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Cystatin C and Neutrophil Gelatinase-Associated Lipocalin as Early Biomarkers for Chronic Kidney Disease in Dogs
- Source :
- Topics in Companion Animal Medicine. 45:100580
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Early diagnosis of chronic kidney disease (CKD) could facilitate timely and appropriate monitoring and therapy. Traditional biomarkers have limitations. Thus, new biomarkers are needed. The objective of the present study was to compare renal biomarkers (including symmetric dimethylarginine [SDMA], cystatin C [CysC], and urine neutrophil gelatinase-associated lipocalin [NGAL]-creatinine ration [UNCR]) and creatinine (CREA) for early detection of CKD in dogs. Nine healthy dogs and 32 dogs with CKD were included in this study. All dogs underwent physical examination, blood analysis (included CREA and SDMA), urinalysis, and imaging examinations. CysC and NGAL levels were measured in serum and urine, respectively. SDMA, CysC, and UNCR were significantly elevated in dogs with CKD and IRIS stage Ι (P < .0001) than in controls. CysC demonstrated a strong correlation with CREA (r2 = 0.6556, P < .0001). CysC (sensitivity 93.55%, specificity 100%) had the highest sensitivity for detecting CKD, followed by UNCR (sensitivity 90%, specificity 100%), SDMA (sensitivity 84.37%, specificity 100%), and CREA (sensitivity 43.75%, specificity 100%). Additionally, CysC and UNCR (sensitivity 88.89%, specificity 100%) exhibited higher sensitivity and specificity than CREA (sensitivity 88.89%, specificity 66.67%) and SDMA (sensitivity 88.89%, specificity 88.89%) in dogs with CKD International Renal Interest Society (IRIS) stage Ι. CysC as a marker of glomerular filtration rate (GFR) and urinary NGAL as a marker of tubular damage could be used to detect CKD early in dogs better than CREA and SDMA.
- Subjects :
- medicine.medical_specialty
Urinalysis
Urinary system
Urology
Renal function
Urine
urologic and male genital diseases
chemistry.chemical_compound
Dogs
Lipocalin-2
medicine
Animals
Dog Diseases
Cystatin C
Renal Insufficiency, Chronic
Small Animals
Creatinine
biology
medicine.diagnostic_test
business.industry
medicine.disease
female genital diseases and pregnancy complications
chemistry
biology.protein
Biomarker (medicine)
business
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 19389736
- Volume :
- 45
- Database :
- OpenAIRE
- Journal :
- Topics in Companion Animal Medicine
- Accession number :
- edsair.doi.dedup.....9881555aeb98a4cef9586c1883ee4737