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Objective: Deep Oscillation® is an electromechanical procedure with deep therapy that allow to create a pulsed electrostatic field between the hand applicator and the processing better tissue nutrition, enhanced cellular metabolism, faster healing. The purpose of this work is to assessment of the outcome of the treatment of spinal pain after hip arthroplasty using Deep osсillation Methods: The study included 85 patients between the ages of 40 and 75 who were referred to the Arena 2 Rehabilitation Center for post hip joint arthroplasty spine pain, including 57 women and 28 men. Patients physical modalities: complex rehabilitation programme including deep oscillation (DO - fibromyalgia programme) and kinesitherapy - active analytic exercises (including isometric exercises) and soft tissue techniques (post-isometric relaxation, stretching of the lumbar fascia, manual massage). Spinal condition was assessed before treatment after treatment using the Modified Oswestry Disability Index (ODI). Results: Mean value of points before treatment - 3.35+1.1, after treatment - 1.36+0.79. p

The development of application software for cyber-physical systems of buildings involves the widespread use of Internet of Things (IoT) integration platforms. In practice, the flexible functionality of IoT platforms often leads to additional costs for software enhancement of existing and connection of new units, in particular digital twins. The paper proposes a technological solution for the implementation of a digital twin of the ventilation process in the IoT control loop of heating, ventilation and air conditioning (HVAC) systems for buildings and industrial facilities. The implementation and execution of the digital twin in the form of a dynamic simulation model in the object-oriented modelling language Modelica in the OpenModelica environment is considered. The IoT platform InfluxData, based on the TICK stack, is considered as an example of an integration environment. It is a horizontally-oriented IoT platform that contains the mechanism for collecting data from devices and the InfluxDB time-series database for storing metrics. To integrate simulation models on Modelica with InfluxDB, an OMPython server is proposed. In this case, the integration scripts are executed in the Python language, which as a result extends the traditional capabilities of the IoT platform significantly to the level of a digitally twinned control system. This HVAC control involves adapting control loops by taking into account the dynamics of the air distribution process over the ventilation network, evaluating and compensating for process inertia. The publication was prepared within the framework of the Academic Fund Program at the HSE University in 2020–2021 (grant № 21-04-039).

An analysis of the contractual loads of heat-consumption objects connected to one of the boiler houses of the Fuel and Energy Complex of St. Petersburg is presented. The analysis was carried out on the basis of the results of processing the readings of heat-metering devices installed at the subscriber inputs of apartment buildings located on the territory of St. Petersburg. The analysis was carried out of the consumption of heat energy for heating during the heating period of 2018/2019, and a comparison was made of the calculated and contractual loads of heat-consumption objects located in the area of operation of the considered source of heat energy. Change in the specific indicators of thermal energy in apartment buildings for heating depending on the series/types of buildings, their number of stories (taking into account the number of entrances), construction periods, and their heated area is shown. Examples of determining the calculated heat load for heating- and hot-water supply of heat-consumption objects according to the data array of general house heat meters, including within the schedule for regulating the supply of heat at the source. The coefficients showing the ratio of the calculated heat load of heat consumption subscribers to the contractual load were obtained. The reserve of thermal power for existing consumers of thermal energy and the source to which these consumers are connected has been identified. The average value of the coefficient, which is the ratio of the calculated heat load for heating to the contractual one, is 0.66, the averaged value of the coefficient, which is the ratio of the calculated heat load for hot-water supply to the contractual one, is 0.82.

The article deals with the determination of the efficiency of a multi-bladed tool equipped with inserts made of oxide-carbide cutting ceramics, depending on the microstructural parameters of the tool material. The microstructural parameters of the oxide-carbide cutting ceramic, which affect the performance of the tool, are proposed to be determined according to the electrical resistance of the tool material. In order to implement the method for determining the working capacity of the instrument, a basic design of the device for measuring the electrical resistance of the material of the instrument is proposed. The device for measuring the electrical resistance of ceramic plates consists of a body made of a dielectric material, with channels for supplying a conductive material and a groove for installing a case with a test sample. During the test, the channels are filled with a liquid conductive material, which fills the cavity formed by the channel of the case, the groove of the case and the plate itself under test. To ensure uniform filling of the cavity, after the introduction of the liquid conductive material, metal balls are installed into the channels, which are made in such a size as to ensure free sliding along the channel, but not to let the liquid pass into the upper part of the channel. The tested ceramic plate is installed in the walls of the removable case. The walls of the removable case include electrodes, which, when the device is in operation, are inserted into a cavity with a liquid conductive material at one end, and are connected to an ohmmeter at the other. Using a device for measuring the electrical resistance of ceramic plates, it is possible to determine the operability of the tool and guarantee its operation without rejection for a certain period of time, which was confirmed by experimental research in the milling of workpieces of machine parts made of gray cast iron. Experimental studies in multi-edge machining with cutters with different values ​​of electrical resistance of ceramic plates made it possible to plot graphs of the dependence of the quality of machining during milling on the operability of the tool and on the time of the machining process.

Objective. To present the clinical and functional results of combined treatment of the complications of long-term silicone oil tamponade in a patient with retinopathy of premature. Materials and methods. A 24-year-old patient diagnosed with stage 4b retinopathy of premature in a single seeing right eye. Between 2011 and 2020 underwent 5 microinvasive revisions of the vitreous cavity with replacement of silicone oil and median duration of silicone oil tamponade of 19+25.5 months over this entire period. Because of the constant migration of emulsified silicone oil to anterior chamber due to weakness of iridolenticular ligaments, band keratopathy developed in the right eye, opacity of the IOL due to the adhesion of precipitates on its anterior and posterior surfaces, pupillary membrane, and aggravation of the proliferative membrane on the ocular surface. UCVA was proectio incerta and IOP was 17 mmHg. The median thickness of the cornea was 853 μm, the average thickness of the corneal calcifications is 57 μm. The patient underwent revision of the vitreous cavity with removal of the pupillary membrane, the next steps were to install bandage sutures in the anterior chamber parallel to iris in two mutually perpendicular surfaces to create additional barriers to silicone oil migration. Then we used 27 mg of K3-EDTA to produce 0.1% chelating solution and to remove corneal calcium deposits. Final stage was YAG – laser discision of precipitates from the IOL surfaces. Results. Postoperatively UCVA of the right eye in 1-month was 0.05, IOP was 17 mmHg and endothelial cell density was 1200 cells / mm2. According to OCT data the median corneal thickness was 640 μm, the thickness of the epithelial layer was 39 μm. Biomicroscopically, cornea was transparent, a single silicone oil vesicle in the lower segment of anterior chamver, the bandage sutures are consistent, the IOL is centered with a transparent optical zone, silicone oil visualized on the fundus, epi- and subretinal proliferates were delimited by laser coagulates, epiretinal membrane was in the macular region. Key words: retinopathy of prematurity, silicone oil, emulsification, ribbon-like keratopathy, bandage threads, EDTA.

Subject. The article considers the capitalization of oil and gas companies. Objectives. The purpose is to research and evaluate the capitalization of the said companies. Methods. The study rests on general scientific methods of analysis. Results. The paper formulates the concept of capitalization as the most important result of the economic efficiency of production, investment attractiveness, and prospects for the development of corporation's business. It shows that the efficiency of using available resources is a crucial factor for capitalization. It considers the opportunities to single out fictitious value in market capitalization, using the fair value calculation method. This enables investors to make more informed investment decisions. The paper also identifies problems related to capitalization growth in the oil and gas business, and gives recommendations for its improvement. Conclusions. Capitalization growth should be seen as the main goal of sustainable development of companies. The concept of market capitalization should be tied to the assessment of economic performance. At the present stage, the paper reveals that the market capitalization index is away from actual business results, with the accumulation of fictitious capital in value.

We report the results of theoretical and experimental studies of a digital system for regulating and stabilising the frequency of a four-frequency Zeeman laser gyroscope (ZLG), in which generation occurs simultaneously on two longitudinal modes with orthogonal circular polarisations; therefore, four light waves propagate in the optical ring resonator. In contrast to a two-frequency Zeeman laser gyroscope, a four-frequency ZLG does not use the intensity modulation signal of one of the light waves, which appears when an alternating magnetic field is applied to the active medium, to analyse the frequency detuning of longitudinal modes from the centre of the active-medium gain contour. At the same time, it is possible to construct a digital perimeter adjustment system (PAS), which allows the resonator perimeter to be adjusted so that the magnetic components of the zero drift of the gyroscope for two longitudinal generation modes are equal and opposite in sign. Due to this, almost complete compensation for the magnetic component of the zero drift of the gyroscope is realised in a four-frequency ZLG. The use of the digital system makes it possible to provide a higher accuracy of the resonator perimeter adjustment than that in a two-frequency ZLG, even with a relatively small bit capacity of the PAS digital-to-analogue conversion (DAC), and to fully take advantage of the capabilities of a four-frequency ZLG to reduce the magnetic sensitivity.

PURPOSE. Perform analysis of the actual heat energy consumption for cold water heating for the hot water utility to the approved standard. Compare different methods of flow control in circulation pipelines of hot water supply systems. Identify ways to improve the efficiency of hot water systems. METHODS. The passive engineering experiment was used to study the operating modes of hot water supply systems of several groups of houses, in which various methods of regulating water consumption in hot water supply systems are implemented. Data collection was carried out using the online system of control and commercial accounting of energy resources. RESULTS. Existing hot water supply systems in residential buildings of Ulyanovsk were inspected under various methods of flow control in circulation pipelines. Features of static and dynamic load control of hot water supply systems were investigated. Analysis of influence of methods of control of thermal load of hot water supply systems on their actual heat consumption was performed. The possibility of bringing the actual operation mode of hot water supply systems to the standard value, on the basis of which consumption is calculated, is estimated. CONCLUSION. Known methods of load control in hot water supply systems and their actual operating conditions do not allow to reach the level of heat consumption that meets the established standards. Conclusions were drawn on the need to revise the regulated indicators of hot water quality and to adjust the method of calculating consumption in hot water supply systems.

In accordance with the Energy Strategy of the Russian Federation for the period of up to 2035, the enhancement of corporate governance is classified as a strategic task for the development of the fuel and energy sector. Legal support of corporate governance in companies with state participation in the energy sector, including companies in the power grid complex, is of great importance. The problems related to the legal support of transparency in the activities of the governing bodies of energy companies in the power grid complex are also of particular relevance. A significant problem of transparency of the governing bodies of energy companies, which still exists, is the identification and bringing the final beneficiaries to subsidiary responsibility. Within this work, the author identified the key problems that arise in case of transparency of activities of the governing bodies of companies of the power grid complex. The expediency of bringing the final beneficiaries of these organizations to subsidiary responsibility is justified, and proposals to improve the transparency and efficiency of the governing bodies of organizations of the power grid complex are made.

The effect of the dilution of a synthesis gas with nitrogen on the activity, selectivity and productivity of a Fischer–Tropsch reactor with a fixed bed of granular catalyst during synthesis on a pilot plant of a full cycle for the conversion of natural gas into synthetic oil is studied experimentally. Experimental data are presented that were obtained at different contents of nitrogen in the synthesis gas: up to 2, 50, and 70%. Analysis of the experimental data shows that diluting the synthesis gas contributes to an increase in the selectivity to C5+, and a decrease in the selectivity to methane. A drop in the reactor’s productivity observed upon the dilution of synthesis gas can be compensated for by increasing the consumption of synthesis gas. The negative effect of decrease in the pressure of FT synthesis from 2 to 1.5 and 1.0 MPa on the catalytic FT synthesis performed on a twice-diluted synthesis gas at a synthesis gas space velocity of 4000 h–1 is demonstrated.

International audience

Background. In recent years, EEG spectral analysis has become increasingly popular due to the development of computer technologies. Among the methods of spectral analysis, various variants of the window Fourier transform are most often used, taking into account the non-stationary nature of the EEG signal. Aims: study of the spectral composition of sleep EEG in patients with chronic disorders of consciousness by the method of discrete Fourier transform with windows in the form of spheroidal sequences. Methods. In this article, the spectral composition of the sleep EEG of 32 patients with impaired consciousness was studied using a discrete Fourier transform with windows in the form of spheroidal sequences. For spectral analysis of EEG sleep, we used polysomnography data obtained overnight. To construct hypnospectrograms, visualize data and research results, we used software written in the Python programming language using the NumPy, scipy, matplotlib, mne, yasa libraries. Results. The correlations between characteristic changes in the spectral composition of sleep EEG and the level of consciousness and the etiology of the disease were detected. Conclusions. Consolidation of sleep and normalization of other circadian rhythms is an important component of both the somatic state of patients in intensive care and, possibly, will become a therapeutic target for the restoration of cognition in patients with chronic impairment of consciousness.

A brief review is dedicated to the latest advances in the field of non-invasive studies of capillary blood flow in humans based on the developments of Russian scientists. Modern computer technologies have significantly expanded the capabilities of researchers and make it possible to obtain information about fundamental processes at the level of the metabolic link of the vascular bed not only in a hospital setting, but also in a remote access mode, which is extremely important in the context of a pandemic caused by the SARS-CoV-2 virus.

Purpose. To evaluate the clinical and functional results of the technique of transcleral fixation of the artificial iridochrustalic diaphragm during its decentration in a patient with aniridia and aphakia. Material and methods. Under observation was a 32-year-old patient K. with a diagnosis on the right eye: iridochrustalic diaphragm decentralization, posttraumatic aniridia, posttraumatic aphakia, who underwent a method of transcleral fixation of a displaced artificial iridochrustalic diaphragm developed at the Academician S. N. Fedorov Eye Microsurgery of the Moscow Ministry of Health of the Russian Federation. Results. Patient K. is subjectively satisfied with the visual functions obtained in the right eye. Conclusion. Thus, this clinical case demonstrates a very successful implementation of the fixation of the iridochrustalic diaphragm with its displacement to obtain satisfactory visual functions in the patient. Key words: aniridia, iridochrustalic diaphragm, transcleral fixation.

To improve accuracy of light attenuation measurements in optical fibres, especially in short ones, tens and hundreds of metres in length, we propose rejecting a conventional reflectometric approach based on Rayleigh scattering intensity measurements. To this end, we propose for the first time the use of boson peaks in Raman scattering, which, on the one hand, produce no interference effects and no related noise in reflectograms, and, on the other, lie within the C-band. Even at a fibre length as short as 50 m, the attenuation measurement error does not exceed 0.002 dB km−1. We demonstrate the possibility of compensating for the temperature variation of boson peak intensity by concurrently obtaining a reflectogram for the anti-Stokes line of the fundamental Raman band.

It is shown that self-forming GeSi nanoislands built into the dielectric–semiconductor interface in the Si(001)-based metal–oxide–semiconductor (MOS) structures with the SiOx and ZrO2(Y) dielectric layers obtained by magnetron sputtering initiate bipolar resistive switching without preliminary electroforming. The I–V characteristics and electrical parameters of the MOS structures in the high- and low-resistance states have been investigated. The change in the charge incorporated in the dielectric at the dielectric–semiconductor interface during resistive switching has been established, which is related to the formation and destruction of conducting filaments. The optically stimulated switching of the MOS structures with the ZrO2(Y) dielectric layer from the high- to low-resistance state has been observed, which is caused by an increase in the conductivity of the space charge region in the Si substrate due to the interband optical absorption in Si leading to the voltage redistribution between Si and ZrO2(Y). A difference between the shapes of the low-signal photovoltage spectra of the MOS structures in the spectral region of the Si intrinsic photosensitivity in the high- and low-resistance states related to the leakage of photoexcited carriers from Si into a metal electrode through filaments has been found.

High-performance harvesting of waste heat energy and its conversion into electric energy via thermo-electrochemical cells is an essential strategy of renewable energy development. Even though there is a large amount of scientific research available, but due to expensive electrode materials and low efficiency, the thermo-electrochemical cells have not found practical application. Here we demonstrated thermo-electrochemical cell with nickel (Ni) hollow microspheres-based electrodes, provided the highest hypothetical Seebeck coefficient of 4.5 mV/K (for aqueous electrolyte based thermocells) until today and open-circuit voltage values of up to 0.2 V. High values of Seebeck coefficient provide the ability to collect low-temperature heat, and high output potential differences which allow to fabricate batteries for commercial power circuits for various microelectronic devices. This work also proposed a mechanism and science behind the electrode processes, which explains a extremely high values of the hypothetical Seebeck coefficient. This is the first time to use Ni hollow microsphere in thermo-electrochemical cell for heat harvesting and thermal energy conversion into electricity. Because of the low cost of Ni microspheres electrode-based developed thermo cells could be commercially feasible for harvesting low-quality thermal energy.

The Orbitrap mass analyzer can provide high mass accuracy and throughput, which has significantly improved proteome research and made this type of instrumentation one of the most frequently applied in proteomics. The efficient use of Orbitrap mass spectrometers requires training. Students in the field of proteomics can benefit from a deeper understanding of the Orbitrap technology to comprehend mass spectral interpretation, troubleshooting, and judgment of experimental settings. Unfortunately, the cost of high-end mass spectrometers limits the implementation of this type of equipment in educational laboratories. Guided by these concerns, we developed an eLearning web application called HUMOS aimed to help teach Orbitrap mass spectrometry. Although a typical proteomics experiment includes the use of several different technologies, such as liquid chromatography, mass spectrometry, and bioinformatics, the learning objectives of HUMOS are focused on mass spectrometry. HUMOS models a mass spectrum of a peptide mixture, allowing us to investigate the influence of mass spectral acquisition parameters. By changing the parameters and observing the differences, students can learn more about the mass spectral resolution, duty cycle, throughput of the analysis, ion accumulation, and spectral dynamic range and get familiar with advanced spectral acquisition methods, such as BoxCar. HUMOS is an open-source software published under the Apache license; the live installation is available at http://humos.bmb.sdu.dk.

Background: Thanks to advances in emergency medical and surgical care, the number of patients experiencing acute critical illnesses is increasing. However, a group of patients in the so-called chronic critical illness (CCI) was formed. In this category of patients, the problem of treating decubital ulcers is relevant, since they are characterized by a combination of prolonged immobilization, severe protein catabolism, neuroendocrine and metabolic disorders, protein-energy malnutrition (PEN) and tissue trophic disorders. Aims: Analyze the correlation of the degree of regeneration of decubital ulcers according to the Bates-Jenson scale in the modification S.Y.R. in relation to indicators of the nutritional status of patients in the CCI after brain damage. Materials and methods: The study included 26 patients with pressure ulcers II, III, IV stage with PEN. To evaluate decubital ulcers, the adapted Bates-Jensen scale in the S.Y.R. modification was used. (with graphic model). The severity of PEN was evaluated by a complex of anthropometric (BMI, shoulder circumference, thickness of the skin-fat fold, circumference of the shoulder muscles) and laboratory (transferrin, absolute lymphocyte count) indicators. The dynamics of anthropometric indicators and the results of laboratory studies were separately considered. Results: As a result, it was found that the change in anthropometric data correlated with laboratory parameters and the healing rate of decubital ulcers in only 26.9% of cases. Moreover, this correlation between the dynamics of transferrin and the absolute number of lymphocytes with the regeneration of decubital ulcers was observed in all patients. The obtained results demonstrated a direct correlation between the dynamics of healing of pressure ulcers and changes in laboratory indicators of nutritional status (as opposed to anthropometry data) in patients who are in a CCI after brain damage. Conclusions: These findings provide an opportunity to review the weight of indicators in assessing the severity of protein-energy malnutrition, as well as introducing the rate of regeneration of a decubital ulcer in the presence of a patient into the assessment of the nutritional status.

A study has been made of the accuracy of measuring the attenuation coefficient in a single-mode optical fiber using Rayleigh reflectometry. It has been theoretically established that the minimum achievable uncertainty of such measurements is determined only by the spectral properties of the probe radiation and decreases with an increase in the length of the measured fiber to the power of 1.5. A statistical analysis of the results of measuring the attenuation coefficient in different segments of a real single-mode fiber by their reflectograms demonstrates results that are consistent with theoretical conclusions. The results set limits on the minimum fiber length for which the attenuation coefficient can be measured with the required accuracy.

The possibility of measuring strain (temperature) over distances up to 85 km in a single-ended optical fiber using the technique of low coherence Rayleigh reflectometry has been demonstrated. The indicated range is provided by employing Raman amplification of radiation in combination with amplification by short erbium doped fiber segments built into the fiber under test. The possibility of tuning a low coherence source in a wide range of wavelengths made it possible to measure strain in the range of 500 μe, which is equivalent to 56°C in units of temperature. At a unit measurement time of 10 min and a spatial resolution of 2.6 m, the standard uncertainty of the strain measurements was 3.8 μe and of the temperature ones was 0.42°C.

Coronavirus disease 2019 (COVID-19) is a novel disease caused by the severe acute respiratory syndrome coronavirus (SARS-CoV)-2 virus that was first detected in December of 2019 in Wuhan, China, and has rapidly spread worldwide. The search for a suitable vaccine as well as effective therapeutics for the treatment of COVID-19 is underway. Drug repurposing screens provide a useful and effective solution for identifying potential therapeutics against SARS-CoV-2. For example, the experimental drug remdesivir, originally developed for Ebola virus infections, has been approved by the US Food and Drug Administration as an emergency use treatment of COVID-19. However, the efficacy and toxicity of this drug need further improvements. In this review, we discuss recent findings on the pathology of coronaviruses and the drug targets for the treatment of COVID-19. Both SARS-CoV-2-specific inhibitors and broad-spectrum anticoronavirus drugs against SARS-CoV, Middle East respiratory syndrome coronavirus, and SARS-CoV-2 will be valuable additions to the anti-SARS-CoV-2 armament. A multitarget treatment approach with synergistic drug combinations containing different mechanisms of action may be a practical therapeutic strategy for the treatment of severe COVID-19. SIGNIFICANCE STATEMENT: Understanding the biology and pathology of RNA viruses is critical to accomplish the challenging task of developing vaccines and therapeutics against SARS-CoV-2. This review highlights the anti-SARS-CoV-2 drug targets and therapeutic development strategies for COVID-19 treatment.

Idiopathic ERM is a fibrocellular proliferation on the inner surface of vitreomacular interface. Vitrectomy in patients with relatively high preoperative visual acuity is preferable, because it prevents further photoreceptor damage. In the late stages of the disease, patients are not satisfied with the results of the treatment after surgical removal of the ERM due to fibrotic remodeling of the vitreomacular interface. The main reason for this is the incompleteness of the retinal morphology restoration and function. Purpouse . To compare the anatomical and clinical functional results of surgical treatment in patients with different visual acuity at different periods of observation. Material and methods . A clinical and functional assessment of early surgical treatment of idiopathic ERM was performed in 75 patients (75 eyes). It consists in the dynamic observation of the best-corrected visual acuity (BCVA), data of central retinal thickness (CRT) and central retinal sensitivity (CRS). Results . The BCVA of patients from the 1st group was 1.00 (0.80; 1.00) already 6 months after the treatment. Also, as soon as possible, the CRS was restored to 27.25 (26.50; 27.90) dB. In the 2nd group, the BCVA and CRS were revealed by the 12th month of observation 0.80 (0.60; 0.90), RS 26.20 (24.50; 27.00). In the 3rd group, BCVA at the end of the entire observation period did not reach maximum values – 0.50 (0.30; 0.60), CRS 23.70 (22.10; 24.75). Increasing of BCVA correlated with the retinal thickness decreasing. Conclusions . Combined surgical treatment for early symptomatic ERM is effective, safe and appropriate to maintain high anatomical and functional results in the postoperative period, which allows to achieve rapid rehabilitation of patients.

Introduction.Neonatal seizures are the most common pathological neurological symptom of the neonatal period, requiring immediate treatment. There are 2 directions in the treatment of seizures: relief of acute life-threatening seizures and supportive antiepileptic therapy of the chronic process. Worldwide phenobarbital is still the first-line medication for neonatal seizures. However, due to contraindications the doctors have to select and prescribe other antiepileptic therapy for both stopping seizures and supportive therapy.Objective.To introduce an algorithm for standardized phased treatment of neonatal seizures from stopping an acute debut to starting supportive chronic therapy according to clinical and electroencephalographic indications.Characteristics of children and research methods.The authors retrospectively analyzed 449 patients born in 2016 – 2017. The inclusion criteria: full-term term newborns with clinical and/or encephalographic verification of seizures in the neonatal period. The authors studied the time distribution parameters of the primary realization of seizures from the time of birth, the genesis of convulsive activity, the effectiveness of antiepileptic therapy.Results.Out of 449 treated children (full-term infants with somatic, surgical and cardiosurgical pathologies) 36 (8.0%) patients had neonatal seizures, 35 (97.33%) children of them had symptomatic seizures. Neonatal genetic epilepsy was diagnosed in 1 (2.77%) child (Otahar syndrome). The investigators revealed the prevalence of the primary realization of convulsive syndrome in newborns in the first 4 days of life. Occasionally the initial debut of seizures occurred in children older than 7 days with congenital metabolic disorders, represented by aminoaciduria. The seizures were stopped without anticonvulsants (correction of transient metabolic disorders – hypoglycemia, hypocalcemia) in 3 (8.33%) children, with phenobarbital monotherapy in 5 (13.89%) children, diazepam monotherapy in 4 (11.11%) children, monotherapy with sodium thiopental – in 5 children (13.89%), valproic acid preparations – in 8 (22.22%) children, a combination of first and second line drugs (sodium thiopental + diazepam; sodium thiopental + phenobrobital) – in 11 ( 30.56%) children. Supportive antiepileptic therapy was carried out using phenobarbital monotherapy in 16 (44.44%) children, valproic acid preparations in 7 (19.44%) children, levetiracetam in 4 (11.12%) children, oxcarbazepine in 2 (5.56 %) children; 7 (19.44%) children were discharged without supportive antiepileptic therapy.Conclusion.Currently anticonvulsant monotherapy is effective in less than 50% of neonatal seizures cases; phenobarbital or diazepam remain the first-line medications. 1/3 of the patients require a combination of antiepileptic therapy. It is of great importance to diagnose and correct transient metabolic disorders before the prescription of anticonvulsant therapy.

By analyzing references, one can obtain interesting information about the kind of research that is being performed, what approaches exist, information about scientists working in a field of interest, the institutions where such research is being carried out, and journals that reflect this information. Citation issues are discussed in the Akusticheskii Zhurnal articles. An analysis of the cited literature showed that with the advent of the Internet, the depth of citation increased, as did the reduced half-life of articles. Attention is drawn to references to Akusticheskii Zhurnal (hereafter – Acoustics or AJ) itself. An analogy is drawn with the statement of academician V.L. Ginzburg that our scientists do not receive the Nobel Prize “primarily due to their colleagues: Soviet physicists,” who, as it turns out, do not really nominate their compatriots. The same can be attributed to the inadequate impact factor of Acoustics, which is decreased by the authors themselves. The issues of information support in the field of Russian-speaking acoustics are discussed.

The specific features of resistive switching, which was initiated by triangular pulses with a high-frequency sine signal imposed on them, in experimental memristor prototypes based on thin films of yttria-stabilized zirconia were examined. It was found that memristors switched by these complex signals have lower switching voltage, higher ratio of currents in low- and high-resistance states, and better long-term current stability than memristors switched by triangular pulses without the sine signal. This improvement of switching parameters is associated with resonance activation of migration of oxygen ions via vacancies in the alternating external electric field.

Background. Rehabilitation of patients with chronic disorders of consciousness is extremely important due to severity of the condition and increasing number of such patients. Disorders of consciousness have led to inability of self-care, need for constant care and complete dependence on outside assistance. Applying noninvasive brain stimulation and rhythmic transcranial magnetic stimulation seems to be perspective methods of rehabilitation. Aim. to evaluate the efficiency of rhythmic transcranial magnetic stimulation of left dorsolateral prefrontal cortex using local navigation in patients with chronic disorders of consciousness. Methods. This prospective study was carried out in patients with chronic disorders of consciousness after severe brain injury. All patients received 10-day treatment with active high-frequency rhythmic transcranial magnetic stimulations of the left dorsolateral prefrontal cortex. Revised coma recovery scale (JFK Coma Recovery Scale-Revised, CRS-R) was used to evaluate the effectiveness of the procedure. Results. After the treatment with rhythmic transcranial magnetic stimulations according to CRS-R 8 out of 12 patients improved their score. The best response was observed in patients in minimally conscious state. There were no cases of adverse events during the treatment. Conclusion. High-frequency rhythmic transcranial magnetic stimulations provide an opportunity to improve level of consciousness in patients after severe brain injury. Using navigation system allows to rule out an inaccuracy in determining the dorsolateral prefrontal cortex. As a result this study proposed the effective and safe protocol for rehabilitation of patients with chronic disorders of consciousness.

The electrophysical characteristics of a multilayer memristive Au/Ta/ZrO2(Y)/TaOx/TiN structure have been studied. Electron and ion electret effects due to charge carrier trapping and ion migration polarization in the dielectric have been discovered. The influence of traps on electroforming processes and resistive switching has been established. The values of activation energy and ion and trap concentrations have been determined. The effect of resistive switching stabilization has been found, which is associated with the specific bilayer structure of TaOx and self-forming tantalum nanoclusters. The nanoclusters serve as electric field concentrators in the course of electroforming and subsequent resistive switching.

The article deals with the mechanics of axial volumetric plastic deformation of axisymmetric parts of the “shaft” type. The functional scheme of automatic control of plastic deformation process is given. The algorithm of sequential discrete plastic deformation along the length of the shaft is developed.

It is proposed to ensure safety in carrying out work on a disconnected overhead power line by using a grounding conductor at the workplace having the impedance at which the induced voltage will be decreased down to permissible values. For reliably determining the necessary grounding conductor impedance, the results from multiple measurements of the induced voltage and current at the overhead power line point in which the work is carried out are used. Based on the results of measurements and solution of the inverse problems, empirical formulas for the functions of induced voltage and current in the considered place at which work on the overhead power line is carried out are determined. The necessary impedance of the grounding conductor at the workplace is determined using the obtained empirical formulas. As a result, a procedure has been developed using which it is possible to determine the grounding conductor impedance that ensures safety of work carried out at the considered place of the disconnected overhead power line whatever the combination of operating currents through the influencing overhead power lines.

// Lubov Mitrofanova 1 , Anton Hazratov 1 , Boris Galkovsky 1 , Andrey Gorshkov 1 , 2 , Danila Bobkov 2 , 3 , Dmitry Gulyaev 4 and Evgeny Shlyakhto 5 1 Almazov National Medical Research Centre, Pathomorphology Research Laboratory, St. Petersburg, Russia 2 Smorodintsev Research Institute of Influenza, Laboratory of Intracellular Signaling and Transport, St. Petersburg, Russia 3 Institute of Cytology of the Russian Academy of Science, Laboratory of Cell Biology in Culture, St. Petersburg, Russia 4 Almazov National Medical Research Centre, Research Department of Neurosurgery, St. Petersburg, Russia 5 Almazov National Medical Research Centre, General Director, St. Petersburg, Russia Correspondence to: Lubov Mitrofanova, email: lubamitr@yandex.ru Keywords: telocytes; pericytes; confocal microscopy; primary culture of glioma telocytes; glioblastoma Received: June 05, 2019 Accepted: October 26, 2019 Published: January 28, 2020 ABSTRACT Telocytes (Tcs) and pericytes (Pcs) are two types of perivascular interstitial cell known to be widespread in various organs and tissues, including the brain. We postulated that Tcs and Pcs may be involved in glioblastoma (GBM) neovascularization. Objective Morphological study of Tc and Pc roles in GBM. Materials and Methods Samples from 15 GBM, 10 diffuse astrocytoma, as well as 5 control samples were studied. We used immunohistochemistry (IHC) with antibodies (Abs) to GFAP, Ki-67, CD117, NeuroD1, NG2, CD34, and SMA. Confocal laser scanning microscopy (CLSM) of 4 glioma tissue cultures and 4 GBM sections was performed with GFAP, CD117, CD34/connexin43, NeuroD1/connexin43, CD34/NG2 and CD13/CD117 Abs. Electron microscopy (EM) of GBM was performed in 4 cases. Results The presence of Tcs and Pcs was shown in GBM (IHC, EM, CLSM) and glioma cultures (CLSM). The Tc immunophenotype was CD117 + /CD34 + /connexin43 + /NeuroD1 + . The Pc immunophenotype was SMA + /NG2 + /CD13 + . The number of Tcs in GBM specimens was 10 times higher than in astrocytoma. We also identified CD13/CD117 and CD34/NG2 co-expressing cells in GBM blood vessels. Conclusion Four immunophenotypes were found in GBM vessels, corresponding to endotheliocytes, Pcs, Tcs, and a mixed Pc/Tc immunophenotype. These and forthcoming improvements in our understanding of the origin and function of Tcs, including their relationship with Pcs, are necessary steps in oncology. Study of these cell types (Tcs, Pcs) and their roles in brain tumor oncogenesis will likely enable improved targeted therapies and support development of new forms of anti-neoplastic drugs.

In this study, the monofractal and multifractal properties of inter-beat (R-R) intervals in cardiac signals for normal and pathology classes were studied and applied to a dataset in PhysioNet which consists of 24 h R-R intervals from 54 healthy subjects (hs) and 92 patients with various diagnoses [44 with congestive heart failure (chf), 25 with atrial fibrillation (af) and 23 diagnosed with sudden death syndrome (sd)]. The results in this study indicate that the most suitable method for estimating the monofractal properties of R-R intervals is detrending moving average (DMA). The Hurst exponents ( H ) of the healthy and pathological groups, calculated using the DMA method, are shown to be statistically different by the Kruskal–Wallis test [p-value

Hypertension remains a pandemic of the 21st century, being a major factor of premature death. The introduction of imaging methods into clinical practice revealed a high prevalence of target organ damage mediated by hypertension. One of the systemic target organs in hypertension is endothelium. Its damage plays an important role in the initiation of the cardiovascular disease continuum. On the other hand, structure and function defects of the endothelium is considered as a possible reason for the increase in blood pressure. This literature review systematizes data on a causal relationship between hypertension and endothelial dysfunction, and discusses the direction of further study of vascular endothelium function.

The problems associated with the absence in the Russian Federation of a single center for the collection and provision of information on Russian-language scientific publications are discussed. A technological scheme is proposed that is useful in creating such a center. The cluster of this center is described via example of acoustic topics, already implemented at the Department of Acoustics, Faculty of Physics, Moscow State University. The corresponding Acoustics portal (http://akdata.ru) is publicly available on the Internet. Entrance points of the portal are the following: the full-text archive of the Acoustics Journal, “Signal Information” on acoustics, and “Information Retrieval System ‘Acoustics’. Russian-language sources”. Work with the system is described. Scientometric data from analyzing the information content of the system are presented for journals, headings, and authors. Bradford’s Law of Scattering of scientific publications is verified using acoustics topics. A list of authors demonstrating publication activity in the field of acoustics is given.

Local resistive switching by complex nonstationary signals in zirconium-dioxide-stabilized films on conducting substrates has been studied by atomic-force microscopy with a conducting probe. Film resistance was switched by triangular voltage pulses on which a high-frequency sinusoidal signal was superimposed. It is found that the ratio of currents through the junction between the probe and film surface in high-resistance and low-resistance states increases after the superposition of a sinusoidal signal (as compared to switching by simple triangular pulses). An increase in the temporal stability of the current strength in these states was also found when switching with a sinusoidal signal. This effect is associated with resonant activation of oxygen ion migration over vacancies in an external ac electric field.

Aim. To study clinical, medical history and paraclinical characteristics of patients with non-ST elevation myocardial infarction (NSTEMI) after coronavirus disease 2019 (COVID-19).Material and methods. The study included 209 patients with NSTEMI who were admitted to the Demikhov City Clinical Hospital (Moscow). The patients were divided into 2 groups: the experimental one (n=104) — those after COVID-19, the control one (n=105) — those without history of COVID-19. All patients underwent routine diagnostic investigations in accordance with current standards and clinical guidelines.Results. The mean age of patients in the experimental group was 61,8±12,2 years, while in the control one — 69,0±13,0 years (p2 =4,97; p=0,0258). The level of C-reactive protein in the experimental group was 19,2 mg/l [4,9; 53,0], and in the control one — 5,6 mg/l [0,4; 21,8] (p=0,0007). The average troponin I level in the experimental group was 2,7 ng/ml [1,3; 8,0], while in the control one — 1,8 ng/ml [0,8; 3,5] (p=0,0091).Conclusion. Patients with NSTEMI after COVID-19 were significantly younger compared to patients without a history of COVID-19. They had less common exertional angina prior to MI, while C-reactive protein and troponin I levels were significantly higher than in the control group. In addition, in NSTEMI patients after COVID-19, the estimated pulmonary artery systolic pressure was significantly higher compared to patients without a history of COVID-19.

Rationale One of the important steps in initial data processing of peptide mass spectra is the detection of peptide features in full-range mass spectra. Ion mobility offers advantages over previous methods performing this detection by providing an additional structure-specific separation dimension. However, there is a lack of open-source software that utilizes these advantages and detects peptide features in mass spectra acquired along with ion mobility data using new instruments such as timsTOF and/or FAIMS-Orbitrap. Methods Recently, a utility called Dinosaur was presented, which provides an efficient way for feature detection in peptide ion mass spectra. In this work we extended its functionality by developing Biosaur software to fully employ the additional information provided by ion mobility data. Biosaur was developed using the Python 3.8 programming language. Results Biosaur supports the processing of data acquired using mass spectrometers with ion mobility capabilities, specifically timsTOF and FAIMS. In addition, it processes mass spectra obtained in negative ion mode and reports cosine correlation table for peptide features which is useful for differentiation between in-source fragments and semi-tryptic peptides. Conclusions Biosaur is a utility for detecting peptide features in liquid chromatography-mass spectra with ion mobility and negative ion supports. The software is distributed with an open-source APACHE 2.0 license and is freely available on Github: https://github.com/abdrakhimov1/Biosaur.

Systematizing and conceptualizing of the components of the patient’s diagnosis at definite Clinical Situations are the important steps in constructing the medical electronic platforms to monitor the drug treatment quality and to realize the process of risk-management of drug care. The risk-management is a hard and expensive process for the non-profit hospitals. The Information technologies have a high potential for solving these problems. The conceptual schemes to construct the multimodal medical electronic platform were discussed. The Information Space of Clinical Practice, Information Field for formulating the detailed patient’s diagnosis at the definite Clinical Situations, Information Environment for the components of the detailed patient’s diagnosis were described.