1. Implementing Pharmacogenomics Testing: Single Center Experience at Arkansas Children's Hospital
- Author
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Jeffery L Clothier, Feliciano B. Yu, Aravindhan Veerapandiyan, David L. Becton, Bobby L. Boyanton, Kevin Bielamowicz, Judy C Allen, Andrew Burrow, Parthak Prodhan, Elizabeth A. Sellars, G. Bradley Schaefer, Joshua L. Kennedy, Don Rule, Patricia Porter-Gill, Jason E. Farrar, and Pritmohinder S. Gill
- Subjects
medicine.medical_specialty ,pediatrics ,phenotype ,genotype ,Medicine (miscellaneous) ,EPIC ,Single Center ,030226 pharmacology & pharmacy ,Clinical decision support system ,Article ,03 medical and health sciences ,0302 clinical medicine ,electronic health records (EHR) ,medicine ,Dosing ,Intensive care medicine ,Adverse effect ,business.industry ,clinical decision support (CDS) ,pharmacogenomics (PGx) ,Precision medicine ,030220 oncology & carcinogenesis ,Pharmacogenomics ,best practice alerts (BPAs) ,Medicine ,Biomarker (medicine) ,genomic indicators ,business - Abstract
Pharmacogenomics (PGx) is a growing field within precision medicine. Testing can help predict adverse events and sub-therapeutic response risks of certain medications. To date, the US FDA lists over 280 drugs which provide biomarker-based dosing guidance for adults and children. At Arkansas Children’s Hospital (ACH), a clinical PGx laboratory-based test was developed and implemented to provide guidance on 66 pediatric medications for genotype-guided dosing. This PGx test consists of 174 single nucleotide polymorphisms (SNPs) targeting 23 clinically actionable PGx genes or gene variants. Individual genotypes are processed to provide per-gene discrete results in star-allele and phenotype format. These results are then integrated into EPIC- EHR. Genomic indicators built into EPIC-EHR provide the source for clinical decision support (CDS) for clinicians, providing genotype-guided dosing.
- Published
- 2021