1. Retinal imaging in Alzheimer's and neurodegenerative diseases
- Author
-
Heather M. Snyder, Lisa J. Bain, Emily Y. Chew, Peter J. Snyder, Melanie C. W. Campbell, Brett E. Bouma, Brian M. Fernandez, Jessica Alber, Chiara La Morgia, Peter van Wijngaarden, Roxana O. Carare, Michael R. Dueñas, Femke H. Bouwman, Maria C. Carrillo, Delia Cabrera DeBuc, Clemens Alt, M Francesca Cordeiro, Maya Koronyo-Hamaoui, Srinivas R. Sadda, and St Marys Development Trust
- Subjects
0301 basic medicine ,Epidemiology ,PROGRESSION ,Disease ,BLOOD-BASED BIOMARKERS ,chemistry.chemical_compound ,0302 clinical medicine ,early detection ,Aged, 80 and over ,Health Policy ,Neurodegeneration ,neurodegeneration ,Brain ,Neurodegenerative Diseases ,Alzheimer's disease ,Middle Aged ,eye ,Psychiatry and Mental health ,retinal imaging ,Retinal imaging ,Life Sciences & Biomedicine ,Clinical Neurology ,Context (language use) ,Retina ,Article ,03 medical and health sciences ,Cellular and Molecular Neuroscience ,AGE ,Developmental Neuroscience ,Disease severity ,Alzheimer Disease ,medicine ,Dementia ,Humans ,Aged ,Science & Technology ,Modalities ,business.industry ,1103 Clinical Sciences ,Retinal ,medicine.disease ,DEFINITION ,030104 developmental biology ,chemistry ,Geriatrics ,Neurosciences & Neurology ,Neurology (clinical) ,Geriatrics and Gerontology ,1109 Neurosciences ,business ,Neuroscience ,030217 neurology & neurosurgery ,Biomarkers - Abstract
In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying biological changes associated with AD, and for tracking progression of disease severity over time. As different retinal imaging modalities provide different types of structural and/or functional information, the discussion reflected on these modalities and their respective strengths and weaknesses. Discussion further focused on the importance of defining the context of use to help guide the development of retinal biomarkers. Moving from research to context of use, and ultimately to clinical evaluation, this article outlines ongoing retinal imaging research today in Alzheimer's and other brain diseases, including a discussion of future directions for this area of study.
- Published
- 2020