91 results on '"Ha Jung Kim"'
Search Results
2. Immediate intravenous iron administration improves anaemia recovery following total knee arthroplasty: A propensity‐matched analysis
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Ha-Jung Kim, Young-Jin Ro, Hyungtae Kim, Hee-Sun Park, Jin-Sun Kim, Seong-Il Bin, and Won Uk Koh
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Transfusion rate ,Anemia, Iron-Deficiency ,business.industry ,Iron ,Total knee arthroplasty ,Intravenous iron ,Anemia ,Hematology ,General Medicine ,Iron deficiency ,medicine.disease ,Ferric Compounds ,FERRIC CARBOXYMALTOSE ,Hemoglobins ,Anesthesia ,Propensity score matching ,Humans ,Medicine ,In patient ,Observational study ,Arthroplasty, Replacement, Knee ,business ,Retrospective Studies - Abstract
BACKGROUND AND OBJECTIVES Patients who undergo total knee arthroplasty (TKA) have a risk of postoperative anaemia. This observational study evaluated whether single-dose intravenous ferric carboxymaltose (FCM) administered immediately after TKA facilitates the correction of anaemia. MATERIALS AND METHODS We retrospectively analysed 722 patients who underwent primary TKA. The FCM group receiving 1000 mg intravenous FCM within one postoperative hour was compared with the non-FCM group that did not receive the medication. A propensity score matching with multiple logistic regression analysis was used to minimize intergroup differences in the baseline characteristics and postoperative blood loss. The rate and severity of postoperative anaemia were compared between the groups, along with haemoglobin (Hb) value, transfusion rate and complications. RESULTS After propensity score matching, 231 patients were included in each group. In the FCM group, the rate of anaemia at postoperative day (POD) 7 (p = 0.021) and postoperative week (POW) 5 (p
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- 2021
3. Long-Term Management of a Refractory Corticosteroid Responsive Tremor Syndrome
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Ji-Hye Lee, Soomin Kim, Hyeon-Jin Kim, Jihee Kim, Migyeong Geum, Ha-Jung Kim, and Yoonji Kim
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Pediatrics ,medicine.medical_specialty ,General Veterinary ,Refractory ,medicine.drug_class ,business.industry ,Long term management ,medicine ,Corticosteroid ,business - Published
- 2021
4. A case of canine blepharoconjunctivitis associated with atopic dermatitis
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Ha-Jung Kim, Ji-Hye Lee, Soomin Kim, Hyeon-Jin Kim, Se Eun Kim, Yoonji Kim, Jihee Kim, and Taejung Kim
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medicine.medical_specialty ,Conjunctiva ,integumentary system ,Erythema ,business.industry ,Meibomian gland ,Atopic dermatitis ,medicine.disease ,Dermatology ,eye diseases ,body regions ,medicine.anatomical_structure ,Edema ,medicine ,Tears ,Generalized erythema ,sense organs ,medicine.symptom ,skin and connective tissue diseases ,Blepharitis ,business - Abstract
An 8-year-old, spayed female Maltese dog was presented with a one-month history of erythema, swelling and alopecia of periocular region with pruritus. The skin lesions were first detected at the age of three years, but this was the first time that symptoms had appeared in the eyes. Physical examination revealed markedly swollen and erythematous eyelids and conjunctiva including Meibomian glands. In addition, periocular alopecia and tears were identified. Slit lamp microscopy revealed erythema of conjunctiva and swelling of Meibomian glands. The Schirmer’s tear test was normal. Impression smear cytology of eyes revealed sterile neutrophils and corneal epithelial cells. There were no virus or bacterial infections in the eyes. On skin examination, generalized erythema was detected but there were no other skin lesions. A case of allergic blepharoconjunctivitis associated with canine atopic dermatitis was diagnosed based on history taking and skin examination. Treatment included cetirizine, cyclosporine, prednisolone and Forus eye drops®. The owner was instructed to wear an Elizabethan collar around his dog's neck at all times and restrict walking. And the diet was changed to hypoallergenic dog food. Medications and environmental restrictions significantly reduced erythema, edema and swelling of meibomian glands. Pruritus was also decreased. Six weeks later, the edema lesions of eyes disappeared.
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- 2021
5. Foreign body reaction to ruptured follicular cysts in dogs
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Kyoung-Oh Cho, Yeong-Bin Baek, and Ha-Jung Kim
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medicine.medical_specialty ,Pathology ,General Veterinary ,Follicular Cyst ,business.industry ,Veterinary medicine ,pyogranuloma ,Case Report ,Case Reports ,medicine.disease ,Mucus ,Keratin debris ,Cytology ,SF600-1100 ,dog ,medicine ,rupture ,Histopathology ,Cutaneous cyst ,Foreign body ,Cyclosporine therapy ,follicular cysts ,business ,keratin - Abstract
Background Cutaneous cysts are common in dogs, and surgical resection is the recommended treatment. However, additional therapy may be required for ruptured follicular cysts with severe cutaneous complications. Case presentation A 3‐year‐old neutered male Samoyed was presented with multifocal masses on the forelimbs. A 5‐year‐old neutered female Maltese was also presented with multiple masses and ruptured lesions, which were ulcerative and painful, around the parotid and submandibular glands. The lesions were examined cytologically. In addition, bacterial and fungal cultures and histopathologic examination were performed. Cutaneous multifocal nodules in the Samoyed could not be diagnosed via cytological examination or bacterial/fungal culture. Histopathology revealed numerous follicular cysts with multiple pyogranulomas of various sizes, some of which contained central keratin debris. In the Maltese, cytologic examination revealed central keratins or enucleated ghost cells in the intact cysts and few keratinized squamous cells mixed with neutrophils, mucus and metachromatic cells in the ruptured cysts. Histopathologic examination revealed severely dilated follicular cysts. Oral steroid and cyclosporine therapy resulted in marked improvement in the aseptic pyogranulomas after 2 weeks in formal case and combined with a surgery for residual cysts in latter case. Conclusions We have reported two canine cases of ruptured follicular cysts causing foreign body‐like aseptic pyogranulomas around cutaneous tissues and their successful management with pharmacological therapy and surgery., We have reported two canine cases of ruptured follicular cysts causing foreign body‐like aseptic pyogranulomas around cutaneous tissues and their successful management with pharmacological therapy and surgery.
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- 2021
6. Cutaneous adverse drug reaction in a dog following firocoxib treatment
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Hui-Yeon Ko, Ha-Jung Kim, Migyeong Geum, and Yeon-Joo Na
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medicine.medical_specialty ,Toy Poodle ,General Veterinary ,Response to therapy ,medicine.diagnostic_test ,business.industry ,Sterile inflammation ,Veterinary medicine ,Case Report ,Case Reports ,medicine.disease ,Dermatology ,chemistry.chemical_compound ,chemistry ,Cytology ,Firocoxib ,Skin biopsy ,SF600-1100 ,dog ,firocoxib ,Medicine ,cutaneous adverse drug reaction ,Cervical collar ,business ,Adverse drug reaction - Abstract
A 9‐year‐old intact female toy poodle was presented with oedema around the neck, including pus and cutaneous necrosis, 2 days after starting firocoxib treatment and placement of a cervical collar for intervertebral disc disease. Cytology of the pus revealed predominantly mature neutrophils with fewer macrophages and lymphocytes, indicating sterile inflammation. Although a skin biopsy could have provided more diagnostic information, it was not performed at presentation. Firocoxib treatment was discontinued, and immunosuppressive therapy including cyclosporine was initiated, which significantly alleviated the skin lesions. The dog recovered fully in 7 weeks. The final diagnosis was a possible cutaneous adverse drug reaction to firocoxib based on history, clinical signs and response to therapy., Firocoxib, a selective cyclooxygenase (COX)‐2 enzyme inhibitor, is commonly prescribed for various conditions in dogs. It can cause a cutaneous adverse drug reaction and this case report describes a successful medical management of that.
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- 2021
7. Effects of hyperthermia on the effective concentration of rocuronium and sugammadex-mediated reversal in isolated phrenic nerve hemidiaphragm preparations of rats
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Hong Seuk Yang, Jae Seok Song, Yong Beom Kim, Jae Moon Choi, Young Mu Kim, Ha Jung Kim, and Jin Sun Kim
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Male ,Hyperthermia ,Diaphragm ,Sugammadex ,Rats, Sprague-Dawley ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,Organ Culture Techniques ,0302 clinical medicine ,030202 anesthesiology ,medicine ,Animals ,Rocuronium ,Phrenic nerve ,Neuromuscular Blockade ,Dose-Response Relationship, Drug ,business.industry ,Antagonist ,030208 emergency & critical care medicine ,medicine.disease ,Rats ,Phrenic Nerve ,Anesthesiology and Pain Medicine ,lcsh:Anesthesiology ,Anesthesia ,Krebs solution ,Neuromuscular blockade ,business ,Research Article ,Neuromuscular Nondepolarizing Agents ,medicine.drug - Abstract
Background Hyperthermia is relatively rare during general anesthesia; however, a few studies have been conducted on hyperthermia and the neuromuscular blockade (NMB) induced by rocuronium, and the reversal of NMB by sugammadex. We investigated the effect of hyperthermia status on the NMB induced by rocuronium, and its reversal by sugammadex, in isolated phrenic nerve hemidiaphragm (PNHD) preparations of the rat. Methods Thirty-three male Sprague-Dawley rat PNHD preparations were randomly assigned to three groups at different temperatures (36 °C, 38 °C, and 40 °C; each group, n = 11, in Krebs solution). The train-of-four (TOF) and twitch height responses were checked mechanomyographically. The PNHD were treated with progressively increasing doses of rocuronium and three effective concentrations (ECs), EC50, EC90, and EC95, of rocuronium were analyzed in each group via nonlinear regression analysis. Then, sugammadex was administered in doses equimolar to rocuronium. Thereafter, the T1 height (%), TOFR (%) and the duration index were measured. Results The EC of rocuronium (EC50, EC90, and EC95) decreased significantly in accordance with increasing temperature. The groups at 36 °C and 40 °C showed clear differences in all areas (all P Conclusion A rise of temperature from 38 °C to 40 °C in rat PNHD preparations proportionally enhanced the NMB induced by rocuronium. In addition, equimolar doses of sugammadex to the administered rocuronium showed a slower recovery time as the temperature rises.
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- 2020
8. Biomarkers for chronic kidney disease in dogs: a comparison study
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Joon-Young Kim, Chang-Min Lee, and Ha-Jung Kim
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Male ,medicine.medical_specialty ,040301 veterinary sciences ,Renal function ,canine ,Physical examination ,urologic and male genital diseases ,Arginine ,Gastroenterology ,Sensitivity and Specificity ,0403 veterinary science ,03 medical and health sciences ,chemistry.chemical_compound ,Dogs ,Internal medicine ,cystatin C ,medicine ,Internal Medicine ,Animals ,Dog Diseases ,Stage (cooking) ,Renal Insufficiency, Chronic ,030304 developmental biology ,0303 health sciences ,Creatinine ,glomerular filtration rate ,General Veterinary ,biology ,medicine.diagnostic_test ,Receiver operating characteristic ,Full Paper ,symmetric dimethylarginine ,business.industry ,creatinine ,04 agricultural and veterinary sciences ,medicine.disease ,female genital diseases and pregnancy complications ,Cystatin C ,chemistry ,biology.protein ,Biomarker (medicine) ,Female ,business ,Biomarkers ,Kidney disease - Abstract
The aim of this study was to determine whether serum symmetric dimethylarginine (SDMA) and cystatin C (CysC) levels can be utilized as more accurate markers of early kidney dysfunction in dogs. Forty-one client-owned dogs with chronic kidney disease (CKD), which were clinically stable, and ten beagles as healthy controls were included. All dogs underwent physical examination, systemic blood pressure measurement, complete blood cell count, and plasma biochemistry analyses. Frozen serum was used for SDMA and CysC analyses. Data analysis was performed using Kruskal Wallis, Pearson's correlation, Bland-Altman plots, and receiver operating characteristic curve. SDMA and CysC levels were significantly higher in patients with CKD at various International Renal Interest Society (IRIS) stages than in the healthy controls. In particular, CysC level was the only biomarker that could indicate the earliest stage of CKD (IRIS stage I). Similar to these results, CysC level showed better sensitivity and specificity compared to the other biomarkers in early CKD dogs.
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- 2020
9. Antibiotics-Induced Dysbiosis of Intestinal Microbiota Aggravates Atopic Dermatitis in Mice by Altered Short-Chain Fatty Acids
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Ha Jung Kim, Soo-Jong Hong, and Seung Hwa Lee
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Pulmonary and Respiratory Medicine ,Immunology ,Gut flora ,Immunoglobulin E ,fatty acids ,03 medical and health sciences ,0302 clinical medicine ,Lactobacillus rhamnosus ,medicine ,microbiota ,Immunology and Allergy ,030223 otorhinolaryngology ,Sensitization ,Atopic dermatitis ,intestines ,biology ,business.industry ,Innate lymphoid cell ,Interleukin ,dysbiosis ,medicine.disease ,biology.organism_classification ,cytokines ,medicine.anatomical_structure ,030228 respiratory system ,probiotics ,biology.protein ,Original Article ,business ,Dysbiosis - Abstract
Purpose Alterations in the intestinal microbiota in early life affects the development of atopic dermatitis (AD) in humans. This study aimed to further investigate the effects of gut dysbiosis in early life in an ovalbumin (OVA)-induced mouse model of AD. Methods The AD mouse model was developed by serial OVA sensitization and mice were treated with an antibiotic cocktail in their drinking water for 2 weeks before primary sensitization. Probiotics (Lactobacillus rhamnosus, 1 × 10⁹ CFU) or 100 μL of fresh fecal supernatant were orally administered daily from 1 week before the first sensitization until the end of the study. Results The AD mice which received antibiotics had significantly aggravated phenotypes, including clinical score, transepidermal water loss, and histopathology, compared to those treated with healthy feces or probiotics. Total systemic immunoglobulin E production and skin interleukin (IL) 4 levels were significantly increased in the antibiotic-treated mice compared to the other groups. Antibiotic treatment also increased the levels of IL17 and group 3 innate lymphoid cells (ILC3) in the gut and significantly suppressed the production of short-chain fatty acids (SCFAs) and decreased the number FOXP3⁺ cells. Conclusions Our results suggest that the status of the gut microbiota in early life in the mouse may play a crucial role in AD development through intestinal SCFA production through regulate the numbers of CD4⁺IL17⁺/CD4⁺FOXP3⁺ regulatory T cells and ILC3s.
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- 2019
10. Current use of neuromuscular blocking agents and antagonists in Korea: a 2018 survey
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Tae-Yun Sung, Hong Seuk Yang, Jae-Ho Lee, Ha Jung Kim, Jae Moon Choi, Yong Beom Kim, Jung Woo Han, Yong Seop Shin, and Jin Sun Kim
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Neuromuscular Blockade ,business.industry ,Neuromuscular Physiology and Pharmacology ,Pyridostigmine bromide ,General Medicine ,Neuromuscular Blocking Agents ,Neuromuscular monitoring ,Vial ,Sugammadex ,Neostigmine ,Pyridostigmine ,Neuromuscular blocking agents ,Clinical Research ,Anesthesia ,medicine ,Rocuronium ,business ,medicine.drug - Abstract
Background Neuromuscular blocking agents (NMBAs) and neuromuscular monitoring in anesthetic management are integral for endotracheal intubation, better visualization of the surgical field, and prevention of residual neuromuscular blockade and pulmonary complications. Sugammadex is a drug that reduces risk of residual neuromuscular blockade, with more rapid recovery compared to anticholinesterase. The purpose of this study was to investigate current usage status of NMBAs and antagonist with neuromuscular monitoring, among anesthesiologists in Korea. Methods Anesthesiologists working in Korea were invited to participate in an online survey via email January 2-February 28, 2018. The questionnaire consisted of 45 items, including preferred NMBAs, antagonists, neuromuscular monitoring, and complications related to the use sugammadex. A total of 174 responses were analyzed. Results Rocuronium was a commonly used NMBA for endotracheal intubation (98%) of hospitals, and maintenance of anesthesia (83.3%) in of hospitals. Sugammadex, pyridostigmine, and neostigmine were used in 89.1%, 87.9%, and 45.4% of hospitals. Neuromuscular monitoring was employed in 79.3% of hospitals; however only 39.7% of hospitals used neuromuscular monitoring before antagonist administration. Usual dosage range of sugammadex was 2.1-4 mg/kg in 35.1% of hospitals, within 2 mg/kg in 34.5% of hospitals, and 1 vial regardless of body weight in 22.4% of hospitals. Sugammadexrelated complications were encountered by 14.9% of respondents. Conclusions This survey indicates several minor problems associated with the use of antagonists and neuromuscular monitoring. However, most anesthesiologists appear to have appropriate information regarding the usage of NMBAs and sugammadex.
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- 2019
11. Comparison of General and Spinal Anaesthesia on Systemic Inflammatory Response in Patients Undergoing Total Knee Arthroplasty: A Propensity Score Matching Analysis
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Stuti Lohia, Young-Jin Ro, Won-Uk Koh, Hyungtae Kim, Ha-Jung Kim, Priodarshi Roychoudhury, and Jin-Sun Kim
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Medicine (General) ,Inflammatory response ,Anesthesia, Spinal ,Article ,C-reactive protein ,R5-920 ,platelet-lymphocyte ratio ,Medicine ,Humans ,General anaesthesia ,In patient ,general anaesthesia ,neutrophil-lymphocyte ratio ,Arthroplasty, Replacement, Knee ,Propensity Score ,Retrospective Studies ,biology ,business.industry ,Medical record ,Confounding ,Spinal anesthesia ,General Medicine ,spinal anaesthesia ,Systemic Inflammatory Response Syndrome ,inflammation ,Anesthesia ,Propensity score matching ,biology.protein ,business - Abstract
Background and Objectives: Some of the postoperative complications following orthopaedic surgeries are associated with a systemic inflammatory response (SIR), which varies depending on the anaesthetic technique. We aimed to compare the effects of general and spinal anaesthesia on the SIR after total knee arthroplasty (TKA), based on C-reactive protein (CRP) levels, the platelet-lymphocyte ratio (PLR), and the neutrophil-lymphocyte ratio (NLR). Materials and Methods: Patients who underwent TKA between January 2014 and December 2018 were included. Electronic medical records of the patients were retrospectively reviewed and analysed. To reduce the impact of potential confounding factors, we performed propensity score matching according to the anaesthetic technique. Results: A total of 1311 TKA cases were analysed. After propensity score matching, the maximal CRP value and changes in CRP levels in the general anaesthesia group were higher than those in the spinal anaesthesia group. However, the maximal NLR and PLR and the changes in NLR and PLR were not different between the two groups. There were no differences in postoperative clinical outcomes. Conclusion: Spinal anaesthesia tended to induce a lower inflammatory response than general anaesthesia when considering CRP levels in patients undergoing TKA. However, the effects of anaesthetic techniques on the overall outcomes were not significant.
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- 2021
12. Ultrasound-Guided Anterior Quadratus Lumborum Block Reduces Postoperative Opioid Consumption and Related Side Effects in Patients Undergoing Total Hip Replacement Arthroplasty: A Propensity Score-Matched Cohort Study
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Pil-Whan Yoon, Ha-Jung Kim, Yeon Ju Kim, Ji-In Park, Sunhyung Lee, Won-Uk Koh, Young-Jin Ro, and Hyungtae Kim
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Hip surgery ,total hip arthroplasty ,biology ,business.industry ,Opioid consumption ,Incidence (epidemiology) ,medicine.medical_treatment ,quadratus lumborum block ,General Medicine ,biology.organism_classification ,Arthroplasty ,Article ,Ultrasound guided ,Pacu ,Anesthesia ,Propensity score matching ,Medicine ,pain ,ultrasound-guided ,medicine.symptom ,business ,Postoperative nausea and vomiting - Abstract
Quadratus lumborum block (QLB) has been shown to be effective for pain relief after hip surgery. This study evaluated the efficacy of ultrasound-guided anterior QLB in pain control after total replacement hip arthroplasty (TRHA). A total of 115 patients receiving anterior QLB were propensity score-matched with 115 patients who did not receive the block. The primary outcome was opioid consumption at 24, 24–48, and 48 postoperative hours. Secondary outcomes included pain scores at the post-anesthesia care unit (PACU), 8, 16, 24, 32, 40, and 48 h length of hospital stay, time to first ambulation, and the incidence of opioid-related side effects. Postoperative opioid consumption 48 h after surgery was significantly lower in the QLB group. Resting, mean, worst, and the difference of resting pain scores compared with preoperative values were significantly lower in the QLB group during the 48 postoperative hours. The length of hospital stay was shorter in the QLB group. The incidence of postoperative nausea and vomiting was significantly lower in the QLB group during the 48 postoperative hours, except at the PACU. This study suggests that anterior QLB provides effective postoperative analgesia for patients undergoing THRA performed using the posterolateral approach.
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- 2021
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13. Regional Nerve Block Decreases the Incidence of Postoperative Delirium in Elderly Hip Fracture
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Won Uk Koh, Hyungtae Kim, Ha-Jung Kim, Ji Wan Kim, Hyun-Chul Shon, and Eic Ju Lim
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Hip surgery ,Hip fracture ,Rehabilitation ,business.industry ,medicine.medical_treatment ,Incidence (epidemiology) ,opioids ,General Medicine ,Femoral fracture ,medicine.disease ,Article ,nerve block ,delirium ,hip fracture ,Anesthesia ,mental disorders ,medicine ,Nerve block ,Medicine ,Delirium ,pain ,Risk factor ,medicine.symptom ,business - Abstract
Postoperative delirium is common in elderly patients with hip fracture. Pain is a major risk factor for delirium, and regional nerve blocks (RNBs) effectively control pain in hip fractures. This study aimed to evaluate the effect of RNB on delirium after hip surgery in elderly patients. This retrospective comparative study was performed in a single institution, and the data were collected from medical records between March 2018 and April 2021. Patients aged ≥60 years who underwent proximal femoral fracture surgery were included, while those with previous psychiatric illness and cognitive impairment were excluded. Two hundred and fifty-two patients were enrolled and divided into an RNB or a control group according to RNB use. Delirium was assessed as the primary outcome and postoperative pain score, pain medication consumption, and rehabilitation assessment as the secondary outcomes. Between the RNB (n = 129) and control groups (n = 123), there was no significant difference in the baseline characteristics. The overall incidence of delirium was 21%, the rate was lower in the RNB group than in the control group (15 vs. 27%, respectively, p = 0.027). The average pain score at 6 h postoperatively was lower in the RNB group than in the control group (2.8 ± 1.5 vs. 3.3 ± 1.6, respectively, p = 0.030). There was no significant difference in the pain score at 12, 24, and 48 h postoperatively, amount of opioids consumed for 2 postoperative days, and time from injury to wheelchair ambulation. We recommend RNB as a standard procedure for elderly patients with hip fracture due to lower delirium incidence and more effective analgesia in the early postoperative period.
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- 2021
- Full Text
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14. Low Psoas Lumbar Vertebral Index Is Associated with Mortality after Hip Fracture Surgery in Elderly Patients: A Retrospective Analysis
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Ha-Jung Kim, Ji-Hoon Sim, Ji-Wan Kim, Sooho Lee, Young-Jin Ro, Hyungtae Kim, and Won-Uk Koh
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medicine.medical_specialty ,Medicine (miscellaneous) ,Hip fracture surgery ,030204 cardiovascular system & hematology ,elderly ,Article ,sarcopenia ,03 medical and health sciences ,0302 clinical medicine ,Lumbar ,Internal medicine ,medicine ,Retrospective analysis ,030212 general & internal medicine ,psoas lumbar vertebra index ,Hip fracture ,business.industry ,Proportional hazards model ,Hazard ratio ,medicine.disease ,mortality ,Confidence interval ,hip fracture ,Sarcopenia ,Medicine ,business - Abstract
The psoas-to-lumbar index (PLVI) has been reported as a simple and easy way to measure central sarcopenia. However, only few studies have evaluated the association between PLVI and survival in surgical patients. This study evaluated the association between preoperative PLVI and mortality in elderly patients who underwent hip fracture surgery. We retrospectively analyzed 615 patients who underwent hip fracture surgery between January 2014 and December 2018. The median value of each PLVI was calculated according to sex, and the patients were categorized into two groups on the basis of the median value (low PLVI group vs. high PLVI group). Cox regression analysis was performed to evaluate the risk factors for 1 year and overall mortalities. The median values of PLVI were 0.62 and 0.50 in men and women, respectively. In the Cox regression analysis, low PLVI was significantly associated with higher 1 year (hazard ratio (HR): 1.87, 95% confidence interval (CI): 1.18–2.96, p = 0.008) and overall mortalities (HR: 1.51, 95% CI: 1.12–2.03, p = 0.006). Low PLVI was significantly associated with a higher mortality. Therefore, PLVI might be an independent predictor of mortality in elderly patients undergoing hip fracture surgery.
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- 2021
15. Protease-Activated Receptors 2-Antagonist Suppresses Asthma by Inhibiting Reactive Oxygen Species-Thymic Stromal Lymphopoietin Inflammation and Epithelial Tight Junction Degradation
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Ha Jung Kim, Soo-Jong Hong, Seung Hwa Lee, and Sekyoo Jeong
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Pulmonary and Respiratory Medicine ,Thymic stromal lymphopoietin ,tight junction ,Immunology ,Inflammation ,Allergic inflammation ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,thymic stromal lymphopoietin ,medicine ,Immunology and Allergy ,030223 otorhinolaryngology ,Protease-activated receptor 2 ,A549 cell ,chemistry.chemical_classification ,reactive oxygen species ,Reactive oxygen species ,medicine.diagnostic_test ,business.industry ,Asthma ,respiratory tract diseases ,Bronchoalveolar lavage ,030228 respiratory system ,chemistry ,Cancer research ,protease-activated receptor 2 ,Original Article ,medicine.symptom ,business - Abstract
Purpose Protease-activated receptor 2 (PAR2) reportedly triggers the immune response in allergic asthma. We aimed to investigate the mechanism on allergic inflammation mediated by PAR2. Methods Human lung epithelial cells (A549 cells) were used for in vitro, and the German cockroach extract (GCE)-induced mouse model was developed for in vivo studies. Results In A549 cells, the levels of reactive oxygen species (ROS) and thymic stromal lymphopoietin (TSLP) were significantly increased by GCE treatment, but were suppressed by PAR2-antagonist (PAR2-ant) or N-acetylcysteine (NAC) treatment. Claudin-1 was degraded by GCE, and was restored by PAR2-ant or NAC in the cells. In the mouse model, the clinical appearance including bronchial hyperresponsiveness, bronchoalveolar lavage fluid analysis and total immunoglobulin E were significantly suppressed by PAR2-ant or NAC. Moreover, TSLP levels in the lung were suppressed by the same treatments in the lung. Claudin-1 was also degraded by GCE, and was restored by PAR2-ant or NAC. Conclusions ROS generation and epidermal tight junction degradation are triggered by protease, followed by the induction of TSLP in allergic asthma. Our findings could suggest that PAR2-ant or anti-oxidants could be considered for allergic diseases as preventive alternatives.
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- 2019
16. Effects of adenosine receptor agonist on the rocuroniuminduced neuromuscular block and sugammadex-induced recovery
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Young Jin Ro, Hong Seuk Yang, Ha Jung Kim, Yong Beom Kim, Hey Ran Choi, Junyong In, Young Jin Chang, and Sangseok Lee
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Male ,Agonist ,medicine.drug_class ,rocuronium ,Pharmacology ,Sugammadex ,Neuromuscular junction ,Rats, Sprague-Dawley ,lcsh:RD78.3-87.3 ,Random Allocation ,Adenosine A1-receptor ,03 medical and health sciences ,Adenosine A1 receptor ,adenosine a-receptor ,0302 clinical medicine ,030202 anesthesiology ,Purinergic P1 Receptor Agonists ,medicine ,Animals ,Experimental Research Article ,Rocuronium ,Neuromuscular Blockade ,Dose-Response Relationship, Drug ,neuromuscular junction ,business.industry ,neuromuscular nondepolarizing agents ,Recovery of Function ,Adenosine receptor ,Rats ,Phrenic Nerve ,Anesthesiology and Pain Medicine ,medicine.anatomical_structure ,lcsh:Anesthesiology ,sugammadex ,business ,030217 neurology & neurosurgery ,Acetylcholine ,medicine.drug - Abstract
Background Several types of receptors are found at neuromuscular presynaptic membranes. Presynaptic inhibitory A1 and facilitatory A2A receptors mediate different modulatory functions on acetylcholine release. This study investigated whether adenosine A1 receptor agonist contributes to the first twitch tension (T1) of train-of-four (TOF) stimulation depression and TOF fade during rocuronium-induced neuromuscular blockade, and sugammadex-induced recovery. Methods Phrenic nerve-diaphragm tissues were obtained from 30 adult Sprague-Dawley rats. Each tissue specimen was randomly allocated to either control group or 2-chloroadenosine (CADO, 10 μM) group. One hour of reaction time was allowed before initiating main experimental data collection. Loading and boost doses of rocuronium were sequentially administered until > 95% depression of the T1 was achieved. After confirming that there was no T1 twitch tension response, 15 min of resting time was allowed, after which sugammadex was administered. Recovery profiles (T1, TOF ratio [TOFR], and recovery index) were collected for 1 h and compared between groups. Results There were statistically significant differences on amount of rocuronium (actually used during experiment), TOFR changes during concentration-response of rocuronium (P = 0.04), and recovery profiles (P < 0.01) of CADO group comparing with the control group. However, at the initial phase of this experiment, dose-response of rocuronium in each group demonstrated no statistically significant differences (P = 0.12). Conclusions The adenosine A1 receptor agonist (CADO) influenced the TOFR and the recovery profile. After activating adenosine receptor, sugammadex-induced recovery from rocuronium-induced neuromuscular block was delayed.
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- 2018
17. Successful Management of a Life Threatening Canine Multicentric Lymphoma with Pulmonary Thromboembolism
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Ha-Jung Kim, Joon-Young Kim, Guk-Hyun Suh, Min-Young Moon, and Hyeong-Il Choi
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medicine.medical_specialty ,General Veterinary ,business.industry ,Medicine ,business ,medicine.disease ,Dermatology ,Lymphoma - Published
- 2018
18. Author response for 'Foreign body reaction to ruptured follicular cysts in dogs'
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Ha-Jung Kim, Kyoung-Oh Cho, and Yeong-Bin Baek
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Pathology ,medicine.medical_specialty ,Follicular Cyst ,business.industry ,medicine ,Foreign body ,business ,medicine.disease - Published
- 2021
19. Comparison of the onset time between 0.375% ropivacaine and 0.25% levobupivacaine for ultrasound-guided infraclavicular brachial plexus block: a randomized-controlled trial
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Sooho Lee, Ki Jinn Chin, Ha-Jung Kim, Hyungtae Kim, Won Uk Koh, Young-Jin Ro, and Jin-Sun Kim
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Adult ,Male ,medicine.drug_class ,Science ,Article ,law.invention ,Upper Extremity ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,030202 anesthesiology ,law ,medicine ,Humans ,Ropivacaine ,030212 general & internal medicine ,Surgical anesthesia ,Anesthetics, Local ,Trial registration ,Ultrasonography, Interventional ,Aged ,Levobupivacaine ,Multidisciplinary ,Local anesthetic ,business.industry ,Middle Aged ,Brachial Plexus Block ,Ultrasound guided ,Infraclavicular brachial plexus block ,Outcomes research ,Anesthesia ,Randomized controlled trials ,Medicine ,Female ,business ,medicine.drug - Abstract
At centers with pressure on rapid operating room turnover, onset time is one of the important considerations for choosing a local anesthetic drug. To hasten the onset of the block, higher concentrations of local anesthetics are sometimes used. However, the use of diluted local anesthetics may be safer. Therefore, we aimed to compare the onset times of equipotential levobupivacaine and ropivacaine at low concentrations for infraclavicular brachial plexus block. Adult patients undergoing upper extremity surgery under ultrasound-guided infraclavicular brachial plexus block at our center were randomly allocated to the levobupivacaine and ropivacaine groups. Infraclavicular brachial plexus block was induced with 0.25% levobupivacaine or 0.375% ropivacaine depending on the assigned group. The degrees of sensory and motor blockade were assessed for 40 min after the administration of local anesthetics. A total of 46 patients were included in the analysis. Infraclavicular brachial plexus block with 0.25% levobupivacaine and 0.375% ropivacaine provided sufficient surgical anesthesia. The sensory onset time of 0.375% ropivacaine was shorter than that of 0.25% levobupivacaine (group R, 15 [15.0–22.5] min; group L, 30 [17.5–35.0] min, p = 0.001). There were no significant differences in other block characteristics and clinical outcomes between the two groups. Thus, when a quicker block onset is required, 0.375% ropivacaine is a better choice than 0.25% levobupivacaine.Trial registration ClinicalTrials.gov (NCT03679897).
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- 2021
20. Importance of Preoperative Screening Strategies for Coronavirus Disease 2019 in Patients Undergoing Cesarean Sections: A Retrospective, Large Single-Center, Observational Cohort Study
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Hyun-Seok Cho, Hye-Sung Won, Young-Jin Ro, Mi-Young Lee, Hyungtae Kim, Ha-Jung Kim, In-Cheol Choi, and Woo-Jong Choi
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medicine.medical_specialty ,2019-20 coronavirus outbreak ,Coronavirus disease 2019 (COVID-19) ,cesarean section ,business.industry ,Obstetrics ,Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ,lcsh:R ,Preoperative screening ,lcsh:Medicine ,COVID-19 ,General Medicine ,030204 cardiovascular system & hematology ,Single Center ,RT–PCR ,Article ,03 medical and health sciences ,0302 clinical medicine ,screening strategy ,Epidemiology ,medicine ,In patient ,030212 general & internal medicine ,business ,Cohort study - Abstract
During the coronavirus disease 2019 (COVID-19) pandemic, many guidelines have recommended postponing non-emergency operations. However, cesarean sections cannot be indefinitely delayed. Our institution has established a COVID-19 screening strategy for patients undergoing cesarean section. We evaluated the usefulness of this screening strategy. Parturients undergoing cesarean section at our center during the first peak of the COVID-19 outbreak were retrospectively analyzed. Each parturient underwent a questionnaire survey evaluating epidemiological correlation and symptoms at admission. Reverse transcriptase–polymerase chain reaction (RT–PCR) testing and/or chest radiography were performed. In total, 296 parturients underwent cesarean section. All elective and 37 emergency cesarean sections were performed in general operating rooms because they were considered to have a low risk of COVID-19 infection through the screening process. However, 42 emergency cases were performed in negative-pressure operating rooms with full personal protective equipment (PPE) because the RT–PCR results could not be confirmed in a timely manner. None of them were positive for RT–PCR, and there were no cases of nosocomial infection. A comprehensive preoperative screening strategy, including symptomatic and epidemiological correlation, PCR, and/or imaging test, should be performed in patients undergoing cesarian section. Further, cesarean sections in parturients with unconfirmed COVID-19 status should be performed in a negative-pressure operating room with appropriate PPE.
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- 2021
21. Prevention and treatment of residual neuromuscular blockade with doxapram during postoperative recovery
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Hee-Sun Park, Hong S Yang, Won Uk Koh, and Ha-Jung Kim
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Neuromuscular Blockade ,business.industry ,Bariatric Surgery ,Airway Extubation ,Postoperative recovery ,Doxapram ,Delayed Emergence from Anesthesia ,Obesity, Morbid ,Anesthesiology and Pain Medicine ,Anesthesia ,medicine ,Humans ,business ,medicine.drug - Published
- 2021
22. Postoperative Pain Control After Arthroscopic Rotator Cuff Repair: Arthroscopy-Guided Continuous Suprascapular Nerve Block Versus Ultrasound-Guided Continuous Interscalene Block
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Kyoung Hwan Koh, Ha-Jung Kim, Hyungtae Kim, Seonjeong Lee, Hyojune Kim, Jeong Hee Park, In-Ho Jeon, Eui-Sup Lee, and Won Uk Koh
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medicine.medical_specialty ,Pain, Postoperative ,medicine.diagnostic_test ,Visual analogue scale ,business.industry ,Arthroscopy ,Brachial Plexus Block ,Surgery ,Rotator Cuff ,Suprascapular nerve block ,medicine.anatomical_structure ,medicine ,Humans ,Orthopedics and Sports Medicine ,Rotator cuff ,Prospective Studies ,medicine.symptom ,Anesthetics, Local ,Prospective cohort study ,business ,Brachial plexus ,Ultrasonography, Interventional ,Interscalene block ,Paresis - Abstract
To compare the clinical efficacy and safety of arthroscopy-guided continuous suprascapular nerve block and ultrasound-guided continuous interscalene block in postoperative analgesia in patients undergoing arthroscopic rotator cuff repair.A prospective study was performed between March and November 2020. In total, 76 patients were enrolled and divided into 2 groups: in the 38 patients of group 1 (arthroscopy-guided continuous suprascapular nerve block), an indwelling catheter was introduced via the Neviaser portal under arthroscopic view before closing the portal at the end of the surgery; and in the 38 patients of group 2 (ultrasound-guided continuous interscalene block), an indwelling catheter was inserted and directed toward the interscalene brachial plexus prior to the surgery under ultrasound guidance. The primary outcome was the pain score measured by the visual analog scale at postoperative 24 hours during admission. Comparisons were conducted at different time points (postoperative 4, 8, 24, and 48 hours). The secondary outcome was any of these events: neurologic complications, such as sensory/motor change in the upper extremities; hemidiaphragmatic paresis; dyspnea; dysphonia; and Horner's syndrome. Opioid usage until postoperative 3 weeks was compared between the groups.The visual analog scale scores in groups 1 and 2 were comparable at each postoperative time point (analysis of variance, P = .919; trends, P = .132). Neurologic deficits were more common in group 2 than in group 1 (8 vs 32 patients, P.001). Decreased excursion of the diaphragm was more common in group 2 (partial or complete paresis of the hemidiaphragm: 1 vs 29 patients, P .001). Opioid consumption was similar in both groups (morphine milligram equivalents per kilogram; 1.75 vs 1.55, P = .195).Our findings show that arthroscopy-guided continuous suprascapular nerve block is not inferior to ultrasound-guided continuous interscalene block for postoperative pain control after arthroscopic rotator cuff repair while showing fewer temporary neurologic complications.Level II, prospective cohort study, interventional study.
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- 2020
23. Respiratory and Systemic Toxicity of Inhaled Artificial Asian Sand Dust in Pigs
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Guk-Hyun Suh, Seon-Deuk Kim, Chang-Min Lee, Keon Hee Kim, Taeho Ahn, Sung-Shik Shin, Ha-Jung Kim, Chun-Sik Bae, and Tae-Hoon Shin
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medicine.medical_specialty ,Physiology ,Histopathological examination ,Systemic inflammation ,General Biochemistry, Genetics and Molecular Biology ,Article ,domestic animal model ,03 medical and health sciences ,0302 clinical medicine ,Air pollutants ,Asian sand dust ,Epidemiology ,medicine ,030212 general & internal medicine ,Respiratory system ,lcsh:Science ,respiratory toxicity ,Ecology, Evolution, Behavior and Systematics ,systemic inflammation ,business.industry ,Paleontology ,Experimental research ,Systemic toxicity ,Space and Planetary Science ,030220 oncology & carcinogenesis ,lcsh:Q ,medicine.symptom ,business - Abstract
Air pollution, particularly caused by Asian sand dust (ASD) and particulate matter (PM), has become one of the leading threats to public health. However, the majority of studies have primarily focused on epidemiological assessment, and in vivo toxicities of certain air pollutants have been poorly elucidated in medium/large-size laboratory animals. To investigate the impact of ASD in domestic animals, 16 Landrace pigs were exposed to an artificial ASD sandstorm for 6 h. All animals were divided in four cages, and a commercial yellow soil was used for generating artificial mineralogical particles. Blood samples were collected, and necropsies were performed before exposure and 6, 12, 24, and 72 h after exposure. Complete blood cell count and the levels of serum biochemical enzymes, blood gas, electrolytes, and a variety of inflammatory cytokines were evaluated. In addition, histopathological examination was conducted. Various test results proved acute lower airway disorders with systemic inflammation in pigs. To our knowledge, this study is the first to describe experimental research in domestic animals concerning the damage caused by artificial ASD exposure. The results of this study suggest that ASD has importance in terms of not only public health but also of ultimate economic losses in the pork industry.
- Published
- 2020
24. Author response for 'Cutaneous adverse drug reaction in a dog following firocoxib treatment'
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Ha-Jung Kim, Migyeong Geum, Yeon-Joo Na, and Hui-Yeon Ko
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chemistry.chemical_compound ,chemistry ,business.industry ,Firocoxib ,Anesthesia ,Medicine ,business ,medicine.disease ,Adverse drug reaction - Published
- 2020
25. Comprehensive pharmacogenomic characterization of gastric cancer
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Yong Jae Shin, Harim Koo, Mi-Suk Kim, Sung Kim, Ji Yeong An, Jung Yong Hong, Ho Yeong Lim, Jae Moon Bae, Yun Jee Seo, Joon Oh Park, Ju Sun Kim, Min Gew Choi, In Kyoung Lee, Moon Hee Sim, Hee Jin Cho, Jeeyun Lee, Do Hyun Nam, Mirinae Kim, Tae Sung Sohn, Kyoung-Mee Kim, Se Hoon Park, Joon-Ho Lee, Won Ki Kang, Jason K. Sa, Ja Yeon Kim, Nam Gu Her, Yeri Lee, Seung Tae Kim, and Ha Jung Kim
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Drug ,lcsh:QH426-470 ,Pharmacogenomic Variants ,Class I Phosphatidylinositol 3-Kinases ,media_common.quotation_subject ,medicine.medical_treatment ,lcsh:Medicine ,Antineoplastic Agents ,Targeted therapy ,Transcriptome ,Gefitinib ,Stomach Neoplasms ,Cell Line, Tumor ,Tumor Cells, Cultured ,RNF11 ,Genetics ,medicine ,Humans ,Pyrroles ,Protein Kinase Inhibitors ,Wnt Signaling Pathway ,Molecular Biology ,PIK3CA-E542K ,Genetics (clinical) ,media_common ,business.industry ,Research ,lcsh:R ,Wnt signaling pathway ,Cancer ,medicine.disease ,Human genetics ,DNA-Binding Proteins ,ErbB Receptors ,lcsh:Genetics ,Pyrimidines ,Receptors, Vascular Endothelial Growth Factor ,Drug Resistance, Neoplasm ,Pharmacogenomics ,Mutation ,Cancer research ,Molecular Medicine ,Gastric cancer ,business ,medicine.drug - Abstract
BackgroundGastric cancer is among the most lethal human malignancies. Previous studies have identified molecular aberrations that constitute dynamic biological networks and genomic complexities of gastric tumors. However, the clinical translation of molecular-guided targeted therapy is hampered by challenges. Notably, solid tumors often harbor multiple genetic alterations, complicating the development of effective treatments.MethodsTo address such challenges, we established a comprehensive dataset of molecularly annotated patient derivatives coupled with pharmacological profiles for 60 targeted agents to explore dynamic pharmacogenomic interactions in gastric cancers.ResultsWe identified lineage-specific drug sensitivities based on histopathological and molecular subclassification, including substantial sensitivities toward VEGFR and EGFR inhibition therapies in diffuse- and signet ring-type gastric tumors, respectively. We identified potential therapeutic opportunities for WNT pathway inhibitors inALK-mutant tumors, a significant association betweenPIK3CA-E542K mutation and AZD5363 response, and transcriptome expression ofRNF11as a potential predictor of response to gefitinib.ConclusionsCollectively, our results demonstrate the feasibility of drug screening combined with tumor molecular characterization to facilitate personalized therapeutic regimens for gastric tumors.
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- 2020
26. Staggered Rather Than Staged or Simultaneous Surgical Strategy May Reduce the Risk of Acute Kidney Injury in Patients Undergoing Bilateral TKA
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Young-Jin Ro, Ha-Jung Kim, Won Uk Koh, Min-Jeong Jang, Jun-Gol Song, and Hee-Sun Park
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Male ,medicine.medical_specialty ,medicine.medical_treatment ,Risk Assessment ,law.invention ,03 medical and health sciences ,Postoperative Complications ,0302 clinical medicine ,030202 anesthesiology ,law ,medicine ,Humans ,Orthopedics and Sports Medicine ,Risk factor ,Arthroplasty, Replacement, Knee ,Aged ,Retrospective Studies ,030222 orthopedics ,business.industry ,Incidence ,Incidence (epidemiology) ,Acute kidney injury ,Retrospective cohort study ,General Medicine ,Acute Kidney Injury ,medicine.disease ,Intensive care unit ,Arthroplasty ,Surgery ,Female ,Risk assessment ,business ,Kidney disease - Abstract
BACKGROUND The strategy for bilateral total knee arthroplasty (TKA) depends on the timing of surgery for each knee. The purpose of this study was to determine whether the type of surgical strategy for bilateral TKA (staggered, staged, or simultaneous) influences the incidence of acute kidney injury (AKI) and related complications. METHODS Enrolled patients from a single tertiary teaching hospital were divided into 3 groups according to the surgical strategy for bilateral TKA: staggered (≤7 days between the first and second procedure; n = 368), staged (8 days to 1 year between the first and second procedure; n = 265), or simultaneous (n = 820). The incidence of AKI as defined by the Kidney Disease Improving Global Outcomes (KDIGO) criteria was assessed. The rates of major postoperative complications, major adverse cardiovascular and cerebral events, intensive care unit (ICU) admissions, and mortality were also evaluated. To reduce the influence of possible confounding factors, inverse probability of treatment weighting based on propensity-score analysis was used. RESULTS The primary outcome was the incidence of AKI according to surgical strategy. The staggered group had a lower rate of AKI compared with the other 2 groups (p < 0.001): 2.4% (9 of 368 patients), 6.0% (16 of 265), and 11.2% (92 of 820) in the staggered, staged, and simultaneous groups, respectively. CONCLUSIONS The type of bilateral TKA strategy was an independent risk factor for the development of AKI. The assessment of additional risk factors for the development of AKI is essential before deciding on surgical strategy. LEVEL OF EVIDENCE Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
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- 2018
27. Ultrasound-Guided Anterior Approach to a Sciatic Nerve Block: Influence of Lower Limb Positioning on the Visibility and Depth of the Sciatic Nerve
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Won Uk Koh, Seong-Il Bin, Ki Jinn Chin, Hyungtae Kim, Hwa‐young Jang, Young-Jin Ro, and Ha-Jung Kim
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Adult ,Supine position ,Adolescent ,Lower limb ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Sciatic nerve block ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography, Interventional ,Aged ,Ultrasonography ,Aged, 80 and over ,030219 obstetrics & reproductive medicine ,Radiological and Ultrasound Technology ,business.industry ,Visibility (geometry) ,Ultrasound ,Nerve Block ,Middle Aged ,Sciatic Nerve ,Ultrasound guided ,Lower Extremity ,Sciatic nerve ,Anterior approach ,business ,Nuclear medicine - Abstract
OBJECTIVES We aimed to identify the optimal lower limb position for an ultrasound (US)-guided anterior approach to a sciatic nerve block. METHODS We included 45 patients who met the following criteria: American Society of Anesthesiologists physical status of 1 to 3, age between 18 and 80 years, and scheduled to undergo knee surgery that required a sciatic nerve block. The lower limbs of each patient were placed in the following 4 positions: N, neutral; ER, external rotation of the hip (angle, 45°); ER/F15, ER (angle, 45°) and flexion (angle, 15°) of the hip; and ER/F45, ER (angle, 45°) and F (angle, 45°) of the hip. An investigator acquired US scans of the sciatic nerve in each position, and the visibility score and depth of the sciatic nerve from the skin were analyzed. RESULTS The visibility scores were significantly higher in positions ER/F15 and ER/F45 than in positions ER and N (P
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- 2019
28. The Effect of Intraoperative Ferric Carboxymaltose in Joint Arthroplasty Patients: A Randomized Trial
- Author
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Hwa-Young Jang, Hee-Sun Park, Ha-Jung Kim, Tae-Yop Kim, Young-Jin Ro, and Won Uk Koh
- Subjects
total knee arthroplasty ,total hip arthroplasty ,Anemia ,medicine.medical_treatment ,lcsh:Medicine ,030204 cardiovascular system & hematology ,Hematocrit ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,medicine ,Saline ,030222 orthopedics ,medicine.diagnostic_test ,business.industry ,Incidence (epidemiology) ,lcsh:R ,iron supplementation ,General Medicine ,Iron deficiency ,medicine.disease ,Arthroplasty ,ferric carboxymaltose ,anemia ,Anesthesia ,Hemoglobin ,business - Abstract
This study assessed the efficacy of intraoperative high-dose intravenous iron therapy in facilitating recovery from postoperative anemia and reducing the transfusion rate in patients with total knee and total hip arthroplasty. This prospective randomized controlled study involved 58 subjects. Group F received 1000 mg intravenous ferric carboxymaltose and Group C received normal saline. The changes in hemoglobin (Hb), hematocrit, iron metabolism variables, transfusion rates, and the arterial partial pressure of oxygen and the fraction of oxygen (PaO2/FiO2) ratio were recorded. There were 29 patients of each group. The change in Hb levels from baseline to 1 month post-surgery was higher in Group F than in Group C (0.3 ±, 1.0 g/dl vs. &minus, 0.8 ±, 0.8 g/dl, p <, 0.001). Functional iron deficiency occurred more frequently in Group C (0% vs. 48.3%, p <, 0.001) after the operation. The incidence of postoperative anemia, transfusion rate and P/F ratio did not significantly differ between the two groups. This study suggests that intraoperative high-dose ferric carboxymaltose during lower limb total arthroplasty can facilitate the recovery from postoperative anemia. Although it could not prevent the occurrence of postoperative anemia or the administration of transfusion, this treatment seemed to overcome surgery-related decrease of iron availability.
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- 2019
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29. Malarone® induced pancreatitis and alopecia in a dog: a case report
- Author
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Ha-Jung Kim, Hyeong-Il Choi, In-Sik Shin, and Hui-Yeon Ko
- Subjects
medicine.medical_specialty ,Adverse drug reaction ,Case Report ,Gastroenterology ,Antimalarials ,Dogs ,Hair cycle ,Babesiosis ,Internal medicine ,Animals ,Medicine ,Dog Diseases ,Adverse effect ,Atovaquone ,Hematology ,lcsh:Veterinary medicine ,General Veterinary ,biology ,business.industry ,Alopecia ,General Medicine ,medicine.disease ,biology.organism_classification ,Drug Combinations ,Proguanil ,Pancreatitis ,Malarone® ,Babesia ,Acute pancreatitis ,lcsh:SF600-1100 ,Female ,business ,Malaria - Abstract
Background Malarone® is a drug used for the treatment of malaria in humans. This drug is also particularly effective in the treatment of canine Babesia gibsoni infections. Malarone® is rarely used in dogs, and its adverse effects have not been widely reported. Its mechanism of action is related to the inhibition of cytochrome b and electron transport in the cell. This is the first known report of the development of acute pancreatitis and alopecia in a dog following the administration of Malarone®. Case presentation A 3-year-old, intact, female Maltese was referred to our clinic with intermittent vomiting and sudden, generalized alopecia. Two months previously, the dog had been prescribed Malarone® for the treatment of a suspected B. gibsoni infection. The dog was evaluated using hematology, radiography, ultrasonography, a PCR for Babesia detection, and a canine pancreatic lipase immunoreactivity (cPLI) assay. The result of the PCR test was negative, whereas the cPLI assay yielded a positive result. Dermatologic examination revealed bacterial infection with hair cycle arrest. Conclusions Based on these findings, drug-induced acute pancreatitis and alopecia with superficial pyoderma were diagnosed. Malarone® may induce severe adverse reactions in dogs. Therefore, careful monitoring for adverse effects is required when using Malarone® in dogs.
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- 2019
30. Cystatin C and Neutrophil Gelatinase-Associated Lipocalin as Early Biomarkers for Chronic Kidney Disease in Dogs
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Migyeong Geum, Joon-Young Kim, Ha-Jung Kim, and Hui-Yeon Ko
- Subjects
medicine.medical_specialty ,Urinalysis ,Urinary system ,Urology ,Renal function ,Urine ,urologic and male genital diseases ,chemistry.chemical_compound ,Dogs ,Lipocalin-2 ,medicine ,Animals ,Dog Diseases ,Cystatin C ,Renal Insufficiency, Chronic ,Small Animals ,Creatinine ,biology ,medicine.diagnostic_test ,business.industry ,medicine.disease ,female genital diseases and pregnancy complications ,chemistry ,biology.protein ,Biomarker (medicine) ,business ,Biomarkers ,Kidney disease - Abstract
Early diagnosis of chronic kidney disease (CKD) could facilitate timely and appropriate monitoring and therapy. Traditional biomarkers have limitations. Thus, new biomarkers are needed. The objective of the present study was to compare renal biomarkers (including symmetric dimethylarginine [SDMA], cystatin C [CysC], and urine neutrophil gelatinase-associated lipocalin [NGAL]-creatinine ration [UNCR]) and creatinine (CREA) for early detection of CKD in dogs. Nine healthy dogs and 32 dogs with CKD were included in this study. All dogs underwent physical examination, blood analysis (included CREA and SDMA), urinalysis, and imaging examinations. CysC and NGAL levels were measured in serum and urine, respectively. SDMA, CysC, and UNCR were significantly elevated in dogs with CKD and IRIS stage Ι (P < .0001) than in controls. CysC demonstrated a strong correlation with CREA (r2 = 0.6556, P < .0001). CysC (sensitivity 93.55%, specificity 100%) had the highest sensitivity for detecting CKD, followed by UNCR (sensitivity 90%, specificity 100%), SDMA (sensitivity 84.37%, specificity 100%), and CREA (sensitivity 43.75%, specificity 100%). Additionally, CysC and UNCR (sensitivity 88.89%, specificity 100%) exhibited higher sensitivity and specificity than CREA (sensitivity 88.89%, specificity 66.67%) and SDMA (sensitivity 88.89%, specificity 88.89%) in dogs with CKD International Renal Interest Society (IRIS) stage Ι. CysC as a marker of glomerular filtration rate (GFR) and urinary NGAL as a marker of tubular damage could be used to detect CKD early in dogs better than CREA and SDMA.
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- 2021
31. Artemisia argyi attenuates airway inflammation in ovalbumin-induced asthmatic animals
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Jong-Choon Kim, Sung-Hyeuk Park, Hyung-Won Ryu, Ha-Jung Kim, Na-Rae Shin, Je-Won Ko, Seong-Hun Jeong, Heung-Joo Yuk, and In-Sik Shin
- Subjects
0301 basic medicine ,Artemisia argyi ,Ovalbumin ,medicine.medical_treatment ,Intraperitoneal injection ,Inflammation ,Immunoglobulin E ,Mice ,03 medical and health sciences ,Mugwort ,Drug Discovery ,Animals ,Medicine ,Extracellular Signal-Regulated MAP Kinases ,Lung ,Sensitization ,Asthma ,Pharmacology ,biology ,Plant Extracts ,business.industry ,respiratory system ,medicine.disease ,Mucus ,030104 developmental biology ,medicine.anatomical_structure ,Artemisia ,Gene Expression Regulation ,Matrix Metalloproteinase 9 ,Immunology ,biology.protein ,Cytokines ,medicine.symptom ,business ,Bronchoalveolar Lavage Fluid - Abstract
Ethnopharmacological relevance Artemisia argyi is a traditional herbal medicine in Korea and commonly called as mugwort. It is traditionally used as food source and tea to control abdominal pain, dysmenorrhea, uterine hemorrhage, and inflammation. Aim of the study We investigated the effects of A. argyi (TOTAL) and dehydromatricarin A (DA), its active component on ovalbumin (OVA)-induced allergic asthma. Materials and methods The animals were sensitized on day 0 and 14 by intraperitoneal injection of OVA with aluminum hydroxide. On day 21, 22 and 23 after the initial sensitization, the animals received an airway challenge with OVA for 1 h using an ultrasonic nebulizer. TOTAL (50 and 100 mg/kg) or DA (10 and 20 mg/kg) were administered to mice by oral gavage once daily from day 18–23. Airway hyperresponsiveness (AHR) was measured 24 h after final OVA challenge. Result TOTAL and DA treated animals reduced inflammatory cell counts, cytokines and AHR in asthmatic animals, which was accompanied with inflammatory cell accumulation and mucus hypersecretion. Furthermore, TOTAL and DA significantly declined Erk phosphorylation and the expression of MMP-9 in asthmatic animals. Conclusion In conclusion, we indicate that Total and DA suppress allergic inflammatory responses caused by OVA challenge. It was considered that A. argyi has a potential for treating allergic asthma.
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- 2017
32. Improvement of Megaesophagus after Treatment of Concurrent Hypothyroidism
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Hyeong-Il Choi, Joon-Young Kim, Ha-Jung Kim, Guk-Hyun Suh, Min-Young Moon, and Gyeong-Bin Ko
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medicine.medical_specialty ,General Veterinary ,business.industry ,Internal medicine ,medicine ,Megaesophagus ,medicine.disease ,business ,Gastroenterology ,After treatment - Published
- 2018
33. Sugammadex-induced anaphylactic shock
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Ha-Jung Kim, Hae Kyung Lee, Hong Seuk Yang, Eung Gyun Kim, and Chan Woo Lee
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business.industry ,Anesthesia ,Neuromuscular Physiology and Pharmacology ,medicine ,Anaphylactic shock ,General Medicine ,business ,Letter to the Editor ,Sugammadex ,medicine.drug - Published
- 2019
34. A Randomized Controlled Trial Comparing Ambu AuraGain and i-gel in Young Pediatric Patients
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Soo-Young Kim, Won Uk Koh, Young-Jin Ro, Hong Seuk Yang, Ha-Jung Kim, and Hee-Sun Park
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Leak ,lcsh:Medicine ,i-gel ,Article ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Primary outcome ,Randomized controlled trial ,030202 anesthesiology ,law ,Medicine ,Adverse effect ,supraglottic airway device ,Ambu AuraGain ,pediatric patients ,business.industry ,lcsh:R ,Clinical performance ,030208 emergency & critical care medicine ,General Medicine ,Supraglottic airway ,Anesthesia ,Breathing ,business ,Airway - Abstract
Supraglottic airway devices have been increasingly used because of their several advantages. Previous studies showed that the small-sized i-gel provides effective ventilation for young pediatric patients, however, few studies have reported the use of AuraGain in these patients. Herein, we compared the clinical performance of AuraGain and i-gel in young pediatric patients aged between 6 months and 6 years old and weighing 5&ndash, 20 kg, who were scheduled to undergo extremity surgery under general anesthesia. In total, 68 patients were enrolled and randomly allocated into two groups: AuraGain group and i-gel group. The primary outcome was the requirement of additional airway maneuvers. We also analyzed insertion parameters, fiberoptic bronchoscopic view, oropharyngeal leak pressure, and peri-operative adverse effects. Compared with the AuraGain group, the i-gel group required more additional airway maneuvers during the placement of the device and maintenance of ventilation. The fiberoptic view was better in the AuraGain group than in the i-gel group. However, the oropharyngeal leak pressure was higher in the i-gel group. AuraGain might be a better choice over i-gel considering the requirement of additional airway maneuvers. However, when a higher oropharyngeal leak pressure is required, the i-gel is more beneficial than AuraGain.
- Published
- 2019
35. TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer
- Author
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Ha Jung Kim, Joohyun Hong, Young Suk Park, Won Ki Kang, Joon Oh Park, Moonhee Shim, Kyung Kim, Se Hoon Park, Kyoung-Mee Kim, Seung Tae Kim, Jung Yong Hong, Ho Yeong Lim, Jung Eun Kim, Jeeyun Lee, Sun-Ju Byeon, and In Kyoung Lee
- Subjects
0301 basic medicine ,Simvastatin ,Poly ADP ribose polymerase ,Antineoplastic Agents ,Pathology and Forensic Medicine ,03 medical and health sciences ,0302 clinical medicine ,In vivo ,Stomach Neoplasms ,Cell Line, Tumor ,polycyclic compounds ,medicine ,Biomarkers, Tumor ,Humans ,cardiovascular diseases ,Cell Proliferation ,Gene knockdown ,Predictive marker ,business.industry ,Thiamin Pyrophosphokinase ,nutritional and metabolic diseases ,Cancer ,Cell Biology ,medicine.disease ,030104 developmental biology ,Apoptosis ,Cell culture ,Drug Resistance, Neoplasm ,030220 oncology & carcinogenesis ,Cancer research ,lipids (amino acids, peptides, and proteins) ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,medicine.drug - Abstract
The potential anti-tumour role of statins has been reported in various cancer types, including gastric cancer (GC). However, there are no biomarkers to identify patients who may benefit most from this treatment. We tested the effects of statins on 8 GC cell lines. Genes differentially expressed in simvastatin-sensitive and -resistant cell lines were used to identify potential biomarkers of simvastatin sensitivity. Patient-derived cell lines were used to mimic in vivo conditions. In simvastatin-sensitive SNU-5 cells, the levels of the PARP and cleaved caspase-3 apoptosis markers increased upon exposure to simvastatin. The levels of the PARP and cleaved caspase-3 levels were unchanged by simvastatin exposure in simvastatin-resistant SNU-668 cells. The proportion of apoptotic cells was increased in SNU-5 cells but not in SNU-668 cells under the same drug exposure conditions. Comparison of differentially expressed genes (DEGs) in sensitive and resistant cell lines identified 31 genes potentially involved in the cellular response to simvastatin. We confirmed that RNA expression of the TPK1 DEG was significantly increased in simvastatin-sensitive cell lines. TPK1 knockdown in a simvastatin-sensitive GC SNU5 cell line, decreased the anti-tumour effects of simvastatin, while TPK1 overexpression enhanced the anti-tumour effect of simvastatin. Therefore, TPK1 expression can be used as a predictive marker of the anti-tumour effects of statin treatment in patients with cancer, especially in those with GC.
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- 2019
36. Remifentanil does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block in the isolated hemidiaphragm of the rat: an ex vivo study
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Yong Beom Kim, Hong Seuk Yang, Hyeun Joon Bae, Hey Ran Choi, Ha-Jung Kim, and Jae Moon Choi
- Subjects
Male ,Remifentanil ,Stimulation ,Sugammadex ,Rats, Sprague-Dawley ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,medicine ,Animals ,Rocuronium ,Phrenic nerve ,Neuromuscular Blockade ,Dose-Response Relationship, Drug ,business.industry ,030208 emergency & critical care medicine ,Rats ,Anesthesiology and Pain Medicine ,Anesthesia ,medicine.symptom ,business ,Ex vivo ,medicine.drug ,Muscle contraction ,Muscle Contraction ,Neuromuscular Nondepolarizing Agents - Abstract
Sugammadex is used to reverse neuromuscular block induced by rocuronium or vecuronium by forming a stable complex. If the binding capacity of any substance to sugammadex is large enough, this molecule will displace rocuronium or vecuronium from the complex. For drugs used in anesthesia, the binding affinity of remifentanil for sugammadex was highest. The aim of the current study was to investigate the decrease in the reversal of neuromuscular blockade with sugammadex by complex formation between remifentanil and sugammadex in the model using isolated hemidiaphragm of the rat. Phrenic nerve-hemidiaphragms from 34 male Sprague–Dawley rats were allocated randomly to four groups: 0 or 100 ng/ml remifentanil with equimolar amounts of sugammadex and 0 or 100 ng/ml remifentanil with three-quarter dose of sugammadex. Muscle contraction responses were recorded during the stimulation of the phrenic nerve by train-of-four (TOF) stimulation. Rocuronium was added to the organ bath with or without 100 ng/ml remifentanil until the first height response (T1) of TOF disappeared completely. Then, equimolar amounts or three-quarter dose of sugammadex was added. Remifentanil has no significant effects on the concentration–response curves of rocuronium. No significant differences were observed in the recoveries of T1 and TOF ratio with time after administration of equimolar amounts or three-quarter dose of sugammadex regardless of the presence of 100 ng/ml remifentanil. Clinical concentration of remifentanil does not inhibit sugammadex reversal after rocuronium-induced neuromuscular block. Sugammadex can be used safely without worrying about the interaction with remifentanil.
- Published
- 2019
37. Effect of Anesthetic Technique on the Occurrence of Acute Kidney Injury after Total Knee Arthroplasty
- Author
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Yon-Ji Go, Ha-Jung Kim, Jun-Gol Song, Young-Jin Ro, Hyungtae Kim, Hee-Sun Park, and Won Uk Koh
- Subjects
medicine.medical_specialty ,total knee arthroplasty ,lcsh:Medicine ,Lower risk ,Article ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,Medicine ,anesthetic technique ,030222 orthopedics ,business.industry ,Medical record ,lcsh:R ,Confounding ,Acute kidney injury ,General Medicine ,Perioperative ,medicine.disease ,acute kidney injury ,Anesthesia ,and total knee arthroplasty ,Propensity score matching ,Anesthetic ,Orthopedic surgery ,business ,medicine.drug - Abstract
Recent studies have reported the advantages of spinal anesthesia over general anesthesia in orthopedic patients. However, little is known about the relationship between acute kidney injury (AKI) after total knee arthroplasty (TKA) and anesthetic technique. This study aimed to identify the influence of anesthetic technique on AKI in TKA patients. We also evaluated whether the choice of anesthetic technique affected other clinical outcomes. We retrospectively reviewed medical records of patients who underwent TKA between January 2008 and August 2016. Perioperative data were obtained and analyzed. To reduce the influence of potential confounding factors, propensity score (PS) analysis was performed. A total of 2809 patients and 2987 cases of TKA were included in this study. A crude analysis of the total set demonstrated a significantly lower risk of AKI in the spinal anesthesia group. After PS matching, the spinal anesthesia group showed a tendency for reduced AKI, without statistical significance. Furthermore, the spinal anesthesia group showed a lower risk of pulmonary and vascular complications, and shortened hospital stay after PS matching. In TKA patients, spinal anesthesia had a tendency to reduce AKI. Moreover, spinal anesthesia not only reduced vascular and pulmonary complications, but also shortened hospital stay.
- Published
- 2019
38. Effect of Total Intravenous Anesthesia vs Volatile Induction With Maintenance Anesthesia on Emergence Agitation After Nasal Surgery: A Randomized Clinical Trial
- Author
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Seungwoo Ku, Hanwool Park, Kyeo-Woon Jung, Ha-Jung Kim, Jun-Young Jo, Seong-Soo Choi, and Se-Ung Park
- Subjects
Adult ,Male ,medicine.medical_treatment ,Nasal Surgical Procedures ,Nitrous Oxide ,Richmond Agitation-Sedation Scale ,Anesthesia, General ,law.invention ,Anesthesia Procedure ,Remifentanil ,03 medical and health sciences ,Sevoflurane ,Young Adult ,0302 clinical medicine ,Emergence Delirium ,Randomized controlled trial ,030202 anesthesiology ,law ,medicine ,Humans ,Single-Blind Method ,Prospective Studies ,030223 otorhinolaryngology ,Propofol ,Original Investigation ,business.industry ,Incidence ,Functional endoscopic sinus surgery ,Middle Aged ,medicine.disease ,Septoplasty ,Analgesics, Opioid ,Otorhinolaryngology ,Emergence delirium ,Intravenous anesthesia ,Anesthesia ,Anesthetics, Inhalation ,Anesthesia, Intravenous ,Surgery ,Female ,business ,Anesthetics, Intravenous ,medicine.drug - Abstract
Importance Emergence agitation is common after nasal surgery under general anesthesia and may lead to serious consequences for the patient, including an increased risk of injury, pain, hemorrhage, and self-extubation. Despite decades of research, studies on the incidence, risk factors, and prevention of emergence agitation in adult patients are ongoing, and opinions differ on the different effects of inhalation and intravenous anesthesia. Objective To investigate the effect of anesthetic method on the occurrence of emergence agitation after nasal surgery. Design, Setting, and Participants This prospective, randomized, single-blind, clinical trial included 80 patients undergoing open rhinoplasty, septoplasty, turbinoplasty, endoscopic sinus surgery, and functional endoscopic sinus surgery under general anesthesia who were randomized to receive total intravenous anesthesia (TIVA) with remifentanil hydrochloride and propofol (n = 40) or volatile induction and maintenance of anesthesia (VIMA) with sevoflurane and nitrous oxide (n = 40) in Asan Medical Center, a tertiary referral center in Seoul, Republic of Korea. Data were collected from August 24 through October 14, 2016, and analyzed from October 26, 2016, through September 14, 2017. Main Outcomes and Measures The occurrence of emergence agitation defined by the following 2 individual criteria: a Richmond Agitation–Sedation Scale score of at least 1 and a Riker Sedation–Agitation Scale score of at least 5 immediately after extubation. Results Among the 80 patients included in the analysis (68.8% men [n = 55]; mean [SD] age, 41.6 [17.9] years), emergence agitation measured by the Richmond Agitation Sedation Scale occurred in 8 of 40 patients (20.0%) in the VIMA group and 1 of 40 (2.5%) in the TIVA group. The risk difference was 17.5 (95% CI, 3.6-31.4). Emergence agitation measured by the Riker Sedation–Agitation Scale score occurred in 10 of 40 patients (25.0%) in the VIMA group and 1 of 40 (2.5%) in the TIVA group. The risk difference was 22.5 (95% CI, 7.3-37.7). Conclusions and Relevance The occurrence of emergence agitation after nasal surgery under general anesthesia can be significantly reduced by using TIVA rather than VIMA. Trial Registration CRIS identifier:KCT0002145
- Published
- 2018
39. Encountering unexpected difficult airway: relationship with the intubation difficulty scale
- Author
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Ha-Jung Kim, Hong Seuk Yang, Young Jin Ro, Won-Uk Koh, and Kyongsun Kim
- Subjects
medicine.medical_specialty ,Scoring system ,Unexpected difficult airway ,medicine.medical_treatment ,unexpected ,intubation ,Unexpected difficult intubation ,scale ,lcsh:RD78.3-87.3 ,03 medical and health sciences ,0302 clinical medicine ,030202 anesthesiology ,Medicine ,Intubation ,Elective surgery ,Intensive care medicine ,Difficult intubation ,difficult ,grade ,Clinical Research Article ,business.industry ,030208 emergency & critical care medicine ,Stylet ,Anesthesiology and Pain Medicine ,lcsh:Anesthesiology ,business - Abstract
Background An unexpected difficult intubation can be very challenging and if it is not managed properly, it may expose the encountered patient to significant risks. The intubation difficulty scale (IDS) has been used as a validated method to evaluate a global degree of intubation difficulty. The aims of this study were to evaluate the prevalence and characteristics of unexpected difficult intubation using the IDS. Methods We retrospectively reviewed 951 patients undergoing elective surgery in a single medical center. Patients expected to have a difficult intubation or who had history of difficult intubation were excluded. Each patient was assessed by the IDS scoring system with seven variables. Total prevalence of difficult intubation and the contributing individual factors were further analyzed. Results For the 951 patients, the difficult intubation cases presenting IDS > 5 was 5.8% of total cases (n = 55). The prevalence of Cormack-Lehane Grade 3 or 4 was 16.2% (n = 154). Most of the difficult intubation cases were managed by simple additional maneuvers and techniques such as stylet application, additional lifting force and laryngeal pressure. Conclusions Unexpected difficult airway was present in 5.8% of patients and most was managed effectively. Among the components of IDS, the Cormack-Lehane grade was most sensitive for predicting difficult intubation.
- Published
- 2016
40. A reciprocal regulatory circuit between CD44 and FGFR2 via c-myc controls gastric cancer cell growth
- Author
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Ha Jung Kim, Kyoung Mee Kim, Sun Young Kim, Myung Soo Kang, Eun Young Choi, and Jihyun Park
- Subjects
musculoskeletal diseases ,0301 basic medicine ,congenital, hereditary, and neonatal diseases and abnormalities ,Transplantation, Heterologous ,Mice, Nude ,Mice, SCID ,Proto-Oncogene Proteins c-myc ,03 medical and health sciences ,0302 clinical medicine ,SOX2 ,Mice, Inbred NOD ,Stomach Neoplasms ,Cancer stem cell ,Cell Line, Tumor ,cancer ,Animals ,Humans ,Medicine ,CD44 ,Receptor, Fibroblast Growth Factor, Type 2 ,Cell Proliferation ,Mice, Knockout ,Mice, Inbred BALB C ,Gene knockdown ,integumentary system ,biology ,Cell growth ,Kinase ,business.industry ,LGR5 ,regulation ,Gene Expression Regulation, Neoplastic ,stomatognathic diseases ,c-Myc ,Hyaluronan Receptors ,030104 developmental biology ,Oncology ,FGFR2 ,030220 oncology & carcinogenesis ,embryonic structures ,Immunology ,Neoplastic Stem Cells ,Cancer research ,biology.protein ,Signal transduction ,business ,Research Paper ,Signal Transduction - Abstract
Despite their suggested importance, the mechanistic roles of FGFR2 and gastric cancer stem cell (GCSC) marker CD44 remain unclear. We investigated cross talk between CD44 and FGFR2. FGFR2 and CD44 positively regulate each other's expression. While FGFR2 suppresses c-Myc transcription, CD44 activates it. c-Myc in turn augments FGFR2 transcription. CD44 knockdown (KD) depleted FGFR2 and other GCSC markers, decreased c-Myc and Sox2 expression, and suppressed tumor growth, whereas CD44 activation led to FGFR2 induction. FGFR2 KD decreased most GCSC marker expression, including CD44, but increased c-Myc and Sox2 expression and attenuated tumor growth. FGFR2 kinase inhibitor and FGFR2 neutralizing antibody decreased the CD44+/hi GCSC fraction. Conversely, FGFR2 overexpression increased CD44 and accelerated tumor growth in mice. FGFR2 was co-expressed and colocalized diffusively with CD44, EpCAM, and LGR5. In contrast, phospho-FGFR2 colocalized densely with CD44, forming an aggregated signaling complex that was prevented by FGFR2 inhibition. The c-Myc KD depleted FGFR2 but not CD44. Similarly to CD44+/hi phenotypes, sorted FGFR+/hi cells had larger volumes, formed more tumor spheres, grew faster in vivo with bigger tumor mass, and expressed more CD44, EpCAM, and HER2. These findings suggest that FGFR2+/hi cells have stemness properties. Moreover, in situ FGFR2 expression in patient-derived gastric cancer tissue correlated with tumorigenic potential in a xenograft model. In conclusion, CD44 and FGFR2 maintain stemness in gastric cancer by differentially regulating c-Myc transcription.
- Published
- 2016
41. Comparison of warming methods for core temperature preservation during total knee arthroplasty using a pneumatic tourniquet
- Author
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Young Jin Ro, Hong Seuk Yang, Ha Jung Kim, Won Uk Koh, and Jong Eun Oh
- Subjects
Esophageal temperature ,medicine.medical_specialty ,Tourniquet ,business.industry ,Total knee replacement ,Total knee arthroplasty ,030208 emergency & critical care medicine ,General Medicine ,Core temperature ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,Pneumatic tourniquet ,030202 anesthesiology ,Anesthesiology ,Anesthesia ,Bladder temperature ,medicine ,business - Published
- 2016
42. Sudden cardiovascular collapse after platelet transfusion during liver transplantation: flat-line thromboelastometry and inferred pulmonary thromboembolism −A case report−
- Author
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Ha Jung Kim, Gyu-Sam Hwang, Sun Kee Kim, In Young Huh, and Hyung Joo Chung
- Subjects
medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,General Medicine ,Liver transplantation ,Surgery ,Thromboelastometry ,Platelet transfusion ,Anesthesia ,medicine ,medicine.symptom ,Line (text file) ,business ,Collapse (medical) - Published
- 2015
43. Effective treatment of eosinophilic granuloma in a cat using tacrolimus with prednisolone
- Author
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Min-young Moon, Guk-Hyun Suh, Yong-Jin Kwon, and Ha-Jung Kim
- Subjects
medicine.medical_specialty ,Eosinophilic granuloma ,business.industry ,Internal medicine ,medicine ,Prednisolone ,Effective treatment ,medicine.disease ,business ,Gastroenterology ,Tacrolimus ,medicine.drug - Published
- 2017
44. Regarding 'Successful Laparoscopic Surgery without Neuromuscular Blockade in a Patient with Malignant Hyperthermia Susceptibility'
- Author
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Ha Jung Kim, Jin Sun Kim, Jae Moon Choi, Hong Seuk Yang, and Won Uk Koh
- Subjects
Laparoscopic surgery ,Neuromuscular Blockade ,medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,medicine.medical_treatment ,Malignant hyperthermia ,MEDLINE ,Obstetrics and Gynecology ,medicine.disease ,Surgery ,medicine ,Humans ,Laparoscopy ,Malignant Hyperthermia ,business - Published
- 2019
45. Malignant hyperthermia and dantrolene sodium
- Author
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Young Jin Ro, Ha Jung Kim, Hong Seuk Yang, Jae Moon Choi, and Won Uk Koh
- Subjects
medicine.medical_specialty ,business.industry ,Malignant hyperthermia ,medicine.disease ,Dantrolene Sodium ,Dantrolene ,lcsh:RD78.3-87.3 ,Anesthesiology and Pain Medicine ,lcsh:Anesthesiology ,Anesthesia ,Anesthesiology ,medicine ,Humans ,business ,Malignant Hyperthermia ,Letter to the Editor - Published
- 2019
46. Sensitization rates of causative allergens for dogs with atopic dermatitis: detection of canine allergen-specific IgE
- Author
-
Hye-Jin Jang, Ha-Jung Kim, Hee-Myung Park, and Min-Hee Kang
- Subjects
Male ,Veterinary medicine ,dogs ,Enzyme-Linked Immunosorbent Assay ,Immunoglobulin E ,Serology ,Dermatitis, Atopic ,serologic allergy test ,immune system diseases ,Allergy test ,otorhinolaryngologic diseases ,Medicine ,Animals ,Dog Diseases ,Sensitization ,General Veterinary ,biology ,atopic dermatitis ,business.industry ,Atopic dermatitis ,respiratory system ,Allergens ,medicine.disease ,biology.organism_classification ,respiratory tract diseases ,medicine.anatomical_structure ,Immunology ,biology.protein ,Brown rice ,Original Article ,Female ,Immunization ,Malassezia ,IgE ,Antibody ,business - Abstract
Allergen-specific IgE serology tests became commercially available in the 1980s. Since then these tests have been widely used to diagnose and treat allergic skin diseases. However, the relationship between a positive reaction and disease occurrence has been controversial. The purpose of this study was to evaluate allergens using a serologic allergy test in dogs with atopic dermatitis (AD). Dogs clinically diagnosed with AD (n = 101) were tested using an allergen-specific IgE immunoassay. Among the total 92 environmental and food allergens, house dust and house dust mites were the most common. Several allergens including airborne pollens and molds produced positive reactions, and which was considered increasing allergens relating to the climate changes. The presence of antibodies against staphylococci and Malassezia in cases of canine AD was warranted in this study. Additionally, strong (chicken, turkey, brown rice, brewer's yeast, and soybean) and weakly (rabbit, vension, duck, and tuna) positive reactions to food allergens could be used for avoidance and limited-allergen trials.
- Published
- 2014
47. Silibinin inhibits the fibrotic responses induced by cigarette smoke via suppression of TGF-β1/Smad 2/3 signaling
- Author
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In-Sik Shin, Young-Kwon Cho, In-Chul Lee, Sung-Hyeuk Park, Ha-Jung Kim, Je-Won Ko, Jong-Choon Kim, Na-Rae Shin, and Jung-Min Ryu
- Subjects
0301 basic medicine ,Male ,Lipopolysaccharide ,Silibinin ,Inflammation ,SMAD ,Smad2 Protein ,Pharmacology ,Toxicology ,Proinflammatory cytokine ,Transforming Growth Factor beta1 ,03 medical and health sciences ,chemistry.chemical_compound ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Tobacco ,medicine ,Animals ,Humans ,Trichrome stain ,Smad3 Protein ,medicine.diagnostic_test ,business.industry ,Smoking ,General Medicine ,Fibrosis ,Mice, Inbred C57BL ,030104 developmental biology ,Bronchoalveolar lavage ,chemistry ,030220 oncology & carcinogenesis ,Silybin ,Immunology ,medicine.symptom ,business ,Food Science ,Transforming growth factor ,Signal Transduction ,Silymarin - Abstract
Cigarette smoke (CS) is generally accepted as a major contributor to chronic obstructive pulmonary disease (COPD) which is characterized by chronic inflammation, fibrotic response, and airway obstruction. In this study, we investigated the preventive effects of silibinin, an active constitute of silymarin on CS and lipopolysaccharide (LPS) exposure-induced fibrotic response. Mice were exposed to CS for 1 h per day (8 cigarettes per day) for 4 weeks. On day 12 and 26, mice were treated with LPS intranasally. Silibinin (10 or 20 mg/kg) was administered orally 1 h before CS exposure. Silibinin markedly decreased the inflammatory cell count in the bronchoalveolar lavage fluid, and reduced levels of proinflammatory mediators. Silibinin suppressed CS + LPS-induced collagen deposition in lung tissue, as evidenced via immunohistochemistry and Masson's trichrome stain. Additionally, silibinin effectively inhibited CS + LPS-mediated expression of transforming growth factor-β1 (TGF-β1) and Smad 2/3 phosphorylation. Taken together, our data indicate that silibinin effectively inhibits the fibrotic response induced by CS + LPS exposure, possibly via suppression of TGF-β1/Smad 2/3 signaling, which results in reduced collagen deposition. These findings suggest that silibinin has therapeutic potential for the treatment of COPD.
- Published
- 2017
48. Association between Recent Acetaminophen Use and Asthma: Modification by Polymorphism at TLR4
- Author
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Young Ho Jung, Seung Hwa Lee, Kang Seo Park, Ji Won Kwon, Hee-Suk Kim, Young Joon Kim, Hyung Young Kim, Ha Jung Kim, So-Yeon Lee, Kyungmo Hong, Ju Hee Seo, Hyo Bin Kim, Byoung Ju Kim, Soo-Jong Hong, Ho Sung Yu, and Mi Jin Kang
- Subjects
Male ,Risk ,Adolescent ,Genotype ,Cross-sectional study ,Bronchial Hyperresponsiveness ,Immunoglobulin E ,Polymorphism, Single Nucleotide ,Immunology, Allergic Disorders & Rheumatology ,Risk Factors ,Surveys and Questionnaires ,medicine ,Humans ,Genetic Predisposition to Disease ,Family history ,Child ,Asthma ,Acetaminophen ,Inflammation ,biology ,business.industry ,digestive, oral, and skin physiology ,General Medicine ,medicine.disease ,Confidence interval ,respiratory tract diseases ,Toll-Like Receptor 4 ,Eosinophils ,Oxidative Stress ,Cross-Sectional Studies ,Bronchial hyperresponsiveness ,Immunology ,biology.protein ,Original Article ,Gene-Environment Interaction ,Female ,Bronchial Hyperreactivity ,business ,Reactive Oxygen Species ,medicine.drug - Abstract
The risk of asthma has been increasing in parallel with use of acetaminophen, which is a potential source of oxidative stress. Toll-like receptor 4 (TLR4) plays a critical role not only in innate immunity, but also in mediating reactive oxygen species induced inflammation. Therefore, we investigated associations between acetaminophen usage and TLR4 polymorphism on asthma and bronchial hyperresponsiveness (BHR). The number of 2,428 elementary school children in Seoul and Jeongeup cities was recruited. Subjects who used acetaminophen with a family history of asthma had an increased risk of both asthma diagnosis ever and current asthma. Individuals with CT+TT genotypes at the TLR4 polymorphism, in combination with acetaminophen usage, also demonstrated an increased risk of asthma diagnosis ever (aOR, 2.08; 95% confidence interval [CI], 1.10-3.92). Family history of asthma and acetaminophen usage were risk factors for BHR. Although TLR4 was not an independent risk factor for BHR, individuals with CT+TT genotypes at the TLR4 polymorphism had an increased risk of BHR when combined with acetaminophen usage (aOR, 1.74; 95% CI, 1.03-2.94). In conclusion, acetaminophen usage may be associated with asthma and BHR in genetically susceptible subjects. This effect may be modified by polymorphism at TLR4. Graphical Abstract
- Published
- 2014
49. Non-neurologic complications following surgery for scoliosis
- Author
-
Hong Seuk Yang, Ha Jung Kim, Hye Jeong Seo, and Young-Jin Ro
- Subjects
Vital capacity ,medicine.medical_specialty ,Clinical Research Article ,Cobb angle ,business.industry ,Retrospective cohort study ,Scoliosis ,medicine.disease ,Logistic regression ,Surgery ,Pulmonary function testing ,lcsh:RD78.3-87.3 ,Anesthesiology and Pain Medicine ,Blood loss ,lcsh:Anesthesiology ,Non-neurologic complication ,medicine ,Anesthesia ,business ,Complication - Abstract
Background: The purpose of this study was to determine the prevalence of non-neurologic complications following surgery for scoliosis and to identify factors that can increase this risk. Methods: The demographic data, medical and surgical histories, and prevalence of non-neurologic complications were reviewed in a retrospective cohort of 602 patients, who had undergone corrective surgery for scoliosis between January 2001 and June 2011. Results: There were 450 patients under 20 years old (U20) and 152 of patients above 20 years old (A20) enrolled in this study. Forty-nine patients in U20 (10.9%) and 18 patients in A20 (11.8%) had post-operative complications. Respiratory complications were most common in U20 (4%) and gastrointestinal complications were most common in A20 (7%). There was no significant difference between the 2 groups in the prevalence of complications. Logistic regression revealed that factors that correlated with an increased odds for complications were Cobb angle (P = 0.001/ P = 0.013, respectively), length of operation time (P = 0.003/P = 0.006, respectively), duration of anesthesia (P < 0.001/ P = 0.005, respectively) and transfusion (P = 0.003/P = 0.015, respectively) in U20 and A20. Also, comorbidities (P = 0.021) in U20, and decreased body mass index (P = 0.030), pre-operative forced vital capacity (P = 0.001), forced expired volume in 1s (P = 0.001), increased numbers of vertebrae fused (P = 0.004), blood loss (P = 0.001) in A20 were associated with increased odds for complications. Conclusions: There was no difference in the prevalence of complication in scoliosis patients by age. The prevalence of complication was dependent on Cobb angle, length of operation time, duration of anesthesia and transfusion of PRBC. Deterioration of preoperative pulmonary function significantly increased risk of post-operative complications in adult patients. (Korean J Anesthesiol 2013; 64: 40-46)
- Published
- 2013
50. Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children
- Author
-
Mi Ae Oh, Hyung Young Kim, Joo Shil Lee, Yee-Jin Shin, Soo-Jong Hong, Dae Jin Song, Sang Heon Cho, Jung Yeon Shim, Ju Hee Seo, Gwang Cheon Jang, Woo Kyung Kim, Hyo Bin Kim, Young Ho Jung, Jung Won Park, Byoung Ju Kim, Ha Jung Kim, Ji Won Kwon, and So-Yeon Lee
- Subjects
Pulmonary and Respiratory Medicine ,business.industry ,Exhalation ,respiratory system ,medicine.disease ,respiratory tract diseases ,Inflammatory mediator ,Nitric oxide ,Atopy ,chemistry.chemical_compound ,chemistry ,Wheezing phenotypes ,Pediatrics, Perinatology and Child Health ,Exhaled nitric oxide ,Immunology ,medicine ,business ,Airway ,Asthma - Abstract
Summary. Background: Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. Objectives: To investigate if FeNO concentrations were correlated with wheezing phenotypes in
- Published
- 2012
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