Search

Purpose:To report a patient with generalized retinal toxicity to mitogen-activated protein inhibitors.Methods:Retrospective case report.Results:Full-field electroretinogram findings indicate a generalized toxicity to the use of the mitogen-activated protein inhibitor trametinib. There was an improve

BACKGROUND To evaluate the outcomes of a heterogeneous group of patients with chronic ulcer receiving a combination regimen of full-field and fractional erbium-doped yttrium aluminum garnet (erbium: YAG) laser applications. METHODS Enrolled in this study were patients with chronic ulcer who had received at least 2 erbium: YAG laser sessions. Fractional applications followed the initial full-field application for debridement. The therapeutic outcomes were evaluated by serial photographs. The primary outcome measure was the proportion of patients achieving complete re-epithelialization at the first year. RESULTS Forty-three treatment regions from 23 patients between 40 and 90 years (F: M = 11:12; age: 60.3 ± 15.5 years, mean ± SD) were eligible. The ulcers' median duration was 24 months (min-max: 2-240 months). The median number of laser sessions was 5 (min-max: 2-12). Of arterial (n = 13), immunologic (n = 9), venous (n = 8), diabetic (n = 8), and mechanical ulcers (n = 5), the primary outcome measure was achieved in 69%, 77.7%, 75%, 88.8%, and 100% of the groups, respectively. CONCLUSION Full-field erbium: YAG laser applications preserve the vascular architecture and enable delicate debridement. Ongoing maintenance fractional laser sessions promote wound healing. Similar to the previous reports of erbium: YAG laser in venous and diabetic ulcers, arterial ulcers, and ulcers of immunologic origin demonstrated an objective treatment response along with different adjuvant approaches.

The adoption of emerging imaging technologies in the medical community is often hampered if they provide a new unfamiliar contrast that requires experience to be interpreted. Here, in order to facilitate such integration, we developed two complementary machine learning approaches, respectively based on feature engineering and on convolutional neural networks (CNN), to perform automatic diagnosis of breast biopsies using dynamic full field optical coherence tomography (D-FF-OCT) microscopy. This new technique provides fast, high resolution images of biopsies with a contrast similar to H&E histology, but without any tissue preparation and alteration. We conducted a pilot study on 51 breast biopsies, and more than 1,000 individual images, and performed standard histology to obtain each biopsy diagnosis. Using our automatic diagnosis algorithms, we obtained an accuracy above 88% at the image level, and above 96% at the biopsy level. Finally, we proposed different strategies to narrow down the spatial scale of the automatic segmentation in order to be able to draw the tumor margins by drawing attention maps with the CNN approach, or by performing high resolution precise annotation of the datasets. Altogether, these results demonstrate the high potential of D-FF-OCT coupled to machine learning to provide a rapid, automatic, and accurate histopathology diagnosis.

Objective To compare lesion conspicuity on synthetic screening mammography (SM) plus digital breast tomosynthesis (DBT) versus full field digital mammography (FFDM) plus DBT. Materials and methods Seven breast imagers each prospectively evaluated 107–228 screening mammograms (FFDM, DBT, and SM; total 1206 examinations) over 12 weeks in sets of 10–50 consecutive examinations. Interpretation sessions alternated as follows: SM + DBT, then FFDM, or FFDM + DBT, then SM. Lesion conspicuity on SM versus FFDM (equal/better versus less) was assessed using proportions with 95% confidence intervals. DBT-only findings were excluded. Results Overall 1082 of 1206 (89.7%) examinations were assessed BI-RADS 1/2, and 124 of 1206 (10.3%) assessed BI-RADS 0. There were 409 evaluated findings, including 134 masses, 119 calcifications, 72 asymmetries, 49 architectural distortion, and 35 focal asymmetries. SM conspicuity compared to FFDM conspicuity for lesions was rated 1) masses: 77 (57%) equal or more conspicuous, 57 (43%) less conspicuous; 2) asymmetries/focal asymmetries: 61 (57%) equal or more conspicuous, and 46 (43%) less conspicuous; 3) architectural distortion: 46 (94%) equal or more conspicuous, 3 (6%) less conspicuous; 4) calcifications: 115 (97%) equal or more conspicuous, 4 (3%) less conspicuous. SM had better conspicuity than FFDM for calcifications and architectural distortion and similar conspicuity for most masses and asymmetries. Conclusion Compared to FFDM, SM has better conspicuity for calcifications and architectural distortion and similar conspicuity for most masses and asymmetries.

In the paper, an alignment methodology of finite element and full-field measurement data of planar specimens is presented. The alignment procedure represents an essential part of modern material response characterisation using heterogeneous strain-field specimens. The methodology addresses both the specimen recognition from a measurement’s image and the alignment procedure and is designed to be applied on a single measurement system. This is essential for its practical application because both processes, shape recognition and alignment, must be performed only after the specimen is fully prepared for the digital image correlation (DIC) measurements (white background and black speckles) and placed into a testing machine. The specimen can be observed with a single camera or with a multi-camera system. The robustness of the alignment method is presented on a treatment of a specimen with a metamaterial-like structure and compared with the well-known iterative closest point (ICP) algorithm. The performance of the methodology is also demonstrated on a real DIC application.

Optical coherence tomography, or in short OCT, is a measurement technique established in the early 1990s for the non-invasive imaging of interfaces in the bulk of biological tissues or other samples. A full-field OCT setup is built from a microscope combined with a Michelson interferometer, where the mirror in one arm is replaced by the sample. Using white light, which is temporally partially coherent, interference fringes disclose the presence of an interface whenever the lengths of both interferometer arms are nearly equal. Scanning one arm allows for a volumetric reconstruction of all interfaces inside the sample. While the importance of OCT in medicine is indisputable, it is hard to teach students the basic aspects of such technology as most available setups tend to be rather complex. It is our purpose to present a fully functional full-field OCT setup that is stripped-down to its essential components and to promote its use in an undergraduate lab course. The contribution is complemented by a description of the basic theory necessary to understand the working principle of OCT.

When retinal activity is increased by exposure to dynamic visual stimuli, blood vessels dilate and the flow of blood within vessels increases to meet the oxygen and glucose demands of the neurons. This relationship is termed ‘neurovascular coupling’ and it is critical for regulating control of the human retinal vasculature. In this study, we used a recently developed technique based on a dual-beam adaptive optics scanning laser ophthalmoscope to measure changes in red blood cell velocities, vessel diameter, and flow in interconnected small parafoveal retinal vessels (t-test showed significant increases in velocity and flow in arterioles and venules. These measurements indicate that the mechanism of neurovascular coupling systematically affects the vascular response in small retinal vessels in order to maintain hemodynamic regulation in the retina when exposed to visual stimulation, in our case flicker. Our findings may provide insight into future investigations on the impairments of neurovascular coupling from vascular diseases such as diabetic mellitus.

Background Although traditional intraoperative assessments (ie, frozen sections) may lower reoperation rates in patients with breast cancer, time/tissue limitations and accuracy concerns have discouraged their routine clinical use. Full-field optical coherence tomography (FFOCT) and dynamic cell imaging (DCI) are novel optical imaging techniques offering rapid histologic approximations that are unfettered by requisite handling steps. This study was conducted to determine the feasibility and diagnostic utility of FFOCT and DCI in examining breast and lymph node specimens during breast cancer surgery. Methods FFOCT and DCI were applied to normal and cancerous breast tissue, benign breast lesions, and resected axillary lymph nodes. The tissues were then subjected to conventional processing and staining (hematoxylin-eosin) for purposes of comparison. Results A total of 314 specimens, including 173 breast biopsies (malignant, 132; benign/normal, 41) and 141 resected lymph nodes (tumor-positive, 48; tumor-negative, 93), were obtained from 158 patients during breast surgery for prospective imaging evaluations. In breast cancer diagnosis, the minimum sensitivities (FFOCT, 85.6%; DCI, 88.6%) and specificities of optical imaging (FFOCT, 85.4%; DCI, 95.1%) were high, although they diverged somewhat in nodal assessments (FFOCT sensitivity, 66.7%; FFOCT specificity, 79.6%; DCI sensitivity, 83.3%; DCI specificity, 98.9%). Conclusions These timely and tissue-sparing optical imaging techniques proved highly accurate in diagnosing breast cancer and nodal metastasis. They compare favorably with routine histologic sections and demonstrate their promise in this setting.

This study proposed a method capable of reconstructing complex deformations of thin-walled special-section beam structures subjected to highly coupled loading cases, in terms of the combination of tension/compression, biaxial bending, and warping torsion. The complex beam deformation was decoupled, depending on axial strain measurement strategy on beam surface, and leads to reconstructed full-field displacements (deformed shapes) as the linear superposition of deformations subject to individual loading types. Full-filed strain/stress distributions can then be derived based on the reconstructed displacements. Particular efforts were focused on reconstructing beam deformation subject to warping torsion, where both rotations angles and warping displacements across the beam cross-section and along the beam length were identified precisely. As a proof-of-concept validation, the effectiveness of the method was examined using finite element analysis, where the deformed shape of a thin-walled hat-section beam under the coupling between uniaxial bending and warping torsion was reconstructed., Experiments were conducted subsequently to reconstruct deformation of an aluminum hat-section beam using distributed optical fiber sensors for the measurement of axial strains on the beam surface. The reconstructed full-field deformed shapes of the beam were compared with the three-dimensional displacement signals captured using a non-contact digital image correlation system. The effectiveness of the proposed methodology for complex deformation reconstruction is possible to be extended to a variety of thin-walled beam-type structures which are typical in civil and aerospace engineering, showing potential contributions in fields such as on-line structural health monitoring and active structural control.

On the basis of advanced functional structures such as aeronautics and astronautics, it is common to arrange strain measurements at finite points on the structure and then reconstruct the displacem...

Background Laser skin resurfacing with erbium-doped yttrium aluminum garnet (Er:YAG) lasers is a newer alternative to CO2 laser treatment, and was developed to reduce common complications. Although Er:YAG lasers have been available for years, safety parameters for efficacious resurfacing with these devices have not previously been available. Objectives The aim of this study was to utilize one practice’s laser treatment settings and outcomes data to identify complication rates for various energies and areas of the face and to offer safe energy/depth parameters for treating each area. Methods A retrospective chart review was performed for full-field confluent laser resurfacing patients treated with a Sciton Contour Tunable Resurfacing Er:YAG laser by the senior author. The data were retroactively analyzed with a time range of 8 years (January 2007-December 2015). Results The overall complication rate for MicroLaserPeels (ablation of 50 µm or less) was 10.1% (20 of 198 treatments) and the rate for deep resurfacing treatments was 26.5% (71 of 268 cases). In MicroLaserPeel treatments the cheek area had the highest complication rate, followed by the forehead, nose, perioral, and eyelid areas, in that order (complication rate range, 0%-9.1%). In deep resurfacing treatments the perioral area had the highest complication rate, 38.6% of 145 cases. This was followed by the lids, cheek, nose, and forehead, in that order (complication rate range, 15.2%-20.9%). There is a correlation between increased depth of ablation and increased rate of complication. Conclusions The study confirmed the efficacy of Er:YAG resurfacing and provides guidance for a safer approach to excellent outcomes. Level of Evidence: 4

A multiplication sampling moire (MSM) method was proposed for robust deformation distribution measurement by performing phase analysis of the second harmonic (second-order frequency) of a single grating pattern. The MSM method has a very strong noise immunity because the second harmonic spectrum is far from the low-frequency region of the background noise in the frequency domain. Phase analysis of an experimental grid image on a carbon fiber-reinforced plastic (CFRP) specimen indicated that the MSM method effectively solved the problem of non-negligible phase measurement errors of conventional methods that extract the fundamental frequency of the grating, in the case of severe local noise. The displacement and strain distributions of CFRP in a tensile test were successfully measured. This method is suitable for deformation measurement of various composite materials.

Background The Electroretinogram is a mass potential, which reflects the summed electrical activity of the retina. Full-field ERG measures the electrical signals from the whole retina in response to a light stimulus. The weakness of the full-field ERG is that it cannot provide topographical information regarding the functional integrity of the retina and cannot detect subtle functional defects. The response is dominated by the peripheral retina due to its predominance of retinal cells. Aim of the Work to investigate the effect of axial length on fullfield (ffERG)and multifocal ERG (mfERG). Subjects and Methods Forty-four eyes of 44 healthy subjects were included in this case series study which has been conducted at Ain shams university hospitals after the approval of the research ethical committee in the faculty of medicine, Ain Shams University between July 2018 and September 2019. Full ophthalmologic examination was performed for all participants, including visual acuity assessment (Best corrected visual acuity) using Snellen chart, calculation of spherical equivalent (SE), slit Lamp biomicroscopy examination with IOP measurement via Goldmann applanation tonometry (GAT), and fundus examination by indirect ophthalmoscope or via 90 D VOLK lens to assess macular area. Axial length measurement, ffERG & mf-ERG. Results; We found that in the absence of fundus changes, mfERG parameters showed decreased amplitudes with increase in axial length. The Six- Rings Response Densities showed negative correlation with AL while there is no significant correlation between Six- Rings Response Densities and SE. The Six- Rings P1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. The Six- Rings N1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. The four- quadrant Response Densities showed negative correlation with AL while there is no significant correlation between four- quadrant Response Densities and SE. The four- quadrant P1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. The four- quadrant N1 Amplitude showed negative correlation with AL while there is no significant correlation between P1 Amplitude and SE. There is no significant correlation between full-field clinical ERG parameters and both AL and SE. Conclusion In the absence of fundus changes, mfERG parameters showed decreased amplitudes with increase in axial length. For correct interpretation of ERG responses in clinical practice, we recommend consideration of axial length measurement when evaluating mfERG responses.

The objective of this study is to characterize the mechanical performances of reclaimed asphalt pavements (RAP), at different percentages in asphalt mixtures. Six formulations R0, R10, R20, R30, R40 and R50 of the same asphalt mixture formula, a semi-coarse asphalt concrete, with a 35/50 pen bitumen were produced in Colas scientific and technical center, in Magny-les-Hameaux, by introducing 0, 10, 20, 20, 30, 40 and 50% RAP, respectively. Indirect tensile strength tests were carried out on three of these specimens (R0, R30 and R50). Stain fields were calculated using a full field measurement method, named the Grid Method (GM) to compare the behavior of the specimens. This method consists in determining and analyzing both displacement and strain fields on the surface of the specimen. Results highlight the difference in behavior between samples both at the micro- and macro-scales.

Fourier-domain full-field optical coherence tomography (FD-FF-OCT) is a fast interferometric imaging technique capable of volumetric sample imaging. However, half of the backscattered light from a sample is lost as it passes through a 50/50 beam splitter, which is at the heart of almost every interferometer. Here, it is demonstrated that this light could be extracted by spatially splitting the illumination pupil plane and detecting it with a separate camera. When a line camera is used to detect the recovered signal, it enables real-time axial imaging of the human cornea in vivo, which serves as a useful visual feedback for aligning a patient for imaging.

Purpose To describe the feasibility of peripheral OCT imaging in retinal diseases using a novel full-field device. Methods A total of 134 consecutive eyes were referred and imaged on the Optos Silverstone swept-source OCT (SS-OCT) (Optos PLC; Dunfermline, UK). Scanning laser ophthalmoscope (SLO) images and the associated SS-OCT images were obtained in the posterior pole, mid-periphery or far periphery based on the nature of the referral and on new areas of interest observed in the optomap images at the time of imaging. Results A total of 134 eyes (96 patients) were enrolled in the study. One hundred and twenty-five eyes (91 patients) with 38 retinal pathologies were prospectively assessed and 9 eyes (5 patients) were excluded due to incomplete image acquisition. The average age of the subjects was 54 years (range 21–92 years). Thirty-nine out of 125 eyes (31%) had macular pathologies. Eighty-six out of 125 eyes (69%) had peripheral only pathologies, an area which cannot be visualized by standard OCT devices with a 50 degree field-of-view. Conclusions The ability to capture peripheral pathologies using an integrated SLO-UWF imaging with full-field swept-source provided high-grade anatomical insight that confirmed the medical and surgical management in a majority of cases. Its use in the mid- and far periphery provides a holistic clinical picture, which can potentially aid in the understanding of various retinal pathologies.

State-of-the-art adaptive optics optical coherence tomography (AO-OCT) presents important limitations, such as small field-of-view (FOV) and require complex, cumbersome hardware, preventing wide clinical deployment. Here, we introduce adaptive-glasses full-field OCT (FFOCT), a compact retinal imaging system allying high resolution, high frame rate (300Hz) and 5° FOV (footprint: 50 cm × 30 cm).

In this work we explore the use of infrared deflectometry in the case of dynamic vibration measurements. This work also aims to provide a comparison of the performances and implementations of visible and infrared deflectometry with measurements conducted on a laboratory test case, a cantilever aluminium beam under impact excitation. The results obtained show that both visible and infrared deflectometry enable measurements with different time and space resolutions, and that infrared deflectometry can be effectively used to perform full-field vibration measurements on an unprepared surface. It could be simply summarized that both techniques have interesting features, and what is earned with one of these techniques is lost on the other. In fact, even if the cameras used for visible and infrared deflectometry techniques have different technical features that directly influence reachable time and space scales, a key advantage is that established methods and algorithms for images post-processing are identical between visible and infrared deflectometry. This practically broadens the range of materials and surfaces that can be tested using the deflectometry technique. The extension of this technique to curved structures is also under consideration, which should provide another additional support to a greater use of deflectometry. With the increasing performance of visible and infrared high-speed cameras combined with their decreasing cost, the measurement of space- and time-resolved experimental data using the non-contact optical deflectometry techniques opens interesting perspectives.

We demonstrate that full-field deflectometry is a viable alternative to interferometry for the characterization of free-form mirrors. Deflectometry does not require the use of a CGH. Instead of measuring the surface height map, the deflectometer measures the surface slopes in two orthogonal directions using the phase-shifting Schlieren method [1]. The surface height map is then reconstructed by integration of the slope maps. We present two instruments. The first one can be mounted in the lathe for in situ measurement. The second is adapted for the characterization of large concave mirrors.

This review presents the main findings from measurements carried out on cereals using chitosan, its derivatives, and nanoparticles. Research into the use of chitosan in agriculture is growing in popularity. Since 2000, 188 original scientific articles indexed in Web of Science, Scopus, and Google Scholar databases have been published on this topic. These have focused mainly on wheat (34.3%), maize (26.3%), and rice (24.2%). It was shown that research on other cereals such as millets and sorghum is scarce and should be expanded to better understand the impact of chitosan use. This review demonstrates that this chitosan is highly effective against the most dangerous diseases and pathogens for cereals. Furthermore, it also contributes to improving yield and chlorophyll content, as well as some plant growth parameters. Additionally, it induces excellent resistance to drought, salt, and low temperature stress and reduces their negative impact on cereals. However, further studies are needed to demonstrate the full field efficacy of chitosan.

Background Studies have reported the application of conventional optical coherence tomography (OCT) in the diagnosis of basal cell carcinoma (BCC). The new OCT provides cellular details similar to those in pathology slides and may reduce user learning time. This study aimed to demonstrate the quality of ex vivo full-field cellular-resolution OCT images and compare the diagnostic accuracy between physicians with varying pathology experience. Materials and methods Sixty histologically confirmed BCCs were selected. Tissue samples were sectioned and scanned using OCT, and their features were compared with those of hematoxylin and eosin (H&E)-stained sections. Thirty images were selected for the test administered to dermatology residents, dermatopathology fellows, and board-certified general pathologists without any OCT experience. The pretest learning included a 3-min instruction and 10-min self-study of four BCC variants. Results Histopathological BCC and normal histological features were clearly recognizable on the OCT images. The pathological BCC features observed in the OCT images correlated with those found in the H&E-stained sections. Seven participants completed the test. The correct answer rates of the residents, fellows, and pathologists were 71%, 68%, and 83% for BCC and 44%, 57%, and 57% for the BCC subtypes, respectively. Conclusion All the participants identified BCC in >70% cases with a learning time of only 13 minutes. The results indicated that cellular-resolution OCT provided high-quality images similar to the conventional pathology slides. Pathology experience did reflect the diagnostic accuracy. However, a longer training time is still needed at all levels to recognize the BCC subtypes correctly.

To investigate the accuracy of the RETeval full-field flicker ERG in the screening of diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) and to determine a suitable range of DR diagnostic reference for patients with type 2 diabetes mellitus (T2DM). This was a cross-sectional study involving 172 subjects with T2DM, including 71 subjects without clinically detectable DR (NDR), 25 subjects with mild non-proliferative diabetic retinopathy (NPDR), 24 subjects with moderate NPDR, 27 subjects with severe NPDR and 25 subjects with proliferative diabetic retinopathy (PDR). All the subjects underwent a full-field flicker ERG using the RETeval device (DR assessment protocol), which is a mydriasis-free, full-field electroretinogram (ERG) recording system. The performance of the DR assessment protocol in detecting the DR (including mild NPDR, moderate NPDR, severe NPDR and PDR) and VTDR was analyzed with the receiver operating characteristic (ROC) curve. For the detection of DR (mild NPDR, moderate NPDR, severe NPDR, PDR), the area under the ROC curve was 0.867 (p

Current vision-based displacement measurement methods have limitations such as being in need of manual targets and parameter adjustment, and significant user involvement to reach the desired result...

Background: Breast cancer in women is a major public health problem throughout the world. To reduce the morbidity and mortality associated with breast cancer, early detection becomes a very important job. Addition of breast Tomosyn-thesis to mammography examination reduced and eliminated tissue overlap especially in women with radiographically dense breast.Aim of Study: To evaluate the impact of adding Digital Breast Tomosynthesis (DBT) to Full Field Digital Mammog-raphy (FFDM) in detection, characterization and diagnosis of mammographically indeterminate breast lesions.Subjects and Methods: The study included 80 patients with 86 indeterminate findings on mammography. DBT ex-amination was done and imaging findings were evaluated before and after the use of DBT.Results: Tomosynthesis showed better diagnostic perform-ance compared to mammography. The sensitivity of Tomo-synthesis was 90%, the specificity was 91.1%, the positive predictive value of 88%, the negative predictive value was 92.7% and the diagnostic accuracy was 91%, while the sensi-tivity of mammography was 62.5%, the specificity was 59%, the positive predictive value was 52.1%, the negative predictive value was 68.8%, and the diagnostic accuracy was 60.4%.Conclusion: DBT significantly enhanced the detection and characterization of indeterminate breast lesions on digital mammography especially in the context of dense breast parenchyma.

Background: Dual Energy Contrast Enhanced Spectral Mammography (DE-CESM) is a new and advanced clinical application of full field (FFDM) and is easily implemented, fast, and reproducible, and breast doses are comparable to those of standard digital mammography, it might be useful for shifting expensive MRI to digital mammography.Aim of Study: To evaluate the enhancing power of the Contrast-Enhanced Spectral Mammography (CESM) on breast lesions and its ability to differentiate malignant from benign masses.Patients and Methods: A prospective study was carried on 20 patients referred to Radio-Diagnosis Department. At the Air Forces Hospital over 12 months for the evaluation of breast masses, all patients were examined by a dual energy contrast enhanced spectral mammography, a complementary B-mode ultrasound and a histopathological examination of all masses.Results: The study included 8 benign (40%) and 12 malignant (60%) masses, 17/20 (85%) of them were enhanced while 3/20 (15%) were not enhanced. The enhanced masses were further subdivided into faint & avid enhancement as well as homogenous, heterogeneous & ring enhancement. Contrast uptake was significantly more frequent by malignant masses (p-value

Optical method has been playing an important role in measuring temperature and deformation at elevated temperatures. Here we propose a simple and effective iterative algorithm to realize accurate and simultaneous measurement of the full-field temperature and deformation of specimens subjected to flame heating at temperatures up to 1000 °C. The algorithm separates the optical images of specimen surface into radiant and reflected parts. The radiant part is used to calculate the full-field temperature by an improved two-color method, and the reflected part is used to obtain the deformation of the specimen surface based on high-temperature digital image correlation method. Experimental validation shows that the proposed method can effectively eliminate the mutual interference between the radiation and reflected light, displaying great potential for synchronous measurement of temperature and deformation with sufficient accuracy by using one camera.

Accurately measured strains are critical when investigating the application of Fiber Reinforced Polymer (FRP) materials, but traditional mechanical strain measurement methods have several critical drawbacks related to the installation process and the recording capabilities of the devices. FRP materials typically used in the civil engineering field feature large asymmetries and heterogeneity originated from the manual installation procedures, as opposed to the highly controlled FRP fabrication methods used in other fields that result in more homogeneous materials. The feasibility of using an optical full-field Digital Image Correlation (DIC) technique for measurement of strain fields on FRP materials used in the civil engineering industry has been investigated and the level of error in the DIC method when using more traditional methods was determined. The main advantage of using DIC over more traditional methods, which is the capacity of DIC to measure full field strains instead of strains at isolated points, has been demonstrated by providing exemplar measurements of various specimens of FRP materials. The reported strain fields are examples of what was obtained during an experimental campaign to understand the behavior of FRP anchors and other materials. The main conclusions drawn from the observation of those strain fields are discussed.

Background: Intraoperative pathological diagnosis such as frozen section and imprint cytology is not routinely recommended in clinical practice because of time and accuracy concerns. Full-field optical coherence tomography (FF-OCT) is a new optical imaging technique that could generate sectioning tomogram from fresh tissue and provide depiction of the morphological structure and pathological changes in minutes without conventional tissue preparation, slicing, and staining, and dynamic cell imaging (DCI) added the viability information of cells/tissue, which could be more important in cancer diagnosis. This study was to evaluate the feasibility and diagnostic value of FF-OCT and DCI in breast lesions and lymph node specimens during breast cancer surgery. Methods: We evaluated normal breast tissue, benign breast lesions, breast cancer and axillary lymph node specimens from 107 patients using FF-OCT and DCI. After the optical assessment, the tissue was paraffin embedded and sent to conventional H&E diagnosis. The similar layer of OCT and H&E images were compared and diagnostic criteria were generated. The diagnostic sensitivity and specificity by two trained surgeons without pathology diagnosis experience were evaluated. Results: A total of 194 specimens were examined, including 143 breast tissue(101 malignant and 42 benign/normal) and 51 lymph nodes(26 metastatic and 25 non-metastatic). On FF-OCT and DCI, normal morphological structures such as adipose, collagen, mammary ducts, and lobules in breast tissue and lymphoid follicle and hilum in lymph nodes were easily recognized. Breast cancer characteristics on H&E imaging correspond to collagen distortion, focal hypointensity, micro-calcification, clustered or linear lively cells et etc on FF-OCT or DCI, which could also be easily distinguished. We included the previously mentioned features to build diagnosis criteria for cancer on FF-OCT and DCI. The average acquisition time is 14±11 minutes. The sensitivity and specificity for breast cancer diagnosis were 92.1% and 94.3% respectively. The sensitivity and specificity for lymph node involvement were 92.3% and 84% respectively. Conclusion: The time- and tissue-saving optical imaging technique yielded high accuracy that was comparable to that of traditional intraoperative and postoperative pathological diagnosis in breast cancer and lymph node metastasis. These results implied the promising application in the intraoperative evaluation and possible decrease of the re-excision rate for breast cancer surgery. Citation Format: Yang H, Zhang S, Guo J, Xie F, Tong F, Cao Y, Liu P, Zhou B, Cheng L, Liu M, Wang S, Peng Y, Wang C, Yang Y, Ma Y, Chen D, Shen D, Wang S. Achiveing rapid intrao-operative diagnosis during breast cancer surgery using high-reloution full-field optical coherence imaging and dynamic cell imaging [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P2-14-18.

This paper presents a non-contact 3D deformation measurement method based on binocular vision. The proposed method was tested in the determination of the deformation and strain of concrete-filled steel tubes. Based on the proposed image-processing algorithm and the principle of 3D deformation measurement, the least-square-based circle-fitting algorithm was presented in this article and was applied to binocular vision systems for the static and dynamic collection of full-field 3D deformation data in concrete-filled steel tubular columns. Three-dimensional reconstruction was performed, and the results obtained were compared with those of a contact measuring tool. The test results showed that the mean relative errors of the maximum convex diameter in the visual static and dynamic measurements were 0.19% and 0.33%, respectively, and the mean relative error in the full-field strain in the visual measurement was between 0.20% and 0.49%, which shows that the proposed visual method comprehensively reflects the deformation process and full-field strain values of the components under engineering ISO Tolerance (IT7) accuracy requirements. This method can be used as a reasonable alternative to traditional contact measuring methods.

The increased use of optical measurement techniques in industrial environments has the potential to increase knowledge and creates an opportunity for a more comprehensive validation of computational predictions. In this paper, a quantitative validation methodology is applied to a 1 m × 1 m panel from an aircraft fuselage subject to compression and torsion, in order to evaluate the predicted response of the panel. A test matrix with four loading cases, namely pre-buckling and post-buckling compression with and without torsion, was used to demonstrate the capabilities of the validation methodology on the industrial component. The out-of-plane displacement fields were analysed with the aid of image decomposition and a validation process was successfully performed using a quantitative metric. The feature vectors, obtained through image decomposition, representing the surface curvature of the physical and virtual specimens were analysed to assess the similarity of the component’s overall curvature. Then, the feature vectors representing measured and predicted displacements for the four loading cases were used to analyse the deformed shapes and conduct a validation process for the simulation outcomes. The predictions of the deformation of the fuselage panel were found to have a high probability of representing the measured data.

In this work, we present a novel application of the full-field energy-dispersive X-ray fluorescence (EDXRF) imaging system based on a MicroPattern Gaseous Detector (2D-THCOBRA) in the cultural heritage field. The detector has an intrinsic imaging capability with spatial resolution of $$400\,{\upmu }\mathrm { m}\ \mathrm {FWHM}$$ , and is energy sensitive, presenting an energy resolution of approximately $$1\ \mathrm {keV\ FWHM}$$ at $$5.9\ \mathrm {keV}$$ . The full-field XRF scanner based on the 2D-THCOBRA detector allows mapping the distribution of elements in large area samples with high detection efficiency ( $$75\%$$ at $$5.9\ \mathrm {keV}$$ ), being a very promising choice for elemental mapping analysis of large area cultural heritage samples. In this work, we have demonstrated the imaging capabilities of the full-field XRF scanner and used it to assess the restoration of a Portuguese faience piece.

International audience; The highest three-dimensional (3D) resolution possible in in-vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics. However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. Here, we mitigate these limitations by combining our compact time-domain full-field OCT (FFOCT) with a multi-actuator adaptive lens positioned just in front of the eye, in a technique we call the adaptive-glasses wavefront sensorless approach. Through this approach, we demonstrate that ocular aberrations can be corrected, increasing the FFOCT signal-to-noise ratio and enabling imaging of different retinal layers with a 2µm × 2µm × 8µm resolution over a 5 o × 5 o field-of-view, without major anisoplanatism influence.; La plus haute résolution tridimensionnelle (3D) possible en imagerie rétinienne in vivo est obtenue en combinant la tomographie par cohérence optique (OCT) et l'optique adaptative. Toutefois, cette combinaison présente des limites importantes, comme un champ de vision réduit et des systèmes complexes et encombrants, ce qui empêche jusqu'à présent la transposition de cette technologie du laboratoire de recherche aux cliniques. Ici, nous atténuons ces limitations en combinant notre OCT compacte à plein champ dans le domaine temporel (FFOCT) avec une lentille adaptative à actionneurs multiples placée juste devant l'œil, dans une technique que nous appelons l'approche des lunettes adaptatives. Grâce à cette approche, nous démontrons que les aberrations oculaires peuvent être corrigées, augmentant le rapport signal/bruit de la FFOCT et permettant l'imagerie de différentes couches de la rétine avec une résolution de 2µm x 2µm x 8µm sur un champ de vision de 5° x 5°, sans influence majeure d'anisoplanatisme.

Optical coherence tomography is widely used in the non-invasive detection of skin cancer. We are proposing an image guiding system integrated in a full-field OCT (FF-OCT) system and an image matching algorithm to register the guiding image onto a dermoscopic image. This guiding system takes the objective optics of FF-OCT system to observe the same vision with OCT. The FOV of the guiding image and FF-OCT is 2*2mm2 and 500*500μm2 respectively. The spatial relation between OCT and the guiding image system is fixed, the OCT imaging location can also be identified. The guiding image is then matched into the clinically used dermoscopic image which has a 20*20 mm2 FOV by an image matching algorithm. The FF-OCT image can be registered on the dermoscopic image through the guiding image. This allows physicians to target the scanning area precisely in the lesion, and record the scanned point to confirm the full lesion. This invention improves the efficiency of the entire examination and allows to follow-ups the lesion at different time.

The treatment of macular diseases requires frequent monitoring by optical coherence tomography (OCT). Home monitoring would reduce the burden of frequent clinical visits and increase therapy adherence. In a pilot study with 47 patients having different macular diseases we tested a proprietary self-examination low-cost full-field OCT (SELFF-OCT). For comparison, scans with a standard clinical spectral domain OCT were taken. Data was graded by a reading center. Patients were able to successfully acquire images that were clinically gradable for 85% of the included eyes. The sensitivity and specificity for an anti-VEGF treatment decision based on the SELFF-OCT was 0.94 and 0.95, respectively.

Off-axis full-field OCT is intended to enable cost-effective imaging of the retina for home diagnosis. Different to common FD-OCT systems, the lateral field of view is acquired in a single shot and the different axial layers are acquired sequentially. During acquisition, motion of the eye results in motion artifacts and misaligned layers. We present a method to track the axial and lateral position of the retina by analyzing the angle and divergence of the backscattered light with a lateral precision of 3.6 µm and an axial precision of 29 µm. This information can be used to correct motion induced errors.

The generation of an optical supercontinuum with short (fs) input pulse duration is a highly complex process that exhibits rich nonlinear dynamics. Here, we show that one can teach a machine learning model to learn the nonlinear dynamics of ultrashort pulse propagation and predict the full-field propagation dynamics of supercontinuum based only on the input pulse characteristics (peak power, duration and chirp).

Dynamic-focusing optical coherence tomography (OCT) can provide ~1-μm isotropic resolution in extended depth of field, and Mirau design is preferred because of lower weight. In previous works, we reported a Mirau-type OCT based on high-radiance spatially-incoherent source. However, the illumination intensity is limited by the etendue. Besides, coherent artifacts increases with the partially coherent illumination scheme. In this report, we introduce a method to narrow illumination linewidth to 5 μm and reduce coherence area to 1 μm2. With spatially incoherent illumination, optimized throughput and low-weight design, low-speckle B-scan can be acquired within 0.25 second.

Visualizing and measuring thin-film thickness at the nanoscale during dynamic evolution has been an open challenge for long term. Here, a joint-imaging method and the thereof innovative procedure are presented for merging digital holography (DH) and white light colorimetric interferometry (WLCI) measurement data in a single intelligent tool. This approach allows a complete quantitative study of the dynamic evolution of freestanding thin films under high spatial resolution and full-field modality over a large area. By merging interferometric and holographic fringes, it is possible to overcome the lack of DH in thickness measurements of ultrathin layers, providing a reliable reference for full-field quantitative mapping of the whole film with interferometric accuracy. Thanks to the proposed approach, the time-related and concentration-related evolution of surfactant film thickness can be studied. The thickness distribution curves reveal the small changes in the film thickness with time and concentration. The reported tool opens a route for comprehending deeply the physics behind the behavior of freestanding thin liquid films as it provides an in situ, continuous monitoring of film formation and dynamic evolution without limits of thickness range and in full-field mode. This can be of fundamental importance to many fields of applications, such as fluids, polymers, biotechnology, bottom-up fabrication, etc.

We present an optimized Fourier-domain full-field optical coherence tomography system for corneal in vivo imaging that uses a line camera for real-time cross-sectional preview and a multimode fiber for preventing retinal damage.

We present a simple computational method for full-field, segmentation-free Fourier-ptychographic reconstruction, which requires only two multiplications prior and after the reconstruction. This way, quantitative widefield reconstruction is possible even in the presence of illumination curvature.

A laser heterodyne vibrometry using high-speed camera is proposed for full-field vibration measurement. A demodulation method is designed to mitigate the speckle noise. The experiment results are verified by the result from a LDV.

Purpose The purpose of this study was to investigate cone function deterioration in patients with retinitis pigmentosa (RP) using full field electroretinogram (ffERG), pattern electroretinogram (pERG), and optical coherence tomography (OCT) and their correlation with visual acuity (VA). Methods Clinical records (2008-2018) of patients with RP undergoing repeat electrophysiology were reviewed. Results of ffERG (30 Hz flicker and fused flicker amplitude [FFAmp]), pERG [p50 and n95], and macular OCT (ellipsoid zone [EZ] and outer segment thickness) were collected. Results One hundred twenty-six eyes from 63 patients (33 women, mean age 35 years) were included. The mean decline in VA was 0.11 ± 0.14 logarithm of minimum angle of resolution (logMAR). The FFAmp decreased by 3.01 ± 5.9 µV with global cone function deteriorating by 18.7% annually. The percentage change in FFAmp (RE [r = 0.553], LE [r = 0.531]), and 30 Hz flicker amplitude (RE [r = 0.615], LE [r = 0.529]) strongly correlated with VA (P < 0.00001). The pERG p50 (15 and 30 degrees) change analyzed in 34 patients showed reduction by 23% and 23.4%, respectively. The percentage change in p50 30 degrees (r = 0.397) correlated with VA and EZ layer (P < 0.05). The EZ layer change was calculated in 45 patients and the shortening and thinning rate was 4.3% and 4.4% annually, respectively. The EZ length percentage change correlated with VA (RE [r = 0.34] and LE [r = 0.466; P < 0.05). Conclusions We quantified the decline in cone function in patients with RP utilizing ffERG and FFAmp measures of residual cone function. These parameters correlated with VA and OCT when measurable. These objective measures may assist in monitoring disease progression. Translational Relevance Residual cone function provides an objective estimate of residual visual function, which aids in counselling patients regarding prognosis.

Disease mechanisms have become better understood in previously incurable forms of early-onset severe retinal dystrophy, such as Leber congenital amaurosis (LCA). This has led to novel treatments and clinical trials that have shown some success. Standard methods to measure vision were difficult if not impossible to perform in severely affected patients with low vision and nystagmus. To meet the need for visual assays, we devised a psychophysical method, which we named full-field stimulus testing (FST). From early versions based on an automated perimeter, we advanced FST to a more available light-emitting diode platform. The journey from invention to use of such a technique in our inherited retinal degeneration clinic is reviewed and many of the lessons learned over the 15 years of application of FST are explained. Although the original purpose and application of FST was to quantify visual thresholds in LCA, there are rare opportunities for FST also to be used beyond LCA to measure aspects of vision in other inherited retinal degenerations; examples are given. The main goal of the current review, however, remains to enable investigators studying and treating LCA to understand how to best use FST and how to reduce artefact and confounding complexities so the test results become more valuable to the understanding of LCA diseases and results of novel interventions.

In order to overcome the coherence-induced artifacts, the illumination heterogeneity as well as a limited dynamic range when using full-field technique, a solution employing a galvanometric beam-steering is proposed, demonstrating the possibility for real-time imaging in terahertz domain. Working toward industrial applications, different imaging illumination process, including Lissajous pattern for fast beam steering, are evaluated thanks to the versatility of the lighting method.