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1. Strategy and technique for colostomy reversal by laparoscopy after left colectomy with end colostomy (Hartmann procedure)

Author: J.-M. Regimbeau, B. Brac, and Charles Sabbagh
Subjects: Reoperation, medicine.medical_specialty, medicine.diagnostic_test, business.industry, medicine.medical_treatment, Anastomosis, Surgical, Left colectomy, Colostomy, General Medicine, Surgery, Colostomy reversal, medicine, Humans, Laparoscopy, business, Colectomy
Published: 2021
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2. Stratégie et technique pour le rétablissement de la continuité par cœlioscopie après colectomie gauche avec colostomie terminale (intervention de Hartmann)

Author: B. Brac, J.-M. Regimbeau, and Charles Sabbagh
Subjects: business.industry, Medicine, Surgery, business
Published: 2021
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3. Is There an Impact of the Duration of Antibiotic Therapy on the Outcome of Nonsurgical Treatment of Complicated Diverticulitis?

Author: Baptiste Brac, Iman Khaoudy, Charles Sabbagh, and Jean-Marc Regimbeau
Subjects: Adult, Male, medicine.medical_specialty, Multivariate analysis, medicine.drug_class, Antibiotics, Diverticulitis, Colonic, medicine, Humans, Abscess, Diverticulitis, Aged, Retrospective Studies, Univariate analysis, business.industry, Retrospective cohort study, General Medicine, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Anti-Bacterial Agents, Surgery, Treatment Outcome, Acute Disease, Drainage, business
Abstract: BACKGROUND Patients treated nonsurgically for complicated diverticulitis are managed by antibiotics. However, there are no recommendations concerning their duration. We aimed to determine the impact of the duration of antibiotic therapy on the risk of failure of nonsurgical treatment of complicated acute diverticulitis. PATIENTS AND METHODS This was a single-center retrospective study of patients with computer tomography (CT)-diagnosed complicated diverticulitis between January 2015 and April 2020. Treatment failure was defined as early recurrence and/or a persistent abscess by control CT. RESULTS In total, 148 patients fulfilled the inclusion criteria [87 men (58.8%), mean age 55±15 y]. The diverticulitis was classified as Hinchey I in 41.9%, Hinchey II in 9.5%, and pericolic free air in 48.6% of cases. The median abscess size was 2.9±1.7 cm. The median duration of antibiotic treatment was 10±4.2 days. The median follow-up was 64±60 months. The rate of failure was 12.8%. In univariate analysis, treatment >10 days (P=0.015) and an abscess >3 cm (P=0.032) were associated with a risk of treatment failure. In multivariate analysis, only the diameter of the abscess remained associated with a risk of failure (odds ratio: 1.6, 95% confidence interval: 1.09-2.4, P=0.01). CONCLUSION This study suggests that there is no need to extend the duration of antibiotic treatment beyond 10 days in nonsurgically treated complicated acute diverticulitis.
Published: 2021
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4. Is There an Optimal Definition for a Positive Circumferential Resection Margin in Locally Advanced Esophageal Cancer?

Author: Clarisse Eveno, Florence Renaud, Christophe Mariette, Hélène Behal, Emmanuelle Leteurtre, Guillaume Piessen, B. Brac, Charlotte Dufour, M. Vanderbeken, Julien Labreuche, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), Université de Picardie Jules Verne (UPJV), Hôpital Claude Huriez [Lille], CHU Lille, Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 (CANTHER), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 (JPArc), Université Lille Nord de France (COMUE)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille, Department of Digestive and Oncological Surgery [Lille], and CHU Lille-CHU Lille-Université de Lille
Subjects: medicine.medical_specialty, animal structures, Multivariate analysis, Esophageal Neoplasms, [SDV]Life Sciences [q-bio], Locally advanced, Surgical oncology, medicine, Humans, Cutoff, Neoplasm Staging, Retrospective Studies, integumentary system, Rectal Neoplasms, business.industry, fungi, Hazard ratio, Margins of Excision, food and beverages, Esophageal cancer, Prognosis, medicine.disease, Esophagectomy, Oncology, embryonic structures, Resection margin, Adenocarcinoma, Surgery, Radiology, Neoplasm Recurrence, Local, business
Abstract: International audience; Background: Two definitions of a positive circumferential resection margin (CRM) in esophageal cancer coexist: one by the College of American Pathologists (CAP) (CRM = 0 mm) and another by the Royal College of Pathologists (RCP) (CRM = pT3) adenocarcinoma or squamous cell carcinoma were selected from 2007 to 2016. The CRM was reassessed using an ocular micrometer. Overall survival (OS) and disease-free survival were estimated with uni- and multivariate analyses. Results The study enrolled 283 patients: 48 with a positive CRM according to the CAP definition and 171 with a positive CRM according to the RCP definition. In the multivariate analysis, a positive CRM according to both definitions was significantly associated with a poor OS (CAP: hazard ratio [HR], 2.26, p < 0.001; RCP: HR, 1.42, p = 0.035). A CRM of 0 mm was predictive of a worse OS and DFS than a CRM of 1 mm or less (p < 0.0001), whereas no significant difference was found between a CRM greater than 1 mm and a CRM of 1 mm or less, indicating that the CAP definition was more accurate for predicting prognosis and recurrence. New cutoff CRM values of 100 mu m in squamous cell carcinoma and 200 mu m in adenocarcinoma were optimal for predicting OS. Conclusion The CAP definition was more accurate for predicting prognosis and recurrence. The study identified a new cutoff value of CRM according to histologic type.
Published: 2021
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5. Anastomose hépaticojéjunale sur le segment III pour sténose biliaire complexe après hépatectomie droite

Author: H. Defives, B. Brac, and J.-M. Regimbeau
Subjects: business.industry, Medicine, Surgery, business
Published: 2022
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6. Adherence to growth hormone therapy guidelines in a real-world French cohort of adult patients with growth hormone deficiency

Author: Aude Brac de la Perriere, Beatrice Villette, Françoise Borson-Chazot, Olivier Chabre, Yves Reznik, Evguenia Hacques, Véronique Kerlan, Marc Klein, and Sylvie Salenave
Subjects: Adult, Male, Pediatrics, medicine.medical_specialty, Waist, Adolescent, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Growth hormone, Hypopituitarism, Growth hormone deficiency, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Patient age, medicine, Humans, Drug Dosage Calculations, Practice Patterns, Physicians', Aged, Dose-Response Relationship, Drug, Adult patients, Human Growth Hormone, business.industry, General Medicine, Middle Aged, medicine.disease, Clinical trial, Somatropin, 030220 oncology & carcinogenesis, Cohort, Female, France, Guideline Adherence, business, Follow-Up Studies
Abstract: Objective Using real-world data from patients with growth hormone deficiency (GHD), we evaluated whether clinical practice in France adheres to international guidelines regarding somatropin dose adjustment, and assessed the long-term effectiveness and safety of somatropin. Methods Data were obtained from a national prospective systematic longitudinal routine follow-up programme of naive/non-naive adults with childhood-onset (CO) or adult-onset (AO) GHD treated with Norditropin® (Novo Nordisk A/S). Results Between 2003 and 2006, 331 treatment-naive and non-naive adults with severe GHD were enrolled and followed for a median duration of approximately 5 years; 328 patients were available for analysis. At baseline, mean patient age was 39.2 years; median standard deviation score (SDS) for insulin-like growth factor−1 (IGF-1) level was −2.2 in naive patients, subsequently fluctuating between −0.1 and +0.3 SDS during the study period. Mean GH doses ranged between 0.25 and 0.51 mg/day (naive patients) and 0.39 and 0.46 mg/day (non-naive patients). Despite generally receiving a higher somatropin dose, women (naive/non-naive) tended to have lower IGF-1 levels than men. Median somatropin dose was consistently higher in patients with CO-GHD than patients with AO-GHD. Extreme IGF-1 values ( + 2 SDS) were not systematically accompanied by somatropin dose adjustments. Waist circumference improved in approximately one third of patients, at a mean 3.5 years. Somatropin was well tolerated; there were no cardiovascular or cerebrovascular events during the 5-year analysis period. Conclusion Current clinical practice of physicians in France follows international guidelines regarding somatropin dose adjustment in adults with GHD. However, dose adjustments are not always sufficient, notably in women, and treatment effects may have been delayed due to low somatropin dose (Clinical trial registration NCT01580605 ).
Published: 2021
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7. Electrically injected parity-time symmetric distributed feedback laser diodes (DFB) for telecom applications

Author: Anatole Lupu, Vincent Brac de la Perrière, Quentin Gaimard, Abderrahim Ramdane, and Henri Benisty
Subjects: Physics, Distributed feedback laser, business.industry, QC1-999, distributed feedback lasers, complex-coupled laser diodes, Physics::Optics, parity-time symmetry, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, 0103 physical sciences, Optoelectronics, Electrical and Electronic Engineering, 010306 general physics, 0210 nano-technology, Parity (mathematics), business, optical feedback, Biotechnology, Diode
Abstract: The new paradigm of parity-time symmetry in quantum mechanics has readily been applied in the field of optics with numerous demonstrations of exotic properties in photonic systems. In this work, we report on the implementation of single frequency electrically injected distributed feedback (DFB) laser diodes based on parity-time symmetric dual gratings in a standard ridge waveguide configuration. We demonstrate enhanced modal discrimination for these devices as compared with index or gain coupled ones, fabricated in the same technology run. Optical transmission probing experiments further show asymmetric amplification in the light propagation confirming the parity-time symmetry signature of unidirectional light behavior. Another asset of these complex coupled devices is further highlighted in terms of robustness to optical feedback.
Published: 2021
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8. Colectomie gauche en urgence avec colostomie terminale (intervention de Hartmann)

Author: B. Brac, Charles Sabbagh, J.-M. Regimbeau, CHU Amiens-Picardie, Simplification des soins chez les patients complexes - UR UPJV 7518 (SSPC), and Université de Picardie Jules Verne (UPJV)
Subjects: 03 medical and health sciences, 0302 clinical medicine, business.industry, [SDV]Life Sciences [q-bio], Medicine, 030211 gastroenterology & hepatology, Surgery, 030230 surgery, business
Published: 2020
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9. Female sex and angiotensin-converting enzyme (ace) insertion/deletion polymorphism amplify the effects of adiposity on blood pressure

Author: Martina Chiriacò, Domenico Tricò, Simone Leonetti, John R. Petrie, Beverley Balkau, Kurt Højlund, Zoltan Pataky, Peter M Nilsson, Andrea Natali, R.J. Heine, J. Dekker, S. de Rooij, G. Nijpels, W. Boorsma, A. Mitrakou, S. Tournis, K. Kyriakopoulou, P. Thomakos, N. Lalic, K. Lalic, A. Jotic, L. Lukic, M. Civcic, J. Nolan, T.P. Yeow, M. Murphy, C. DeLong, G. Neary, M.P. Colgan, M. Hatunic, T. Konrad, H. Böhles, S. Fuellert, F. Baer, H. Zuchhold, A. Golay, E. Harsch Bobbioni, V. Barthassat, V. Makoundou, T.N.O. Lehmann, T. Merminod, C. Perry, F. Neary, C. MacDougall, K. Shields, L. Malcolm, M. Laakso, U. Salmenniemi, A. Aura, R. Raisanen, U. Ruotsalainen, T. Sistonen, M. Laitinen, H. Saloranta, S.W. Coppack, N. McIntosh, J. Ross, L. Pettersson, P. Khadobaksh, M. Laville, F. Bonnet, A. Brac de la Perriere, C. Louche-Pelissier, C. Maitrepierre, J. Peyrat, S. Beltran, A. Serusclat, R. Gabriel, E.M. Sánchez, R. Carraro, A. Friera, B. Novella, P. Nilsson, M. Persson, G. Östling, O. Melander, P. Burri, P.M. Piatti, L.D. Monti, E. Setola, E. Galluccio, F. Minicucci, A. Colleluori, M. Walker, I.M. Ibrahim, M. Jayapaul, D. Carman, C. Ryan, K. Short, Y. McGrady, D. Richardson, H. Beck-Nielsen, P. Staehr, V. Vestergaard, C. Olsen, L. Hansen, G.B. Bolli, F. Porcellati, C. Fanelli, P. Lucidi, F. Calcinaro, A. Saturni, E. Ferrannini, E. Muscelli, S. Pinnola, M. Kozakova, A. Casolaro, B.D. Astiarraga, G. Mingrone, C. Guidone, A. Favuzzi, P. Di Rocco, C. Anderwald, M. Bischof, M. Promintzer, M. Krebs, M. Mandl, A. Hofer, A. Luger, W. Waldhäusl, M. Roden, J.M. Dekker, A. Mari, J. Petrie, P. Gaffney, G. Boran, A. Kok, S. Patel, A. Gastaldelli, D. Ciociaro, M.T. Guillanneuf, L. Mhamdi, L. Landucci, S. Hills, L. Mota, G. Pacini, C. Cavaggion, A. Tura, and S.A. Hills
Subjects: Adult, Male, medicine.medical_specialty, Genotype, Blood Pressure, Peptidyl-Dipeptidase A, Polymorphism, Single Nucleotide, Body Mass Index, angiotensin-converting enzyme, Sex Factors, INDEL Mutation, Polymorphism (computer science), Internal medicine, Internal Medicine, Sex characteristics, Medicine, Insertion deletion, Humans, Genetic Predisposition to Disease, Body mass index, Adiposity, biology, business.industry, Female sex, Angiotensin-converting enzyme, Middle Aged, Pathophysiology, Endocrinology, Blood pressure, Hypertension, biology.protein, Waist circumference, Female, sex characteristics, Waist Circumference, business, adiposity, blood pressure, body mass index, waist circumference
Abstract: The pathophysiological link between adiposity and blood pressure is not completely understood, and evidence suggests an influence of sex and genetic determinants. We aimed to identify the relationship between adiposity and blood pressure, independent of a robust set of lifestyle and metabolic factors, and to examine the modulating role of sex and Angiotensin-Converting Enzyme (ACE) insertion/deletion (I/D) polymorphisms. In the Relationship Between Insulin Sensitivity and Cardiovascular Disease (RISC) study cohort, 1211 normotensive individuals, aged 30 to 60 years and followed-up after 3.3 years, were characterized for lifestyle and metabolic factors, body composition, and ACE genotype. Body mass index (BMI) and waist circumference (WC) were independently associated with mean arterial pressure, with a stronger relationship in women than men (BMI: r =0.40 versus 0.30; WC: r =0.40 versus 0.30, both P ID and II ACE genotypes in both sexes ( P ACE genotype only in women ( P =0.03). A 5 cm larger WC at baseline increased the risk of developing hypertension at follow-up only in women (odds ratio, 1.56 [95% CI, 1.15–2.10], P =0.004) and in II genotype carriers (odds ratio, 1.87 [95% CI, 1.09–3.20], P =0.023). The hypertensive effect of adiposity is more pronounced in women and in people carrying the II variant of the ACE genotype, a marker of salt sensitivity.
Published: 2022
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10. Phase 3 and extension study of modified-release hydrocortisone in the treatment of congenital adrenal hyperplasia

Author: Monica Stikkelbroeck, Deborah P Merke, Aled Rees, Kerry Maltby, Wiebke Arlt, la Perriere Aude Brac de, Nicole Reisch, Anders Juul, Peter Treasure, Alexander Lewis, John Porter, Colin Perry, Philippe Touraine, Alessandro Prete, Angelica Lindén Hirschberg, Richard J. Ross, John Newell-Price, and Ashwini Mallappa
Subjects: medicine.medical_specialty, Endocrinology, business.industry, Internal medicine, Extension study, Phase (matter), medicine, Congenital adrenal hyperplasia, medicine.disease, business, Hydrocortisone, medicine.drug
Published: 2021
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11. Hepatico-jejunal anastomosis on segment III for complex biliary stricture after right hepatectomy

Author: B. Brac, J.-M. Regimbeau, and H. Defives
Subjects: medicine.medical_specialty, Cholestasis, business.industry, medicine.medical_treatment, Anastomosis, Surgical, Anastomosis, Roux-en-Y, General Medicine, Constriction, Pathologic, Surgery, Hepatico-jejunal anastomosis, Biliary Tract Surgical Procedures, Medicine, Hepatectomy, Humans, business
Published: 2021

12. Exposure to Glucocorticoids in the First Part of Fetal Life is Associated with Insulin Secretory Defect in Adult Humans

Author: Tiphaine Vidal-Trecan, B. Blondeau, Véronique Tardy-Guidollet, Jean-Pierre Riveline, Baz Baz, Sabrina Fetita, Philippe Boudou, Fidaa Ibrahim, Yves Morel, J.-L. Nguewa, Eric Vicaut, Aude Brac de la Perriere, Jean-François Gautier, and Bernadette Breant
Subjects: Adult, Blood Glucose, Male, 0301 basic medicine, medicine.medical_specialty, Offspring, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, 030209 endocrinology & metabolism, Biochemistry, Dexamethasone, Islets of Langerhans, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Pregnancy, Risk Factors, Internal medicine, Insulin Secretion, Humans, Insulin, Medicine, Glucocorticoids, Fetal Therapies, Fetus, Adrenal Hyperplasia, Congenital, business.industry, Biochemistry (medical), Glucagon secretion, Glucose Tolerance Test, Virilism, 030104 developmental biology, Diabetes Mellitus, Type 2, Case-Control Studies, Prenatal Exposure Delayed Effects, Glucose Clamp Technique, Gestation, Female, business, Body mass index, Glucocorticoid, medicine.drug
Abstract: Objective High glucocorticoid levels in rodents inhibit development of beta cells during fetal life and lead to insulin deficiency in adulthood. To test whether similar phenomena occur in humans, we compared beta-cell function in adults who were exposed to glucocorticoids during the first part of fetal life with that of nonexposed subjects. Research Design and Methods The study was conducted in 16 adult participants exposed to glucocorticoids during the first part of fetal life and in 16 nonexposed healthy participants with normal glucose tolerance who were matched for age, sex, and body mass index (BMI). Exposed participants had been born to mothers who were treated with dexamethasone 1 to 1.5 mg/day from the sixth gestational week (GW) to prevent genital virilization in children at risk of 21-hydroxylase deficiency. We selected offspring of mothers who stopped dexamethasone before the 18th GW following negative genotyping of the fetus. Insulin and glucagon secretion were measured during an oral glucose tolerance test (OGTT) and graded intravenous (IV) glucose and arginine tests. Insulin sensitivity was measured by hyperinsulinemic-euglycemic-clamp. Results Age, BMI, and anthropometric characteristics were similar in the 2 groups. Insulinogenic index during OGTT and insulin sensitivity during the clamp were similar in the 2 groups. In exposed subjects, insulin secretion during graded IV glucose infusion and after arginine administration decreased by 17% (P = 0.02) and 22% (P = 0.002), respectively, while glucagon secretion after arginine increased. Conclusion Overexposure to glucocorticoids during the first part of fetal life is associated with lower insulin secretion at adult age, which may lead to abnormal glucose tolerance later in life.
Published: 2019
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13. X chromosome gene dosage as a determinant of congenital malformations and of age-related comorbidity risk in patients with Turner syndrome, from childhood to early adulthood

Author: Elodie Fiot, Delphine Zénaty, Priscilla Boizeau, Jérémie Haignere, Sophie Dos Santos, Juliane Léger, J C Carel, S Cabrol, P Chanson, S Christin-Maitre, C Courtillot, B Donadille, J Dulon, M Houang, M Nedelcu, I Netchine, M Polak, S Salenave, D Samara-Boustani, D Simon, P Touraine, M Viaud, H Bony, K Braun, R Desailloud, A M Bertrand, B Mignot, F Schillo, P Barat, V Kerlan, C Metz, E Sonnet, Y Reznik, V Ribault, H Carla, I Tauveron, C Bensignor, F Huet, B Verges, O Chabre, C Dupuis, A Spiteri, M Cartigny, C Stuckens, J Weill, A Lienhardt, C Naud-Saudreau, F Borson-Chazot, A Brac de la Perriere, M Pugeat, T Brue, R Reynaud, G Simonin, F Paris, C Sultan, B Leheup, G Weryha, S Baron, B Charbonnel, S Dubourdieu, E Baechler, P Fenichel, K Wagner, F Compain, H Crosnier, C Personnier, B Delemer, A C Hecart, P F Souchon, M De Kerdanet, F Galland, S Nivot-Adamiak, M Castanet, C Lecointre, O Richard, N Jeandidier, S Soskin, P Lecomte, M Pepin-Donat, P Pierre, Centre de Référence des Maladies Endocriniennes Rares de la Croissance [APHP Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Cité (UPCité), Service de pédiatrie générale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Diderot - Paris 7 (UPD7), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Département de génétique [Robert Debré], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - École de sages-femmes Baudelocque (UPD ESF Baudelocque), Université Paris Descartes - Paris 5 (UPD5), Hôpital Robert Debré, Maladies neurodéveloppementales et neurovasculaires (NeuroDiderot (UMR_S_1141 / U1141)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), French Turner Syndrome Study Group, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Maladies génétiques d'expression pédiatrique (U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), CHU Amiens-Picardie, Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Nutrition et Neurobiologie intégrée (NutriNeuro), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Brestois Santé Agro Matière (IBSAM), Université de Brest (UBO)-Université de Brest (UBO), Service d'Endocrinologie (CHRU - Endocrino), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service d'endocrinologie [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Unité de nutrition et métabolisme protéique, Institut National de la Recherche Agronomique (INRA), Lipides - Nutrition - Cancer (U866) (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA), Service d'Endocrinologie (GRENOBLE - Endocrino), CHU Grenoble, Department of Geology and Applied Geology, University of Mons [Belgium] (UMONS), Centre de Recherche en Cancérologie de Lyon (UNICANCER/CRCL), Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Nutrition-Génétique et Exposition aux Risques Environnementaux (NGERE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), European Organization for Nuclear Research (CERN), Service d'Endocrinologie - Diabète - Nutrition [Reims], Université de Reims Champagne-Ardenne (URCA)-Hôpital Robert Debré-Centre Hospitalier Universitaire de Reims (CHU Reims), Centre d'Immunologie de Marseille - Luminy (CIML), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Différenciation et communication neuronale et neuroendocrine (DC2N), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Rouen University Hospital, Laboratoire d'ingénierie circulation transports (LICIT), Institut National de Recherche sur les Transports et leur Sécurité (INRETS)-École Nationale des Travaux Publics de l'État (ENTPE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université de Paris (UP), Université Paris Diderot - Paris 7 (UPD7)-Hôpital Robert Debré-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université Bordeaux Segalen - Bordeaux 2-Institut National de la Recherche Agronomique (INRA)-Université Sciences et Technologies - Bordeaux 1-Institut Polytechnique de Bordeaux-Ecole nationale supérieure de chimie, biologie et physique, Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), Eq 4, Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Léon Bérard [Lyon]-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Groupement Hospitalier Lyon-Est (GHE), Hospices Civils de Lyon (HCL)-Hospices Civils de Lyon (HCL)-Centre de médecine nucléaire, Fédération d'endocrinologie-Groupement hospitalier Lyon-Est-Fédération d'endocrinologie-Groupement hospitalier Lyon-Est, Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Robert Debré-Université de Paris, Université Paris Diderot - Paris 7 (UPD7)-Hôpital Robert Debré-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris]-Université Paris Diderot - Paris 7 (UPD7), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP Hôpital universitaire Robert-Debré [Paris], École de sages-femmes Baudelocque (ESF Baudelocque), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris, Laboratoire de Physique Corpusculaire - Clermont-Ferrand (LPC), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre hospitalier universitaire d'Amiens (CHU Amiens-Picardie), Hôpital Jean Minjoz, Nutrition et Neurobiologie intégrée (NutriNeur0), Ecole nationale supérieure de chimie, biologie et physique-Institut Polytechnique de Bordeaux-Université Sciences et Technologies - Bordeaux 1-Institut National de la Recherche Agronomique (INRA)-Université Bordeaux Segalen - Bordeaux 2, Université de Brest (UBO), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Bourgogne (UB)-Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation de Dijon (ENSBANA)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université d'Angers (UA)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Robert Debré-Université Paris Cité (UPC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)
Subjects: Adult, Heart Defects, Congenital, medicine.medical_specialty, Pediatrics, Adolescent, Endocrinology, Diabetes and Metabolism, Karyotype, Ring chromosome, Gene Dosage, Turner Syndrome, 030209 endocrinology & metabolism, Comorbidity, Type 2 diabetes, Kidney, Y chromosome, Congenital Abnormalities, Cohort Studies, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Risk Factors, Internal medicine, Turner syndrome, MESH: Chromosome, Human, X/genetics, Congenital Abnormalities/genetics, Kidney Diseases/epidemiology, Turner Syndrome/genetics, medicine, Humans, Cumulative incidence, Child, 030223 otorhinolaryngology, X chromosome, Retrospective Studies, Chromosomes, Human, X, [SDV.GEN]Life Sciences [q-bio]/Genetics, Mosaicism, business.industry, Age Factors, Retrospective cohort study, General Medicine, medicine.disease, 3. Good health, Female, Kidney Diseases, business, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: ObjectiveTurner Syndrome is associated with several phenotypic conditions associated with a higher risk of subsequent comorbidity. We aimed to evaluate the prevalence of congenital malformations and the occurrence of age-related comorbid conditions and to determine whether the frequencies of congenital and acquired conditions depend on X chromosome gene dosage, as a function of karyotype subgroup.Design and methodsThis national retrospective observational cohort study includes 1501 patients. We evaluated the prevalence of congenital malformations and the cumulative incidence of subsequent specific comorbidities at five-year intervals, from the ages of 10 to 30 years, with stratification by karyotype subgroup: 45,X (n = 549), 45,X/46,isoXq (n = 280), 46,X,r(X)/46,XX (n = 106), 45,X/46,XX (n = 221), presence of Y (n = 87).ResultsMedian age was 9.4 (3.7–13.7) years at first evaluation and 16.8 (11.2–21.4) years at last evaluation. Congenital heart (18.9%) malformations were more frequent in 45,X patients, and congenital renal (17.2%) malformations were more frequent in 45,X, 45,X/46,isoXq and 46,X,r(X)/46,XX patients than in those with 45,X/46,XX mosaicism or a Y chromosome (P ConclusionThese data suggest that X gene chromosome dosage, particularly for Xp genes, contributes to the risk of developing comorbidities.
Published: 2019
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14. High-uniformity dielectric U-shaped surface relief grating coupler for AR headsets

Author: Bobin Varghese, Valter Drazic, Laurent Blonde, Valerie Allie, V. Brac De La Perriere, and Oksana Shramkova
Subjects: Diffraction, Waveguide (electromagnetism), Optics, Materials science, Computer simulation, business.industry, Physics::Optics, Dielectric, Grating, business, Diffraction efficiency, Diffraction grating, Surface relief grating
Abstract: In this work we propose a new type of symmetrical surface relief diffractive grating for waveguide -based Augmented Reality near-eye display system with a wide Field of View (FoV). We demonstrate that by using a dual-mode symmetrical in-coupling system and angular pupil tiling, we can extend the overall horizontal FoV. Our grating coupler is optimized for the second diffraction orders. The proposed concept is validated numerically via full-wave electromagnetic analysis of a 1D diffraction grating. Measurements of the diffraction efficiency of the micro-fabricated prototype are compared with the results of the numerical simulation.
Published: 2021
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15. Self- and proxy-reported outcomes after surgery in people with disorders/differences of sex development (DSD) in Europe (dsd-LIFE)

Author: Marion Rapp, Lise Duranteau, Tim C. van de Grift, Justine Schober, Angelica L. Hirschberg, Susanne Krege, Anna Nordenstrom, Robert Roehle, Ute Thyen, Claire Bouvattier, Baudewijntje P.C. Kreukels, Agneta Nordenskjold, Birgit Kohler, Uta Neumann, Peggy Cohen-Kettenis, Baudewijntje Kreukels, Annelou de Vries, Wiebke Arlt, Claudia Wiesemann, Jolanta Slowikowska-Hilczer, Aude Brac de la Perriere, Charles Sultan, Francoise Paris, Nicole Reisch, Annette Richter-Unruh, Hedi Claahsen van der Grinten, Anna Nordenström, Agneta Nordenskjöld, Catherine Pienkowski, Maria Szarras-Czapnik, Plastic, Reconstructive and Hand Surgery, Psychiatry, Medical psychology, APH - Aging & Later Life, APH - Mental Health, Amsterdam Reproduction & Development (AR&D), VU University medical center, APH - Quality of Care, APH - Health Behaviors & Chronic Diseases, Universität zu Lübeck [Lübeck], AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), VU University Medical Center [Amsterdam], UPMC Hamot [Erie], Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Kliniken Essen-Mitte, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Institut de Recherche en Cancérologie de Montpellier (IRCM - U1194 Inserm - UM), CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), and Adult Psychiatry
Subjects: Adult, medicine.medical_specialty, Disorders of sex development, Adolescent, Urology, Breast surgery, medicine.medical_treatment, 030232 urology & nephrology, Physical examination, Clinical examination, Genital surgery, [SDV.MHEP.UN]Life Sciences [q-bio]/Human health and pathology/Urology and Nephrology, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Recall bias, Turner syndrome, medicine, Humans, Sex organ, Patient Reported Outcome Measures, Medical diagnosis, [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics, medicine.diagnostic_test, business.industry, Sexual Development, medicine.disease, Urogenital Surgical Procedures, Patient reported outcome, 3. Good health, Surgery, Europe, Cross-Sectional Studies, Pediatrics, Perinatology and Child Health, Patient-reported outcome, Klinefelter syndrome, business
Abstract: Summary Background Surgery is performed in many individuals with disorders/differences of sex development (DSD). Irreversibility of some surgical procedures, lack of information about the procedures, and lack of follow-up care for physical and psychological outcomes, lead to wish for more knowledge from both surgeons and patients. After the consensus conference in 2006, multidisciplinary care is provided to a higher degree with psychological support and more restricted surgical procedures. Outcome studies after genital surgery often lack of patient's perspective. Objective To describe surgical procedures in relation to diagnosis, to evaluate the outcomes of surgery through genital examination, and through patient's and observer's satisfaction with the anatomical and functional result after genital surgery. Study design In a cross-sectional clinical study performed in six European countries in 2014/15, we have included 500 participants where surgery was performed, from a total of 1040 adolescents (≥16years) and adults with a DSD. Diagnoses included Turner syndrome (n = 301), mixed gonadal dysgenesis (45,XO/46,XY; n = 45), Klinefelter syndrome (n = 218), XYY (n = 1), 46, XY DSD (n = 222) and 46, XX DSD (n = 253). Study protocol included clinical report files, an optional gynecological or urological examination, patient reported outcomes including received surgical interventions, satisfaction with appearance and function after surgery, and impact of the surgical procedure on life. Results Five hundred participants had received genital or breast surgery, with the highest rate in 46, XY DSD and the lowest in Turner syndrome. Altogether; 240 participants had feminizing surgery, 112 had masculinizing surgery, and 217 underwent gonadectomy. Physicians evaluated anatomical appearance at genital examination as poor in less than 10%. Dissatisfaction with anatomical appearance was reported by 22% of the participants, dissatisfaction with function by 20%. Being (very) dissatisfied with anatomical appearance and function was reported by 13% of the study participants. Most participants reported no impact, or positive impact, of the surgical procedures on their lives, but 29% experienced a negative effect of gonadectomy on their life. Discussion There might be a selection bias and/or a recall bias for participating in our studies. Due to poor data quality about surgical procedures performed in the past, we also relied on participants memory about surgical procedures in their past. Ideally, patient reported outcomes should be evaluated both before and after surgical procedures. Conclusion A vast majority are satisfied with appearance and function, but still genital or breast surgery have a long-lasting effect on patient's life. Self-reported satisfaction is usually lower than the observer's evaluation regarding both appearance and function. Download : Download high-res image (217KB) Download : Download full-size image Summary Figure . Satisfaction with anatomy and function after genital surgery in individuals with DSD (appearance: n = 244; function: n = 257) (n = total number of participants).
Published: 2021
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16. Current clinical practice of prenatal dexamethasone treatment in at risk pregnancies for classic 21‑hydroxylase deficiency in Europe

Author: Gravholt Claus Højbjerg, Claire Bouvattier, Anders Juul, Juliane Leger, L. Claahsen-van der Grinten Hedi, Stephanie Allen, Justin H Davies, Marco Bonomi, Martine Cools, la Perriere Aude Brac de, Diego Yeste, Florian W. Kiefer, Federico Baronio, Nicole Reisch, Leonidas A. Phylactou, Eystein S. Husebye, Carla Scaroni, Véronique Tardy, Jarmila Vojtkova, Marco Cappa, Wiebke K. Fenske, Tadej Battelino, Philippe Touraine, Julia Rohayem, Hanna F. Nowotny, Dorr Helmut Gunther, Ezio Ghigo, Sara Brucker, Gesine Meyer, Uta Neumann, Oliver Blankenstein, Annamaria Colao, Jérôme Bertherat, Angela Hübner, Nicole Unger, S Faisal Ahmed, Gianni Russo, Philippe Chanson, and Svetlana Lajic
Subjects: Clinical Practice, medicine.medical_specialty, biology, Obstetrics, business.industry, 21-Hydroxylase, biology.protein, medicine, business, Dexamethasone, medicine.drug
Published: 2021
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17. Modified-Release Hydrocortisone in Congenital Adrenal Hyperplasia

Author: Alessandro Prete, F. Peter Treasure, Nicole Reisch, Wiebke Arlt, John Porter, Aude Brac de la Perriere, Colin Perry, Angelica Lindén Hirschberg, Richard J. Ross, Ashwini Mallappa, Philippe Touraine, Deborah P. Merke, Anders Juul, Nike M. M. L. Stikkelbroeck, Kerry Maltby, D. Aled Rees, John Newell-Price, National Institutes of Health [Bethesda] (NIH), Queens Elizabeth Hospital [Birmingham], University of Birmingham [Birmingham], Hospices Civils de Lyon (HCL), Karolinska University Hospital [Stockholm], Rigshospitalet [Copenhagen], Copenhagen University Hospital, University of Sheffield [Sheffield], Queen Elizabeth University Hospital (Glasgow), Cardiff University, University-Hospital Munich-Großhadern [München], Radboud University Medical Centre [Nijmegen, The Netherlands], Service d’endocrinologie et médecine de la reproduction [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Diurnal Ltd, and University of Cambridge [UK] (CAM)
Subjects: Male, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, Anti-Inflammatory Agents, Phases of clinical research, Biochemistry, Gastroenterology, 0302 clinical medicine, Endocrinology, 030212 general & internal medicine, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Middle Aged, [SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism, Prognosis, 3. Good health, Tolerability, Female, adrenal insufficiency, Glucocorticoid, AcademicSubjects/MED00250, medicine.drug, Cortisol secretion, Adult, medicine.medical_specialty, 030209 endocrinology & metabolism, Context (language use), 21-hydroxylase deficiency, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Internal medicine, Adrenal insufficiency, medicine, congenital adrenal hyperplasia, Humans, Congenital adrenal hyperplasia, hydrocortisone, Online Only Articles, Clinical Research Articles, Aged, Hydrocortisone, Adrenal Hyperplasia, Congenital, business.industry, Biochemistry (medical), medicine.disease, glucocorticoid, business, Follow-Up Studies
Abstract: Context Standard glucocorticoid therapy in congenital adrenal hyperplasia (CAH) regularly fails to control androgen excess, causing glucocorticoid overexposure and poor health outcomes. Objective We investigated whether modified-release hydrocortisone (MR-HC), which mimics physiologic cortisol secretion, could improve disease control. Methods A 6-month, randomized, phase 3 study was conducted of MR-HC vs standard glucocorticoid, followed by a single-arm MR-HC extension study. Primary outcomes were change in 24-hour SD score (SDS) of androgen precursor 17-hydroxyprogesterone (17OHP) for phase 3, and efficacy, safety and tolerability of MR-HC for the extension study. Results The phase 3 study recruited 122 adult CAH patients. Although the study failed its primary outcome at 6 months, there was evidence of better biochemical control on MR-HC, with lower 17OHP SDS at 4 (P = .007) and 12 (P = .019) weeks, and between 07:00h to 15:00h (P = .044) at 6 months. The percentage of patients with controlled 09:00h serum 17OHP ( Conclusion MR-HC improved biochemical disease control in adults with reduction in steroid dose over time and patient-reported benefit.
Published: 2021
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18. Position statement on the diagnosis and management of premature/primary ovarian insufficiency (except Turner Syndrome)

Author: Régis Coutant, Maud Bidet, Sophie Catteau-Jonard, Geneviève Plu-Bureau, Anne Bachelot, Lise Duranteau, Phillipe Touraine, Aude Brac de la Perriere, Juliane Léger, Justine Hugon-Rodin, Jean-Pierre Siffroi, Jean Victor Blanc, Véronique Kerlan, Michael Grynberg, Micheline Misrahi, Muriel Houang, Sophie Christin-Maitre, Jean Claude Carel, Michel Polak, Charlotte Sonigo, Delphine Zenaty, B. Donadille, Claire Bouvattier, Laïla El-Khattabi, Frédérique Albarel, Nicolas Chevalier, Maria Givony, Rachel Reynaud, Catherine Pienkowski, Couvet, Sandrine, CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Sorbonne Université (SU), Centre de référence des Maladies Endocriniennes Rares de la Croissance [CHU Saint-Antoine AP-HP] (CRMERC), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Assistance Publique - Hôpitaux de Marseille (APHM), CHU Pitié-Salpêtrière [AP-HP], Clinique mutualiste La Sagesse, Université Paris-Saclay, AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon, Hospices Civils de Lyon (HCL), Hôpital Jeanne de Flandre [Lille], Université Côte d'Azur (UCA), Hôpital Robert Debré, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier Saint-Joseph [Paris], CHU Trousseau [APHP], AP-HP - Hôpital Antoine Béclère [Clamart], Université de Brest (UBO), Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital Robert Debré Paris, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Necker - Enfants Malades [AP-HP], Hôpital de la Timone [CHU - APHM] (TIMONE), Maladies génétiques d'expression pédiatrique [CHU Trousseau] (Inserm U933), Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Trousseau [APHP], and UF de Génétique chromosomique [CHU Trousseau]
Subjects: Adult, Anti-Mullerian Hormone, Pediatrics, medicine.medical_specialty, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Primary ovarian insufficiency, Premature ovarian insufficiency, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, MESH: Fragile X Mental Retardation Protein, X chromosome, Fragile X Mental Retardation Protein, Endocrinology, Turner syndrome, MESH: Follicle Stimulating Hormone, medicine, Hormonal replacement therapy, Humans, Chemotherapy, MESH: Humans, business.industry, Oocyte donation, MESH: Hormone Replacement Therapy, MESH: Adult, General Medicine, MESH: Primary Ovarian Insufficiency, medicine.disease, FMR1, Radiation therapy, [SDV] Life Sciences [q-bio], MESH: France, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, Transgender hormone therapy, Etiology, MESH: Anti-Mullerian Hormone, Female, France, Follicle Stimulating Hormone, business, FMR1 premutation, MESH: Female, Hormone
Abstract: International audience; Premature ovarian insufficiency (POI) is a rare pathology affecting 1-2% of under-40 year-old women, 1 in 1000 under-30 year-olds and 1 in 10,000 under-20 year-olds. There are multiple etiologies, which can be classified as primary (chromosomal, genetic, auto-immune) and secondary or iatrogenic (surgical, or secondary to chemotherapy and/or radiotherapy). Despite important progress in genetics, more than 60% of cases of primary POI still have no identifiable etiology; these cases are known as idiopathic POI. POI is defined by the association of 1 clinical and 1 biological criterion: primary or secondary amenorrhea or spaniomenorrhea of>4 months with onset before 40 year of age, and elevated follicle-stimulating hormone (FSH)>25IU/L on 2 assays at>4 weeks' interval. Estradiol level is low, and anti-Müllerian hormone (AMH) levels have usually collapsed. Initial etiological work-up comprises auto-immune assessment, karyotype, FMR1 premutation screening and gene-panel study. If all of these are normal, the patient and parents may be offered genome-wide analysis under the "France Génomique" project. The term ovarian insufficiency suggests that the dysfunction is not necessarily definitive. In some cases, ovarian function may fluctuate, and spontaneous pregnancy is possible in around 6% of cases. In confirmed POI, hormone replacement therapy is to be recommended at least up to the physiological menopause age of 51 years. Management in a rare diseases center may be proposed.
Published: 2021
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19. Quality of Life in Men With Congenital Adrenal Hyperplasia Due to 21-Hydroxylase Deficiency

Author: Nicole Reisch, Wiebke Arlt, Antonius E. van Herwaarden, Birgit Köhler, Paul N. Span, Annette Richter-Unruh, Henrik Falhammar, Claire Bouvattier, Anna Nordenström, Hedi L Claahsen-van der Grinten, Emma A Webb, Manon Engels, Aude Brac de la Perriere, Nike M. M. L. Stikkelbroeck, Nel Roeleveld, Myrthe J. M. Verhees, Fred C.G.J. Sweep, and Marion Rapp
Subjects: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, WHOQOL BREF, Severity of Illness Index, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Young Adult, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Congenital adrenal hyperplasia due to 21-hydroxylase deficiency, 21 hydroxylase deficiency, Quality of life, Prednisone, Surveys and Questionnaires, Internal medicine, medicine, Humans, Congenital adrenal hyperplasia, Dexamethasone, Original Research, lcsh:RC648-665, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], Adrenal Hyperplasia, Congenital, business.industry, Hyperandrogenism, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], medicine.disease, humanities, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], 3. Good health, CYP21A2, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Mental Health, quality of life, 030220 oncology & carcinogenesis, Population study, Self Report, business, congenital adrenal hyperplasia (CAH), Hypoaldosteronism, medicine.drug
Abstract: Contains fulltext : 232500.pdf (Publisher’s version ) (Open Access) Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21OHD) is a disorder of adrenal steroid biosynthesis, leading to hypocortisolism, hypoaldosteronism, and hyperandrogenism. Impaired quality of life (QoL) has been demonstrated in women with CAH, but data on men with CAH are scarce. We hypothesized that disease severity and poor treatment control are inversely associated with QoL. In this study, 109 men (16-68 years) with 21OHD were included. The WHOQOL-BREF questionnaire was used to measure self-reported QoL domain scores on a 0-100 scale, where higher scores reflect better QoL. QoL domain scores were compared to published data on healthy and chronically ill reference populations from France, Germany, the Netherlands, and the United Kingdom. Differences in QoL scores among groups of disease severity and treatment control were tested within the study population. Overall, the men with CAH in this study appeared to rate their QoL as good. Median domain scores were 78.6 (IQR: 67.9-85.7) for physical health, 79.2 (IQR: 66.7-87.5) for psychological health, 75.0 (IQR: 58.3-83.3) for social relationships, and 81.3 (IQR: 71.9-90.6) for environment. In general, these scores were similar to WHOQOL-BREF domain scores in healthy references and higher compared to chronically ill reference populations. The domain scores did not differ among genotype groups, but patients with undertreatment or increased 17-hydroxyprogestrone concentrations scored higher on several QoL domains (p
Published: 2021

20. Parity-time Symmetric gratings in 1550 nm Distributed-Feedback lasers diodes: insight on device design rules

Author: Henri Benisty, Vincent Brac de la Perrière, Anatole Lupu, Abderrahim Ramdane, Laboratoire Charles Fabry / Nanophotonique, Laboratoire Charles Fabry (LCF), Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Centre de Nanosciences et de Nanotechnologies (C2N), and Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)
Subjects: Coupling, Physics, [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], business.industry, Physics::Optics, Statistical and Nonlinear Physics, 02 engineering and technology, Grating, Laser, 01 natural sciences, Atomic and Molecular Physics, and Optics, law.invention, 020210 optoelectronics & photonics, Optics, Reflection (mathematics), law, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Photonics, 010306 general physics, business, Lasing threshold, Free-space optical communication, Diode
Abstract: We build on former results from our work on parity-time symmetric gratings implemented in 1550 nm distributed-feedback laser diodes to address the design issues raised by the first trends we observed. These laser diodes are of a complex-coupled nature, with modulations of both real and imaginary parts of the effective index, with a relative phase related to the parity-time symmetry. The unidirectionality of the photonic behavior in the reflection mode is dependent on the level of extra losses incurred by the metallic grating used to implement fixed loss modulation onto a nearly uniform gain, either as a first-order or a third-order grating. The observed behavior suggests that facets play a large role in setting the desired unidirectional lasing operation points, with preferential emission on one side. We explore this issue, which is of generic interest for the coupling of parity-time symmetric structures to open space.
Published: 2021
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21. Exposure to glucocorticoids in the first part of fetal life is associated with insulin secretory defect in adult humans

Author: Boudou P, B. Blondeau, J.F. Gautier, J.-L. Nguewa, Fetita S, Fidaa Ibrahim, Yves Morel, J.P. Riveline, Breant B, Vicaut E, B. Baz, Vidal-Trecan T, Tardy-Guidollet, and Brac de la Perriere A
Subjects: medicine.medical_specialty, Fetus, Endocrinology, business.industry, Insulin, medicine.medical_treatment, Internal medicine, medicine, business
Published: 2020
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22. A Phase III randomized, controlled trial of a modified-release hydrocortisone formulation in the treatment of classic congenital adrenal hyperplasia

Author: Richard J. Ross, Phillippe Touraine, Anders Juul, Peter Treasure, Deborah P. Merke, Ashwini Mallappa, Linden Angelica Hirschberg, John Newell-Price, Kerry Matlby, Colin Perry, Nicole Reisch, Wiebke Arlt, la Perriere Aude Brac de, Aled Rees, John Porter, Nike M. M. L. Stikkelbroeck, and Alessandro Prete
Subjects: medicine.medical_specialty, Randomized controlled trial, law, business.industry, Urology, Classic Congenital Adrenal Hyperplasia, Medicine, business, law.invention, Hydrocortisone, medicine.drug
Published: 2020
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23. One hour post-load plasma glucose and 3 year risk of worsening fasting and 2 hour glucose tolerance in the RISC cohort

Author: Manco, Melania, Mari, Andrea, Petrie, John, Mingrone, Geltrude, Balkau, Beverley, Amsterdam, for the EGIR-RISC study group., Heine, Rj, Dekker, J, S de Rooij, Nijpels, G, W Boorsma Athens, Greece:, A Mitrakou, Tournis, S, Kyriakopoulou, K, P Thomakos Belgrade, Serbia:, N Lalic, Lalic, K, Jotic, A, Lukic, L, M Civcic Dublin, Ireland:, J Nolan, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, M Hatunic Frankfurt, Germany:, T Konrad, Böhles, H, Fuellert, S, Baer, F, H Zuchhold Geneva, Switzerland:, A Golay, E Harsch Bobbioni, Barthassat, V, Makoundou, V, Tno, Lehmann, T Merminod Glasgow, Scotland, UK: JR Petrie, Perry, C, Neary, F, Macdougall, C, Shields, K, L Malcolm Kuopio, Finland:, M Laakso, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, H Saloranta London, England, UK: SW Coppack, Mcintosh, N, Ross, J, Pettersson, L, P Khadobaksh Lyon, France:, M Laville, F Bonnet (now Rennes), A Brac de la Perriere, Louche-Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, A Serusclat Madrid, Spain:, R Gabriel, Sánchez, Em, Carraro, R, Friera, A, B Novella Malmö, Sweden (1):, P Nilsson, Persson, M, G Östling (2):, O Melander, P Burri Milan, Italy: PM Piatti, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, A Colleluori Newcastle-upon-Tyne, Uk:, M Walker, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, D Richardson Odense, Denmark:, H Beck-Nielsen, Staehr, P, Højlund, K, Vestergaard, V, Olsen, C, L Hansen Perugia, Italy: GB Bolli, Porcellati, F, Fanelli, C, Lucidi, P, Calcinaro, F, A Saturni Pisa, Italy:, E Ferrannini, Natali, A, Muscelli, E, Pinnola, S, Kozakova, M, Casolaro, A, BD Astiarraga Rome, Italy:, G Mingrone, Guidone, C, Favuzzi, A, P Di Rocco Vienna, Austria:, C Anderwald, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, and Roden, M
Subjects: Post-load glucose, Adult, Male, Blood Glucose, 0301 basic medicine, Diagnostic criteria, Endocrinology, Diabetes and Metabolism, Physiology, 030209 endocrinology & metabolism, Prediabetic State, 03 medical and health sciences, Endocrinology, 0302 clinical medicine, Research Letter, Internal Medicine, medicine, Humans, Prediabetes, Plasma glucose, Glucose tolerance test, Post-challenge glucose, Prediabetes phenotype, Progression, medicine.diagnostic_test, business.industry, Fasting, Female, Glucose Tolerance Test, Middle Aged, Settore MED/13 - ENDOCRINOLOGIA, Human physiology, medicine.disease, Diabetes and Metabolism, 030104 developmental biology, Cohort, business
Abstract: The affiliation details for Geltrude Mingrone are corrected below.
Published: 2018
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24. Natural history of percutaneous drainage of postoperative collection following colorectal surgery: in which patients can follow-up imaging be dispensed with before drain removal?

Author: C. Chivot, T. Yzet, B Robert, B. Brac, Charles Sabbagh, and J.-M. Regimbeau
Subjects: Male, medicine.medical_specialty, Percutaneous, Urology, 03 medical and health sciences, Postoperative Complications, 0302 clinical medicine, Internal medicine, medicine, Appendectomy, Humans, Radiology, Nuclear Medicine and imaging, In patient, Drainage, Retrospective Studies, Radiological and Ultrasound Technology, business.industry, Patient Selection, Gastroenterology, Retrospective cohort study, Middle Aged, Hepatology, Colorectal surgery, Surgery, Natural history, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Drain removal, business, Colorectal Surgery
Abstract: Colorectal surgery is complicated by postoperative collections in up to 25% of cases depending on local conditions. The aim of this study was to identify predictive factors of success of percutaneous drainage of collections in order to avoid follow-up imaging. All consecutive patients between January 2009 and December 2016, who had undergone elective or emergency colorectal surgery (colorectal surgery and appendectomy) complicated by a postoperative collection treated by percutaneous drainage with follow-up imaging prior to drain removal, were included in this single-center and retrospective study. The primary objective was to assess predictive factors of success of the first attempt of percutaneous drainage of collections. Secondary objectives were to describe the natural history of percutaneous drainage of postoperative collections after colorectal surgery and the overall success rate of percutaneous drainage. Fifty-three patients underwent percutaneous drainage of a postoperative collection during the study period and were included in this study. Complete resolution of the collection was observed on the first follow-up radiological examination in 36 patients (58%). In multivariate analysis, post-appendectomy collections (OR = 3.19 (1.14–9.27), p = 0.002) and reduction of the leukocyte count (OR = 3.22 (1.28–8.1), p = 0.013) were significantly associated with success of percutaneous drainage. This is the first study to address that follow-up imaging prior to drain removal might not be necessary in patients undergoing drainage of post-appendectomy collections and/or with more than 30% reduction of the leukocyte count at the first follow-up examination.
Published: 2018
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25. MANAGEMENT OF ENDOCRINE DISEASE Hyperandrogenic states in women: pitfalls in laboratory diagnosis

Author: Michel Pugeat, Aude Brac de la Perriere, Gerald Raverot, Véronique Raverot, Ingrid Plotton, and Henri Déchaud
Subjects: medicine.medical_specialty, medicine.drug_class, Endocrinology, Diabetes and Metabolism, Physiology, 030209 endocrinology & metabolism, Normal values, Androgen Excess, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Sex hormone-binding globulin, Tandem Mass Spectrometry, Sex Hormone-Binding Globulin, Internal medicine, Humans, Medicine, Testosterone, Congenital adrenal hyperplasia, 030219 obstetrics & reproductive medicine, Endocrine disease, biology, Free testosterone, Clinical Laboratory Techniques, business.industry, Testosterone (patch), General Medicine, medicine.disease, Androgen, Androgens, biology.protein, Female, Hyperandrogenism, business
Abstract: Measuring total testosterone level is the first-line approach in assessing androgen excess in women. The main pitfalls in measuring testosterone relate to its low concentration and to the structural similarity between circulating androgens and testosterone, requiring accurate techniques with high specificity and sensitivity. These goals can be achieved by immunoassay using a specific anti-testosterone monoclonal antibody, ideally after an extraction step. Liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) will be commonly used for measuring testosterone, providing optimal accuracy with a low limit of detection. Yet, the pitfalls of these two techniques are well identified and must be recognized and systematically addressed. In general, laboratories using direct testosterone immunoassay and mass spectrometry need to operate within a quality framework and be actively engaged in external quality control processes and standardization, so as to ensure appropriate interpretation irrespective of the particular laboratory. Circulating testosterone is strongly bound to sex-hormone-binding globulin (SHBG), and SHBG levels are typically low in overweight hyperandrogenic patients. Thus, low SHBG may decrease circulating testosterone to normal values, which will mask androgen excess status. One way to avoid this pitfall, awaiting direct free testosterone assays that are yet to be developed, is to measure SHBG and calculate free testosterone. A few other pitfalls will be discussed in this review, including those of adrenal androgen exploration, with the aim of helping clinicians to better handle laboratory investigation of androgen excess disorders in women.
Published: 2018
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26. Validated Nomogram Predicting 6-Month Survival in Pancreatic Cancer Patients Receiving First-Line 5-Fluorouracil, Oxaliplatin, and Irinotecan

Author: Lorenzo Fornaro, Cindy Neuzillet, Rosella Spadi, Francesco Montagnani, Alfredo Falcone, Caterina Vivaldi, Mario Clerico, Francesco Leone, Aurélia Meurisse, Maria Antonietta Satolli, Pasquale Lombardi, Gianna Musettini, Elisa Sperti, Enrico Vasile, Emmanuele De Luca, Dewi Vernerey, Astrid Lièvre, Andrea Casadei-Gardini, Paola Buscaglia, Angélique Vienot, Julien Edeline, Alessandro Passardi, Clémence Brac, Giulia Pasquini, Massimo Aglietta, Fornaro, L., Leone, F., Vienot, A., Casadei Gardini, A., Vivaldi, C., Lievre, A., Lombardi, P., De Luca, E., Vernerey, D., Sperti, E., Musettini, G., Satolli, M. A., Edeline, J., Spadi, R., Neuzillet, C., Falcone, A., Pasquini, G., Clerico, M., Passardi, A., Buscaglia, P., Meurisse, A., Aglietta, M., Brac, C., Vasile, E., Montagnani, F., Jonchère, Laurent, Azienda Ospedaliera Universitaria Pisana, Istituti di Ricovero e Cura a Carattere Scientifico (IRCCS), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Università degli studi di Torino = University of Turin (UNITO), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (UR 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Nutrition, Métabolismes et Cancer (NuMeCan), Institut National de la Recherche Agronomique (INRA)-Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie [Paris], CRLCC Eugène Marquis (CRLCC), Fondazione ARCO Onlus, Università degli Studi di Modena e Reggio Emilia, Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Turin, Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)
Subjects: Oncology, Male, Multivariate analysis, FOLFIRINOX, [SDV]Life Sciences [q-bio], Computer-Assisted, 0302 clinical medicine, Clinical parameters, Laboratory parameters, Prognosis, Risk categories, Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Biomarkers, Tumor, Female, Fluorouracil, Follow-Up Studies, Humans, Irinotecan, Middle Aged, Numerical Analysis, Computer-Assisted, Oxaliplatin, Pancreatic Neoplasms, Retrospective Studies, Survival Rate, Nomograms, Clinical endpoint, Numerical Analysis, Tumor, Gastroenterology, 3. Good health, [SDV] Life Sciences [q-bio], 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, medicine.drug, medicine.medical_specialty, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, Internal medicine, medicine, Performance status, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Nomogram, Confidence interval, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, business, Biomarkers
Abstract: International audience; BACKGROUND:FOLFIRINOX (leucovorin, 5-fluorouracil, irinotecan, and oxaliplatin) is an option for fit patients with metastatic (MPC) and locally advanced unresectable (LAPC) pancreatic cancer. However, no criteria reliably identify patients with better outcomes.PATIENTS AND METHODS:We investigated putative prognostic factors among 137 MPC/LAPC patients treated with triplet chemotherapy. Association with 6-month survival status (primary endpoint) was assessed by multivariate logistic regression models. A nomogram predicting the risk of death at 6 months was built by assigning a numeric score to each identified variable, weighted on its level of association with survival. External validation was performed in an independent data set of 206 patients. The study was registered at ClinicalTrials.gov (NCT03590275).RESULTS:Four variables (performance status, liver metastases, baseline carbohydrate antigen 19-9 level, and neutrophil-to-lymphocyte ratio) were found to be associated with 6-month survival by multivariate analysis or had sufficient clinical plausibility to be included in the nomogram. Accuracy was confirmed in the validation cohort (C index = 0.762; 95% confidence interval, 0.713-0.825). After grouping all cases, 4 subsets with different outcomes were identified by 0, 1, 2, or > 2 poor prognostic features (P < .0001).CONCLUSION:The nomogram we constructed accurately predicts the risk of death in the first 6 months after initiation of FOLFIRINOX in MPC/LAPC patients. This tool could be useful to guide communication about prognosis, and to inform the design and interpretation of clinical trials.
Published: 2019
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27. Day-case surgery for minor laparoscopic liver surgery: a pertinent innovation?

Author: B. Brac, Lionel Rebibo, J. Dembinski, Rachid Badaoui, P. Leourier, and J.-M. Regimbeau
Subjects: Liver surgery, medicine.medical_specialty, Hepatology, business.industry, General surgery, Gastroenterology, Medicine, Day case surgery, Minor (academic), business
Published: 2021
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28. Risk of autoimmune diseases and human papilloma virus (HPV) vaccines: Six years of case-referent surveillance

Author: Lamiae Grimaldi-Bensouda, Michel Rossignol, Isabelle Koné-Paut, Alain Krivitzky, Christine Lebrun-Frenay, Johanna Clet, David Brassat, Caroline Papeix, Marc Nicolino, Pierre-Yves Benhamou, Olivier Fain, Nathalie Costedoat-Chalumeau, Marie-France Courcoux, Jean-François Viallard, Bertrand Godeau, Thomas Papo, Patrick Vermersch, Isabelle Bourgault-Villada, Gerard Breart, Lucien Abenhaim, Firas Abbas, Abdelhakim Abdelmoumni, Pascal Hilliquin, Elisabeth Requeda, Daniel Adoue, Christian Agard, Agathe Masseau, Nathalie Aladjidi, Helder Fernandes, Gwendal Lemasson, Yves Perel, Isabelle Raymond, Olivier Richer, Anne Vital, Emma Allain-Launay, Marie Bru, Caroline Thomas, Jean-Jacques Altman, Daniel Amsallem, Nazmiye Aras, Latifato Boukari, Marie Dubrel, Edouard Letellier, Nadine Lucidarme, Arsène Mekinian, Anne-Sophie Morin, Jérôme Stirnemann, Catherine Atlan, Dominique Audry, Jérôme Augustin, Redouane Bakir, Pablo Bartolucci, Xavier Chevalier, Constance Guillaud, Mehdi Khellaf, Nicolas Limal, Valentine Lousteau, Matthieu Mahevas, Gayane Méliksetyan, Marc Michel, Mathilde Roumier, Sophie Bayart, Fabrice Bonnet, Olivier Decaux, Amine Bekherraz, Benoit Brihaye, Roger Dachez, Eric Daugas, Gilles Hayem, Olivier Meyer, Elisa Pasqualoni, Karim Sacre, Florence Travert, Hélène Bellon, Jacques Beltrand, François Lefrere, Albane Simon, Olivier Benveniste, Francis Bolgert, Raphael De Paz, Sophie Demeret, Bruno Fautrel, Sophie Jacqueminet, Céline Louapre, Elizabeth Maillart, Nathalie Morel, Julie Rigabert, Philippe Bensaid, Claire Berger, Patrick Berquin, Anne-Gaëlle Le Moing, Stéphane Berroir, Gérard Besson, Célia Boutte, Olivier Casez, Bernard Bonnotte, Sylvain Audia, Cécile Bossu-Estour, Anne Bourgarit, Alain Dupuy, Homa Keshmandt, Bertrand Bourre, Aude Brac, Agnès Perrin, Corinne Pondarré, Sylvie Villar-Fimbel, Isabelle Bruckert, Anne Cosson, Nadine Magy-Bertrand, Guillaume Tisserand, William Camu, Bertrand Carlander, Raul Juntas Morales, Claude Cances, Marlene Pasquet, Maria Angela Castilla Lievre, Stephanie Chabroux, Mamoud Charif, Emmanuel Chatelus, Jean Sibilia, Jacqueline Chevrant-Breton, Sylvaine Clavel, Françoise Bille-Turc, Jacques Cohen, Marie France Courcoux, Guy Leverger, Laurent Machet, Jean-Marie Cuisset, Pascale Cony-Makhoul, Paul Darsy, Sandrine Favre, Pierrick Giraud, Laurence Leitenschenck, Irène Monteiro, Chafika Morati, Jérôme DeSeze, Monica Dinulescu, Taher Dhaoui, Florence Dommange-Romero, Elisabeth Drevard, Clémentine Dupuis, Marie-Laure Dumuis, Jean-Marc Durand, Samia Farad, Pierre Lecomte, Peggy Pierre, Fanny Fouyssac, Philippe Gaudin, Alain Gautier, Justine Gellen-Dautremer, Irène Jarrin, Pascal Richette, Emilie Georget, Pierre Gras, Thibault Moreau, Eric Giraud, Maya Hacini, Anne Mayer, Cécile Guillaumat, Séverine Guillaume, Corinne Guitton, Isabelle Kone-Paut, Céline Marsaud, Linda Rossi, Marie-Hélène Guyot, Patrick Hassler, Claude Heimfert, Olivier Heinzlef, Brigitte Hillion, Catherine Hocquelet, Helene Husson, Pierre Ichai, Eric Jeziorski, Chantal Job Deslandre, Véronique Le Guern, Kamen Kamenov, Véronique Kerlan, Philippe Lemoine, Laurent Misery, Brigitte Pan-Petesch, Pierre Labauge, Michel Rodier, Chadi Lacade, Berthe Razafimahefa, Karim Lachgar, Marie-Pierre Larmarau, Thierry Leblanc, Patrick Lefèbvre, Philippe Lejoyeux, Charles Leske, Kim Ly, Laurent Magy, Sylvie Mansuy, Richard Marechaud, Marie-Laure Martin Negrier, Guilhem Sole, Jean Maupetit, Françoise Mazingue, Stéphanie Mochon, Blidi Moktar, Donald Morcamp, Nathalie Morlet-Barla, Guillaume Nicolas, Vivien Pautot, Isabelle Pellier, Jean-Luc Verret, Olivier Outteryck, Beatrice Pallot-Prades, Jean Michel Paquet, Xavier Puechal, Annie Sortais, Jean Pelletier, Audrey Rico, Dominique Pez, Bruno Stankoff, Philippe Quittet, Claude Rémy, Eléna Roba, Hélène Rosario, Nathalie Roudaut, Emmanuel Sonnet, Michel Ruel, Samuel Sebban, Pauline Schaepelynck, Marie-Jeanne Simonin, Christophe Vial, Jean-Francois Viallard, Isabelle Ladedan, Thierry Zenone, LASER ANALYTICA, Paris (LA-SER), Centre d'enseignement Cnam Paris (CNAM Paris), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM), Service de Rhumatologie [CHU Bicêtre], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Bicêtre, Centre de référence des maladies auto-inflammatoires, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de médecine interne [Avicenne], Hôpital Avicenne [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [CHU Nice], Hôpital Pasteur [Nice] (CHU)-Centre Hospitalier Universitaire de Nice (CHU Nice), CHU Bordeaux [Bordeaux], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), CHU Grenoble, Service de médecine interne [CHU Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Service de médecine interne et centre de référence des maladies rares [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], CHU Trousseau [APHP], Service de médecine interne et maladies infectieuses [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Saint-André, Service de médecine interne [Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Centre de recherche sur l'Inflammation (CRI (UMR_S_1149 / ERL_8252 / U1149)), Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Département Hospitalo-Universitaire Fibrosis, Inflammation, Remodeling in cardiovascular, respiratory and renal diseases (Paris), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Claude Huriez [Lille], CHU Lille, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Ambroise Paré [AP-HP], Equipe 1 : EPOPé - Épidémiologie Obstétricale, Périnatale et Pédiatrique (CRESS - U1153), Université Paris Descartes - Paris 5 (UPD5)-Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), DHU Risques Et Grossesse, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), CHU Toulouse [Toulouse], Service de neurologie 1 [CHU Pitié-Salpétrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Service d'hématologie-immunologie-oncologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de la Recherche Agronomique (INRA)-Université Paris Diderot - Paris 7 (UPD7)-Université Paris Descartes - Paris 5 (UPD5)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Bicêtre, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Hôpital Avicenne, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Cochin [AP-HP], Service d’oncologie hématologie pédiatrique [CHU Trousseau], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Diderot - Paris 7 (UPD7), Lille Inflammation Research International Center (LIRIC), Hôpital Claude Huriez, Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Hôpital Ambroise Paré, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Service de Neurologie [CHU Pitié-Salpêtrière], IFR70-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), and Centre National de la Recherche Scientifique (CNRS)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)
Subjects: Adult, Male, Risk, Pediatrics, medicine.medical_specialty, Adolescent, Immunology, HPV vaccines, Autoimmune Diseases, Autoimmune thyroiditis, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Autoimmune disease, Odds Ratio, medicine, Humans, Immunology and Allergy, Papillomavirus Vaccines, 030212 general & internal medicine, Family history, Young adult, Child, HPV vaccine, business.industry, Pharmacoepidemiology, Papillomavirus Infections, Odds ratio, medicine.disease, Thrombocytopenic purpura, Connective tissue disease, Confidence interval, 3. Good health, Population Surveillance, [SDV.IMM]Life Sciences [q-bio]/Immunology, Female, business, 030217 neurology & neurosurgery, Follow-Up Studies
Abstract: Background Safety of HPV vaccines is still in question due to reports of autoimmune diseases (ADs) following HPV immunization. Objectives To assess the risk of ADs associated with HPV vaccination of female adolescents/young adults in France. Methods Systematic prospective case-referent study conducted to assess the risks associated with real-life use of HPV vaccines. Cases were female 11–25 years old with incident ADs [central demyelination/multiple sclerosis (CD/MS), connective tissue disease (CTD), Guillain-Barre syndrome (GBS), type-1 diabetes (T1D), autoimmune thyroiditis (AT), and idiopathic thrombocytopenic purpura (ITP)]. Cases were consecutively and prospectively identified at specialized centers across France (2008–2014) and individually matched by age and place of residence to referents recruited in general practice. Risk was computed using multivariate conditional logistic regression models adjusted for family history of ADs, living in France (north/south), co-medications and co-vaccinations. Results With a total of 478 definite cases matched to 1869 referents, all ADs combined were negatively associated to HPV vaccination with an adjusted odds ratio of 0.58 (95% confidence interval: 0.41–0.83). Similar results were obtained for CD/MS, AT, CT, and T1D, the last two not reaching statistical significance. No association was found for ITP and GBS. Sensitivity analyses combining definite and possible cases with secondary time window showed similar results. Conclusion Exposure to HPV vaccines was not associated with an increased risk of ADs within the time period studied. Results were robust to case definitions and time windows of exposure. Continued active surveillance is needed to confirm this finding for individual ADs.
Published: 2017
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29. P43 IS THERE AN OPTIMAL DEFINITION FOR POSITIVE CIRCUMFERENTIAL RESECTION MARGIN IN LOCALLY ADVANCED OESOPHAGEAL CANCER?

Author: Clarisse Eveno, Emmanuelle Leteurtre, Guillaume Piessen, B. Brac, Christophe Mariette, Marguerite Messier, Florence Renaud, and Hélène Behal
Subjects: medicine.medical_specialty, business.industry, Gastroenterology, medicine, Locally advanced, Cancer, Circumferential resection margin, General Medicine, Radiology, business, medicine.disease
Abstract: Aim The utility of Circumferential Resection Margin (CRM) status in predicting prognosis in oesophageal cancer remains controversial, with two different definitions of a positive CRM, one from the College of American Pathologists (CAP) (tumour at margin) and the other from the Royal College of Pathologists (RCP) (tumour within 1 mm)1-3. This study aimed to analyze the validity of these definitions in oesophageal tumours and explore the optimal cutoff value for CRM to predict survival. Background & Methods Patients who underwent curative radical oesophageal resection for locally advanced (>pT2) adenocarcinoma or squamous cell carcinoma of the oesophagus were selected from 2007 to 2016. Patients with positive longitudinal resection margins were excluded. CRM was histologically reassessed using an ocular micrometer. Overall survival (OS) and disease-free survival (DFS) were estimated with uni and multivariate analyses. Results From 860 resected patients, 283 fulfilling the inclusion criteria were selected. CRM was measured as follows: CRM=0mm (n=48), 01mm (n=112). In univariate (figure 1) and multivariate analysis R1 resection, according to both definitions was significantly associated with poor OS (CAP: HR=2.26,p Conclusion Among existing definitions of CRM, CAP definition was more accurate to predict prognosis and recurrence. New cutoffs are promising.
Published: 2019
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30. Restoring robust binary switching operation and exceptional point using long-period grating-assisted parity-time symmetric couplers

Author: Abderrahim Ramdane, Quentin Gaimard, Anatole Lupu, Henri Benisty, Vincent Brac de la Perrière, Centre de Nanosciences et Nanotechnologies (C2N (UMR_9001)), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Charles Fabry / Naphel, Laboratoire Charles Fabry (LCF), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS)-Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut d'Optique Graduate School (IOGS), and ANR-18-CE24-0024,PARTISYMO,Dispositifs fonctionnels actifs à symétrie Parité-Temps(2018)
Subjects: Acoustics and Ultrasonics, Exceptional point, Binary number, Physics::Optics, 02 engineering and technology, Grating, 01 natural sciences, Optical switch, Parity-Time symmetry, [SPI]Engineering Sciences [physics], 020210 optoelectronics & photonics, Optics, Long period, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, 010306 general physics, Optical switching, Physics, business.industry, Parity (physics), Integrated optics, Condensed Matter Physics, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, business
Abstract: International audience; The impact of imbalance in waveguides propagation constants among Parity-Time symmetric coupled waveguides and/or of a complex-valued coupling coefficient is assessed. The narrow tolerance found implies that attempts to tightly control waveguides parameters appear as elusive because of fabrication technology limitations, calling for more feasible mitigation avenues. It is shown that a grating-assisted Parity-Time symmetric coupler design restores both technologically robust binary switching operation and exceptional point. In addition the proposed design is compatible with birefringence compensation techniques providing polarization-independent operation as well as coupling and/or gain-loss profile modulation techniques that extend the control of switching operation in the Parity-Time symmetric phase. Using wavelength as an additional tuning parameter near exceptional points opens promising avenues for manipulating the trajectory on Riemann sheets in topological photonics applications.
Published: 2019
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31. Are neglected breast cancer relates to lifestyle and socioeconomic environment?

Author: Anne-lise Farcy, Gabrielle Selmes, Eleonora De Maio, Lacaze Jean Louis, F. Tremollieres, Carole Domenech, Clemence Brac de la Perriere, Mony Ung, Cyrille Delpierre, Florence Dalenc, Charlotte Vaysse, and Bastien Cabarrou
Subjects: Cancer Research, Breast cancer, Oncology, business.industry, Incidence (epidemiology), Environmental health, medicine, medicine.disease, business, Socioeconomic status
Abstract: e18542 Background: The incidence of patients with neglected breast cancer (NBC) in high-income countries remains an issue. It may be important to clarify their characteristics to adapt prevention policy. The purpose of present study was to describe the clinical and socio-economic features of patients with NBC at diagnosis. Methods: We conducted a retrospective analysis of 110 patients treated in our institution between January 2018 and December 2019 for a NBC. Diagnosis of NBC was made when patients deliberately delayed the first consultation for more than 3 months, despite the suspicious nature of the abnormality, or when breast cancer was described as neglected by physicians. Locally advanced breast cancer related to diagnostic delay and those for which the patients did not initially worry, were not retained. Results: The median age was 70 years [31-98], 51.8 % had more than 70 years. Delay between the first signs and the first consultation, was 3 to 6 months for 17 patients (20.5%), 6 and 12 months for 24 (21.1%) and more than 1 year for 36 (43.4%). 51 (47.2 %) patients lived alone, 52 (48.1%) lived with a third person and 5 (4.6%) were institutionalized. 47 (44.3%) were in a relationship, 27 (25.5%) were single and 32 (30.2%) were widow or separated, 84 (76.4%) had at least one child, 79 (76.4%) patients had at least one caregiver. 63 patients (57.3%) had regular medical follow-up due to chronic disease. 26 (23.6%) had psychiatric disorders. Concerning socio-economic position, 57 (51%) were employees, 16 (14%) were executive or intermediate profession, 11 (10%) had a higher intellectual profession, 11 (10%) were workers, 9 (10%) did not have an occupation, 3 (3%) were craftsmen, shopkeepers, or company managers and 3 (3%) were farmers. According to the score of the French European Deprivation Index (FEDI), 60 (55.6%) lived in areas of low to extremely low socio-economic level. In comparison with a series of 89 patients, treated for a non-neglected BC, NBC was more prevalent among single, separated, or widowed patients (p=0,0002), those living alone or institutionalized (p=0,01). It also concerns childless patients (p=0,02) and those who had no caregiver (p=0,02) or with psychiatric disorder (p=0,004). Employees and workers are more represented among negligent patients (p=0,01). There was no statistical difference in socioeconomic feature according to the FEDI (p=0,2). In multivariate analysis, living alone and psychiatric disorders were independent risk factors for NBC (respectively: OR= 2,27, IC95% [1,11-5,65], p=0,02; OR= 6,88, IC95% [1,76;26,84], p=0,005). Conclusions: We present the largest cohort of NBC. Patients with NBC appear to be more precarious psychologically, socially, and economically. Prospective studies are necessary to strengthen and deepen the associations found to optimize the screening policy and the education of physicians.
Published: 2021
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32. Manuscripts in Bihari Calligraphy: Preliminary Remarks on a Little-Known Corpus

Author: Eloïse Brac De La Perrière
Subjects: Cultural Studies, Literature, History, Visual Arts and Performing Arts, business.industry, media_common.quotation_subject, Art, Sufism, Indian subcontinent, Writing style, Divination, Calligraphy, business, media_common
Abstract: Within the corpus of manuscripts attributed to Sultanate India (thirteenth to sixteenth centuries), one group of Korans stands out. These Korans, which are in the Bihari script, follow precise and recurrent rules. They are defined by the use of Bihari calligraphy, a writing style specific to the Indian subcontinent, as well as by a common ornamentation and a particular page layout that reveals a complex hermeneutical system. This system is made up of different categories of texts related to the Koran, among which are repeated references to the canonical readings, or qiraʾāt. Several manuscripts also contain a book of divination (fālnāma) appended at the end. The oldest specimens are among the earliest known manuscripts for India, even though their production extended into the nineteenth century, which raises numerous questions about the milieu in which they may have come into existence and the uses for which they may have been intended.
Published: 2016
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33. The Auger Raman Lidar: several years of continuous observations

Author: Rizi, V., Aab, A., Abreu, P., Aglietta, M., Albuquerque, I. F. M., Albury, J. M., Allekotte, I., Almela, A., Alvarez Castillo, J., Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Asorey, H., Assis, P., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Barreira Luz, R. J., Baur, S., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Bierman, P. L., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Bonifazi, C., Borodai, N., Botti, A. M., Brac, J., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Calcagni, L., Cancio, A., Canfora, F., Carceller, J. M., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jong, S. J., De Mauro, G., de Mello Neto, J. R. T., De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Dhital, N., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., dos Anjos, R. C., Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Escoba, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzi, N., Feldbusch, F., Fenu, F., Ferreyro, L. P., Figueira, J. M., Filipčič, A., Freire, M. M., Fujii, T., Fuster, A., García, B., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glombitza, J., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Halliday, R., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Hill, G. C., Hojvat, C., Holt, E. M., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Johnsen, J. A., Josebachuili, M., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Kemmerich, N., Kemp, J., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Kuempel, D., Kukec Mezek, G., Kuotb Awad, A., Lago, B. L., Lahurd, D., Lang, R. G., Legumina, R., Leigui de Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., López, R., López Casado, A., Lorek, R., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mancarella, G., Mandat, D., Mantsc, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Martínez Bravo, O., Mathes, H. J., Mathys, S., Matthews, J., Matthiae, G., Mayotte, E., Mazu, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Michal, S., Micheletti, M. I., Middendorf, L., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Morlino, G., Mostafá, M., Müller, A. L., Muller, M. A., Müller, S., Mussa, R., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlin, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Poh, J., Pont, B., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Ristori, P., Rodrigues de Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schauer, M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schröder, S., Schumacher, J., Sciutto, S. J., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Šmída, R., Snow, G. R., Sommers, P., Soriano, J. F., Souchard, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Stolpovskiy, M., Streich, A., Suarez, F., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Šupík, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Timmermans, C., Todero Peixoto, C. J., Tomé, B., Torralba Elipe, G., Travnicek, P., Trini, M., Tueros, M., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J. F., Valiño, I., Valore, L., van Bodegom, P., van den Berg, A. M., van Vliet, A., Varela, E., Vargas Cárdenas, B., Vázquez, R. A., Veberič, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Wat, A. A., Weber, M., Weindl, A., Wiedeński, M., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Medina Hernandez, C., Iarlori, M., and Pietropaolo, E.
Subjects: Pierre Auger Observatory, Materials science, 010308 nuclear & particles physics, business.industry, Raman lidar, Physics, QC1-999, Optical transparency, Laser, 01 natural sciences, Fluorescence spectroscopy, Auger, law.invention, symbols.namesake, Optics, law, 0103 physical sciences, symbols, ddc:530, 010306 general physics, business, Raman spectroscopy
Abstract: The Raman lidar at the Central (Raman) Laser Facility of the Pierre Auger Observatory in Argentina, has been operational since September 2013. In this paper, the Auger Raman Lidar performance is discussed in terms of the data quality for the assessment of the aerosol contribution to the atmospheric UV optical transparency, and how much this is important for the reconstruction of the UHECR properties, based on the Auger Fluorescence Detector observations.
Published: 2019
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34. An Overview on H2020 Project 'ReSHEALience'

Author: Viktor Mechtcherine, Peter Deegan, M. Cruz Alonso, Patrick Bamonte, Enrico Maria Gastaldo-Brac, Ruben Paul Borg, Stamatina Sideri, Alba Peled, Carmine Pascale, Cristina Suesta Falcó, Francesco Animato, Liberato Ferrara, Pedro Serna, Aleksej Tretjakov, Esteban Camacho Torregrosa, and European Commission
Subjects: Engineering, business.industry, Durability Assessment-based Design (DAD), Ultra High Durability Concrete (UHDC), Durability Assessment-based Design (DAD), modelling, green energy, Blue Growth, heritage conservation, 0211 other engineering and technologies, 020101 civil engineering, 02 engineering and technology, Blue Growth, Ultra High Durability Concrete (UHDC), Bridge (interpersonal), Construction engineering, 0201 civil engineering, Cultural heritage, modelling, green energy, 021105 building & construction, Asset management, heritage conservation, business, Built environment
Abstract: Trabajo presentado al International Association for Bridge and Structural Engineering (IABSE): Towards a Resilient Built Environment - Risk and Asset Management, celebrado en Guimarães (Portugal) del 27 al 29 de marzo de 2019., In the framework of H2020, the European Commission recently funded the project ReSHEALience (www.uhdc.eu). The main idea behind the project is that the long-term behaviour of structures under extremely aggressive exposure conditions can highly benefit from the use of high performance materials, in the framework of durability-based design approaches. The project consortium, coordinated by Politecnico di Milano, features 14 partners from 8 different countries, including 6 academic/research institutions and 8 industrial partners, covering the whole value chain from producers of concrete constituents to construction companies to stake-holders and end-users. The main goals of the project are the development (a) of an Ultra High Durability Concrete (UHDC) and (b) a Durability Assessment-based Design (DAD) methodology to improve structure durability and predict long-term performance under Extremely Aggressive Exposures (EAE). The project will tailor the composition of UHDC, by upgrading the UHPC/UHPFRC concept through the incorporation of tailored nanoscale constituents., The ReSHEALience project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 760824.
Published: 2019

35. FRAM telescopes and their measurements of aerosol content at the Pierre Auger Observatory and at future sites of the Cherenkov Telescope Array

Author: Janeček, P., Aab, A., Abreu, P., Aglietta, M., Albuquerque, I. F. M., Albury, J. M., Allekotte, I., Almela, A., Alvarez Castillo, J., Alvarez-Muñiz, J., Anastasi, G. A., Anchordoqui, L., Andrada, B., Andringa, S., Aramo, C., Asorey, H., Assis, P., Avila, G., Badescu, A. M., Balaceanu, A., Barbato, F., Barreira Luz, R. J., Baur, S., Becker, K. H., Bellido, J. A., Berat, C., Bertaina, M. E., Bertou, X., Bierman, P. L., Biteau, J., Blaess, S. G., Blanco, A., Blazek, J., Bleve, C., Boháčová, M., Bonifazi, C., Borodai, N., Botti, A. M., Brac, J., Bretz, T., Bridgeman, A., Briechle, F. L., Buchholz, P., Bueno, A., Buitink, S., Buscemi, M., Caballero-Mora, K. S., Caccianiga, L., Calcagni, L., Cancio, A., Canfora, F., Carceller, J. M., Caruso, R., Castellina, A., Catalani, F., Cataldi, G., Cazon, L., Chinellato, J. A., Chudoba, J., Chytka, L., Clay, R. W., Cobos Cerutti, A. C., Colalillo, R., Coleman, A., Coluccia, M. R., Conceição, R., Consolati, G., Contreras, F., Cooper, M. J., Coutu, S., Covault, C. E., Daniel, B., Dasso, S., Daumiller, K., Dawson, B. R., Day, J. A., de Almeida, R. M., de Jong, S. J., De Mauro, G., de Mello Neto, J. R. T., De Mitri, I., de Oliveira, J., de Souza, V., Debatin, J., Deligny, O., Dhital, N., Díaz Castro, M. L., Diogo, F., Dobrigkeit, C., D'Olivo, J. C., Dorosti, Q., dos Anjos, R. C., Dova, M. T., Dundovic, A., Ebr, J., Engel, R., Erdmann, M., Escoba, C. O., Etchegoyen, A., Falcke, H., Farmer, J., Farrar, G., Fauth, A. C., Fazzi, N., Feldbusch, F., Fenu, F., Ferreyro, L. P., Figueira, J. M., Filipčič, A., Freire, M. M., Fujii, T., Fuster, A., García, B., Gemmeke, H., Gherghel-Lascu, A., Ghia, P. L., Giaccari, U., Giammarchi, M., Giller, M., Głas, D., Glombitza, J., Golup, G., Gómez Berisso, M., Gómez Vitale, P. F., González, N., Goos, I., Góra, D., Gorgi, A., Gottowik, M., Grubb, T. D., Guarino, F., Guedes, G. P., Guido, E., Halliday, R., Hampel, M. R., Hansen, P., Harari, D., Harrison, T. A., Harvey, V. M., Haungs, A., Hebbeker, T., Heck, D., Heimann, P., Hill, G. C., Hojvat, C., Holt, E. M., Homola, P., Hörandel, J. R., Horvath, P., Hrabovský, M., Huege, T., Hulsman, J., Insolia, A., Isar, P. G., Jandt, I., Johnsen, J. A., Josebachuili, M., Jurysek, J., Kääpä, A., Kampert, K. H., Keilhauer, B., Kemmerich, N., Kemp, J., Klages, H. O., Kleifges, M., Kleinfeller, J., Krause, R., Kuempel, D., Kukec Mezek, G., Kuotb Awad, A., Lago, B. L., Lahurd, D., Lang, R. G., Legumina, R., Leigui de Oliveira, M. A., Lenok, V., Letessier-Selvon, A., Lhenry-Yvon, I., Lo Presti, D., Lopes, L., López, R., López Casado, A., Lorek, R., Luce, Q., Lucero, A., Malacari, M., Mallamaci, M., Mancarella, G., Mandat, D., Mantsc, P., Mariazzi, A. G., Mariş, I. C., Marsella, G., Martello, D., Martinez, H., Martínez Bravo, O., Mathes, H. J., Mathys, S., Matthews, J., Matthiae, G., Mayotte, E., Mazu, P. O., Medina-Tanco, G., Melo, D., Menshikov, A., Merenda, K. -D., Michal, S., Micheletti, M. I., Middendorf, L., Miramonti, L., Mitrica, B., Mockler, D., Mollerach, S., Montanet, F., Morello, C., Morlino, G., Mostafá, M., Müller, A. L., Muller, M. A., Müller, S., Mussa, R., Nellen, L., Nguyen, P. H., Niculescu-Oglinzanu, M., Niechciol, M., Nitz, D., Nosek, D., Novotny, V., Nožka, L., Nucita, A., Núñez, L. A., Olinto, A., Palatka, M., Pallotta, J., Papenbreer, P., Parente, G., Parra, A., Pech, M., Pedreira, F., Pękala, J., Pelayo, R., Peña-Rodriguez, J., Pereira, L. A. S., Perlin, M., Perrone, L., Peters, C., Petrera, S., Phuntsok, J., Pierog, T., Pimenta, M., Pirronello, V., Platino, M., Poh, J., Pont, B., Porowski, C., Prado, R. R., Privitera, P., Prouza, M., Puyleart, A., Querchfeld, S., Quinn, S., Ramos-Pollan, R., Rautenberg, J., Ravignani, D., Reininghaus, M., Ridky, J., Riehn, F., Risse, M., Ristori, P., Rizi, V., Rodrigues de Carvalho, W., Rodriguez Rojo, J., Roncoroni, M. J., Roth, M., Roulet, E., Rovero, A. C., Ruehl, P., Saffi, S. J., Saftoiu, A., Salamida, F., Salazar, H., Saleh, A., Salina, G., Sanabria Gomez, J. D., Sánchez, F., Santos, E. M., Santos, E., Sarazin, F., Sarmento, R., Sarmiento-Cano, C., Sato, R., Savina, P., Schauer, M., Scherini, V., Schieler, H., Schimassek, M., Schimp, M., Schmidt, D., Scholten, O., Schovánek, P., Schröder, F. G., Schröder, S., Schumacher, J., Sciutto, S. J., Shellard, R. C., Sigl, G., Silli, G., Sima, O., Šmída, R., Snow, G. R., Sommers, P., Soriano, J. F., Souchard, J., Squartini, R., Stanca, D., Stanič, S., Stasielak, J., Stassi, P., Stolpovskiy, M., Streich, A., Suarez, F., Suárez-Durán, M., Sudholz, T., Suomijärvi, T., Supanitsky, A. D., Šupík, J., Szadkowski, Z., Taboada, A., Taborda, O. A., Tapia, A., Timmermans, C., Todero Peixoto, C. J., Tomé, B., Torralba Elipe, G., Travnicek, P., Trini, M., Tueros, M., Ulrich, R., Unger, M., Urban, M., Valdés Galicia, J. F., Valiño, I., Valore, L., van Bodegom, P., van den Berg, A. M., van Vliet, A., Varela, E., Vargas Cárdenas, B., Vázquez, R. A., Veberič, D., Ventura, C., Vergara Quispe, I. D., Verzi, V., Vicha, J., Villaseñor, L., Vorobiov, S., Wahlberg, H., Wainberg, O., Wat, A. A., Weber, M., Weindl, A., Wiedeński, M., Wiencke, L., Wilczyński, H., Winchen, T., Wirtz, M., Wittkowski, D., Wundheiler, B., Yang, L., Yushkov, A., Zas, E., Zavrtanik, D., Zavrtanik, M., Zehrer, L., Zepeda, A., Zimmermann, B., Ziolkowski, M., Zong, Z., Zuccarello, F., Juryšek, J., Blažek, Ji., Trávníček, P., Mandát, D., Karpov, S., Cunniffe, R., Mašek, M., Jelínek, M., and Ebrová, I.
Subjects: Pierre Auger Observatory, High Energy Astrophysical Phenomena (astro-ph.HE), business.product_category, 010308 nuclear & particles physics, QC1-999, Physics, Atmospheric transparency, FOS: Physical sciences, Telephoto lens, Cherenkov Telescope Array, 01 natural sciences, Aerosol, law.invention, Telescope, law, Continuous use, Temporal resolution, 0103 physical sciences, ddc:530, 010306 general physics, business, Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - High Energy Astrophysical Phenomena, Instrumentation and Methods for Astrophysics (astro-ph.IM), Remote sensing
Abstract: A FRAM (F/(Ph)otometric Robotic Atmospheric Monitor) telescope is a system of a robotic mount, a large-format CCD camera and a fast telephoto lens that can be used for atmospheric monitoring at any site when information about the atmospheric transparency is required with high spatial or temporal resolution and where continuous use of laser-based methods for this purpose would interfere with other observations. The original FRAM has been operated at the Pierre Auger Observatory in Argentina for more than a decade, while three more FRAMs are foreseen to be used by the Cherenkov Telescope Array (CTA). The CTA FRAMs are being deployed ahead of time to characterize the properties of the sites prior to the operation of the CTA telescopes; one FRAM has been running on the planned future CTA site in Chile for a year while two others are expected to become operational before the end of 2018. We report on the hardware and current status of operation and/or deployment of all the FRAM instruments in question as well as on some of the preliminary results of integral aerosol measurements by the FRAMs in Argentina and Chile, Comment: Proceedings of AtmoHEAD 2018
Published: 2019

36. Voice dissatisfaction in individuals with a disorder of sex development

Author: Nygren, Ulrika, Södersten, Maria, Thyen, Ute, Köhler, Birgit, Nordenskjöld, Agneta, Cohen-Kettenis, Peggy, Vries, Annelou, Arlt, Wiebke, Wiesemann, Claudia, Slowikowska-Hilczer, Jolanta, Perriere, Aude Brac, Sultan, Charles, Paris, Francoise, Bouvattier, Claire, Reisch, Nicole, Richter-Unruh, Annette, Grinten, Hedi, Nordenström, Anna, Pienkowski, Catherine, Szarras-Czapnik, Maria, Humboldt University Of Berlin, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de Radiobiologie Cellulaire et Moléculaire (IRCM), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Humboldt-Universität zu Berlin, Medical psychology, Pediatric surgery, APH - Mental Health, and APH - Quality of Care
Subjects: Adult, Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Psychological intervention, Turner Syndrome, Gonadal dysgenesis, 030209 endocrinology & metabolism, Vocal Cords, Affect (psychology), Patient advocacy, feminization, Young Adult, 03 medical and health sciences, Klinefelter Syndrome, 0302 clinical medicine, Endocrinology, Patient satisfaction, Internal medicine, Health care, medicine, gender, Humans, Disorders of sex development, virilization, pitch, Disorder of Sex Development, 46,XY, hormones, business.industry, Sexual Development, androgens, voice, medicine.disease, 3. Good health, Distress, self-ratings, Cross-Sectional Studies, 030220 oncology & carcinogenesis, Quality of Life, Female, business, Clinical psychology
Abstract: Objective: Changes of sex hormone levels in disorders of sex development (DSD) can affect the body, including the vocal folds, during and after foetal development. The voice is a gender characteristic that may also be affected. There is a lack of knowledge on voice alteration in DSD. To explore this in different forms of DSD, we describe the prevalence of voice alterations and investigate patient satisfaction with voice. Design: The study is part of dsd-LIFE, a multicentre cross-sectional clinical evaluation project assessing the long-term outcomes of surgical, hormonal and psychological interventions in individuals with DSD. Patients: The study included 1040 individuals with different forms of DSD, that is Turner and Klinefelter syndromes, different degrees of gonadal dysgenesis and 46 XY DSD. Participants were recruited through patient advocacy groups and health care. Measurements: Satisfaction with voice, Adam's apple, if patient's self-identified gender was mistaken on the phone leading to distress. Results: A vast majority of the participants with DSD (between 58.3% to 82% in various groups) were not satisfied with their voice, and approximately 15% (n = 147) were mistaken on the phone in accordance with self-identified gender. For 102 participants, this caused distress. Conclusions: We have identified that voice problems are a cause of distress in all forms of DSD. This result needs to be confirmed and compared with controls. We recommend that evaluation of the voice should be included in future international guidelines for management of DSD.
Published: 2019
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37. Single frequency semiconductor laser exploiting the concept of Parity-Time symmetry

Author: Henri Benisty, V. Brac la de Perriere, Anatole Lupu, Abderrahim Ramdane, and Quentin Gaimard
Subjects: Physics, business.industry, Physics::Optics, Parity (physics), 02 engineering and technology, 021001 nanoscience & nanotechnology, Laser, law.invention, Optical reflection, Semiconductor laser theory, 020210 optoelectronics & photonics, Semiconductor, Optics, Fiber Bragg grating, law, 0202 electrical engineering, electronic engineering, information engineering, 0210 nano-technology, business, Refractive index, Coherence (physics)
Abstract: The principle of gain-loss modulation lying in the heart of Parity-Time symmetric optics is exploited for realization of single frequency DFB lasers. Due to the “unidirectional” gain discrimination mechanism induced by the complex refractive index Bragg grating, it is expected that the coherence of such a laser would be highly tolerant with respect to the optical feedback.
Published: 2018
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38. Understanding waveguide-based architecture and ways to robust monolithic optical combiner for smart glasses

Author: Vincent Brac de la Perrière
Subjects: Fabrication, Computer science, business.industry, ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION, Holography, Electrical engineering, Virtual reality, Collimated light, law.invention, Small form factor, Sight, law, Augmented reality, business, Waveguide
Abstract: With the emergence of Augmented Reality (AR) and Virtual Reality (VR) headset during the past decade, firms and academic laboratory have worked on the design of optical combiners to increase the performances and form factor of the optical combiners. Most of the smart glasses on the market have the asset of being small, which eases the integration of the combiner in a head worn device. Most of them (Google glass, Vusix) use prism-like architecture, where the collimation and deflection of the light is performed by one single optical piece. This approach reduces the size and tolerance issues of the device. Other companies (Optinvent, Microsoft, Lumus) came with waveguide architecture, in which the light is collimated by a lens or group of lens, injected in a slab waveguide and extracted in front of the eye of the user. This way, the image is brought right in front of the eye, where prism like architecture displays an image in the peripheral sight of the user. These optical combiners however suffer from low tolerances and fabrication complexity as several pieces are combined. The injection and extraction of image rays in the waveguide can be performed either by holograms or slanted mirrors. Each technology has its downturns but for now the performances of holographic combiners were deceiving, resulting in chromatic dispersion and thus degradation of MTF. This paper relates the work on a waveguide-type optical architecture designed for smart glasses. The system described in this paper was conceived as a solution for smart glasses uses, for which the main concerns are the size of the eye box, adaptability, and a small form factor. Good optical performances were obtained, with a resolution of around 1.2px/arcmin, together with a large eye box.
Published: 2018
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39. Triple-A syndrome: a wide spectrum of adrenal dysfunction

Author: Florence Roucher-Boulez, Michel Pugeat, Christophe Vial, Aude Jacquez, Laurence Guignat, Gerald Raverot, Yves Morel, Marc Nicolino, Aude Brac de la Perriere, Delphine Chau, Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN), Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National de la Recherche Agronomique (INRA), Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hospices Civils de Lyon (HCL)
Subjects: Male, Endocrinology, Diabetes and Metabolism, [SDV]Life Sciences [q-bio], Alacrima, Cohort Studies, Basal (phylogenetics), 0302 clinical medicine, Endocrinology, Renin, Child, Aldosterone, defects, Dehydroepiandrosterone Sulfate, Peripheral Nervous System Diseases, General Medicine, deficiency, Middle Aged, families, Prognosis, 3. Good health, achalasia, Phenotype, medicine.anatomical_structure, Disease Progression, Female, France, patient, Glucocorticoid, medicine.drug, wd-repeat protein, Adult, medicine.medical_specialty, Allgrove Syndrome, Adolescent, medicine.drug_class, Nerve Tissue Proteins, 030209 endocrinology & metabolism, Triple-A syndrome, allgrove syndrome, Young Adult, 03 medical and health sciences, Endocrinology & Metabolism, Adrenocorticotropic Hormone, Zona fasciculata, Internal medicine, medicine, Adrenal insufficiency, Humans, aaas gene, Glucocorticoids, Aged, Retrospective Studies, business.industry, medicine.disease, Zona Reticularis, Esophageal Achalasia, Nuclear Pore Complex Proteins, insufficiency, Mineralocorticoid, Zona Fasciculata, mutation, Cognition Disorders, business, 030217 neurology & neurosurgery, Adrenal Insufficiency
Abstract: Objective Triple-A or Allgrove syndrome is an autosomal recessive disorder due to mutations in the AAAS gene, which encodes a nucleoporin named ALADIN. It is characterized by a classical clinical triad: alacrima, achalasia and adrenal insufficiency, the canonic symptoms that are associated with progressive peripheral neuropathy. Only a few cohorts have been reported. The objective of the present study was to characterize the various spectra of adrenal function in Triple-A patients. Methods A retrospective clinical and biological monitoring of 14 patients (10 families) was done in a single multidisciplinary French center. All had AAAS gene sequenced and adrenal function evaluation. Results Nine different AAAS mutations were found, including one new mutation: c.755G>C, p.(Trp252Ser). Regarding adrenal function, defects of the zona fasciculata and reticularis were demonstrated by increased basal ACTH levels and low DHEAS levels in all cases regardless of the degree of glucocorticoid deficiency. In contrast, mineralocorticoid function was always conserved: i.e., normal plasma renin level associated with normal aldosterone level. The main prognostic feature was exacerbation of neuropathy and cognitive disorders. Conclusions These data suggest that, in Triple-A patients, adrenal function can be deficient, insufficient or compensated. In our cohort after the first decade of life, there does not appear to be any degradation of adrenal function over time. However, patients with compensated adrenal function should be informed and educated to manage a glucocorticoid replacement therapy in case of stressful conditions, with no need for systematic long-term treatment.
Published: 2018
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40. Religious Donations, Ritual Offerings, and Humanitarian Aid: Fields of Practice According to Forms of Giving in Burma

Author: Bénédicte Brac de la Perrière
Subjects: 060303 religions & theology, 060101 anthropology, Humanitarian aid, business.industry, Buddhism, Religious studies, Gender studies, 06 humanities and the arts, 0603 philosophy, ethics and religion, language.human_language, Burmese, Context analysis, Donation, Ethnography, language, 0601 history and archaeology, business, Psychology, Database transaction, Social psychology, Reciprocity (cultural anthropology)
Abstract: In this paper, the religious donation–meaning oriented interactions that occur between a lay donor and his or her monastic recipient or between laypeople and religious institutions as a whole–is first examined in the Burmese Buddhist context, in regard to the Maussian theory of the gift. The formal analysis of ‘serving rice’ to monks during their daily alms tour, the main form of religious donation, demonstrates that it is in keeping with the definition of a free gift rather than involving reciprocity, although it is supposed to be rewarded by merit through an impersonal process. Then, moving from a formal analysis of the ethnography of religious donation (ahlu) to the contextual analysis of the differentiated uses of various forms of giving in contemporary Burma, the discussion aims at highlighting differences with practices of ‘ritual offering’ (kadaw bwe) and ‘humanitarian aid’(ke hse yay) showing how these different forms of interaction shape contrasted fields of practice. The transaction occurring in religious donations then emerges as setting into motion a crucial social process, the enactment and reproduction of the difference in status between monastics and laypeople that is one of the main social processes contributing to the differentiation of a Buddhist-defined ‘religious field’.
Published: 2015
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41. The 1995 Inc. 500 almanac

Author: Kerr, John and Selph, Brac
Subjects: Corporations -- Statistics -- Analysis, Business, general, Business
Abstract: The Vital Statistics Average 1994 revenues $22,906,000 Average number of employees 118.7 Average age of company (in years) 8.7 Median 1994 revenues $8,873,000 Median 1994 profitability range 1%-5% Median amount [...]
Published: 1995

42. Gonadal function in adult male patients with congenital adrenal hyperplasia

Author: M Engels, K Gehrmann, H Falhammar, E A Webb, A Nordenström, F C Sweep, P N Span, A E van Herwaarden, J Rohayem, A Richter-Unruh, C Bouvattier, B Köhler, B B Kortmann, W Arlt, N Roeleveld, N Reisch, N M M L Stikkelbroeck, H L Claahsen-van der Grinten, Peggy Cohen-Kettenis, Annelou de Vries, Claudia Wiesemann, Jolanta Slowikowska-Hilczer, Aude Brac de la Perriere, Charles Sultan, Francoise Paris, Ute Thyen, Catherine Pienkowski, and Maria Szarras-Czapnik
Subjects: Male, Endocrinology, Diabetes and Metabolism, 0302 clinical medicine, Endocrinology, Hydroxyprogesterones, Odds Ratio, Prevalence, Medicine, Testosterone, Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17], 030219 obstetrics & reproductive medicine, Sperm Count, medicine.diagnostic_test, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], General Medicine, Middle Aged, Women's cancers Radboud Institute for Health Sciences [Radboudumc 17], Europe, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Sperm Motility, Gonadotropin, Adult, medicine.medical_specialty, Adolescent, medicine.drug_class, 030209 endocrinology & metabolism, Context (language use), Semen analysis, Young Adult, 03 medical and health sciences, All institutes and research themes of the Radboud University Medical Center, Testicular Neoplasms, Internal medicine, Adrenal Rest Tumor, Humans, Congenital adrenal hyperplasia, Androstenedione, Aged, Adrenal Hyperplasia, Congenital, business.industry, Hypogonadism, Oligospermia, Odds ratio, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Semen Analysis, Cross-Sectional Studies, Testicular adrenal rest tumor, business, Gonadotropins
Abstract: Context Current knowledge on gonadal function in congenital adrenal hyperplasia (CAH) is mostly limited to single-center/country studies enrolling small patient numbers. Overall data indicate that gonadal function can be compromised in men with CAH. Objective To determine gonadal function in men with CAH within the European ‘dsd-LIFE’ cohort. Design Cross-sectional clinical outcome study, including retrospective data from medical records. Methods Fourteen academic hospitals included 121 men with CAH aged 16–68 years. Main outcome measures were serum hormone concentrations, semen parameters and imaging data of the testes. Results At the time of assessment, 14/69 patients had a serum testosterone concentration below the reference range; 7 of those were hypogonadotropic, 6 normogonadotropic and 1 hypergonadotropic. In contrast, among the patients with normal serum testosterone (55/69), 4 were hypogonadotropic, 44 normogonadotropic and 7 hypergonadotropic. The association of decreased testosterone with reduced gonadotropin concentrations (odds ratio (OR) = 12.8 (2.9–57.3)) was weaker than the association between serum androstenedione/testosterone ratio ≥1 and reduced gonadotropin concentrations (OR = 39.3 (2.1–732.4)). Evaluation of sperm quality revealed decreased sperm concentrations (15/39), motility (13/37) and abnormal morphology (4/28). Testicular adrenal rest tumor (TART)s were present in 39/80 patients, with a higher prevalence in patients with the most severe genotype (14/18) and in patients with increased current 17-hydroxyprogesterone 20/35) or androstenedione (12/18) serum concentrations. Forty-three children were fathered by 26/113 patients. Conclusions Men with CAH have a high risk of developing hypothalamic-pituitary-gonadal disturbances and spermatogenic abnormalities. Regular assessment of endocrine gonadal function and imaging for TART development are recommended, in addition to measures for fertility protection.
Published: 2018

43. Active functional devices using parity-time symmetry optics (Conference Presentation)

Author: Henri Benisty, Vincent Brac de la Perrière, Abderrahim Ramdane, and Anatole Lupu
Subjects: Physics, business.industry, Antisymmetric relation, Physics::Optics, Metamaterial, 01 natural sciences, Waveguide (optics), Optical switch, 010309 optics, Resonator, Optics, Fiber Bragg grating, 0103 physical sciences, Optoelectronics, Photonics, 010306 general physics, business, Photonic crystal
Abstract: The progress of nanotechnologies has triggered the emergence of many photonic artificial structures: photonic crystals, metamaterials, plasmonic resonators. Recently the intriguing class of PT-symmetric devices, referring to Parity-Time symmetry [1] has attracted much attention. The characteristic feature of PT-symmetry is that the structures' refractive index profile is complex-valued due to the presence of alternating gain and loss regions in the system. Apart from fundamental research motivations, the tremendous interest in these artificial systems is strongly driven by the practical outcomes expected to foster a new generation of tunable, reconfigurable and non-reciprocal devices. The principle of gain-loss modulation lying in the heart of PT-symmetry optics enables a range of innovative solutions in the field of integrated optics at 1.5μm [2-7]. By using PT-symmetric coupled waveguides and Bragg reflectors as fundamental building blocks, it is possible to build a wide variety of functional optical devices. The PT-symmetry principle provides an alternative way for the realization of active devices that could become functional in a new platform for integrated optics. For instance one major bottleneck of the III-V/Si hybrid integration approach is that each type of active devices (laser, modulator, etc) requires a specific composition of III-V semiconductor alloy, involving a variety of (re)growth challenges. The advantage of the PT-symmetry solution is that the fabrication of all these devices can be done with a single stack of III-V semiconductor alloys that greatly simplifies the technological process. The aim of the current contribution is to provide a survey of the most promising applications of PT-symmetry in photonics with a particular emphases on the transition from theoretical concepts to experimental devices. The intention is to draw attention to the risks and issues related to the practical implementation that are most often overlooked in the basic theoretical models. An analysis of solutions to circumvent or overcome these issues to achieve a proper devices operation will be presented. Preliminary results on the experimental realization of PT symmetric structures using III-V's technology will be communicated. [1] C. M. Bender and S. Boettcher, “Real spectra in non-Hermitian Hamiltonians having PT-symmetry,” Phys. Rev. Lett. 80, 5243 (1998). [2] J. Ctyroký, V. Kuzmiak, and S. Eyderman, “Waveguide structures with antisymmetric gain/loss profile,” Opt. Express 18, 21585-21593 (2010). [3] A. Lupu, H. Benisty, A. Degiron, “Switching using PT symmetry in plasmonic systems: positive role of the losses,” Opt. Express 21, 21651-21668 (2013). [4] S. Phang, A. Vukovic, H. Susanto, T. M. Benson, and Ph. Sewell, “Ultrafast optical switching using parity-time symmetric Bragg gratings. J. Opt. Soc. Am. B 30, 2984 (2013). [5] H. Benisty, A. Lupu, A. Degiron, “Transverse periodic PT symmetry for modal demultiplexing in optical waveguides,” Phys. Rev. A 91, 053825 (2015). [6] S. Phang, A. Vukovic, S. C. Creagh, P. D. Sewell, G. Gradoni, T. M. Benson, T. M. “Localized Single Frequency Lasing States in a Finite Parity-Time Symmetric Resonator Chain,” Scientific Reports, 6, 20499 (2016). [7] A. Lupu, H. Benisty, A. Lavrinenko, “Tailoring spectral properties of binary PT-symmetric gratings by using duty cycle methods,” JSTQE 22, 35-41 (2016).
Published: 2017
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44. Gemcitabine as second-line chemotherapy after Folfirinox failure in advanced pancreatic adenocarcinoma: A retrospective study

Author: Astrid Lièvre, Samuel Le Sourd, Anaïs Bodere, Bérengère Leconte, Marc Pracht, Julien Edeline, Estelle Le Pabic, Pascal Artru, Clémence Brac, Juliette Viaud, CHU Pontchaillou [Rennes], Service d'oncologie médicale, CRLCC Eugène Marquis (CRLCC), Hôpital privé Jean Mermoz, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies de l'Appareil Digestif, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies de l'Appareil Digestif [CHU Rennes], Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), and Jonchère, Laurent
Subjects: Oncology, Male, FOLFIRINOX, medicine.medical_treatment, Deoxycytidine, 0302 clinical medicine, Medicine, Advanced pancreatic cancer, Aged, 80 and over, second-line chemotherapy, Gastroenterology, gemcitabine, Middle Aged, 3. Good health, Tolerability, Fluorouracil, 030220 oncology & carcinogenesis, Disease Progression, Folfirinox, 030211 gastroenterology & hepatology, Female, France, medicine.drug, Adult, medicine.medical_specialty, Antimetabolites, Antineoplastic, [SDV.SP.MED] Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Drug-Related Side Effects and Adverse Reactions, [SDV.CAN]Life Sciences [q-bio]/Cancer, Adenocarcinoma, 03 medical and health sciences, [SDV.CAN] Life Sciences [q-bio]/Cancer, [SDV.SP.MED]Life Sciences [q-bio]/Pharmaceutical sciences/Medication, Internal medicine, Humans, Survival analysis, Aged, Retrospective Studies, Chemotherapy, Hepatology, Performance status, business.industry, [SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Survival Analysis, Gemcitabine, [SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology, Discontinuation, Pancreatic Neoplasms, Multivariate Analysis, business
Abstract: International audience; BACKGROUND: Pancreatic adenocarcinoma (PA) is diagnosed in most cases at an advanced stage requiring chemotherapy. Folfirinox is the standard first-line treatment. After Folfirinox failure, gemcitabine alone is routinely used as second-line therapy without data supporting this attitude.AIM: Determine the response rate and outcome of patients with advanced PA treated with gemcitabine after Folfirinox failure.METHODS: We retrospectively analyzed all consecutive patients treated with gemcitabine after Folfirinox failure for a locally advanced or metastatic PA between 2009 and 2015. Progression-free survival (PFS) and overall survival (OS) were calculated using the Kaplan-Meier method. Response rate, control rate and tolerability were assessed.RESULTS: 96 patients were included (male, 51%; median age, 62; performance status (PS) 0-1, 47%). Median duration on gemcitabine was 2.1 months. The overall disease control rate was 40%. Median OS was 3.7 months (95%CI: 2.5-5.2) and median PFS was 2.1 months (95%CI: 2.0-2.6). Reasons for treatment discontinuation were mostly progression (51%). Age at diagnosis and PS were independently associated with OS in multivariate analysis (HR of 1.86; p=0.0055 and 2.42; p
Published: 2017
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45. Hormone therapy and patient satisfaction with treatment, in a large cohort of diverse disorders of sex development

Author: Peggy T. Cohen-Kettenis, Robert Röhle, Nicole Reisch, Claire Bouvattier, Hedi Claahsen van der Grinten, Ute Thyen, Jolanta Słowikowska-Hilczer, Aude Brac de la Perriere, Anna Nordenström, Birgit Köhler, Medical psychology, Pediatric surgery, APH - Mental Health, and APH - Quality of Care
Subjects: Adult, Male, medicine.medical_specialty, Pediatrics, Adolescent, medicine.drug_class, Hormone Replacement Therapy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Disorders of Sex Development, 030209 endocrinology & metabolism, Medication Adherence, Cohort Studies, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, 0302 clinical medicine, Endocrinology, Patient satisfaction, Internal medicine, Turner syndrome, Medicine, Humans, Testosterone, business.industry, Information Dissemination, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], medicine.disease, Europe, Transgender hormone therapy, Patient Satisfaction, 030220 oncology & carcinogenesis, Cohort, Female, Hormone therapy, Klinefelter syndrome, business, Progestin
Abstract: Objectives: To describe and investigate the hormone treatments in individuals with different forms of disorders of sex development (DSD) and the patients' own views on their treatment. Design: Multicentre cross-sectional clinical evaluation, dsd-LIFE in 6 European countries from February 2014 to September 2015. Participants: A total of 1040 adolescents and adults (≥16 years) with different DSD conditions. Main outcomes measures: Hormone replacement, information received and patient satisfaction. Results: Included were women with Turner syndrome (301), 46,XX GD (n = 20), and women with 45,X/46XY (n = 24). Individuals with Klinefelter syndrome (n = 218), 46,XX males (n = 6), individuals with different forms of 46,XY DSD (n = 243): 46,XY DSD conditions (n = 222), men with 45,X/46XY (n = 21) 46,XX CAH, (n = 226). Oestrogen ± progestin was used by 306 (81%) individuals, 72 (19%) received ethinylestradiol and 198 had testosterone treatment. The overall adherence was good, with 10% of women with oestrogen and 5% of those on testosterone had stopped the medication despite 20% reporting dissatisfaction with the treatment, mostly because of psychological side effects. Glucocorticoid replacement in patients with CAH was very seldom stopped. More than 75% were satisfied with the information about the treatment, but the satisfaction with information about treatment options and side effects was lower. Conclusions: More than 50% in the total cohort had hormone replacement. Although adherence was generally good, this study shows that hormone replacement therapy may be improved. This may be achieved by better individualization of the treatment and by providing specific information to patients regarding both long-term and short-term hormonal effects and side effects.
Published: 2017
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46. MON-PO377: Are Body Composition Parameters Associated with the Clinical Outcome of Patients with Advanced Pancreatic Cancer Receiving Fluoropyrimidine-Based Chemotherapy?

Author: Ronan Thibault, J. Viaud, L. Lacaze, C. Brac de la Perriere, M. Som, Boris Campillo-Gimenez, and Julien Edeline
Subjects: Oncology, medicine.medical_specialty, Chemotherapy, Nutrition and Dietetics, business.industry, Internal medicine, medicine.medical_treatment, Pancreatic cancer, medicine, Critical Care and Intensive Care Medicine, medicine.disease, business, Outcome (game theory)
Published: 2019
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47. Prediction Model of Alcohol Intoxication from Facial Temperature Dynamics Based on K-Means Clustering Driven by Evolutionary Computing

Author: Martin Augustynek, Clément Noel, Dominik Vilimek, Jan Kubicek, Alice Krestanova, Martin Cerny, Tomas Kantor, Bastien Faure-Brac, Marek Penhaker, Radomír Ščurek, and Eva Kotalova
Subjects: Physics and Astronomy (miscellaneous), Computer science, General Mathematics, 02 engineering and technology, evolutionary optimization, 01 natural sciences, Evolutionary computation, Set (abstract data type), Alcohol intoxication, IR image, 0202 electrical engineering, electronic engineering, information engineering, Computer Science (miscellaneous), medicine, Segmentation, alcohol intoxication, features tracking, Cluster analysis, image segmentation, business.industry, lcsh:Mathematics, 010401 analytical chemistry, Process (computing), k-means clustering, Pattern recognition, Image segmentation, lcsh:QA1-939, medicine.disease, 0104 chemical sciences, Chemistry (miscellaneous), 020201 artificial intelligence & image processing, Artificial intelligence, business, ABC
Abstract: Alcohol intoxication is a significant phenomenon, affecting many social areas, including work procedures or car driving. Alcohol causes certain side effects including changing the facial thermal distribution, which may enable the contactless identification and classification of alcohol-intoxicated people. We adopted a multiregional segmentation procedure to identify and classify symmetrical facial features, which reliably reflects the facial-temperature variations while subjects are drinking alcohol. Such a model can objectively track alcohol intoxication in the form of a facial temperature map. In our paper, we propose the segmentation model based on the clustering algorithm, which is driven by the modified version of the Artificial Bee Colony (ABC) evolutionary optimization with the goal of facial temperature features extraction from the IR (infrared radiation) images. This model allows for a definition of symmetric clusters, identifying facial temperature structures corresponding with intoxication. The ABC algorithm serves as an optimization process for an optimal cluster&rsquo, s distribution to the clustering method the best approximate individual areas linked with gradual alcohol intoxication. In our analysis, we analyzed a set of twenty volunteers, who had IR images taken to reflect the process of alcohol intoxication. The proposed method was represented by multiregional segmentation, allowing for classification of the individual spatial temperature areas into segmentation classes. The proposed method, besides single IR image modelling, allows for dynamical tracking of the alcohol-temperature features within a process of intoxication, from the sober state up to the maximum observed intoxication level.
Published: 2019
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48. Fertility outcome and information on fertility issues in individuals with different forms of disorders of sex development: findings from the dsd-LIFE study

Author: Jolanta Słowikowska-Hilczer, Angelica Lindén Hirschberg, Hedi Claahsen-van der Grinten, Nicole Reisch, Claire Bouvattier, Ute Thyen, Peggy Cohen Kettenis, Robert Roehle, Birgit Köhler, Anna Nordenström, Birgit Kohler, Peggy Cohen-Kettenis, Annelou de Vries, Wiebke Arlt, Claudia Wiesemann, Jolanta Slowikowska-Hilczer, Aude Brac de la Perriere, Charles Sultan, Francoise Paris, Annette Richter-Unruh, Anna Nordenstrom, Catherine Pienkowski, Maria Szarras-Czapnik, Medical psychology, Pediatric surgery, APH - Mental Health, APH - Quality of Care, Department of Andrology and Reproductive Endocrinology [Medical University of Łódź], Medical University of Łódź (MUL), Karolinska Institute, Stockholm University, Koordinierungszentrum für klinische Studien MUW, Humboldt-Universität zu Berlin, Department of Women's and Children's Health, Karolinska Institutet [Stockholm]-Karolinska University Hospital [Stockholm], VU medisch centrum, Department of Reproductive Endocrinology, Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Institut de recherche en cancérologie de Montpellier (IRCM - U896 Inserm - UM1), Université Montpellier 1 (UM1)-CRLCC Val d'Aurelle - Paul Lamarque-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Service d'endocrinologie pédiatrique [CHU Bicêtre], Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and Radboud University Medical Center [Nijmegen]
Subjects: Male, Parents, Health Knowledge, Attitudes, Practice, medicine.medical_treatment, Disorders of Sex Development, DSD, Outcome (game theory), 0302 clinical medicine, Pregnancy, Surveys and Questionnaires, Disorders of sex development, Medical diagnosis, media_common, 030219 obstetrics & reproductive medicine, Obstetrics and Gynecology, Vascular damage Radboud Institute for Molecular Life Sciences [Radboudumc 16], Middle Aged, 3. Good health, Europe, Phenotype, Reproductive Health, Patient Satisfaction, Cohort, Female, Infertility, Female, Adult, medicine.medical_specialty, Adolescent, Reproductive Techniques, Assisted, media_common.quotation_subject, [SDV.CAN]Life Sciences [q-bio]/Cancer, 030209 endocrinology & metabolism, Fertility, MESH: Access to Information, Access to Information, 03 medical and health sciences, Young Adult, All institutes and research themes of the Radboud University Medical Center, Patient Education as Topic, Intervention (counseling), Adoption, medicine, Humans, Congenital adrenal hyperplasia, Genetic Predisposition to Disease, Infertility, Male, Aged, Gynecology, Assisted reproductive technology, business.industry, [SDV.BDLR]Life Sciences [q-bio]/Reproductive Biology, patient views, medicine.disease, patient information, Cross-Sectional Studies, Reproductive Medicine, Family medicine, business
Abstract: International audience; OBJECTIVE:To investigate fertility outcome in individuals with different forms of disorders of sex development (DSD), if assisted reproductive technology (ART) was used, and the patients' satisfaction with the information they had received.DESIGN:A cross-sectional multicenter study, dsd-LIFE.SETTING:Not applicable.PATIENT(S):A total of 1,040 patients aged ≥16 years with different DSD diagnoses participated.INTERVENTION(S):A web-based questionnaire was filled out by all participants. The participants could chose to take part in somatic investigations including ultrasonography.MAIN OUTCOME MEASURE(S):Information on partner, number of children, ART, adoption and step-children, general health, presence of gonads and uterus, current education and economic situation, received information on fertility issues, and satisfaction with the information, was collected.RESULT(S):In the total cohort, mean age 32 years, 33% lived with a partner, but only 14% reported having at least one child including 7% with ART, 4% adopted. Only 3.5% of the total cohort had been able to reproduce without ART, most frequently women with congenital adrenal hyperplasia, and only 0.7% of participants with other diagnoses. Of the participants, 72% had received information on fertility, but 17% were not satisfied with the information.CONCLUSION(S):Fertility outcome is significantly reduced in all types of DSD; however, fertility potential should be assessed individually. The satisfaction with how fertility problems have been discussed can be improved. The care of patients with DSD is complex, should be individualized, and new treatment possibilities incorporated. A close collaboration in multidisciplinary teams is therefore essential to improve the situation for individuals with DSD.
Published: 2017
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49. Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study

Author: Kozakova, M, Natali, A, Dekker, J, Beck Nielsen, H, Laakso, M, Nilsson, P, Balkau, B, Ferrannini, E, Heine, Rj, de Rooij, S, Nijpels, G, Boorsma, W, Mitrakou, A, Tournis, S, Kyriakopoulou, K, Thomakos, P, Lalic, N, Lalic, K, Jotic, A, Lukic, L, Civcic, M, Nolan, J, Yeow, Tp, Murphy, M, Delong, C, Neary, G, Colgan, Mp, Hatunic, M, Konrad, T, Böhles, H, Fuellert, S, Baer, F, Zuchhold, H, Golay, A, Harsch Bobbioni, E, Barthassat, V, Makoundou, V, Lehmann, Tn, Merminod, T, Petrie Dundee JR, Perry, C, Neary, F, Macdougall, C, Shields, K, Malcolm, L, Salmenniemi, U, Aura, A, Raisanen, R, Ruotsalainen, U, Sistonen, T, Laitinen, M, Saloranta, H, Coppack, Sw, Mcintosh, N, Ross, J, Pettersson, L, Khadobaksh, P, Laville, M, Bonnet, F, Brac de la Perriere, A, Louche Pelissier, C, Maitrepierre, C, Peyrat, J, Beltran, S, Serusclat, A, Gabriel, R, Sánchez, Em, Carraro, R, Friera, A, Novella, B, Persson, M, Östling, G, Melander, O, Burri, P, Piatti, Pm, Monti, Ld, Setola, E, Galluccio, E, Minicucci, F, Colleluori, A, Walker, M, Ibrahim, Im, Jayapaul, M, Carman, D, Ryan, C, Short, K, Mcgrady, Y, Richardson, D, Staehr, P, Hojlund, K, Vestergaard, V, Olsen, C, Hansen, L, Bolli, Geremia Brunetto, Porcellati, Francesca, Fanelli, Carmine Giuseppe, Lucidi, Paola, Calcinaro, Filippo, Saturni, A, Muscelli, E, Pinnola, S, Mingrone, G, Guidone, C, Favuzzi, A, Di Rocco, P, Anderwald, C, Bischof, M, Promintzer, M, Krebs, M, Mandl, M, Hofer, A, Luger, A, Waldhäusl, W, Roden, M, Balkau, Dekker, Ferrannini, Mari, A, Natali, Gaffney, P, Boran, G, Kok, A, Patel, S, Gastaldelli, A, Ciociaro, D, Guillanneuf, Mt, Mhamdi, L, Mota, L, Pacini, G, Cavaggion, C, Hills, Sa, Landucci, L, Mota, L., Epidemiology and Data Science, and EMGO - Lifestyle, overweight and diabetes
Subjects: Adult, Blood Glucose, Carotid Artery Diseases, Male, medicine.medical_specialty, Adipokine, Carotid Intima-Media Thickness, Risk Assessment, Sensitivity and Specificity, Cohort Studies, Insulin resistance, Age Distribution, Adipokines, Diabetes mellitus, Internal medicine, medicine.artery, medicine, Humans, Common carotid artery, cardiovascular diseases, Sex Distribution, Retrospective Studies, business.industry, Incidence, Fatty Acids, Insulin sensitivity, Cholesterol, LDL, Glucose Tolerance Test, Middle Aged, medicine.disease, Prognosis, Endocrinology, Intima-media thickness, Cardiovascular Diseases, Cohort, Glucose Clamp Technique, cardiovascular system, Female, Insulin Resistance, Cardiology and Cardiovascular Medicine, business, Dyslipidemia
Abstract: Objective— Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated. Approach and Results— We studied a European cohort of 525 men and 655 women (mean age, 44±8 years) free of conditions known to affect carotid wall (diabetes mellitus, hypertension, and dyslipidemia). All subjects received an oral glucose tolerance test, a euglycemic hyperinsulinemic clamp (M/I as a measure of insulin sensitivity), and B-mode carotid ultrasound. In 833 participants (380 men), the carotid ultrasound was repeated after 3 years. In men, baseline intima-media thickness in the common carotid artery (CCA-IMT) was significantly higher ( P P Conclusions— In young-to-middle aged apparently healthy people, the association of CCA-IMT with insulin sensitivity and its metabolic correlates differs between men and women. Lower insulin sensitivity is associated with higher IMT only in men; this association seems to be mediated by circulating free fatty acids and adipocytokines. In women, CCA-IMT is independently associated with fasting plasma glucose.
Published: 2013
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50. Laparoscopic Treatment of a Large Gastric Pouch Following Gastric Band Slippage

Author: Jean-Philippe Lemouel, Baptiste Brac, Jean-Marc Regimbeau, and Lionel Rebibo
Subjects: Gastric pouch, Reoperation, medicine.medical_specialty, Gastroplasty, Gastric banding, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, 03 medical and health sciences, 0302 clinical medicine, stomatognathic system, Medicine, Humans, 030212 general & internal medicine, Obesity, Laparoscopy, Device Removal, Nutrition and Dietetics, medicine.diagnostic_test, business.industry, digestive, oral, and skin physiology, Stomach, Middle Aged, digestive system diseases, Surgery, Gastric band, stomatognathic diseases, Chronic Disease, Postoperative Nausea and Vomiting, Female, Pouch, Complication, business, Laparoscopic treatment, Oral feeding
Abstract: Gastric band slippage with formation of a gastric pouch is a frequent complication after gastric banding. There is no consensus on the treatment of this condition, which differs within and between centers. Here, we describe our treatment of a large gastric pouch after gastric band slippage. Despite removal of the band, the pouch caused oral feeding intolerance.The video shows our treatment of large gastric pouch following gastric banding and surgical revision. A 45-year-old woman with history of gastric banding was referred to our center for persistent oral feeding intolerance following gastric band removal.We found that a large gastric pouch was responsible for extrinsic compression and thus required revisional surgery after optimization of the patient's nutritional status. Video endoscopy revealed a large gastric pouch, which was responsible for oral feeding intolerance. Intra-operative exploration then revealed major adhesions, which had probably caused the pouch to form. During surgery that was somewhat analogous to sleeve gastrectomy, we removed the adhesions and resected the gastric pouch. The operating time was 70 min. An uneventful postoperative course enabled rapid discharge (on postoperative day 2).The formation of a large gastric pouch is a rare complication of chronic gastric band slippage. Following nutritional optimization, surgery is required.
Published: 2016

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