, thus poor device performance. By using the strategy of asymmetric end groups, we were able to achieve near optimal energy level match, resulting in higher open-circuit voltage (VOC) and power conversion efficiency (PCE) compared with those given by the PM6:BTP-4F system. Our strategy can be useful and potentially applied to other material systems for maximizing efficiency of non-fullerene PSCs.
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- 2020
46. Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates 2,4,6‐trinitrobenzenesulfonic acid‐induced colitis via repressing toll‐like receptor 4/nuclear factor‐kappa B
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Zhi‐Li Chen, Lei Lei, Jian‐Hua He, Jian‐Hua Wu, You‐Jun Yuan, Xu Li, and Xiao‐Sheng Cai
- Subjects
Male ,Interleukin-1beta ,Pharmacology ,Inflammatory bowel disease ,PCSK9 ,chemistry.chemical_compound ,0302 clinical medicine ,TLR4 ,RNA, Small Interfering ,Chemokine CCL2 ,lcsh:R5-920 ,biology ,PCSK9 Inhibitors ,NF-kappa B ,General Medicine ,Colitis ,Intercellular Adhesion Molecule-1 ,030220 oncology & carcinogenesis ,Myeloperoxidase ,Kexin ,030211 gastroenterology & hepatology ,Proprotein Convertase 9 ,medicine.symptom ,lcsh:Medicine (General) ,Signal Transduction ,Colon ,Genetic Vectors ,Inflammation ,Adenoviridae ,Proinflammatory cytokine ,03 medical and health sciences ,2,4,6-Trinitrobenzenesulfonic acid ,medicine ,Animals ,Rats, Wistar ,Peroxidase ,Interleukin-6 ,Tumor Necrosis Factor-alpha ,business.industry ,NF‐κB ,Body Weight ,Proprotein convertase ,medicine.disease ,digestive system diseases ,Rats ,Toll-Like Receptor 4 ,Gene Expression Regulation ,Trinitrobenzenesulfonic Acid ,chemistry ,biology.protein ,business - Abstract
Inflammatory bowel disease (IBD) is characterized by recurring inflammatory disorders in digestive system, and devoid of effective treatment. Proprotein convertase subtilisin/kexin type 9 (PCSK9), stimulated via inflammation whose inhibition could decrease secretion of inflammatory factors. We then determined whether inhibition of PCSK9 could improve the inflammation. First, rats model of colitis was first established via administration of 2,4,6‐trinitrobenzenesulfonic acid (TNBS), and then verified via determination of body weight loss, myeloperoxidase (MPO) activity, and histopathological analysis of colonic damage. Results showed that treatment with TNBS induced a great body weight loss, MPO activity increase, and serious colonic damage, showing an obviously character of IBD. PCSK9 was elevated in TNBS‐induced rats, and PCSK9 inhibition delivered by adenovirus vector increased the body weight, decreased MPO activity, and ameliorated histological change of colon. Second, the protective effect of PCSK9 inhibition against TNBS‐induced colitis was accompanied by decrease of proinflammatory factors secretion, including tumor necrosis factor‐α, interleukin‐1β, interleukin‐6, intercellular adhesion molecule 1, and monocyte chemoattractant protein‐1. TNBS could activate toll‐like receptor 4 (TLR4)/nuclear factor‐kappa B (NF‐κB) signaling pathway, while PCSK9 inhibition suppressed activation of TLR4/NF‐κB in TNBS‐induced rats. In conclusion, PCSK9 inhibition attenuated TNBS‐induced rat colitis through anti‐inflammatory effect under inactivation of TLR4/NF‐κB, suggesting potential therapeutic strategy in IBD.
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- 2020
47. Antibody responses to SARS-CoV-2 in patients with COVID-19
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Hua Wen Liu, Jun Yuan, Jin Jing Li, Hai Jun Deng, Shao Bo Wu, Xiao Ping Cui, Man Man Zhu, Fang Gong, Juan Chen, Jie Li Hu, Xiao He Luo, Zhi Jie Li, Xiao Feng Li, Wen Guang Tian, Li Hu, Liu Ping, Chun Hui Lang, Jing Wang, Kun Deng, Yuan Hu, Kun Wang, Li Hua Yu, Jing Fu Qiu, Deqiang Wang, Cheng Jun Xue, Yong Zhang, Bai Zhong Liu, Xiao-li Zhang, Yin Yin Xu, Yong Lin, Qing Jun Yang, Fan Zhang, Xian Xiang Zhang, Zhan Mo, Xue Fei Cai, Yao Kai Chen, Qin Li, Ailong Huang, Ji Hua Ren, Xia Mao Liu, De Chun Zhang, Ni Tang, Quanxin Long, Gui Cheng Wu, Jiang Lin Xiang, Li Wang, Pu Liao, Xiaojun Tang, Hong Xin Du, Zheng Zhou, and Chang Chun Niu
- Subjects
Adult ,Male ,0301 basic medicine ,Coronavirus disease 2019 (COVID-19) ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,Pneumonia, Viral ,Antibodies, Viral ,Antiviral Agents ,Asymptomatic ,General Biochemistry, Genetics and Molecular Biology ,Serology ,Betacoronavirus ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Seroconversion ,Pandemics ,Aged ,biology ,SARS-CoV-2 ,business.industry ,COVID-19 ,General Medicine ,Middle Aged ,medicine.disease ,Pneumonia ,Titer ,030104 developmental biology ,Immunoglobulin M ,Immunoglobulin G ,030220 oncology & carcinogenesis ,Antibody Formation ,Immunology ,biology.protein ,Female ,Antibody ,medicine.symptom ,Coronavirus Infections ,business - Abstract
We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.
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- 2020
48. The design of Apache IoTDB distributed framework
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Yi Xu, Huang Xiangdong, Tianan Li, Dongfang Mao, Jun Yuan, and Jianmin Wang
- Subjects
General Computer Science ,Computer science ,business.industry ,Data management ,Distributed computing ,Hash function ,Strong consistency ,Eventual consistency ,Metadata ,Consistency (database systems) ,Metadata management ,Synchronization (computer science) ,business ,Engineering (miscellaneous) - Abstract
Apache Internet of Things Database (IoTDB) is a new open-source timeseries database management system. A distributed data management system not only needs to solve the problem of metadata synchronization between nodes caused by data partition and multiple replicas, but also needs to support efficient query request processing. To solve the problem of metadata synchronization among nodes, we propose a dual-layer granularity metadata management strategy. Based on the consistency hash partitioning method and Raft protocol, we designed a distributed framework that supports both strong consistency query and eventual consistency query. Based on the single-machine version of Apache IoTDB, we carried out the system implementation and experimental test. Compared with the single-level granularity management strategy, the test results showed that the two-level granularity metadata management strategy takes less memory resources and improves the write performance by $5%\sim10%$. Also, the results showed that the read and write performance of the distributed Apache IoTDB increases linearly with the extension of cluster size.
- Published
- 2020
49. Can Combined Screening of Ultrasound and Elastography Improve Breast Cancer Identification Compared with MRI in Women with Dense Breasts-a Multicenter Prospective Study
- Author
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Wen Xu, Hong-Yuan Xue, Pintong Huang, Yang Gu, Weiwei Zhan, Qi Zhou, Xiaoyan Xie, Luying Gao, Ping Zhou, En-Sheng Xue, Yuxin Jiang, Bao-Ming Luo, Wu Chen, Hong-Yu Ding, Chun-Quan Zhang, Cai Chang, Qing Zhou, Jia-Wei Tian, Zhong-Ping Mu, Yu-Ming Mu, Hongyan Wang, Jian-Feng Guo, Li Liu, Ying Gu, Hong-Qiao Wang, Jian-Jun Yuan, Li-Xue Yin, Jin-Feng Xu, Chun-Song Kang, You-Bin Deng, Yu-Hong Zhang, Jie Li, Jianchu Li, Wei-Dong Ren, Hui Wang, Man Chen, Haitao Ran, Tong Jiao, Jie-Ying Zhang, Xiang-Xiang Jing, and Sheng-Lan Guo
- Subjects
Breast imaging ,Malignancy ,Ultrasound (US) ,030218 nuclear medicine & medical imaging ,Dense breast ,03 medical and health sciences ,0302 clinical medicine ,Breast cancer ,Breast Imaging Reporting and Data System (BI-RADS) ,medicine ,Magnetic resonance imaging (MRI) ,Prospective cohort study ,Pathological ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Magnetic resonance imaging ,medicine.disease ,Oncology ,030220 oncology & carcinogenesis ,Elastography ,business ,Nuclear medicine ,Research Paper - Abstract
Objectives: To assess the performance of elastography (ES) and ultrasound (US) in predicting the malignancy of breast lesions and to compare their combined diagnostic value with that of magnetic resonance imaging (MRI). Materials and Methods: The study prospectively enrolled 242 female patients with dense breasts treated in 35 heath care facilities in China between November 2018 and October 2019. Based on conventional US and elastography, radiologists classified the degree of suspicion of breast lesions according to the US Breast Imaging Reporting and Data System (BI-RADS) criteria. The diagnostic value was compared between US BI-RADS and MRI BI-RADS, with pathological results used as the reference standard. Results: The results demonstrated that irregular tumor shape, a nonparallel growth orientation, indistinct margins, angular contours, microcalcifications, color Doppler flow and ES score on US imaging were significantly related to breast cancer in dense breasts (P=0.001; P=0.001; P=0.008; P
- Published
- 2020
50. All-Optical Switching and Multiple Logic Gates Based on Hybrid Square–Rectangular Laser
- Author
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Yong-Zhen Huang, Jia-Chen Liu, Fu-Li Wang, Jun-Yuan Han, Jin-Long Xiao, Yue-De Yang, and You-Zeng Hao
- Subjects
Materials science ,Extinction ratio ,business.industry ,Physics::Optics ,NAND gate ,Saturable absorption ,NAND logic ,Optical switch ,Atomic and Molecular Physics, and Optics ,Optical bistability ,Logic gate ,Optoelectronics ,Photonics ,business - Abstract
All-optical switching and multiple logic gates are experimentally demonstrated using AlGaInAs/InP hybrid square-rectangular lasers. Controllable bistability induced by saturable absorption in the square microcavity is achieved around the threshold with the square cavity in an open circuit state. Based on the bistability, all-optical switching operation is realized by injecting set/reset optical signals with the wavelengths around the lasing mode of 1529.9 nm and another high-Q mode at 1560 nm. Furthermore, mode competitions between three resonant modes around 1541 nm with an interval of 1.2 nm are used to realize all-optical multiple logic gates of NOT, NOR, and NAND functions under low-power optical pulses, with injecting currents to the square and rectangular sections. The static extinction ratio of 34, 40 and 24 dB are obtained for NOT, NOR, and NAND gates, respectively, and the dynamic extinction ratio over 10 dB of NOT function at 15 Gb/s, NOR and NAND functions at 2 Gb/s are demonstrated. With the merits of multifunctional operations, large optical injection wavelength tolerant ranges, low power consumption, small footprint and suitability for on-chip integration, the device offers a potential solution for all-optical signal processing in photonic integration circuits.
- Published
- 2020
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