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Erythropoietin and Brain Magnetic Resonance Imaging Findings in Hypoxic-Ischemic Encephalopathy: Volume of Acute Brain Injury and 1-Year Neurodevelopmental Outcome

Authors :
Amit M. Mathur
Shasha Bai
Chunqiao Luo
Dennis E. Mayock
Taeun Chang
Yvonne W. Wu
Raghu H. Ramakrishnaiah
Sandra E. Juul
Robert C. McKinstry
G. Bradley Schaefer
Krisa P. Van Meurs
Sarah B. Mulkey
Source :
The Journal of pediatrics. 186
Publication Year :
2016

Abstract

In the Neonatal Erythropoietin and Therapeutic Hypothermia Outcomes study, 9/20 erythropoietin-treated vs 12/24 placebo-treated infants with hypoxic-ischemic encephalopathy had acute brain injury. Among infants with acute brain injury, the injury volume was lower in the erythropoietin than the placebo group (P = .004). Higher injury volume correlated with lower 12-month neurodevelopmental scores. Trial registration ClinicalTrials.gov : NCT01913340 .

Details

ISSN :
10976833
Volume :
186
Database :
OpenAIRE
Journal :
The Journal of pediatrics
Accession number :
edsair.doi.dedup.....918f4bfc53dffdd582d71d6e920470d6